Single Point Mutation in Bin/Amphiphysin/Rvs (BAR) Sequence of Endophilin Impairs Dimerization, Membrane Shaping, and Src Homology 3 Domain-mediated Partnership*
Identifieur interne : 001538 ( Main/Exploration ); précédent : 001537; suivant : 001539Single Point Mutation in Bin/Amphiphysin/Rvs (BAR) Sequence of Endophilin Impairs Dimerization, Membrane Shaping, and Src Homology 3 Domain-mediated Partnership*
Auteurs : Anna Gortat [France] ; Mabel Jouve San-Roman [France] ; Christian Vannier [France] ; Anne A. Schmidt [France]Source :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2011.
Abstract
Url:
DOI: 10.1074/jbc.M111.325837
PubMed: 22167186
PubMed Central: 3281743
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000471
- to stream Pmc, to step Curation: 000468
- to stream Pmc, to step Checkpoint: 000665
- to stream Ncbi, to step Merge: 000E25
- to stream Ncbi, to step Curation: 000E25
- to stream Ncbi, to step Checkpoint: 000E25
- to stream Main, to step Merge: 001613
- to stream Main, to step Curation: 001538
Le document en format XML
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<country xml:lang="fr">France</country>
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<country xml:lang="fr">France</country>
<wicri:regionArea>From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris</wicri:regionArea>
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<country xml:lang="fr">France</country>
<wicri:regionArea>From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris</wicri:regionArea>
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<wicri:regionArea>From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Single Point Mutation in Bin/Amphiphysin/Rvs (BAR) Sequence of Endophilin Impairs Dimerization, Membrane Shaping, and Src Homology 3 Domain-mediated Partnership<xref ref-type="fn" rid="FN1">*</xref>
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<author><name sortKey="Gortat, Anna" sort="Gortat, Anna" uniqKey="Gortat A" first="Anna" last="Gortat">Anna Gortat</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<author><name sortKey="San Roman, Mabel Jouve" sort="San Roman, Mabel Jouve" uniqKey="San Roman M" first="Mabel Jouve" last="San-Roman">Mabel Jouve San-Roman</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
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<author><name sortKey="Vannier, Christian" sort="Vannier, Christian" uniqKey="Vannier C" first="Christian" last="Vannier">Christian Vannier</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris</wicri:regionArea>
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<settlement type="city">Paris</settlement>
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<author><name sortKey="Schmidt, Anne A" sort="Schmidt, Anne A" uniqKey="Schmidt A" first="Anne A." last="Schmidt">Anne A. Schmidt</name>
<affiliation wicri:level="3"><nlm:aff id="aff1">From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>From the CNRS, UMR7592, Institut Jacques Monod, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris</wicri:regionArea>
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<series><title level="j">The Journal of Biological Chemistry</title>
<idno type="ISSN">0021-9258</idno>
<idno type="eISSN">1083-351X</idno>
<imprint><date when="2011">2011</date>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
The BAR domain is a dimeric module controlling membrane curvature.</p>
<p><bold>Results:</bold>
We identify leucine 215 involved in stabilizing the dimer interface and characterize the incidence of its substitution in SH3-mediated partnership in endophilins.</p>
<p><bold>Conclusion:</bold>
Altered BAR conformation/rigidity impairs membrane binding, shaping, and partnership.</p>
<p><bold>Significance:</bold>
This mutation in other BAR domain-containing proteins may unravel unanticipated functional relationships between the BAR domain and other structural units.</p>
</div>
</front>
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<name sortKey="San Roman, Mabel Jouve" sort="San Roman, Mabel Jouve" uniqKey="San Roman M" first="Mabel Jouve" last="San-Roman">Mabel Jouve San-Roman</name>
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