Effect of subthalamic nucleus stimulation on obsessive-compulsive disorder in a patient with Parkinson disease
Identifieur interne : 003021 ( Main/Exploration ); précédent : 003020; suivant : 003022Effect of subthalamic nucleus stimulation on obsessive-compulsive disorder in a patient with Parkinson disease
Auteurs : Denys Fontaine [France] ; Vianney Mattei ; Michel Borg ; Daniel Von Langsdorff ; Marie-Noelle Magnie ; Stéphane Chanalet ; Philippe Robert ; Philippe PaquisSource :
- Journal of neurosurgery [ 0022-3085 ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Electric Stimulation Therapy, Human, Humans, Male, Middle Aged, Nervous system diseases, Obsessive compulsive disorder, Obsessive-Compulsive Disorder (etiology), Obsessive-Compulsive Disorder (therapy), Parkinson Disease (complications), Parkinson Disease (psychology), Parkinson Disease (therapy), Parkinson disease, Psychosurgery, Severity of Illness Index, Subthalamic Nucleus (physiology), Subthalamic nucleus, Surgery, Treatment, Treatment Outcome.
- MESH :
- complications : Parkinson Disease.
- etiology : Obsessive-Compulsive Disorder.
- physiology : Subthalamic Nucleus.
- psychology : Parkinson Disease.
- therapy : Obsessive-Compulsive Disorder, Parkinson Disease.
- Electric Stimulation Therapy, Humans, Male, Middle Aged, Severity of Illness Index, Treatment Outcome.
Abstract
The authors report on a patient with Parkinson disease (PD) and severe obsessive-compulsive disorder (OCD). in whom bilateral stimulation of the subthalamic nucleus (STN) was used to treat both PD and OCD symptoms. This 49-year-old man had displayed symptoms of PD for 13 years. Progressively, his motor disability became severe despite optimal medical treatment. In parallel, he suffered severe OCD for 16 years, with obsessions of accumulation and compulsions of gathering and rubbing that lasted more than 8 hours per day. Bilateral high-frequency STN stimulation was performed to treat motor disability. After surgery (at 1-year follow up), motor and OCD symptoms were dramatically improved. The pre- and postoperative Yale-Brown Obsessive-Compulsive Scale scores were 32 and 1, respectively. No additional antiparkinsonian drugs were administered. This case and other recent reports indicate that OCD symptoms can be improved by deep brain stimulation, a finding that opens new perspectives in the surgical treatment of severe and medically intractable OCD.
Url:
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The authors report on a patient with Parkinson disease (PD) and severe obsessive-compulsive disorder (OCD). in whom bilateral stimulation of the subthalamic nucleus (STN) was used to treat both PD and OCD symptoms. This 49-year-old man had displayed symptoms of PD for 13 years. Progressively, his motor disability became severe despite optimal medical treatment. In parallel, he suffered severe OCD for 16 years, with obsessions of accumulation and compulsions of gathering and rubbing that lasted more than 8 hours per day. Bilateral high-frequency STN stimulation was performed to treat motor disability. After surgery (at 1-year follow up), motor and OCD symptoms were dramatically improved. The pre- and postoperative Yale-Brown Obsessive-Compulsive Scale scores were 32 and 1, respectively. No additional antiparkinsonian drugs were administered. This case and other recent reports indicate that OCD symptoms can be improved by deep brain stimulation, a finding that opens new perspectives in the surgical treatment of severe and medically intractable OCD.</div>
</front>
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<tree><noCountry><name sortKey="Borg, Michel" sort="Borg, Michel" uniqKey="Borg M" first="Michel" last="Borg">Michel Borg</name>
<name sortKey="Chanalet, Stephane" sort="Chanalet, Stephane" uniqKey="Chanalet S" first="Stéphane" last="Chanalet">Stéphane Chanalet</name>
<name sortKey="Magnie, Marie Noelle" sort="Magnie, Marie Noelle" uniqKey="Magnie M" first="Marie-Noelle" last="Magnie">Marie-Noelle Magnie</name>
<name sortKey="Mattei, Vianney" sort="Mattei, Vianney" uniqKey="Mattei V" first="Vianney" last="Mattei">Vianney Mattei</name>
<name sortKey="Paquis, Philippe" sort="Paquis, Philippe" uniqKey="Paquis P" first="Philippe" last="Paquis">Philippe Paquis</name>
<name sortKey="Robert, Philippe" sort="Robert, Philippe" uniqKey="Robert P" first="Philippe" last="Robert">Philippe Robert</name>
<name sortKey="Von Langsdorff, Daniel" sort="Von Langsdorff, Daniel" uniqKey="Von Langsdorff D" first="Daniel" last="Von Langsdorff">Daniel Von Langsdorff</name>
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<country name="France"><noRegion><name sortKey="Fontaine, Denys" sort="Fontaine, Denys" uniqKey="Fontaine D" first="Denys" last="Fontaine">Denys Fontaine</name>
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