La maladie de Parkinson en France (serveur d'exploration)

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Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson's disease

Identifieur interne : 005004 ( Main/Exploration ); précédent : 005003; suivant : 005005

Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson's disease

Auteurs : P. Gaspar [France] ; C. Duyckaerts [France] ; C. Alvarez ; F. Javoy-Agid ; B. Berger

Source :

RBID : Pascal:92-0073596

Descripteurs français

English descriptors

Abstract

The motor areas of the cerebral cortex contain dense dopaminergic and noradrenergic innervation in humans. We looked for changes of these innervations in cases with Parkinson's disease (PD). The density of fibers immunolabeled with tyrosine hydroxylase or dopamine-beta-hydroxylase was evaluated in the primary motor, premotor, and prefrontal cortical regions in 6 cases with PD and 7 control cases. Reductions of both noradrenergic and dopaminergic cortical innervations were observed, with similar magnitudes of reduction found in the motor and prefrontal regions of the cortex


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Le document en format XML

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<div type="abstract" xml:lang="en">The motor areas of the cerebral cortex contain dense dopaminergic and noradrenergic innervation in humans. We looked for changes of these innervations in cases with Parkinson's disease (PD). The density of fibers immunolabeled with tyrosine hydroxylase or dopamine-beta-hydroxylase was evaluated in the primary motor, premotor, and prefrontal cortical regions in 6 cases with PD and 7 control cases. Reductions of both noradrenergic and dopaminergic cortical innervations were observed, with similar magnitudes of reduction found in the motor and prefrontal regions of the cortex</div>
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   |wiki=    Wicri/Sante
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   |clé=     Pascal:92-0073596
   |texte=   Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson's disease
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