ParkinsonFranceV1, Main, Exploration, bibRecord, 005914

[Gene therapy in Parkinson disease: a promising future treatment?].

Identifieur interne : 005914 ( Main/Exploration ); précédent : 005913; suivant : 005915

[Gene therapy in Parkinson disease: a promising future treatment?].

Auteurs : Claire Golé [France] ; Romain Reboul ; Pascale Pisano

Source :

Therapie [ 0040-5957 ]

RBID : pubmed:22031685

English descriptors

KwdEn :
- Aromatic-L-Amino-Acid Decarboxylases (genetics), Clinical Trials as Topic, Genetic Therapy (methods), Genetic Therapy (trends), Genetic Vectors, Glutamate Decarboxylase (genetics), Humans, Parkinson Disease (therapy), Tyrosine 3-Monooxygenase (genetics).
MESH :
- chemical , genetics : Aromatic-L-Amino-Acid Decarboxylases, Glutamate Decarboxylase, Tyrosine 3-Monooxygenase.
- methods : Genetic Therapy.
- therapy : Parkinson Disease.
- trends : Genetic Therapy.
- Clinical Trials as Topic, Genetic Vectors, Humans.

Abstract

Parkinson disease is a neurodegenerative pathology with high incidence. Current treatments ease the symptoms but don't stop the development of the disease and aren't without any major side effects. Although this pathology is not specifically caused by genetic abnormalities, the involvement of numerous proteins in the pathophysiological process enables us to give an interest to gene therapy. This hypothesis has been upheld by positive results on animals and by five phase I trials on humans but may be attenuated by the first phase II trial recently published showing modest efficiency and multiple side effects. However, these preliminary results will need to be reinforced by more important trials in order to be sure of the safety and get efficacy data, which will allow us to give an opinion upon this new way of treatment.

DOI: 10.2515/therapie/2011062
PubMed: 22031685

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">Parkinson disease is a neurodegenerative pathology with high incidence. Current treatments ease the symptoms but don't stop the development of the disease and aren't without any major side effects. Although this pathology is not specifically caused by genetic abnormalities, the involvement of numerous proteins in the pathophysiological process enables us to give an interest to gene therapy. This hypothesis has been upheld by positive results on animals and by five phase I trials on humans but may be attenuated by the first phase II trial recently published showing modest efficiency and multiple side effects. However, these preliminary results will need to be reinforced by more important trials in order to be sure of the safety and get efficacy data, which will allow us to give an opinion upon this new way of treatment.</div>
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La maladie de Parkinson en France (serveur d'exploration)

[Gene therapy in Parkinson disease: a promising future treatment?].

[Gene therapy in Parkinson disease: a promising future treatment?].

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.