ParkinsonFranceV1, Main, Exploration, bibRecord, 004894

Dextromethorphan O-demethylase activity in rat brain microsomes

Identifieur interne : 004894 ( Main/Exploration ); précédent : 004893; suivant : 004895

Dextromethorphan O-demethylase activity in rat brain microsomes

Auteurs : C. Jolivalt [France] ; A. Minn [France] ; M. Vincent-Viry [France] ; M.-M. Galteau [France] ; G. Siest [France]

Source :

Neuroscience letters [ 0304-3940 ] ; 1995.

RBID : Pascal:95-0202117

Descripteurs français

Pascal (Inist)
- Encéphale, Microsome, Activité enzymatique, Déméthylation, Dextrométhorphane, Cytochrome P450, Forme moléculaire, Rat.

English descriptors

KwdEn :
- Brain (vertebrata), Cytochrome P450, Demethylation, Enzymatic activity, Microsome, Molecular form, Rat.

Abstract

CYP2D, a genetically variable isoform of cytochrome P450, has been characterized mainly in the liver and the brain of mammals by measurement of debrisoquine hydroxylase activity. Moreover, «poor debrisoquine metabolizer» phenotype is significantly increased in Parkinson's disease patients. We present here the first demonstration that the activity of the CYP2D isoform can be characterized in rat brain microsomes by the measurement of dextromethorphan O-demethylase capacity. The cerebral formation of dextrorphan, an antagonist of the N-methyl-D-aspartate receptor, was inhibited by the presence of quinidine and N-methyl-4-phenylpyridinium (MPP⁺), a dopaminergic neurotoxin inducing a chemical parkinsonism in humans

Affiliations:

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to stream Main, to step Curation: 004894

Le document en format XML

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<front><div type="abstract" xml:lang="en">CYP2D, a genetically variable isoform of cytochrome P450, has been characterized mainly in the liver and the brain of mammals by measurement of debrisoquine hydroxylase activity. Moreover, «poor debrisoquine metabolizer» phenotype is significantly increased in Parkinson's disease patients. We present here the first demonstration that the activity of the CYP2D isoform can be characterized in rat brain microsomes by the measurement of dextromethorphan O-demethylase capacity. The cerebral formation of dextrorphan, an antagonist of the N-methyl-D-aspartate receptor, was inhibited by the presence of quinidine and N-methyl-4-phenylpyridinium (MPP<sup>+</sup>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Dextromethorphan O-demethylase activity in rat brain microsomes

Dextromethorphan O-demethylase activity in rat brain microsomes

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri