Distinct Changes in cAMP and Extracellular Signal-Regulated Protein Kinase Signalling in L-DOPA-Induced Dyskinesia
Identifieur interne : 001A48 ( Main/Exploration ); précédent : 001A47; suivant : 001A49Distinct Changes in cAMP and Extracellular Signal-Regulated Protein Kinase Signalling in L-DOPA-Induced Dyskinesia
Auteurs : Emanuela Santini [Suède] ; Veronique Sgambato-Faure [France] ; Qin Li [France, République populaire de Chine] ; Marc Savasta [France] ; Sandra Dovero [France] ; Gilberto Fisone [Suède] ; Erwan Bezard [France, République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2010.
Abstract
In rodents, the development of dyskinesia produced by L-DOPA in the dopamine-depleted striatum occurs in response to increased dopamine D1 receptor-mediated activation of the cAMP - protein kinase A and of the Ras-extracellular signal-regulated kinase (ERK) signalling pathways. However, very little is known, in non-human primates, about the regulation of these signalling cascades and their association with the induction, manifestation and/or maintenance of dyskinesia.
We here studied, in the gold-standard non-human primate model of Parkinson's disease, the changes in PKA-dependent phosphorylation of DARPP-32 and GluR1 AMPA receptor, as well as in ERK and ribosomal protein S6 (S6) phosphorylation, associated to acute and chronic administration of L-DOPA. Increased phosphorylation of DARPP-32 and GluR1 was observed in both L-DOPA first-ever exposed and chronically-treated dyskinetic parkinsonian monkeys. In contrast, phosphorylation of ERK and S6 was enhanced preferentially after acute L-DOPA administration and decreased during the course of chronic treatment.
Dysregulation of cAMP signalling is maintained during the course of chronic L-DOPA administration, while abnormal ERK signalling peaks during the initial phase of L-DOPA treatment and decreases following prolonged exposure. While cAMP signalling enhancement is associated with dyskinesia, abnormal ERK signalling is associated with priming.
Url:
DOI: 10.1371/journal.pone.0012322
PubMed: 20808799
PubMed Central: 2925943
Affiliations:
- France, République populaire de Chine, Suède
- Aquitaine, Auvergne-Rhône-Alpes, Nouvelle-Aquitaine, Rhône-Alpes, Svealand
- Bordeaux, Grenoble, Pékin, Stockholm
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000849
- to stream Pmc, to step Curation: 000846
- to stream Pmc, to step Checkpoint: 000766
- to stream Ncbi, to step Merge: 000C05
- to stream Ncbi, to step Curation: 000C05
- to stream Ncbi, to step Checkpoint: 000C05
- to stream Hal, to step Corpus: 000313
- to stream Hal, to step Curation: 000313
- to stream Hal, to step Checkpoint: 000746
- to stream Main, to step Merge: 001B63
- to stream Main, to step Curation: 001A48
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distinct Changes in cAMP and Extracellular Signal-Regulated Protein Kinase Signalling in L-DOPA-Induced Dyskinesia</title><author><name sortKey="Santini, Emanuela" sort="Santini, Emanuela" uniqKey="Santini E" first="Emanuela" last="Santini">Emanuela Santini</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Sgambato Faure, Veronique" sort="Sgambato Faure, Veronique" uniqKey="Sgambato Faure V" first="Veronique" last="Sgambato-Faure">Veronique Sgambato-Faure</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U836, Grenoble Institut des Neurosciences, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique UMR 5229 - Université Claude Bernard Lyon I, Bron, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique UMR 5229 - Université Claude Bernard Lyon I, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U836, Grenoble Institut des Neurosciences, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Dovero, Sandra" sort="Dovero, Sandra" uniqKey="Dovero S" first="Sandra" last="Dovero">Sandra Dovero</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Fisone, Gilberto" sort="Fisone, Gilberto" uniqKey="Fisone G" first="Gilberto" last="Fisone">Gilberto Fisone</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20808799</idno><idno type="pmc">2925943</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2925943</idno><idno type="RBID">PMC:2925943</idno><idno type="doi">10.1371/journal.pone.0012322</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000849</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000849</idno><idno type="wicri:Area/Pmc/Curation">000846</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000846</idno><idno type="wicri:Area/Pmc/Checkpoint">000766</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000766</idno><idno type="wicri:Area/Ncbi/Merge">000C05</idno><idno type="wicri:Area/Ncbi/Curation">000C05</idno><idno type="wicri:Area/Ncbi/Checkpoint">000C05</idno><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:inserm-00628011</idno><idno type="url">http://www.hal.inserm.fr/inserm-00628011</idno><idno type="wicri:Area/Hal/Corpus">000313</idno><idno type="wicri:Area/Hal/Curation">000313</idno><idno type="wicri:Area/Hal/Checkpoint">000746</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000746</idno><idno type="wicri:doubleKey">1932-6203:2010:Santini E:distinct:changes:in</idno><idno type="wicri:Area/Main/Merge">001B63</idno><idno type="wicri:Area/Main/Curation">001A48</idno><idno type="wicri:Area/Main/Exploration">001A48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Distinct Changes in cAMP and Extracellular Signal-Regulated Protein Kinase Signalling in L-DOPA-Induced Dyskinesia</title><author><name sortKey="Santini, Emanuela" sort="Santini, Emanuela" uniqKey="Santini E" first="Emanuela" last="Santini">Emanuela Santini</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Sgambato Faure, Veronique" sort="Sgambato Faure, Veronique" uniqKey="Sgambato Faure V" first="Veronique" last="Sgambato-Faure">Veronique Sgambato-Faure</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U836, Grenoble Institut des Neurosciences, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique UMR 5229 - Université Claude Bernard Lyon I, Bron, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Neuroscience Cognitive, Centre National de la Recherche Scientifique UMR 5229 - Université Claude Bernard Lyon I, Bron</wicri:regionArea><wicri:noRegion>Bron</wicri:noRegion><wicri:noRegion>Bron</wicri:noRegion></affiliation></author><author><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><affiliation wicri:level="3"><nlm:aff id="aff2"><addr-line>INSERM U836, Grenoble Institut des Neurosciences, Grenoble, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U836, Grenoble Institut des Neurosciences, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Dovero, Sandra" sort="Dovero, Sandra" uniqKey="Dovero S" first="Sandra" last="Dovero">Sandra Dovero</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Fisone, Gilberto" sort="Fisone, Gilberto" uniqKey="Fisone G" first="Gilberto" last="Fisone">Gilberto Fisone</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden</addr-line></nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Neuroscience, Karolinska Institutet, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Victor Segalen-Bordeaux 2, Centre National de la Recherche Scientifique, Bordeaux Institute of Neuroscience, UMR 5227, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Lab Animal Sciences, China Academy of Medical Sciences, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>In rodents, the development of dyskinesia produced by L-DOPA in the dopamine-depleted striatum occurs in response to increased dopamine D1 receptor-mediated activation of the cAMP - protein kinase A and of the Ras-extracellular signal-regulated kinase (ERK) signalling pathways. However, very little is known, in non-human primates, about the regulation of these signalling cascades and their association with the induction, manifestation and/or maintenance of dyskinesia.</p></sec><sec><title>Methodology/Results</title><p>We here studied, in the gold-standard non-human primate model of Parkinson's disease, the changes in PKA-dependent phosphorylation of DARPP-32 and GluR1 AMPA receptor, as well as in ERK and ribosomal protein S6 (S6) phosphorylation, associated to acute and chronic administration of L-DOPA. Increased phosphorylation of DARPP-32 and GluR1 was observed in both L-DOPA first-ever exposed and chronically-treated dyskinetic parkinsonian monkeys. In contrast, phosphorylation of ERK and S6 was enhanced preferentially after acute L-DOPA administration and decreased during the course of chronic treatment.</p></sec><sec><title>Conclusion</title><p>Dysregulation of cAMP signalling is maintained during the course of chronic L-DOPA administration, while abnormal ERK signalling peaks during the initial phase of L-DOPA treatment and decreases following prolonged exposure. While cAMP signalling enhancement is associated with dyskinesia, abnormal ERK signalling is associated with priming.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cotzias, Gc" uniqKey="Cotzias G">GC Cotzias</name></author><author><name sortKey="Papavasiliou, Ps" uniqKey="Papavasiliou P">PS Papavasiliou</name></author><author><name sortKey="Gellene, R" uniqKey="Gellene R">R Gellene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenner, P" uniqKey="Jenner P">P Jenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aubert, I" uniqKey="Aubert I">I Aubert</name></author><author><name sortKey="Guigoni, C" uniqKey="Guigoni C">C Guigoni</name></author><author><name sortKey="Hakansson, K" uniqKey="Hakansson K">K Hakansson</name></author><author><name sortKey="Qin, L" uniqKey="Qin L">L Qin</name></author><author><name sortKey="Dovero, S" uniqKey="Dovero S">S Dovero</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Picconi, B" uniqKey="Picconi B">B Picconi</name></author><author><name sortKey="Centonze, D" uniqKey="Centonze D">D Centonze</name></author><author><name sortKey="Hakansson, K" uniqKey="Hakansson K">K Hakansson</name></author><author><name sortKey="Bernardi, G" uniqKey="Bernardi G">G Bernardi</name></author><author><name sortKey="Greengard, P" uniqKey="Greengard P">P Greengard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pavon, N" uniqKey="Pavon N">N Pavon</name></author><author><name sortKey="Martin, Ab" uniqKey="Martin A">AB Martin</name></author><author><name sortKey="Mendialdua, A" uniqKey="Mendialdua A">A Mendialdua</name></author><author><name sortKey="Moratalla, R" uniqKey="Moratalla R">R Moratalla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santini, E" uniqKey="Santini E">E Santini</name></author><author><name sortKey="Valjent, E" uniqKey="Valjent E">E Valjent</name></author><author><name sortKey="Usiello, A" uniqKey="Usiello A">A Usiello</name></author><author><name sortKey="Carta, M" uniqKey="Carta M">M Carta</name></author><author><name sortKey="Borgkvist, A" uniqKey="Borgkvist A">A Borgkvist</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Westin, Je" uniqKey="Westin J">JE Westin</name></author><author><name sortKey="Vercammen, L" uniqKey="Vercammen L">L Vercammen</name></author><author><name sortKey="Strome, Em" uniqKey="Strome E">EM Strome</name></author><author><name sortKey="Konradi, C" uniqKey="Konradi C">C Konradi</name></author><author><name sortKey="Cenci, Ma" uniqKey="Cenci M">MA Cenci</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gerfen, Cr" uniqKey="Gerfen C">CR Gerfen</name></author><author><name sortKey="Miyachi, S" uniqKey="Miyachi S">S Miyachi</name></author><author><name sortKey="Paletzki, R" uniqKey="Paletzki R">R Paletzki</name></author><author><name sortKey="Brown, P" uniqKey="Brown P">P Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bezard, E" uniqKey="Bezard E">E Bezard</name></author><author><name sortKey="Ferry, S" uniqKey="Ferry S">S Ferry</name></author><author><name sortKey="Mach, U" uniqKey="Mach U">U Mach</name></author><author><name sortKey="Stark, H" uniqKey="Stark H">H Stark</name></author><author><name sortKey="Leriche, L" uniqKey="Leriche L">L Leriche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bezard, E" uniqKey="Bezard E">E Bezard</name></author><author><name sortKey="Dovero, S" uniqKey="Dovero S">S Dovero</name></author><author><name sortKey="Prunier, C" uniqKey="Prunier C">C Prunier</name></author><author><name sortKey="Ravenscroft, P" uniqKey="Ravenscroft P">P Ravenscroft</name></author><author><name sortKey="Chalon, S" uniqKey="Chalon S">S Chalon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nadjar, A" uniqKey="Nadjar A">A Nadjar</name></author><author><name sortKey="Brotchie, Jm" uniqKey="Brotchie J">JM Brotchie</name></author><author><name sortKey="Guigoni, C" uniqKey="Guigoni C">C Guigoni</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Zhou, Sb" uniqKey="Zhou S">SB Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernagut, Po" uniqKey="Fernagut P">PO Fernagut</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Dovero, S" uniqKey="Dovero S">S Dovero</name></author><author><name sortKey="Chan, P" uniqKey="Chan P">P Chan</name></author><author><name sortKey="Wu, T" uniqKey="Wu T">T Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ahmed, Mr" uniqKey="Ahmed M">MR Ahmed</name></author><author><name sortKey="Berthet, A" uniqKey="Berthet A">A Berthet</name></author><author><name sortKey="Bychkov, E" uniqKey="Bychkov E">E Bychkov</name></author><author><name sortKey="Porras, G" uniqKey="Porras G">G Porras</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berton, O" uniqKey="Berton O">O Berton</name></author><author><name sortKey="Guigoni, C" uniqKey="Guigoni C">C Guigoni</name></author><author><name sortKey="Li, Q" uniqKey="Li Q">Q Li</name></author><author><name sortKey="Bioulac, Bh" uniqKey="Bioulac B">BH Bioulac</name></author><author><name sortKey="Aubert, I" uniqKey="Aubert I">I Aubert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Snyder, Gl" uniqKey="Snyder G">GL Snyder</name></author><author><name sortKey="Girault, Ja" uniqKey="Girault J">JA Girault</name></author><author><name sortKey="Chen, Jy" uniqKey="Chen J">JY Chen</name></author><author><name sortKey="Czernik, Aj" uniqKey="Czernik A">AJ Czernik</name></author><author><name sortKey="Kebabian, Jw" uniqKey="Kebabian J">JW Kebabian</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roche, Kw" uniqKey="Roche K">KW Roche</name></author><author><name sortKey="O Brien, Rj" uniqKey="O Brien R">RJ O'Brien</name></author><author><name sortKey="Mammen, Al" uniqKey="Mammen A">AL Mammen</name></author><author><name sortKey="Bernhardt, J" uniqKey="Bernhardt J">J Bernhardt</name></author><author><name sortKey="Huganir, Rl" uniqKey="Huganir R">RL Huganir</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roux, Pp" uniqKey="Roux P">PP Roux</name></author><author><name sortKey="Shahbazian, D" uniqKey="Shahbazian D">D Shahbazian</name></author><author><name sortKey="Vu, H" uniqKey="Vu H">H Vu</name></author><author><name sortKey="Holz, Mk" uniqKey="Holz M">MK Holz</name></author><author><name sortKey="Cohen, Ms" uniqKey="Cohen M">MS Cohen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santini, E" uniqKey="Santini E">E Santini</name></author><author><name sortKey="Heiman, M" uniqKey="Heiman M">M Heiman</name></author><author><name sortKey="Greengard, P" uniqKey="Greengard P">P Greengard</name></author><author><name sortKey="Valjent, E" uniqKey="Valjent E">E Valjent</name></author><author><name sortKey="Fisone, G" uniqKey="Fisone G">G Fisone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Santini, E" uniqKey="Santini E">E Santini</name></author><author><name sortKey="Alcacer, C" uniqKey="Alcacer C">C Alcacer</name></author><author><name sortKey="Cacciatore, S" uniqKey="Cacciatore S">S Cacciatore</name></author><author><name sortKey="Heiman, M" uniqKey="Heiman M">M Heiman</name></author><author><name sortKey="Herve, D" uniqKey="Herve D">D Herve</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corvol, Jc" uniqKey="Corvol J">JC Corvol</name></author><author><name sortKey="Muriel, Mp" uniqKey="Muriel M">MP Muriel</name></author><author><name sortKey="Valjent, E" uniqKey="Valjent E">E Valjent</name></author><author><name sortKey="Feger, J" uniqKey="Feger J">J Feger</name></author><author><name sortKey="Hanoun, N" uniqKey="Hanoun N">N Hanoun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Ds" uniqKey="Kim D">DS Kim</name></author><author><name sortKey="Palmiter, Rd" uniqKey="Palmiter R">RD Palmiter</name></author><author><name sortKey="Cummins, A" uniqKey="Cummins A">A Cummins</name></author><author><name sortKey="Gerfen, Cr" uniqKey="Gerfen C">CR Gerfen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>République populaire de Chine</li><li>Suède</li></country><region><li>Aquitaine</li><li>Auvergne-Rhône-Alpes</li><li>Nouvelle-Aquitaine</li><li>Rhône-Alpes</li><li>Svealand</li></region><settlement><li>Bordeaux</li><li>Grenoble</li><li>Pékin</li><li>Stockholm</li></settlement></list><tree><country name="Suède"><region name="Svealand"><name sortKey="Santini, Emanuela" sort="Santini, Emanuela" uniqKey="Santini E" first="Emanuela" last="Santini">Emanuela Santini</name></region><name sortKey="Fisone, Gilberto" sort="Fisone, Gilberto" uniqKey="Fisone G" first="Gilberto" last="Fisone">Gilberto Fisone</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Sgambato Faure, Veronique" sort="Sgambato Faure, Veronique" uniqKey="Sgambato Faure V" first="Veronique" last="Sgambato-Faure">Veronique Sgambato-Faure</name></region><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><name sortKey="Dovero, Sandra" sort="Dovero, Sandra" uniqKey="Dovero S" first="Sandra" last="Dovero">Sandra Dovero</name><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><name sortKey="Sgambato Faure, Veronique" sort="Sgambato Faure, Veronique" uniqKey="Sgambato Faure V" first="Veronique" last="Sgambato-Faure">Veronique Sgambato-Faure</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Li, Qin" sort="Li, Qin" uniqKey="Li Q" first="Qin" last="Li">Qin Li</name></noRegion><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A48 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A48 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:2925943
|texte= Distinct Changes in cAMP and Extracellular Signal-Regulated Protein Kinase Signalling in L-DOPA-Induced Dyskinesia
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:20808799" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |