Deep Brain Stimulation for Parkinson’s Disease with Early Motor Complications: A UK Cost-Effectiveness Analysis
Identifieur interne : 000309 ( Main/Exploration ); précédent : 000308; suivant : 000310Deep Brain Stimulation for Parkinson’s Disease with Early Motor Complications: A UK Cost-Effectiveness Analysis
Auteurs : Tomasz Fundament [Pologne] ; Paul R. Eldridge [Royaume-Uni] ; Alexander L. Green [Royaume-Uni] ; Alan L. Whone [Royaume-Uni] ; Rod S. Taylor [Royaume-Uni] ; Adrian C. Williams [Royaume-Uni] ; W. M. Michael Schuepbach [Suisse, France]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
Parkinson’s disease (PD) is a debilitating illness associated with considerable impairment of quality of life and substantial costs to health care systems. Deep brain stimulation (DBS) is an established surgical treatment option for some patients with advanced PD. The EARLYSTIM trial has recently demonstrated its clinical benefit also in patients with early motor complications. We sought to evaluate the cost-effectiveness of DBS, compared to best medical therapy (BMT), among PD patients with early onset of motor complications, from a United Kingdom (UK) payer perspective.
We developed a Markov model to represent the progression of PD as rated using the Unified Parkinson's Disease Rating Scale (UPDRS) over time in patients with early PD. Evidence sources were a systematic review of clinical evidence; data from the EARLYSTIM study; and a UK Clinical Practice Research Datalink (CPRD) dataset including DBS patients. A mapping algorithm was developed to generate utility values based on UPDRS data for each intervention. The cost-effectiveness was expressed as the incremental cost per quality-adjusted life-year (QALY). One-way and probabilistic sensitivity analyses were undertaken to explore the effect of parameter uncertainty.
Over a 15-year time horizon, DBS was predicted to lead to additional mean cost per patient of £26,799 compared with BMT (£73,077/patient versus £46,278/patient) and an additional mean 1.35 QALYs (6.69 QALYs versus 5.35 QALYs), resulting in an incremental cost-effectiveness ratio of £19,887 per QALY gained with a 99% probability of DBS being cost-effective at a threshold of £30,000/QALY. One-way sensitivity analyses suggested that the results were not significantly impacted by plausible changes in the input parameter values.
These results indicate that DBS is a cost-effective intervention in PD patients with early motor complications when compared with existing interventions, offering additional health benefits at acceptable incremental cost. This supports the extended use of DBS among patients with early onset of motor complications.
Url:
DOI: 10.1371/journal.pone.0159340
PubMed: 27441637
PubMed Central: 4956248
Affiliations:
- France, Pologne, Royaume-Uni, Suisse
- Angleterre, Canton de Berne, Midlands de l'Ouest, Oxfordshire, Île-de-France
- Berne, Birmingham, Oxford, Paris
- Université d'Oxford
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Michael Schuepbach</name><affiliation wicri:level="3"><nlm:aff id="aff007"><addr-line>Movement Disorders Center, Department of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland</addr-line></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Movement Disorders Center, Department of Neurology, Bern University Hospital and University of Bern, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Assistance Publique Hôpitaux de Paris, Centre d’Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière, Département de Neurologie, Université Pierre et Marie Curie–Paris 6 et INSERM, CHU Pitié-Salpêtrière, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Assistance Publique Hôpitaux de Paris, Centre d’Investigation Clinique 9503, Institut du Cerveau et de la Moelle épinière, Département de Neurologie, Université Pierre et Marie Curie–Paris 6 et INSERM, CHU Pitié-Salpêtrière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Parkinson’s disease (PD) is a debilitating illness associated with considerable impairment of quality of life and substantial costs to health care systems. Deep brain stimulation (DBS) is an established surgical treatment option for some patients with advanced PD. The EARLYSTIM trial has recently demonstrated its clinical benefit also in patients with early motor complications. We sought to evaluate the cost-effectiveness of DBS, compared to best medical therapy (BMT), among PD patients with early onset of motor complications, from a United Kingdom (UK) payer perspective.</p></sec><sec id="sec002"><title>Methods</title><p>We developed a Markov model to represent the progression of PD as rated using the Unified Parkinson's Disease Rating Scale (UPDRS) over time in patients with early PD. Evidence sources were a systematic review of clinical evidence; data from the EARLYSTIM study; and a UK Clinical Practice Research Datalink (CPRD) dataset including DBS patients. A mapping algorithm was developed to generate utility values based on UPDRS data for each intervention. The cost-effectiveness was expressed as the incremental cost per quality-adjusted life-year (QALY). One-way and probabilistic sensitivity analyses were undertaken to explore the effect of parameter uncertainty.</p></sec><sec id="sec003"><title>Results</title><p>Over a 15-year time horizon, DBS was predicted to lead to additional mean cost per patient of £26,799 compared with BMT (£73,077/patient versus £46,278/patient) and an additional mean 1.35 QALYs (6.69 QALYs versus 5.35 QALYs), resulting in an incremental cost-effectiveness ratio of £19,887 per QALY gained with a 99% probability of DBS being cost-effective at a threshold of £30,000/QALY. One-way sensitivity analyses suggested that the results were not significantly impacted by plausible changes in the input parameter values.</p></sec><sec id="sec004"><title>Conclusion</title><p>These results indicate that DBS is a cost-effective intervention in PD patients with early motor complications when compared with existing interventions, offering additional health benefits at acceptable incremental cost. This supports the extended use of DBS among patients with early onset of motor complications.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Pringsheim, T" uniqKey="Pringsheim T">T Pringsheim</name></author><author><name sortKey="Jette, N" uniqKey="Jette N">N Jette</name></author><author><name sortKey="Frolkis, A" uniqKey="Frolkis A">A Frolkis</name></author><author><name sortKey="Steeves, Tdl" uniqKey="Steeves T">TDL Steeves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horstink, M" uniqKey="Horstink M">M Horstink</name></author><author><name sortKey="Tolosa, E" uniqKey="Tolosa E">E Tolosa</name></author><author><name sortKey="Bonuccelli, U" uniqKey="Bonuccelli U">U Bonuccelli</name></author><author><name sortKey="Deuschl, G" uniqKey="Deuschl G">G Deuschl</name></author><author><name sortKey="Friedman, A" uniqKey="Friedman A">a Friedman</name></author><author><name sortKey="Kanovsky, P" uniqKey="Kanovsky P">P Kanovsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alves, G" uniqKey="Alves G">G Alves</name></author><author><name sortKey="Wentzel Larsen, T" uniqKey="Wentzel Larsen T">T Wentzel-Larsen</name></author><author><name sortKey="Aarsland, D" uniqKey="Aarsland D">D Aarsland</name></author><author><name sortKey="Larsen, Jp" uniqKey="Larsen J">JP Larsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leibson, Cl" uniqKey="Leibson C">CL Leibson</name></author><author><name sortKey="Maraganore, Dm" uniqKey="Maraganore D">DM Maraganore</name></author><author><name sortKey="Bower, Jh" uniqKey="Bower J">JH Bower</name></author><author><name sortKey="Ransom, Je" uniqKey="Ransom J">JE Ransom</name></author><author><name sortKey="O Rien, Pc" uniqKey="O Rien P">PC O’Brien</name></author><author><name sortKey="Rocca, Wa" uniqKey="Rocca W">WA Rocca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riedel, O" uniqKey="Riedel O">O Riedel</name></author><author><name sortKey="Klotsche, J" uniqKey="Klotsche J">J Klotsche</name></author><author><name sortKey="Spottke, A" uniqKey="Spottke A">a Spottke</name></author><author><name sortKey="Deuschl, G" uniqKey="Deuschl G">G Deuschl</name></author><author><name sortKey="Forstl, H" uniqKey="Forstl H">H Förstl</name></author><author><name sortKey="Henn, F" uniqKey="Henn F">F Henn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrag, A" uniqKey="Schrag A">A Schrag</name></author><author><name sortKey="Hovris, A" uniqKey="Hovris A">A Hovris</name></author><author><name sortKey="Morley, D" uniqKey="Morley D">D Morley</name></author><author><name sortKey="Quinn, N" uniqKey="Quinn N">N Quinn</name></author><author><name sortKey="Jahanshahi, M" uniqKey="Jahanshahi M">M Jahanshahi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winter, Y" uniqKey="Winter Y">Y Winter</name></author><author><name sortKey="Von Campenhausen, S" uniqKey="Von Campenhausen S">S von Campenhausen</name></author><author><name sortKey="Popov, G" uniqKey="Popov G">G Popov</name></author><author><name sortKey="Reese, Jp" uniqKey="Reese J">JP Reese</name></author><author><name sortKey="Balzer Geldsetzer, M" uniqKey="Balzer Geldsetzer M">M Balzer-Geldsetzer</name></author><author><name sortKey="Kukshina, A" uniqKey="Kukshina A">A Kukshina</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Quittenbaum, Bh" uniqKey="Quittenbaum B">BH Quittenbaum</name></author><author><name sortKey="Grahn, B" uniqKey="Grahn B">B Grahn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Riazi, A" uniqKey="Riazi A">A Riazi</name></author><author><name sortKey="Hobart, Jc" uniqKey="Hobart J">JC Hobart</name></author><author><name sortKey="Lamping, Dl" uniqKey="Lamping D">DL Lamping</name></author><author><name sortKey="Fitzpatrick, R" uniqKey="Fitzpatrick R">R Fitzpatrick</name></author><author><name sortKey="Freeman, J A" uniqKey="Freeman J">J a Freeman</name></author><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C Jenkinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrag, A" uniqKey="Schrag A">A Schrag</name></author><author><name sortKey="Jahanshahi, M" uniqKey="Jahanshahi M">M Jahanshahi</name></author><author><name sortKey="Quinn, N" uniqKey="Quinn N">N Quinn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rahman, S" uniqKey="Rahman S">S Rahman</name></author><author><name sortKey="Griffin, Hj" uniqKey="Griffin H">HJ Griffin</name></author><author><name sortKey="Quinn, Np" uniqKey="Quinn N">NP Quinn</name></author><author><name sortKey="Jahanshahi, M" uniqKey="Jahanshahi M">M Jahanshahi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Visser, M" uniqKey="Visser M">M Visser</name></author><author><name sortKey="Van Rooden, Sm" uniqKey="Van Rooden S">SM van Rooden</name></author><author><name sortKey="Verbaan, D" uniqKey="Verbaan D">D Verbaan</name></author><author><name sortKey="Marinus, J" uniqKey="Marinus J">J Marinus</name></author><author><name sortKey="Stiggelbout, Am" uniqKey="Stiggelbout A">AM Stiggelbout</name></author><author><name sortKey="Van Hilten, Jj" uniqKey="Van Hilten J">JJ van Hilten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marras, C" uniqKey="Marras C">C Marras</name></author><author><name sortKey="Mcdermott, Mp" uniqKey="Mcdermott M">MP McDermott</name></author><author><name sortKey="Rochon, Pa" uniqKey="Rochon P">PA Rochon</name></author><author><name sortKey="Tanner, Cm" uniqKey="Tanner C">CM Tanner</name></author><author><name sortKey="Naglie, G" uniqKey="Naglie G">G Naglie</name></author><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woodford, H" uniqKey="Woodford H">H Woodford</name></author><author><name sortKey="Walker, R" uniqKey="Walker R">R Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spottke, Ae" uniqKey="Spottke A">AE Spottke</name></author><author><name sortKey="Reuter, M" uniqKey="Reuter M">M Reuter</name></author><author><name sortKey="Machat, O" uniqKey="Machat O">O Machat</name></author><author><name sortKey="Bornschein, B" uniqKey="Bornschein B">B Bornschein</name></author><author><name sortKey="Von Campenhausen, S" uniqKey="Von Campenhausen S">S Von Campenhausen</name></author><author><name sortKey="Berger, K" uniqKey="Berger K">K Berger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Findley, L" uniqKey="Findley L">L Findley</name></author><author><name sortKey="Aujla, M" uniqKey="Aujla M">M Aujla</name></author><author><name sortKey="Bain, Pg" uniqKey="Bain P">PG Bain</name></author><author><name sortKey="Baker, M" uniqKey="Baker M">M Baker</name></author><author><name sortKey="Beech, C" uniqKey="Beech C">C Beech</name></author><author><name sortKey="Bowman, C" uniqKey="Bowman C">C Bowman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dengler, I" uniqKey="Dengler I">I Dengler</name></author><author><name sortKey="Leukel, N" uniqKey="Leukel N">N Leukel</name></author><author><name sortKey="Meuser, T" uniqKey="Meuser T">T Meuser</name></author><author><name sortKey="Jost, Wh" uniqKey="Jost W">WH Jost</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vossius, C" uniqKey="Vossius C">C Vossius</name></author><author><name sortKey="Gjerstad, M" uniqKey="Gjerstad M">M Gjerstad</name></author><author><name sortKey="Baas, H" uniqKey="Baas H">H Baas</name></author><author><name sortKey="Larsen, Jp" uniqKey="Larsen J">JP Larsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pechevis, M" uniqKey="Pechevis M">M Péchevis</name></author><author><name sortKey="Clarke, Ce" uniqKey="Clarke C">CE Clarke</name></author><author><name sortKey="Vieregge, P" uniqKey="Vieregge P">P Vieregge</name></author><author><name sortKey="Khoshnood, B" uniqKey="Khoshnood B">B Khoshnood</name></author><author><name sortKey="Deschaseaux Voinet, C" uniqKey="Deschaseaux Voinet C">C Deschaseaux-Voinet</name></author><author><name sortKey="Berdeaux, G" uniqKey="Berdeaux G">G Berdeaux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dodel, Rc" uniqKey="Dodel R">RC Dodel</name></author><author><name sortKey="Singer, M" uniqKey="Singer M">M Singer</name></author><author><name sortKey="Kohne Volland, R" uniqKey="Kohne Volland R">R Köhne-Volland</name></author><author><name sortKey="Szucs, T" uniqKey="Szucs T">T Szucs</name></author><author><name sortKey="Rathay, B" uniqKey="Rathay B">B Rathay</name></author><author><name sortKey="Scholz, E" uniqKey="Scholz E">E Scholz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccrone, P" uniqKey="Mccrone P">P McCrone</name></author><author><name sortKey="Allcock, Lm" uniqKey="Allcock L">LM Allcock</name></author><author><name sortKey="Burn, Dj" uniqKey="Burn D">DJ Burn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ker Nen, T" uniqKey="Ker Nen T">T Keränen</name></author><author><name sortKey="Kaakkola, S" uniqKey="Kaakkola S">S Kaakkola</name></author><author><name sortKey="Sotaniemi, K" uniqKey="Sotaniemi K">K Sotaniemi</name></author><author><name sortKey="Laulumaa, V" uniqKey="Laulumaa V">V Laulumaa</name></author><author><name sortKey="Haapaniemi, T" uniqKey="Haapaniemi T">T Haapaniemi</name></author><author><name sortKey="Jolma, T" uniqKey="Jolma T">T Jolma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maurel, F" uniqKey="Maurel F">F Maurel</name></author><author><name sortKey="Lilliu, H" uniqKey="Lilliu H">H Lilliu</name></author><author><name sortKey="Le Pen, C" uniqKey="Le Pen C">C Le Pen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schrag, A" uniqKey="Schrag A">A Schrag</name></author><author><name sortKey="Banks, P" uniqKey="Banks P">P Banks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hagell, P" uniqKey="Hagell P">P Hagell</name></author><author><name sortKey="Nordling, S" uniqKey="Nordling S">S Nordling</name></author><author><name sortKey="Reimer, J" uniqKey="Reimer J">J Reimer</name></author><author><name sortKey="Grabowski, M" uniqKey="Grabowski M">M Grabowski</name></author><author><name sortKey="Persson, U" uniqKey="Persson U">U Persson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Deuschl, G" uniqKey="Deuschl G">G Deuschl</name></author><author><name sortKey="Schade Brittinger, C" uniqKey="Schade Brittinger C">C Schade-Brittinger</name></author><author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name></author><author><name sortKey="Volkmann, J" uniqKey="Volkmann J">J Volkmann</name></author><author><name sortKey="Sch Fer, H" uniqKey="Sch Fer H">H Schäfer</name></author><author><name sortKey="Botzel, K" uniqKey="Botzel K">K Bötzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weaver, F" uniqKey="Weaver F">F Weaver</name></author><author><name sortKey="Follett, K" uniqKey="Follett K">K Follett</name></author><author><name sortKey="Stern, M" uniqKey="Stern M">M Stern</name></author><author><name sortKey="Hur, K" uniqKey="Hur K">K Hur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams, A" uniqKey="Williams A">A Williams</name></author><author><name sortKey="Gill, S" uniqKey="Gill S">S Gill</name></author><author><name sortKey="Varma, T" uniqKey="Varma T">T Varma</name></author><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C Jenkinson</name></author><author><name sortKey="Quinn, N" uniqKey="Quinn N">N Quinn</name></author><author><name sortKey="Mitchell, R" uniqKey="Mitchell R">R Mitchell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dams, J" uniqKey="Dams J">J Dams</name></author><author><name sortKey="Siebert, U" uniqKey="Siebert U">U Siebert</name></author><author><name sortKey="Bornschein, B" uniqKey="Bornschein B">B Bornschein</name></author><author><name sortKey="Volkmann, J" uniqKey="Volkmann J">J Volkmann</name></author><author><name sortKey="Deuschl, G" uniqKey="Deuschl G">G Deuschl</name></author><author><name sortKey="Oertel, Wh" uniqKey="Oertel W">WH Oertel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eggington, S" uniqKey="Eggington S">S Eggington</name></author><author><name sortKey="Valldeoriola, F" uniqKey="Valldeoriola F">F Valldeoriola</name></author><author><name sortKey="Chaudhuri, Kr" uniqKey="Chaudhuri K">KR Chaudhuri</name></author><author><name sortKey="Ashkan, K" uniqKey="Ashkan K">K Ashkan</name></author><author><name sortKey="Annoni, E" uniqKey="Annoni E">E Annoni</name></author><author><name sortKey="Deuschl, G" uniqKey="Deuschl G">G Deuschl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valldeoriola, F" uniqKey="Valldeoriola F">F Valldeoriola</name></author><author><name sortKey="Morsi, O" uniqKey="Morsi O">O Morsi</name></author><author><name sortKey="Tolosa, E" uniqKey="Tolosa E">E Tolosa</name></author><author><name sortKey="Rumia, J" uniqKey="Rumia J">J Rumià</name></author><author><name sortKey="Marti, Mj" uniqKey="Marti M">MJ Martí</name></author><author><name sortKey="Martinez Martin, P" uniqKey="Martinez Martin P">P Martínez-Martín</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Schuepbach, Wmm" uniqKey="Schuepbach W">WMM Schuepbach</name></author><author><name sortKey="Rau, J" uniqKey="Rau J">J Rau</name></author><author><name sortKey="Knudsen, K" uniqKey="Knudsen K">K Knudsen</name></author><author><name sortKey="Volkmann, J" uniqKey="Volkmann J">J Volkmann</name></author><author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name></author><author><name sortKey="Timmermann, L" uniqKey="Timmermann L">L Timmermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuepbach, Wmm" uniqKey="Schuepbach W">WMM Schuepbach</name></author><author><name sortKey="Maltete, D" uniqKey="Maltete D">D Maltête</name></author><author><name sortKey="Houeto, Jl" uniqKey="Houeto J">JL Houeto</name></author><author><name sortKey="Du Montcel, St" uniqKey="Du Montcel S">ST Du Montcel</name></author><author><name sortKey="Mallet, L" uniqKey="Mallet L">L Mallet</name></author><author><name sortKey="Welter, Ml" uniqKey="Welter M">ML Welter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caro, Jj" uniqKey="Caro J">JJ Caro</name></author><author><name sortKey="Briggs, Ah" uniqKey="Briggs A">AH Briggs</name></author><author><name sortKey="Siebert, U" uniqKey="Siebert U">U Siebert</name></author><author><name sortKey="Kuntz, Km" uniqKey="Kuntz K">KM Kuntz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siebert, U" uniqKey="Siebert U">U Siebert</name></author><author><name sortKey="Alagoz, O" uniqKey="Alagoz O">O Alagoz</name></author><author><name sortKey="Bayoumi, Am" uniqKey="Bayoumi A">AM Bayoumi</name></author><author><name sortKey="Jahn, B" uniqKey="Jahn B">B Jahn</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author><author><name sortKey="Leinonen, M" uniqKey="Leinonen M">M Leinonen</name></author><author><name sortKey="Kuoppam Ki, M" uniqKey="Kuoppam Ki M">M Kuoppamäki</name></author><author><name sortKey="Nissinen, H" uniqKey="Nissinen H">H Nissinen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jankovic, J" uniqKey="Jankovic J">J Jankovic</name></author><author><name sortKey="Kapadia, As" uniqKey="Kapadia A">AS Kapadia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewitt, Pa" uniqKey="Lewitt P">PA LeWitt</name></author><author><name sortKey="Boroojerdi, B" uniqKey="Boroojerdi B">B Boroojerdi</name></author><author><name sortKey="Surmann, E" uniqKey="Surmann E">E Surmann</name></author><author><name sortKey="Poewe, W" uniqKey="Poewe W">W Poewe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reinoso, G" uniqKey="Reinoso G">G Reinoso</name></author><author><name sortKey="Allen, Jc" uniqKey="Allen J">JC Allen</name></author><author><name sortKey="Au, W L" uniqKey="Au W">W-L Au</name></author><author><name sortKey="Seah, S H" uniqKey="Seah S">S-H Seah</name></author><author><name sortKey="Tay, K Y" uniqKey="Tay K">K-Y Tay</name></author><author><name sortKey="Tan, Lcs" uniqKey="Tan L">LCS Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name></author><author><name sortKey="Batir, A" uniqKey="Batir A">A Batir</name></author><author><name sortKey="Van Blercom, N" uniqKey="Van Blercom N">N Van Blercom</name></author><author><name sortKey="Chabardes, S" uniqKey="Chabardes S">S Chabardes</name></author><author><name sortKey="Fraix, V" uniqKey="Fraix V">V Fraix</name></author><author><name sortKey="Ardouin, C" uniqKey="Ardouin C">C Ardouin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schuepbach, Wmm" uniqKey="Schuepbach W">WMM Schuepbach</name></author><author><name sortKey="Chastan, N" uniqKey="Chastan N">N Chastan</name></author><author><name sortKey="Welter, Ml" uniqKey="Welter M">ML Welter</name></author><author><name sortKey="Houeto, Jl" uniqKey="Houeto J">JL Houeto</name></author><author><name sortKey="Mesnage, V" uniqKey="Mesnage V">V Mesnage</name></author><author><name sortKey="Bonnet, Am" uniqKey="Bonnet A">AM Bonnet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wider, C" uniqKey="Wider C">C Wider</name></author><author><name sortKey="Pollo, C" uniqKey="Pollo C">C Pollo</name></author><author><name sortKey="Bloch, J" uniqKey="Bloch J">J Bloch</name></author><author><name sortKey="Burkhard, Pr" uniqKey="Burkhard P">PR Burkhard</name></author><author><name sortKey="Vingerhoets, Fjg" uniqKey="Vingerhoets F">FJG Vingerhoets</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gervais Bernard, H" uniqKey="Gervais Bernard H">H Gervais-Bernard</name></author><author><name sortKey="Xie Brustolin, J" uniqKey="Xie Brustolin J">J Xie-Brustolin</name></author><author><name sortKey="Mertens, P" uniqKey="Mertens P">P Mertens</name></author><author><name sortKey="Polo, G" uniqKey="Polo G">G Polo</name></author><author><name sortKey="Klinger, H" uniqKey="Klinger H">H Klinger</name></author><author><name sortKey="Adamec, D" uniqKey="Adamec D">D Adamec</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moro, E" uniqKey="Moro E">E Moro</name></author><author><name sortKey="Lozano, Am" uniqKey="Lozano A">AM Lozano</name></author><author><name sortKey="Pollak, P" uniqKey="Pollak P">P Pollak</name></author><author><name sortKey="Agid, Y" uniqKey="Agid Y">Y Agid</name></author><author><name sortKey="Rehncrona, S" uniqKey="Rehncrona S">S Rehncrona</name></author><author><name sortKey="Volkmann, J" uniqKey="Volkmann J">J Volkmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fasano, A" uniqKey="Fasano A">A Fasano</name></author><author><name sortKey="Romito, Lm" uniqKey="Romito L">LM Romito</name></author><author><name sortKey="Daniele, A" uniqKey="Daniele A">A Daniele</name></author><author><name sortKey="Piano, C" uniqKey="Piano C">C Piano</name></author><author><name sortKey="Zinno, M" uniqKey="Zinno M">M Zinno</name></author><author><name sortKey="Bentivoglio, Ar" uniqKey="Bentivoglio A">AR Bentivoglio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zibetti, M" uniqKey="Zibetti M">M Zibetti</name></author><author><name sortKey="Merola, A" uniqKey="Merola A">A Merola</name></author><author><name sortKey="Rizzi, L" uniqKey="Rizzi L">L Rizzi</name></author><author><name sortKey="Ricchi, V" uniqKey="Ricchi V">V Ricchi</name></author><author><name sortKey="Angrisano, S" uniqKey="Angrisano S">S Angrisano</name></author><author><name sortKey="Azzaro, C" uniqKey="Azzaro C">C Azzaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Merola, A" uniqKey="Merola A">A Merola</name></author><author><name sortKey="Espay, Aj" uniqKey="Espay A">AJ Espay</name></author><author><name sortKey="Romagnolo, A" uniqKey="Romagnolo A">A Romagnolo</name></author><author><name sortKey="Bernardini, A" uniqKey="Bernardini A">A Bernardini</name></author><author><name sortKey="Rizzi, L" uniqKey="Rizzi L">L Rizzi</name></author><author><name sortKey="Rosso, M" uniqKey="Rosso M">M Rosso</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Peretz, C" uniqKey="Peretz C">C Peretz</name></author><author><name sortKey="Chillag Talmor, O" uniqKey="Chillag Talmor O">O Chillag-Talmor</name></author><author><name sortKey="Linn, S" uniqKey="Linn S">S Linn</name></author><author><name sortKey="Gurevich, T" uniqKey="Gurevich T">T Gurevich</name></author><author><name sortKey="El Ad, B" uniqKey="El Ad B">B El-Ad</name></author><author><name sortKey="Silverman, B" uniqKey="Silverman B">B Silverman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Williams Gray, Ch" uniqKey="Williams Gray C">CH Williams-Gray</name></author><author><name sortKey="Mason, Sl" uniqKey="Mason S">SL Mason</name></author><author><name sortKey="Evans, Jr" uniqKey="Evans J">JR Evans</name></author><author><name sortKey="Foltynie, T" uniqKey="Foltynie T">T Foltynie</name></author><author><name sortKey="Brayne, C" uniqKey="Brayne C">C Brayne</name></author><author><name sortKey="Robbins, Tw" uniqKey="Robbins T">TW Robbins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Duarte, J" uniqKey="Duarte J">J Duarte</name></author><author><name sortKey="Garcia, Olmos Lm" uniqKey="Garcia O">Olmos LM García</name></author><author><name sortKey="Mendoza, A" uniqKey="Mendoza A">A Mendoza</name></author><author><name sortKey="Claveria, Le" uniqKey="Claveria L">LE Clavería</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Macleod, Ad" uniqKey="Macleod A">AD Macleod</name></author><author><name sortKey="Taylor, Ksm" uniqKey="Taylor K">KSM Taylor</name></author><author><name sortKey="Counsell, Ce" uniqKey="Counsell C">CE Counsell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marras, C" uniqKey="Marras C">C Marras</name></author><author><name sortKey="Mcdermott, Mp" uniqKey="Mcdermott M">MP McDermott</name></author><author><name sortKey="Rochon, Pa" uniqKey="Rochon P">PA Rochon</name></author><author><name sortKey="Tanner, Cm" uniqKey="Tanner C">CM Tanner</name></author><author><name sortKey="Naglie, G" uniqKey="Naglie G">G Naglie</name></author><author><name sortKey="Rudolph, A" uniqKey="Rudolph A">A Rudolph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Forsaa, E" uniqKey="Forsaa E">E Forsaa</name></author><author><name sortKey="Larsen, J" uniqKey="Larsen J">J Larsen</name></author><author><name sortKey="Alves, G" uniqKey="Alves G">G Alves</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skorvanek, M" uniqKey="Skorvanek M">M Skorvanek</name></author><author><name sortKey="Rosenberger, J" uniqKey="Rosenberger J">J Rosenberger</name></author><author><name sortKey="Rajnicova, I" uniqKey="Rajnicova I">I Rajnicova</name></author><author><name sortKey="Van Dijk, J" uniqKey="Van Dijk J">J van Dijk</name></author><author><name sortKey="Groothoff, J" uniqKey="Groothoff J">J Groothoff</name></author><author><name sortKey="Gdovinova, Z" uniqKey="Gdovinova Z">Z Gdovinova</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Bloem, Br" uniqKey="Bloem B">BR Bloem</name></author><author><name sortKey="Grimbergen, Yam" uniqKey="Grimbergen Y">YAM Grimbergen</name></author><author><name sortKey="Cramer, M" uniqKey="Cramer M">M Cramer</name></author><author><name sortKey="Willemsen, M" uniqKey="Willemsen M">M Willemsen</name></author><author><name sortKey="Zwinderman, Ah" uniqKey="Zwinderman A">AH Zwinderman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, K Y" uniqKey="Cheng K">K-Y Cheng</name></author><author><name sortKey="Lin, W C" uniqKey="Lin W">W-C Lin</name></author><author><name sortKey="Chang, W N" uniqKey="Chang W">W-N Chang</name></author><author><name sortKey="Lin, T K" uniqKey="Lin T">T-K Lin</name></author><author><name sortKey="Tsai, N W" uniqKey="Tsai N">N-W Tsai</name></author><author><name sortKey="Huang, C C" uniqKey="Huang C">C-C Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Contreras, A" uniqKey="Contreras A">A Contreras</name></author><author><name sortKey="Grandas, F" uniqKey="Grandas F">F Grandas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gazibara, T" uniqKey="Gazibara T">T Gazibara</name></author><author><name sortKey="Pekmezovic, T" uniqKey="Pekmezovic T">T Pekmezovic</name></author><author><name sortKey="Kisic, Tepavcevic D" uniqKey="Kisic T">Tepavcevic D Kisic</name></author><author><name sortKey="Tomic, A" uniqKey="Tomic A">A Tomic</name></author><author><name sortKey="Stankovic, I" uniqKey="Stankovic I">I Stankovic</name></author><author><name sortKey="Kostic, Vs" uniqKey="Kostic V">VS Kostic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kataoka, H" uniqKey="Kataoka H">H Kataoka</name></author><author><name sortKey="Tanaka, N" uniqKey="Tanaka N">N Tanaka</name></author><author><name sortKey="Eng, M" uniqKey="Eng M">M Eng</name></author><author><name sortKey="Saeki, K" uniqKey="Saeki K">K Saeki</name></author><author><name sortKey="Kiriyama, T" uniqKey="Kiriyama T">T Kiriyama</name></author><author><name sortKey="Eura, N" uniqKey="Eura N">N Eura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kerr, Gk" uniqKey="Kerr G">GK Kerr</name></author><author><name sortKey="Worringham, Cj" uniqKey="Worringham C">CJ Worringham</name></author><author><name sortKey="Cole, Mh" uniqKey="Cole M">MH Cole</name></author><author><name sortKey="Lacherez, Pf" uniqKey="Lacherez P">PF Lacherez</name></author><author><name sortKey="Wood, Jm" uniqKey="Wood J">JM Wood</name></author><author><name sortKey="Silburn, Pa" uniqKey="Silburn P">PA Silburn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Latt, Md" uniqKey="Latt M">MD Latt</name></author><author><name sortKey="Lord, Sr" uniqKey="Lord S">SR Lord</name></author><author><name sortKey="Morris, Jgl" uniqKey="Morris J">JGL Morris</name></author><author><name sortKey="Fung, Vsc" uniqKey="Fung V">VSC Fung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindholm, B" uniqKey="Lindholm B">B Lindholm</name></author><author><name sortKey="Hagell, P" uniqKey="Hagell P">P Hagell</name></author><author><name sortKey="Hansson, O" uniqKey="Hansson O">O Hansson</name></author><author><name sortKey="Nilsson, Mh" uniqKey="Nilsson M">MH Nilsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matinolli, M" uniqKey="Matinolli M">M Matinolli</name></author><author><name sortKey="Korpelainen, Jt" uniqKey="Korpelainen J">JT Korpelainen</name></author><author><name sortKey="Sotaniemi, Ka" uniqKey="Sotaniemi K">KA Sotaniemi</name></author><author><name sortKey="Myllyl, V V" uniqKey="Myllyl V">V V Myllylä</name></author><author><name sortKey="Korpelainen, R" uniqKey="Korpelainen R">R Korpelainen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parashos, Sa" uniqKey="Parashos S">SA Parashos</name></author><author><name sortKey="Wielinski, Cl" uniqKey="Wielinski C">CL Wielinski</name></author><author><name sortKey="Giladi, N" uniqKey="Giladi N">N Giladi</name></author><author><name sortKey="Gurevich, T" uniqKey="Gurevich T">T Gurevich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudzi Ska, M" uniqKey="Rudzi Ska M">M Rudzińska</name></author><author><name sortKey="Bukowczan, S" uniqKey="Bukowczan S">S Bukowczan</name></author><author><name sortKey="Sto Ek, J" uniqKey="Sto Ek J">J Stożek</name></author><author><name sortKey="Zajdel, K" uniqKey="Zajdel K">K Zajdel</name></author><author><name sortKey="Mirek, E" uniqKey="Mirek E">E Mirek</name></author><author><name sortKey="Chwala, W" uniqKey="Chwala W">W Chwała</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Voss, Ts" uniqKey="Voss T">TS Voss</name></author><author><name sortKey="Elm, Jj" uniqKey="Elm J">JJ Elm</name></author><author><name sortKey="Wielinski, Cl" uniqKey="Wielinski C">CL Wielinski</name></author><author><name sortKey="Aminoff, Mj" uniqKey="Aminoff M">MJ Aminoff</name></author><author><name sortKey="Bandyopadhyay, D" uniqKey="Bandyopadhyay D">D Bandyopadhyay</name></author><author><name sortKey="Chou, Kl" uniqKey="Chou K">KL Chou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wielinski, Cl" uniqKey="Wielinski C">CL Wielinski</name></author><author><name sortKey="Erickson Davis, C" uniqKey="Erickson Davis C">C Erickson-Davis</name></author><author><name sortKey="Wichmann, R" uniqKey="Wichmann R">R Wichmann</name></author><author><name sortKey="Walde Douglas, M" uniqKey="Walde Douglas M">M Walde-Douglas</name></author><author><name sortKey="Parashos, Sa" uniqKey="Parashos S">SA Parashos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wood, Bh" uniqKey="Wood B">BH Wood</name></author><author><name sortKey="Bilclough, Ja" uniqKey="Bilclough J">JA Bilclough</name></author><author><name sortKey="Bowron, A" uniqKey="Bowron A">A Bowron</name></author><author><name sortKey="Walker, Rw" uniqKey="Walker R">RW Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kent, S" uniqKey="Kent S">S Kent</name></author><author><name sortKey="Gray, A" uniqKey="Gray A">A Gray</name></author><author><name sortKey="Schlackow, I" uniqKey="Schlackow I">I Schlackow</name></author><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C Jenkinson</name></author><author><name sortKey="Mcintosh, E" uniqKey="Mcintosh E">E McIntosh</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Martin, P" uniqKey="Martinez Martin P">P Martínez-Martín</name></author><author><name sortKey="Rodriguez Blazquez, C" uniqKey="Rodriguez Blazquez C">C Rodríguez-Blázquez</name></author><author><name sortKey="Forjaz, Mj" uniqKey="Forjaz M">MJ Forjaz</name></author><author><name sortKey="Alvarez Sanchez, M" uniqKey="Alvarez Sanchez M">M Álvarez-Sánchez</name></author><author><name sortKey="Arakaki, T" uniqKey="Arakaki T">T Arakaki</name></author><author><name sortKey="Bergareche Yarza, A" uniqKey="Bergareche Yarza A">a. Bergareche-Yarza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kadastik Eerme, L" uniqKey="Kadastik Eerme L">L Kadastik-Eerme</name></author><author><name sortKey="Rosenthal, M" uniqKey="Rosenthal M">M Rosenthal</name></author><author><name sortKey="Paju, T" uniqKey="Paju T">T Paju</name></author><author><name sortKey="Muldmaa, M" uniqKey="Muldmaa M">M Muldmaa</name></author><author><name sortKey="Taba, P" uniqKey="Taba P">P Taba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dams, J" uniqKey="Dams J">J Dams</name></author><author><name sortKey="Klotsche, J" uniqKey="Klotsche J">J Klotsche</name></author><author><name sortKey="Bornschein, B" uniqKey="Bornschein B">B Bornschein</name></author><author><name sortKey="Reese, Jp" uniqKey="Reese J">JP Reese</name></author><author><name sortKey="Balzer Geldsetzer, M" uniqKey="Balzer Geldsetzer M">M Balzer-Geldsetzer</name></author><author><name sortKey="Winter, Y" uniqKey="Winter Y">Y Winter</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mccabe, C" uniqKey="Mccabe C">C McCabe</name></author><author><name sortKey="Claxton, K" uniqKey="Claxton K">K Claxton</name></author><author><name sortKey="Culyer, Aj" uniqKey="Culyer A">AJ Culyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcintosh, E" uniqKey="Mcintosh E">E McIntosh</name></author><author><name sortKey="Gray, A" uniqKey="Gray A">A Gray</name></author><author><name sortKey="Daniels, J" uniqKey="Daniels J">J Daniels</name></author><author><name sortKey="Gill, S" uniqKey="Gill S">S Gill</name></author><author><name sortKey="Ives, N" uniqKey="Ives N">N Ives</name></author><author><name sortKey="Jenkinson, C" uniqKey="Jenkinson C">C Jenkinson</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Drapier, S" uniqKey="Drapier S">S Drapier</name></author><author><name sortKey="Gillioz, A S" uniqKey="Gillioz A">A-S Gillioz</name></author><author><name sortKey="Leray, E" uniqKey="Leray E">E Leray</name></author><author><name sortKey="Peron, J" uniqKey="Peron J">J Péron</name></author><author><name sortKey="Rouaud, T" uniqKey="Rouaud T">T Rouaud</name></author><author><name sortKey="Marchand, A" uniqKey="Marchand A">A Marchand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antonini, A" uniqKey="Antonini A">A Antonini</name></author><author><name sortKey="Mancini, F" uniqKey="Mancini F">F Mancini</name></author><author><name sortKey="Canesi, M" uniqKey="Canesi M">M Canesi</name></author><author><name sortKey="Zangaglia, R" uniqKey="Zangaglia R">R Zangaglia</name></author><author><name sortKey="Isaias, Iu" uniqKey="Isaias I">IU Isaias</name></author><author><name sortKey="Manfredi, L" uniqKey="Manfredi L">L Manfredi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antonini, A" uniqKey="Antonini A">a Antonini</name></author><author><name sortKey="Odin, P" uniqKey="Odin P">P Odin</name></author><author><name sortKey="Opiano, L" uniqKey="Opiano L">L Opiano</name></author><author><name sortKey="Tomantschger, V" uniqKey="Tomantschger V">V Tomantschger</name></author><author><name sortKey="Pacchetti, C" uniqKey="Pacchetti C">C Pacchetti</name></author><author><name sortKey="Pickut, B" uniqKey="Pickut B">B Pickut</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antonini, A" uniqKey="Antonini A">A Antonini</name></author><author><name sortKey="Yegin, A" uniqKey="Yegin A">A Yegin</name></author><author><name sortKey="Preda, C" uniqKey="Preda C">C Preda</name></author><author><name sortKey="Bergmann, L" uniqKey="Bergmann L">L Bergmann</name></author><author><name sortKey="Poewe, W" uniqKey="Poewe W">W Poewe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez, Hh" uniqKey="Fernandez H">HH Fernandez</name></author><author><name sortKey="Standaert, Dg" uniqKey="Standaert D">DG Standaert</name></author><author><name sortKey="Hauser, Ra" uniqKey="Hauser R">RA Hauser</name></author><author><name sortKey="Lang, Ae" uniqKey="Lang A">AE Lang</name></author><author><name sortKey="Fung, Vsc" uniqKey="Fung V">VSC Fung</name></author><author><name sortKey="Klostermann, F" uniqKey="Klostermann F">F Klostermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Martin, P" uniqKey="Martinez Martin P">P Martinez-Martin</name></author><author><name sortKey="Reddy, P" uniqKey="Reddy P">P Reddy</name></author><author><name sortKey="Katzenschlager, R" uniqKey="Katzenschlager R">R Katzenschlager</name></author><author><name sortKey="Antonini, A" 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Trevisani</name></author><author><name sortKey="Contini, E" uniqKey="Contini E">E Contini</name></author><author><name sortKey="Gragnaniello, D" uniqKey="Gragnaniello D">D Gragnaniello</name></author><author><name sortKey="Capone, J" uniqKey="Capone J">J Capone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Olanow, Cw" uniqKey="Olanow C">CW Olanow</name></author><author><name sortKey="Kieburtz, K" uniqKey="Kieburtz K">K Kieburtz</name></author><author><name sortKey="Odin, P" uniqKey="Odin P">P Odin</name></author><author><name sortKey="Espay, Aj" uniqKey="Espay A">AJ Espay</name></author><author><name sortKey="Standaert, Dg" uniqKey="Standaert D">DG Standaert</name></author><author><name sortKey="Fernandez, Hh" uniqKey="Fernandez H">HH Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slevin, Jt" uniqKey="Slevin J">JT Slevin</name></author><author><name sortKey="Fernandez, Hh" uniqKey="Fernandez H">HH Fernandez</name></author><author><name sortKey="Zadikoff, C" uniqKey="Zadikoff C">C Zadikoff</name></author><author><name sortKey="Hall, C" uniqKey="Hall C">C Hall</name></author><author><name sortKey="Eaton, S" uniqKey="Eaton S">S Eaton</name></author><author><name sortKey="Dubow, J" uniqKey="Dubow J">J Dubow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Caceres Redondo, Mt" uniqKey="Caceres Redondo M">MT Cáceres-Redondo</name></author><author><name sortKey="Carrillo, F" uniqKey="Carrillo F">F Carrillo</name></author><author><name sortKey="Lama, Mj" uniqKey="Lama M">MJ Lama</name></author><author><name sortKey="Huertas Fernandez, I" uniqKey="Huertas Fernandez I">I Huertas-Fernández</name></author><author><name sortKey="Vargas Gonzalez, L" uniqKey="Vargas Gonzalez L">L Vargas-González</name></author><author><name sortKey="Carballo, M" uniqKey="Carballo M">M Carballo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Honig, H" uniqKey="Honig H">H Honig</name></author><author><name sortKey="Antonini, A" uniqKey="Antonini A">A Antonini</name></author><author><name sortKey="Martinez Martin, P" uniqKey="Martinez Martin P">P Martinez-Martin</name></author><author><name sortKey="Forgacs, I" uniqKey="Forgacs I">I Forgacs</name></author><author><name sortKey="Faye, Gc" uniqKey="Faye G">GC Faye</name></author><author><name sortKey="Fox, T" uniqKey="Fox T">T Fox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karlsborg, M" uniqKey="Karlsborg M">M Karlsborg</name></author><author><name sortKey="Korbo, L" uniqKey="Korbo L">L Korbo</name></author><author><name sortKey="Regeur, L" uniqKey="Regeur L">L Regeur</name></author><author><name sortKey="Glad, A" uniqKey="Glad A">a Glad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valldeoriola, F" uniqKey="Valldeoriola F">F Valldeoriola</name></author><author><name sortKey="Puig Junoy, J" uniqKey="Puig Junoy J">J Puig-Junoy</name></author><author><name sortKey="Puig Peir, R" uniqKey="Puig Peir R">R Puig-Peiró</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Pologne</li><li>Royaume-Uni</li><li>Suisse</li></country><region><li>Angleterre</li><li>Canton de Berne</li><li>Midlands de l'Ouest</li><li>Oxfordshire</li><li>Île-de-France</li></region><settlement><li>Berne</li><li>Birmingham</li><li>Oxford</li><li>Paris</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Pologne"><noRegion><name sortKey="Fundament, Tomasz" sort="Fundament, Tomasz" uniqKey="Fundament T" first="Tomasz" last="Fundament">Tomasz Fundament</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Eldridge, Paul R" sort="Eldridge, Paul R" uniqKey="Eldridge P" first="Paul R." last="Eldridge">Paul R. Eldridge</name></noRegion><name sortKey="Green, Alexander L" sort="Green, Alexander L" uniqKey="Green A" first="Alexander L." last="Green">Alexander L. Green</name><name sortKey="Taylor, Rod S" sort="Taylor, Rod S" uniqKey="Taylor R" first="Rod S." last="Taylor">Rod S. Taylor</name><name sortKey="Whone, Alan L" sort="Whone, Alan L" uniqKey="Whone A" first="Alan L." last="Whone">Alan L. Whone</name><name sortKey="Williams, Adrian C" sort="Williams, Adrian C" uniqKey="Williams A" first="Adrian C." last="Williams">Adrian C. Williams</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Schuepbach, W M Michael" sort="Schuepbach, W M Michael" uniqKey="Schuepbach W" first="W. M. Michael" last="Schuepbach">W. M. Michael Schuepbach</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Schuepbach, W M Michael" sort="Schuepbach, W M Michael" uniqKey="Schuepbach W" first="W. M. Michael" last="Schuepbach">W. M. 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