Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease
Identifieur interne : 003D62 ( Main/Exploration ); précédent : 003D61; suivant : 003D63Time course of changes in striatal dopamine transporters and D2 receptors with specific iodinated markers in a rat model of Parkinson's disease
Auteurs : Sylvie Chalon [France] ; Patrick Emond [France] ; Sylvie Bodard [France] ; Marie-Paule Vilar [France] ; Cynthia Thiercelin [France] ; Jean-Claude Besnard [France] ; Denis Guilloteau [France]Source :
- Synapse [ 0887-4476 ] ; 1999-02.
English descriptors
- KwdEn :
- 6‐hydroxydopamine, Animals, Benzamides, Carrier Proteins (metabolism), Corpus Striatum (diagnostic imaging), Dopamine (pharmacokinetics), Dopamine Antagonists (pharmacokinetics), Dopamine Plasma Membrane Transport Proteins, Iodine Radioisotopes (pharmacokinetics), Male, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Nortropanes (pharmacokinetics), Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Pyrrolidines, Radiopharmaceuticals (pharmacokinetics), Rats, Rats, Wistar, Receptors, Dopamine D2 (biosynthesis), SPET, Time Factors, Tomography, Emission-Computed, Single-Photon, dopamine, tropane derivative.
- MESH :
- chemical , biosynthesis : Receptors, Dopamine D2.
- chemical , metabolism : Carrier Proteins.
- chemical , pharmacokinetics : Dopamine, Dopamine Antagonists, Iodine Radioisotopes, Nortropanes, Radiopharmaceuticals.
- chemical : Benzamides, Dopamine Plasma Membrane Transport Proteins, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Pyrrolidines.
- diagnostic imaging : Corpus Striatum, Parkinson Disease.
- metabolism : Parkinson Disease.
- Animals, Male, Rats, Rats, Wistar, Time Factors, Tomography, Emission-Computed, Single-Photon.
Abstract
The time course of the loss in presynaptic dopamine transporters (DAT) and of the increase in postsynaptic dopamine D2 receptors (D2R) was studied in a rat model of Parkinson's disease. For this, in vitro autoradiographic experiments were performed in the striatum using (E)‐N‐(3‐iodoprop‐2‐enyl)‐2β‐carbomethoxy‐3β‐(4′‐methylphenyl) nortropane (PE2I), a new single photon emission tomography (SPET) ligand for DAT, and iodobenzamide (IBZM), a SPET ligand for D2R. A significant decrease in [125I]PE2I binding was observed as early as 24 h after 6‐hydroxydopamine lesion, whereas no change occurred in [125I]IBZM binding. At 48 h postlesion, PE2I binding was 50% decreased, while IBZM binding was 30% increased. Between 3 and 14 days postlesion, PE2I binding had almost totally disappeared and IBZM binding remained increased by around 40–50%. From these animal experiments, it can be assumed that PE2I would be very efficient for the detection of a reduction in the number of DAT reflecting neuronal loss, thus allowing early diagnosis of Parkinson's disease. The exploration of both DAT and D2R would improve follow‐up of this disease. Synapse 31:134–139, 1999. © 1999 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/(SICI)1098-2396(199902)31:2<134::AID-SYN6>3.0.CO;2-V
Affiliations:
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(metabolism)</term><term>Pyrrolidines</term><term>Radiopharmaceuticals (pharmacokinetics)</term><term>Rats</term><term>Rats, Wistar</term><term>Receptors, Dopamine D2 (biosynthesis)</term><term>SPET</term><term>Time Factors</term><term>Tomography, Emission-Computed, Single-Photon</term><term>dopamine</term><term>tropane derivative</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Receptors, Dopamine D2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carrier Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Dopamine</term><term>Dopamine Antagonists</term><term>Iodine Radioisotopes</term><term>Nortropanes</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Benzamides</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins</term><term>Nerve Tissue Proteins</term><term>Pyrrolidines</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term><term>Time Factors</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The time course of the loss in presynaptic dopamine transporters (DAT) and of the increase in postsynaptic dopamine D2 receptors (D2R) was studied in a rat model of Parkinson's disease. For this, in vitro autoradiographic experiments were performed in the striatum using (E)‐N‐(3‐iodoprop‐2‐enyl)‐2β‐carbomethoxy‐3β‐(4′‐methylphenyl) nortropane (PE2I), a new single photon emission tomography (SPET) ligand for DAT, and iodobenzamide (IBZM), a SPET ligand for D2R. A significant decrease in [125I]PE2I binding was observed as early as 24 h after 6‐hydroxydopamine lesion, whereas no change occurred in [125I]IBZM binding. At 48 h postlesion, PE2I binding was 50% decreased, while IBZM binding was 30% increased. Between 3 and 14 days postlesion, PE2I binding had almost totally disappeared and IBZM binding remained increased by around 40–50%. From these animal experiments, it can be assumed that PE2I would be very efficient for the detection of a reduction in the number of DAT reflecting neuronal loss, thus allowing early diagnosis of Parkinson's disease. The exploration of both DAT and D2R would improve follow‐up of this disease. Synapse 31:134–139, 1999. © 1999 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Centre-Val de Loire</li><li>Région Centre</li></region><settlement><li>Tours</li></settlement></list><tree><country name="France"><region name="Centre-Val de Loire"><name sortKey="Chalon, Sylvie" sort="Chalon, Sylvie" uniqKey="Chalon S" first="Sylvie" last="Chalon">Sylvie Chalon</name></region><name sortKey="Besnard, Jean Laude" sort="Besnard, Jean Laude" uniqKey="Besnard J" first="Jean-Claude" last="Besnard">Jean-Claude Besnard</name><name sortKey="Bodard, Sylvie" sort="Bodard, Sylvie" uniqKey="Bodard S" first="Sylvie" last="Bodard">Sylvie Bodard</name><name sortKey="Chalon, Sylvie" sort="Chalon, Sylvie" uniqKey="Chalon S" first="Sylvie" last="Chalon">Sylvie Chalon</name><name sortKey="Emond, Patrick" sort="Emond, Patrick" uniqKey="Emond P" first="Patrick" last="Emond">Patrick Emond</name><name sortKey="Guilloteau, Denis" sort="Guilloteau, Denis" uniqKey="Guilloteau D" first="Denis" last="Guilloteau">Denis Guilloteau</name><name sortKey="Thiercelin, Cynthia" sort="Thiercelin, Cynthia" uniqKey="Thiercelin C" first="Cynthia" last="Thiercelin">Cynthia Thiercelin</name><name sortKey="Vilar, Marie Aule" sort="Vilar, Marie Aule" uniqKey="Vilar M" first="Marie-Paule" last="Vilar">Marie-Paule Vilar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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