A study of salivary secretion in Parkinson's disease.
Identifieur interne : 005A11 ( Main/Exploration ); précédent : 005A10; suivant : 005A12A study of salivary secretion in Parkinson's disease.
Auteurs : H. Bagheri [France] ; C. Damase-Michel ; M. Lapeyre-Mestre ; S. Cismondo ; D. O'Connell ; J M Senard ; O. Rascol ; J L MontastrucSource :
- Clinical neuropharmacology [ 0362-5664 ]
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Antiparkinson Agents (therapeutic use), Dopamine Agonists (therapeutic use), Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Prospective Studies, Salivation (drug effects), Sex Factors, Sialorrhea (drug therapy), Sialorrhea (etiology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agonists, Levodopa.
- complications : Parkinson Disease.
- drug effects : Salivation.
- drug therapy : Parkinson Disease, Sialorrhea.
- etiology : Sialorrhea.
- Adult, Age Factors, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prospective Studies, Sex Factors.
Abstract
Hypersialorrhea is frequently reported in patients with idiopathic Parkinson's Disease (PD). Excessive production of saliva, swallowing difficulties, or both could explain this complaint. Dopamine (DA) has been shown to modulate salivary secretion in a number of vertebrate and invertebrate species. The present study was performed to compare the unstimulated salivary flow in 83 patients with PD (8 untreated and 75 treated with levodopa + DA agonist) and in 65 age- and sex-matched control subjects. The Mann-Whitney U-test showed a significantly lower salivary flow in treated patients with PD (535 +/- 42 mg/2 min) (p < 0.002) and de novo patients (447 +/- 141) (p < 0.03) compared to controls (834 +/- 68 mg/2 min) with no relation with age or sex. Finally, the present study of reduced salivary flow in PD suggests that complaints of hypersialorrhea are not caused by a salivary defect, but could be explained by difficulties in swallowing. The decrease in salivary flow could be explained by autonomic dysfunction in PD.
PubMed: 10442250
Affiliations:
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Damase-Michel</name></author><author><name sortKey="Lapeyre Mestre, M" sort="Lapeyre Mestre, M" uniqKey="Lapeyre Mestre M" first="M" last="Lapeyre-Mestre">M. Lapeyre-Mestre</name></author><author><name sortKey="Cismondo, S" sort="Cismondo, S" uniqKey="Cismondo S" first="S" last="Cismondo">S. Cismondo</name></author><author><name sortKey="O Connell, D" sort="O Connell, D" uniqKey="O Connell D" first="D" last="O'Connell">D. O'Connell</name></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>1999 Jul-Aug</MedlineDate></PubDate></date><idno type="RBID">pubmed:10442250</idno><idno type="pmid">10442250</idno><idno type="wicri:Area/PubMed/Corpus">001393</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001393</idno><idno type="wicri:Area/PubMed/Curation">001352</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001352</idno><idno type="wicri:Area/PubMed/Checkpoint">001352</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001352</idno><idno type="wicri:Area/Ncbi/Merge">000047</idno><idno type="wicri:Area/Ncbi/Curation">000047</idno><idno type="wicri:Area/Ncbi/Checkpoint">000047</idno><idno type="wicri:doubleKey">0362-5664::Bagheri H:a:study:of</idno><idno type="wicri:Area/Main/Merge">006548</idno><idno type="wicri:Area/Main/Curation">005A11</idno><idno type="wicri:Area/Main/Exploration">005A11</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A study of salivary secretion in Parkinson's disease.</title><author><name sortKey="Bagheri, H" sort="Bagheri, H" uniqKey="Bagheri H" first="H" last="Bagheri">H. Bagheri</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Medical and Clinical Pharmacology, Inserm U317, Faculty of Medicine, Hôpitaux de Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Medical and Clinical Pharmacology, Inserm U317, Faculty of Medicine, Hôpitaux de Toulouse</wicri:regionArea><wicri:noRegion>Hôpitaux de Toulouse</wicri:noRegion><wicri:noRegion>Hôpitaux de Toulouse</wicri:noRegion></affiliation></author><author><name sortKey="Damase Michel, C" sort="Damase Michel, C" uniqKey="Damase Michel C" first="C" last="Damase-Michel">C. Damase-Michel</name></author><author><name sortKey="Lapeyre Mestre, M" sort="Lapeyre Mestre, M" uniqKey="Lapeyre Mestre M" first="M" last="Lapeyre-Mestre">M. Lapeyre-Mestre</name></author><author><name sortKey="Cismondo, S" sort="Cismondo, S" uniqKey="Cismondo S" first="S" last="Cismondo">S. Cismondo</name></author><author><name sortKey="O Connell, D" sort="O Connell, D" uniqKey="O Connell D" first="D" last="O'Connell">D. O'Connell</name></author><author><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></author><author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name></author><author><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name></author></analytic><series><title level="j">Clinical neuropharmacology</title><idno type="ISSN">0362-5664</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiparkinson Agents (therapeutic use)</term><term>Dopamine Agonists (therapeutic use)</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Prospective Studies</term><term>Salivation (drug effects)</term><term>Sex Factors</term><term>Sialorrhea (drug therapy)</term><term>Sialorrhea (etiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Salivation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Sialorrhea</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Sialorrhea</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Sex Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hypersialorrhea is frequently reported in patients with idiopathic Parkinson's Disease (PD). Excessive production of saliva, swallowing difficulties, or both could explain this complaint. Dopamine (DA) has been shown to modulate salivary secretion in a number of vertebrate and invertebrate species. The present study was performed to compare the unstimulated salivary flow in 83 patients with PD (8 untreated and 75 treated with levodopa + DA agonist) and in 65 age- and sex-matched control subjects. The Mann-Whitney U-test showed a significantly lower salivary flow in treated patients with PD (535 +/- 42 mg/2 min) (p < 0.002) and de novo patients (447 +/- 141) (p < 0.03) compared to controls (834 +/- 68 mg/2 min) with no relation with age or sex. Finally, the present study of reduced salivary flow in PD suggests that complaints of hypersialorrhea are not caused by a salivary defect, but could be explained by difficulties in swallowing. The decrease in salivary flow could be explained by autonomic dysfunction in PD.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Cismondo, S" sort="Cismondo, S" uniqKey="Cismondo S" first="S" last="Cismondo">S. Cismondo</name><name sortKey="Damase Michel, C" sort="Damase Michel, C" uniqKey="Damase Michel C" first="C" last="Damase-Michel">C. Damase-Michel</name><name sortKey="Lapeyre Mestre, M" sort="Lapeyre Mestre, M" uniqKey="Lapeyre Mestre M" first="M" last="Lapeyre-Mestre">M. Lapeyre-Mestre</name><name sortKey="Montastruc, J L" sort="Montastruc, J L" uniqKey="Montastruc J" first="J L" last="Montastruc">J L Montastruc</name><name sortKey="O Connell, D" sort="O Connell, D" uniqKey="O Connell D" first="D" last="O'Connell">D. O'Connell</name><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name><name sortKey="Senard, J M" sort="Senard, J M" uniqKey="Senard J" first="J M" last="Senard">J M Senard</name></noCountry><country name="France"><noRegion><name sortKey="Bagheri, H" sort="Bagheri, H" uniqKey="Bagheri H" first="H" last="Bagheri">H. Bagheri</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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