External and implanted pumps for apomorphine infusion in parkinsonism.
Identifieur interne : 004B07 ( Main/Exploration ); précédent : 004B06; suivant : 004B08External and implanted pumps for apomorphine infusion in parkinsonism.
Auteurs : P. Pollak [France] ; A L Benabid ; P. Limousin ; C L Gervason ; E. Jeanneau-NicolleSource :
- Acta neurochirurgica. Supplementum ; 1993.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (therapeutic use), Adult, Aged, Animals, Apomorphine (administration & dosage), Apomorphine (pharmacology), Apomorphine (therapeutic use), Female, Humans, Infusion Pumps, Implantable, Macaca fascicularis, Male, Middle Aged, Motor Activity (drug effects), Parkinson Disease (drug therapy), Receptors, Dopamine (drug effects).
- MESH :
- chemical , administration & dosage : Apomorphine.
- chemical , drug effects : Receptors, Dopamine.
- chemical , pharmacology : Apomorphine.
- chemical , therapeutic use : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Apomorphine.
- drug effects : Motor Activity.
- drug therapy : Parkinson Disease.
- Adult, Aged, Animals, Female, Humans, Infusion Pumps, Implantable, Macaca fascicularis, Male, Middle Aged.
Abstract
Continuous delivery of dopaminergic agents to the striatum is a major challenge to improve the treatment of Parkinson's disease. Apomorphine is one of the best candidates because of its solubility and its D1 and D2 receptor agonist properties. Seventeen Parkinsonian patients suffering from severe L-dopa-induced on-off effects were treated by continuous subcutaneous (SC) infusion with a portable minipump. Administration of intracerebroventricular (ICV) apomorphine was carried out in 7 macaca fascicularis monkeys using implanted programmable pumps. Four of the monkeys were made Parkinsonian by MPTP injections. In patients receiving apomorphine, the mean duration of daily off periods was reduced by 61%. Psychiatric side effects were rare but SC nodules occurred in all patients and the external infusion method was therefore difficult to implement. In monkeys, the implanted system was well tolerated. ICV apomorphine infusion led to CSF apomorphine concentrations higher than the same apomorphine dose infused i.m. Motor function was considerably improved in two MPTP monkeys during the time of ICV infusion and 30 min after its arrest. Long-term ICV administration could not be carried out because of catheter blockage and/or apomorphine toxicity. SC and ICV apomorphine infusions are efficient for controlling motor activity in Parkinsonism but long-term toxicity remains to be studied further.
PubMed: 8109301
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001728
- to stream PubMed, to step Curation: 001687
- to stream PubMed, to step Checkpoint: 001687
- to stream Ncbi, to step Merge: 001D23
- to stream Ncbi, to step Curation: 001D23
- to stream Ncbi, to step Checkpoint: 001D23
- to stream Main, to step Merge: 005492
- to stream Main, to step Curation: 004B07
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">External and implanted pumps for apomorphine infusion in parkinsonism.</title>
<author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical and Biological Neurosciences, INSERM U-318, Joseph Fourier University of Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical and Biological Neurosciences, INSERM U-318, Joseph Fourier University of Grenoble</wicri:regionArea>
<wicri:noRegion>Joseph Fourier University of Grenoble</wicri:noRegion>
<wicri:noRegion>Joseph Fourier University of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name>
</author>
<author><name sortKey="Limousin, P" sort="Limousin, P" uniqKey="Limousin P" first="P" last="Limousin">P. Limousin</name>
</author>
<author><name sortKey="Gervason, C L" sort="Gervason, C L" uniqKey="Gervason C" first="C L" last="Gervason">C L Gervason</name>
</author>
<author><name sortKey="Jeanneau Nicolle, E" sort="Jeanneau Nicolle, E" uniqKey="Jeanneau Nicolle E" first="E" last="Jeanneau-Nicolle">E. Jeanneau-Nicolle</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1993">1993</date>
<idno type="RBID">pubmed:8109301</idno>
<idno type="pmid">8109301</idno>
<idno type="wicri:Area/PubMed/Corpus">001728</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001728</idno>
<idno type="wicri:Area/PubMed/Curation">001687</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001687</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001687</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001687</idno>
<idno type="wicri:Area/Ncbi/Merge">001D23</idno>
<idno type="wicri:Area/Ncbi/Curation">001D23</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001D23</idno>
<idno type="wicri:Area/Main/Merge">005492</idno>
<idno type="wicri:Area/Main/Curation">004B07</idno>
<idno type="wicri:Area/Main/Exploration">004B07</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">External and implanted pumps for apomorphine infusion in parkinsonism.</title>
<author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical and Biological Neurosciences, INSERM U-318, Joseph Fourier University of Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Clinical and Biological Neurosciences, INSERM U-318, Joseph Fourier University of Grenoble</wicri:regionArea>
<wicri:noRegion>Joseph Fourier University of Grenoble</wicri:noRegion>
<wicri:noRegion>Joseph Fourier University of Grenoble</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name>
</author>
<author><name sortKey="Limousin, P" sort="Limousin, P" uniqKey="Limousin P" first="P" last="Limousin">P. Limousin</name>
</author>
<author><name sortKey="Gervason, C L" sort="Gervason, C L" uniqKey="Gervason C" first="C L" last="Gervason">C L Gervason</name>
</author>
<author><name sortKey="Jeanneau Nicolle, E" sort="Jeanneau Nicolle, E" uniqKey="Jeanneau Nicolle E" first="E" last="Jeanneau-Nicolle">E. Jeanneau-Nicolle</name>
</author>
</analytic>
<series><title level="j">Acta neurochirurgica. Supplementum</title>
<imprint><date when="1993" type="published">1993</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (therapeutic use)</term>
<term>Adult</term>
<term>Aged</term>
<term>Animals</term>
<term>Apomorphine (administration & dosage)</term>
<term>Apomorphine (pharmacology)</term>
<term>Apomorphine (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Infusion Pumps, Implantable</term>
<term>Macaca fascicularis</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (drug effects)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Receptors, Dopamine (drug effects)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Receptors, Dopamine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term>
<term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Animals</term>
<term>Female</term>
<term>Humans</term>
<term>Infusion Pumps, Implantable</term>
<term>Macaca fascicularis</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Continuous delivery of dopaminergic agents to the striatum is a major challenge to improve the treatment of Parkinson's disease. Apomorphine is one of the best candidates because of its solubility and its D1 and D2 receptor agonist properties. Seventeen Parkinsonian patients suffering from severe L-dopa-induced on-off effects were treated by continuous subcutaneous (SC) infusion with a portable minipump. Administration of intracerebroventricular (ICV) apomorphine was carried out in 7 macaca fascicularis monkeys using implanted programmable pumps. Four of the monkeys were made Parkinsonian by MPTP injections. In patients receiving apomorphine, the mean duration of daily off periods was reduced by 61%. Psychiatric side effects were rare but SC nodules occurred in all patients and the external infusion method was therefore difficult to implement. In monkeys, the implanted system was well tolerated. ICV apomorphine infusion led to CSF apomorphine concentrations higher than the same apomorphine dose infused i.m. Motor function was considerably improved in two MPTP monkeys during the time of ICV infusion and 30 min after its arrest. Long-term ICV administration could not be carried out because of catheter blockage and/or apomorphine toxicity. SC and ICV apomorphine infusions are efficient for controlling motor activity in Parkinsonism but long-term toxicity remains to be studied further.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><noCountry><name sortKey="Benabid, A L" sort="Benabid, A L" uniqKey="Benabid A" first="A L" last="Benabid">A L Benabid</name>
<name sortKey="Gervason, C L" sort="Gervason, C L" uniqKey="Gervason C" first="C L" last="Gervason">C L Gervason</name>
<name sortKey="Jeanneau Nicolle, E" sort="Jeanneau Nicolle, E" uniqKey="Jeanneau Nicolle E" first="E" last="Jeanneau-Nicolle">E. Jeanneau-Nicolle</name>
<name sortKey="Limousin, P" sort="Limousin, P" uniqKey="Limousin P" first="P" last="Limousin">P. Limousin</name>
</noCountry>
<country name="France"><noRegion><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P" last="Pollak">P. Pollak</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004B07 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004B07 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:8109301 |texte= External and implanted pumps for apomorphine infusion in parkinsonism. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:8109301" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |