ParkinsonFranceV1, Main, Exploration, bibRecordById, Pascal:97-0355689

Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease : Evidence for association of a DRD2 allele

Identifieur interne : 004440 ( Main/Exploration ); précédent : 004439; suivant : 004441

Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease : Evidence for association of a DRD2 allele

Auteurs : V. Plante-Bordeneuve [France] ; D. Taussig [France] ; F. Thomas [France] ; G. Said [France] ; N. W. Wood [Royaume-Uni] ; C. D. Marsden [Royaume-Uni] ; A. E. Harding [Royaume-Uni]

Source :

Neurology [ 0028-3878 ] ; 1997.

RBID : Pascal:97-0355689

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Réaction chaîne polymérase, Gène, Amine oxidase (flavin-containing), Récepteur dopaminergique D2, Protéine transport, Exploration, Pathogénie, Homme, Dopamine, Etude comparative.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Alleles, Amine oxidase (flavin-containing), Carrier Proteins (genetics), Carrier protein, Comparative study, D2 Dopamine receptor, Dopamine, Dopamine Plasma Membrane Transport Proteins, Exploration, Family Health, Gene, Human, Humans, Membrane Glycoproteins, Membrane Transport Proteins, Monoamine Oxidase (genetics), Nerve Tissue Proteins (genetics), Parkinson Disease (genetics), Parkinson disease, Pathogenesis, Polymerase chain reaction, Polymorphism, Genetic, Receptors, Dopamine D2 (genetics).
MESH :
- chemical , genetics : Carrier Proteins, Monoamine Oxidase, Nerve Tissue Proteins, Receptors, Dopamine D2.
- genetics : Parkinson Disease.
- Alleles, Dopamine Plasma Membrane Transport Proteins, Family Health, Humans, Membrane Glycoproteins, Membrane Transport Proteins, Polymorphism, Genetic.

Abstract

Article abstract-We assessed the role of four candidate genes encoding proteins involved in dopaminergic transmission, the dopamine transporter (DAT), the dopamine receptor D2 (DRD2), and the main catabolic enzymes of dopamine, monoamine oxidase A (MAOA) and B (MAOB), through allelic association studies in a population of familial and sporadic Parkinson's disease (PD). Using intronic polymorphisms of the four candidate genes, we studied the allelic distributions of the polymorphic markers in 18 affected members, one patient was chosen randomly from each PD family; 60 sporadic PD and 60 healthy unrelated control subjects were matched for sex and for country of origin. All subjects were white. To complete the study of the DRD2, we subsequently tested 40 additional sporadic PD and 40 control patients, who were recruited using a similar procedure. For DAT, MAOA, MAOB polymorphisms, similar allelic frequencies were present in familial, sporadic PD and control patients. In contrast, at the DRD2 locus, the overall allelic distribution was significantly different in the sporadic PD ( p < 0.01) and in the familial PD groups ( p < 0.05), each was compared with the controls. The odd ratios were significant ( p < 0.01) in sporadic PD and in familial PD for allele 3 with respective values of 1.84 (95% CI, 1.23-2.74) and 2.83 (95% CI, 1.32-6.08). Individuals who were homozygous for allele 3 were 2.3 times more frequent in the sporadic PD than in controls. Results suggest that DRD2, but not DAT, MAOA and MAOB, might be a genetic determinant of PD in the population tested.

Affiliations:

Le document en format XML

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<term>Amine oxidase (flavin-containing)</term>
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<term>Carrier protein</term>
<term>Comparative study</term>
<term>D2 Dopamine receptor</term>
<term>Dopamine</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
<term>Exploration</term>
<term>Family Health</term>
<term>Gene</term>
<term>Human</term>
<term>Humans</term>
<term>Membrane Glycoproteins</term>
<term>Membrane Transport Proteins</term>
<term>Monoamine Oxidase (genetics)</term>
<term>Nerve Tissue Proteins (genetics)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson disease</term>
<term>Pathogenesis</term>
<term>Polymerase chain reaction</term>
<term>Polymorphism, Genetic</term>
<term>Receptors, Dopamine D2 (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term>
<term>Monoamine Oxidase</term>
<term>Nerve Tissue Proteins</term>
<term>Receptors, Dopamine D2</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alleles</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
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<term>Humans</term>
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<front><div type="abstract" xml:lang="en">Article abstract-We assessed the role of four candidate genes encoding proteins involved in dopaminergic transmission, the dopamine transporter (DAT), the dopamine receptor D2 (DRD2), and the main catabolic enzymes of dopamine, monoamine oxidase A (MAOA) and B (MAOB), through allelic association studies in a population of familial and sporadic Parkinson's disease (PD). Using intronic polymorphisms of the four candidate genes, we studied the allelic distributions of the polymorphic markers in 18 affected members, one patient was chosen randomly from each PD family; 60 sporadic PD and 60 healthy unrelated control subjects were matched for sex and for country of origin. All subjects were white. To complete the study of the DRD2, we subsequently tested 40 additional sporadic PD and 40 control patients, who were recruited using a similar procedure. For DAT, MAOA, MAOB polymorphisms, similar allelic frequencies were present in familial, sporadic PD and control patients. In contrast, at the DRD2 locus, the overall allelic distribution was significantly different in the sporadic PD ( p < 0.01) and in the familial PD groups ( p < 0.05), each was compared with the controls. The odd ratios were significant ( p < 0.01) in sporadic PD and in familial PD for allele 3 with respective values of 1.84 (95% CI, 1.23-2.74) and 2.83 (95% CI, 1.32-6.08). Individuals who were homozygous for allele 3 were 2.3 times more frequent in the sporadic PD than in controls. Results suggest that DRD2, but not DAT, MAOA and MAOB, might be a genetic determinant of PD in the population tested.</div>
</front>
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<li>Royaume-Uni</li>
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La maladie de Parkinson en France (serveur d'exploration)

Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease : Evidence for association of a DRD2 allele

Evaluation of four candidate genes encoding proteins of the dopamine pathway in familial and sporadic Parkinson's disease : Evidence for association of a DRD2 allele

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Descripteurs français

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson en France (serveur d'exploration)
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