Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson's disease
Identifieur interne : 005004 ( Main/Exploration ); précédent : 005003; suivant : 005005Alterations of dopaminergic and noradrenergic innervations in motor cortex in Parkinson's disease
Auteurs : P. Gaspar [France] ; C. Duyckaerts [France] ; C. Alvarez ; F. Javoy-Agid ; B. BergerSource :
- Annals of neurology [ 0364-5134 ] ; 1991.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
The motor areas of the cerebral cortex contain dense dopaminergic and noradrenergic innervation in humans. We looked for changes of these innervations in cases with Parkinson's disease (PD). The density of fibers immunolabeled with tyrosine hydroxylase or dopamine-beta-hydroxylase was evaluated in the primary motor, premotor, and prefrontal cortical regions in 6 cases with PD and 7 control cases. Reductions of both noradrenergic and dopaminergic cortical innervations were observed, with similar magnitudes of reduction found in the motor and prefrontal regions of the cortex
Affiliations:
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Le document en format XML
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<term>Immunocytochemistry</term>
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<front><div type="abstract" xml:lang="en">The motor areas of the cerebral cortex contain dense dopaminergic and noradrenergic innervation in humans. We looked for changes of these innervations in cases with Parkinson's disease (PD). The density of fibers immunolabeled with tyrosine hydroxylase or dopamine-beta-hydroxylase was evaluated in the primary motor, premotor, and prefrontal cortical regions in 6 cases with PD and 7 control cases. Reductions of both noradrenergic and dopaminergic cortical innervations were observed, with similar magnitudes of reduction found in the motor and prefrontal regions of the cortex</div>
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