Abnormal reciprocal inhibition between antagonist muscles in Parkinson's disease
Identifieur interne : 003C15 ( Main/Exploration ); précédent : 003C14; suivant : 003C16Abnormal reciprocal inhibition between antagonist muscles in Parkinson's disease
Auteurs : S. Meunier [France] ; S. Pol [France] ; J. L. Houeto [France] ; M. Vidailhet [France]Source :
- Brain [ 0006-8950 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Antiparkinson Agents (therapeutic use), Electric Stimulation, Electromyography, Exploration, Female, Forearm (innervation), H-Reflex, Human, Humans, Male, Median Nerve (physiology), Median Nerve (physiopathology), Middle Aged, Motor Activity (physiology), Motor Neurons (physiology), Muscle, Skeletal (innervation), Muscle, Skeletal (physiology), Muscle, Skeletal (physiopathology), Neural Pathways (physiology), Neural Pathways (physiopathology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Radial Nerve (physiology), Radial Nerve (physiopathology), Reciprocal inhibition, Reference Values, Wrist Joint (physiology), Wrist Joint (physiopathology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents.
- drug therapy : Parkinson Disease.
- innervation : Forearm, Muscle, Skeletal.
- physiology : Median Nerve, Motor Activity, Motor Neurons, Muscle, Skeletal, Neural Pathways, Radial Nerve, Wrist Joint.
- physiopathology : Median Nerve, Muscle, Skeletal, Neural Pathways, Parkinson Disease, Radial Nerve, Wrist Joint.
- Adult, Aged, Electric Stimulation, Electromyography, Female, H-Reflex, Humans, Male, Middle Aged, Reference Values.
Abstract
Disynaptic Ia reciprocal inhibition acts, at the spinal level, by actively inhibiting antagonist motor neurons and reducing the inhibition of agonist motor neurons. The deactivation of this pathway in Parkinson's disease is still debated. Disynaptic reciprocal inhibition of H reflexes in the forearm flexor muscles was examined in 15 control subjects and 16 treated parkinsonian patients at rest and at the onset of a voluntary wrist flexion. Two patients were reassessed 18 h after withdrawal of antiparkinsonian medication. At rest, the level of Ia reciprocal inhibition between the wrist antagonist muscles was not significantly different between patients and controls. In contrast, clear abnormalities of this inhibition were revealed by voluntary movements in the patients. In normal subjects, at the onset of a wrist flexion, Ia reciprocal inhibition showed a large decrease, and we argue that this decrease is supraspinal in origin. On the less affected sides of the patients the descending modulation was still present but lower than in controls; on the more affected sides this modulation had vanished almost completely. These movement-induced abnormalities of disynaptic Ia reciprocal inhibition were closely associated with Parkinson's disease but were probably not dependent on L-dopa. They could play a role in the disturbances of precise voluntary movements observed in Parkinson's disease.
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Affiliations:
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Le document en format XML
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Meunier</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinical Neurophysiology, Réeducation, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S." last="Pol">S. Pol</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Clinical Neurophysiology, Réeducation, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J. L." last="Houeto">J. L. Houeto</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U289, Hôpital de la Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M." last="Vidailhet">M. 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The deactivation of this pathway in Parkinson's disease is still debated. Disynaptic reciprocal inhibition of H reflexes in the forearm flexor muscles was examined in 15 control subjects and 16 treated parkinsonian patients at rest and at the onset of a voluntary wrist flexion. Two patients were reassessed 18 h after withdrawal of antiparkinsonian medication. At rest, the level of Ia reciprocal inhibition between the wrist antagonist muscles was not significantly different between patients and controls. In contrast, clear abnormalities of this inhibition were revealed by voluntary movements in the patients. In normal subjects, at the onset of a wrist flexion, Ia reciprocal inhibition showed a large decrease, and we argue that this decrease is supraspinal in origin. On the less affected sides of the patients the descending modulation was still present but lower than in controls; on the more affected sides this modulation had vanished almost completely. These movement-induced abnormalities of disynaptic Ia reciprocal inhibition were closely associated with Parkinson's disease but were probably not dependent on L-dopa. They could play a role in the disturbances of precise voluntary movements observed in Parkinson's disease.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Meunier, S" sort="Meunier, S" uniqKey="Meunier S" first="S." last="Meunier">S. Meunier</name></region><name sortKey="Houeto, J L" sort="Houeto, J L" uniqKey="Houeto J" first="J. L." last="Houeto">J. L. Houeto</name><name sortKey="Pol, S" sort="Pol, S" uniqKey="Pol S" first="S." last="Pol">S. Pol</name><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M." last="Vidailhet">M. Vidailhet</name><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M." last="Vidailhet">M. Vidailhet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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