[Drugs, Parkinson's disease and parkinsonian syndroms: recent advances in pharmacovigilance].
Identifieur interne : 005920 ( Main/Exploration ); précédent : 005919; suivant : 005921[Drugs, Parkinson's disease and parkinsonian syndroms: recent advances in pharmacovigilance].
Auteurs : Jean-Louis Montastruc [France] ; Agnès Sommet ; Pascale Olivier ; Haleh Bagheri ; Mireille Gony ; Maryse Lapeyre-Mestre ; Christine Brefel-Courbon ; Joachim Ferreira ; Laurent Schmitt ; Jean-Michel Senard ; Olivier RascolSource :
- Therapie [ 0040-5957 ]
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Dopamine Agonists.
- geographic : France.
- drug therapy : Parkinson Disease, Parkinsonian Disorders.
- standards : Drug Prescriptions.
- statistics & numerical data : Accidents, Traffic.
- Humans.
Abstract
This paper reviews recent data on the pharmacovigilance of antiparkinsonian drugs and drugs inducing parkinsonian syndroms. Sudden sleep attacks were first described in 1999 with dopamine agonists. In fact, they can be induced by all the dopaminergic antiparkinsonian drugs. Favorising factors are duration of the disease, dose of dopaminergic drugs, daytime somnolence or dysautonomia. This adverse drug reaction can be serious leading, for example, to road accidents. Cardiac valvulopathies were more recently (end of 2002) described with pergolide. Thus, this dopamine agonist should now be prescribed as a last choice among dopamine agonists. Dopamine drugs (levodopa as well as dopamine agonists) can induce hypersexual behaviours or pathological gambling. Among the long list of drugs inducing parkinsonian syndroms, recent data suggest the involvement of serotoninergic antidepressants, valproic acid and trimetazidine. Finally, these data on pharmacovigilance allow to precise the physiological role of dopamine: beside its motor and psychic effects, dopamine is also involved in the sleep-arousal control. It is also an important mediator for pleasure, hedonic regulations and sexual behaviour. This review also underlines the major role of spontaneous reports to the pharmacovigilance systems to identify new adverse drug reactions.
PubMed: 16792152
Affiliations:
- France
- Midi-Pyrénées, Occitanie (région administrative)
- Toulouse
- Université Toulouse III - Paul Sabatier
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Le document en format XML
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Paul Sabatier</orgName></affiliation></author><author><name sortKey="Sommet, Agnes" sort="Sommet, Agnes" uniqKey="Sommet A" first="Agnès" last="Sommet">Agnès Sommet</name></author><author><name sortKey="Olivier, Pascale" sort="Olivier, Pascale" uniqKey="Olivier P" first="Pascale" last="Olivier">Pascale Olivier</name></author><author><name sortKey="Bagheri, Haleh" sort="Bagheri, Haleh" uniqKey="Bagheri H" first="Haleh" last="Bagheri">Haleh Bagheri</name></author><author><name sortKey="Gony, Mireille" sort="Gony, Mireille" uniqKey="Gony M" first="Mireille" last="Gony">Mireille Gony</name></author><author><name sortKey="Lapeyre Mestre, Maryse" sort="Lapeyre Mestre, Maryse" uniqKey="Lapeyre Mestre M" first="Maryse" last="Lapeyre-Mestre">Maryse Lapeyre-Mestre</name></author><author><name sortKey="Brefel Courbon, Christine" sort="Brefel Courbon, Christine" uniqKey="Brefel Courbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name></author><author><name sortKey="Ferreira, Joachim" sort="Ferreira, Joachim" uniqKey="Ferreira J" first="Joachim" last="Ferreira">Joachim Ferreira</name></author><author><name sortKey="Schmitt, Laurent" sort="Schmitt, Laurent" uniqKey="Schmitt L" first="Laurent" last="Schmitt">Laurent Schmitt</name></author><author><name sortKey="Senard, Jean Michel" sort="Senard, Jean Michel" uniqKey="Senard J" first="Jean-Michel" last="Senard">Jean-Michel Senard</name></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></author></analytic><series><title level="j">Therapie</title><idno type="ISSN">0040-5957</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accidents, Traffic (statistics & numerical data)</term><term>Antiparkinson Agents (adverse effects)</term><term>Dopamine Agonists (adverse effects)</term><term>Drug Prescriptions (standards)</term><term>France</term><term>Humans</term><term>Parkinson Disease (drug therapy)</term><term>Parkinsonian Disorders (drug therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Drug Prescriptions</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Accidents, Traffic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This paper reviews recent data on the pharmacovigilance of antiparkinsonian drugs and drugs inducing parkinsonian syndroms. Sudden sleep attacks were first described in 1999 with dopamine agonists. In fact, they can be induced by all the dopaminergic antiparkinsonian drugs. Favorising factors are duration of the disease, dose of dopaminergic drugs, daytime somnolence or dysautonomia. This adverse drug reaction can be serious leading, for example, to road accidents. Cardiac valvulopathies were more recently (end of 2002) described with pergolide. Thus, this dopamine agonist should now be prescribed as a last choice among dopamine agonists. Dopamine drugs (levodopa as well as dopamine agonists) can induce hypersexual behaviours or pathological gambling. Among the long list of drugs inducing parkinsonian syndroms, recent data suggest the involvement of serotoninergic antidepressants, valproic acid and trimetazidine. Finally, these data on pharmacovigilance allow to precise the physiological role of dopamine: beside its motor and psychic effects, dopamine is also involved in the sleep-arousal control. It is also an important mediator for pleasure, hedonic regulations and sexual behaviour. This review also underlines the major role of spontaneous reports to the pharmacovigilance systems to identify new adverse drug reactions.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Toulouse</li></settlement><orgName><li>Université Toulouse III - Paul Sabatier</li></orgName></list><tree><noCountry><name sortKey="Bagheri, Haleh" sort="Bagheri, Haleh" uniqKey="Bagheri H" first="Haleh" last="Bagheri">Haleh Bagheri</name><name sortKey="Brefel Courbon, Christine" sort="Brefel Courbon, Christine" uniqKey="Brefel Courbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name><name sortKey="Ferreira, Joachim" sort="Ferreira, Joachim" uniqKey="Ferreira J" first="Joachim" last="Ferreira">Joachim Ferreira</name><name sortKey="Gony, Mireille" sort="Gony, Mireille" uniqKey="Gony M" first="Mireille" last="Gony">Mireille Gony</name><name sortKey="Lapeyre Mestre, Maryse" sort="Lapeyre Mestre, Maryse" uniqKey="Lapeyre Mestre M" first="Maryse" last="Lapeyre-Mestre">Maryse Lapeyre-Mestre</name><name sortKey="Olivier, Pascale" sort="Olivier, Pascale" uniqKey="Olivier P" first="Pascale" last="Olivier">Pascale Olivier</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Schmitt, Laurent" sort="Schmitt, Laurent" uniqKey="Schmitt L" first="Laurent" last="Schmitt">Laurent Schmitt</name><name sortKey="Senard, Jean Michel" sort="Senard, Jean Michel" uniqKey="Senard J" first="Jean-Michel" last="Senard">Jean-Michel Senard</name><name sortKey="Sommet, Agnes" sort="Sommet, Agnes" uniqKey="Sommet A" first="Agnès" last="Sommet">Agnès Sommet</name></noCountry><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean-Louis" last="Montastruc">Jean-Louis Montastruc</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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