Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson’s disease
Identifieur interne : 002E78 ( Main/Exploration ); précédent : 002E77; suivant : 002E79Subthalamic nucleus stimulation induces deficits in decoding emotional facial expressions in Parkinson’s disease
Auteurs : K. Dujardin [France] ; S. Blairy [Belgique] ; L. Defebvre [France] ; P. Krystkowiak [France] ; U. Hess [Canada] ; S. Blond [France] ; A. Destée [France]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 2004-02.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- AC, anterior commissure, AMDP-AT, Association of Methodology and Documentation in Psychiatry-anxiety, Affect, Aphasia (diagnosis), Aphasia (etiology), Basal Ganglia (physiopathology), Cognition Disorders (diagnosis), Cognition Disorders (etiology), DRS, dementia rating scale, EFE, emotional facial expression, Electric Stimulation Therapy (adverse effects), Electric Stimulation Therapy (instrumentation), Electrodes, Implanted, Facial Expression, Facial expression, Female, Functional Laterality (physiology), Humans, MADRS, Montgomery and Asberg dementia rating scale, MMSE, mini-mental state examination, Male, Middle Aged, Nervous system diseases, Neuropsychological Tests, PC, posterior commissure, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Parkinson’s disease, Perceptual Disorders (diagnosis), Perceptual Disorders (etiology), STN stimulation, STN, subthalamic nucleus, Severity of Illness Index, Subthalamic Nucleus (physiology), Subthalamic nucleus, UPDRS, unified Parkinson’s disease rating scale, Visual Perception, WAIS-R, Wechsler adult intelligence scale, revised, emotion processing, limbic system.
- MESH :
- adverse effects : Electric Stimulation Therapy.
- diagnosis : Aphasia, Cognition Disorders, Parkinson Disease, Perceptual Disorders.
- etiology : Aphasia, Cognition Disorders, Perceptual Disorders.
- instrumentation : Electric Stimulation Therapy.
- physiology : Functional Laterality, Subthalamic Nucleus.
- physiopathology : Basal Ganglia, Parkinson Disease.
- therapy : Parkinson Disease.
- Affect, Electrodes, Implanted, Facial Expression, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index, Visual Perception.
Abstract
Background: Bilateral subthalamic nucleus (STN) stimulation is recognised as a treatment for parkinsonian patients with severe levodopa related motor complications. Although adverse effects are infrequent, some behavioural disturbances have been reported. Objective: To investigate the consequences of STN stimulation on emotional information processing in Parkinson’s disease by assessing the performance of an emotional facial expression (EFE) decoding task in a group of patients before and after surgery. Methods: 12 non-demented patients with Parkinson’s disease were studied. They were assessed one month before surgery and three months after. Their ability to decode EFEs was assessed using a standardised quantitative task. Overall cognitive function, executive function, visuospatial perception, depression, and anxiety were also measured. Twelve healthy controls were matched for age, sex, and duration of education. Results: Before surgery, the patients showed no impairment in EFE decoding compared with the controls. Their overall cognitive status was preserved but they had a moderate dysexecutive syndrome. Three months after surgery, they had significant impairment of EFE decoding. This was not related to their overall cognitive status or to depression/anxiety scores. Visuospatial perception was not impaired. There was no change in the extent of the dysexecutive syndrome except for a reduction in phonemic word fluency. Conclusions: Bilateral STN stimulation disturbs negative emotional information processing in Parkinson’s disease. The impairment appears specific and unrelated to certain secondary variables. This behavioural complication of STN may have implications for the patient’s social life.
Url:
- https://api.istex.fr/document/F69EDCF3B7599D713046EE000A5A2ACFA13FD967/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1738891
DOI: 10.1136/jnnp.2003.013656
Affiliations:
- Belgique, Canada, France
- Hauts-de-France, Nord-Pas-de-Calais, Québec, Région de Bruxelles-Capitale
- Bruxelles, Lille, Montréal
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<term>AMDP-AT, Association of Methodology and Documentation in Psychiatry-anxiety</term>
<term>Affect</term>
<term>Aphasia (diagnosis)</term>
<term>Aphasia (etiology)</term>
<term>Basal Ganglia (physiopathology)</term>
<term>Cognition Disorders (diagnosis)</term>
<term>Cognition Disorders (etiology)</term>
<term>DRS, dementia rating scale</term>
<term>EFE, emotional facial expression</term>
<term>Electric Stimulation Therapy (adverse effects)</term>
<term>Electric Stimulation Therapy (instrumentation)</term>
<term>Electrodes, Implanted</term>
<term>Facial Expression</term>
<term>Facial expression</term>
<term>Female</term>
<term>Functional Laterality (physiology)</term>
<term>Humans</term>
<term>MADRS, Montgomery and Asberg dementia rating scale</term>
<term>MMSE, mini-mental state examination</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>PC, posterior commissure</term>
<term>Parkinson Disease (diagnosis)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Parkinson’s disease</term>
<term>Perceptual Disorders (diagnosis)</term>
<term>Perceptual Disorders (etiology)</term>
<term>STN stimulation</term>
<term>STN, subthalamic nucleus</term>
<term>Severity of Illness Index</term>
<term>Subthalamic Nucleus (physiology)</term>
<term>Subthalamic nucleus</term>
<term>UPDRS, unified Parkinson’s disease rating scale</term>
<term>Visual Perception</term>
<term>WAIS-R, Wechsler adult intelligence scale, revised</term>
<term>emotion processing</term>
<term>limbic system</term>
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<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation Therapy</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Aphasia</term>
<term>Cognition Disorders</term>
<term>Parkinson Disease</term>
<term>Perceptual Disorders</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Aphasia</term>
<term>Cognition Disorders</term>
<term>Perceptual Disorders</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term>
<term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Affect</term>
<term>Electrodes, Implanted</term>
<term>Facial Expression</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Severity of Illness Index</term>
<term>Visual Perception</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Mimique</term>
<term>Noyau sousthalamique</term>
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<front><div type="abstract" xml:lang="en">Background: Bilateral subthalamic nucleus (STN) stimulation is recognised as a treatment for parkinsonian patients with severe levodopa related motor complications. Although adverse effects are infrequent, some behavioural disturbances have been reported. Objective: To investigate the consequences of STN stimulation on emotional information processing in Parkinson’s disease by assessing the performance of an emotional facial expression (EFE) decoding task in a group of patients before and after surgery. Methods: 12 non-demented patients with Parkinson’s disease were studied. They were assessed one month before surgery and three months after. Their ability to decode EFEs was assessed using a standardised quantitative task. Overall cognitive function, executive function, visuospatial perception, depression, and anxiety were also measured. Twelve healthy controls were matched for age, sex, and duration of education. Results: Before surgery, the patients showed no impairment in EFE decoding compared with the controls. Their overall cognitive status was preserved but they had a moderate dysexecutive syndrome. Three months after surgery, they had significant impairment of EFE decoding. This was not related to their overall cognitive status or to depression/anxiety scores. Visuospatial perception was not impaired. There was no change in the extent of the dysexecutive syndrome except for a reduction in phonemic word fluency. Conclusions: Bilateral STN stimulation disturbs negative emotional information processing in Parkinson’s disease. The impairment appears specific and unrelated to certain secondary variables. This behavioural complication of STN may have implications for the patient’s social life.</div>
</front>
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