ParkinsonFranceV1, Main, Exploration, bibRecord, 004143

Ouabain-induced increase in dopamine release from mouse striatal slices is antagonized by riluzole

Identifieur interne : 004143 ( Main/Exploration ); précédent : 004142; suivant : 004144

Ouabain-induced increase in dopamine release from mouse striatal slices is antagonized by riluzole

Auteurs : A. Boireau [France] ; M. Meunier [France] ; A. Imperato [France]

Source :

Journal of pharmacy and pharmacology [ 0022-3573 ] ; 1998.

RBID : Pascal:99-0043435

Descripteurs français

Pascal (Inist)
- Riluzole, Anticonvulsivant, Psychotrope, Activité biologique, Mécanisme action, Animal, Souris, Système nerveux central, Corps strié, In vitro, Dopamine, Catécholamine, Neurotransmetteur, Antagoniste calcium, Neuroprotecteur, Canal ionique, Calcium, Benzothiazole.
Wicri :
- topic : Calcium.

English descriptors

KwdEn :
- Animal, Anticonvulsant, Benzothiazole, Biological activity, Calcium, Calcium antagonist, Catecholamine, Central nervous system, Corpus striatum, Dopamine, In vitro, Ionic channel, Mechanism of action, Mouse, Neuroprotective agent, Neurotransmitter, Psychotropic, Riluzole.

Abstract

We have examined the effects of riluzole, a neuroprotective drug which stabilizes voltage-dependent sodium channels in their inactivated state and inhibits the release of glutamate in-vivo and in-vitro, on the release of newly taken up [³H]dopamine induced by ouabain, a potent and selective inhibitor of Na⁺/K⁺-ATPase in mouse striatal slices in-vitro. Riluzole potently (IC50 (concentration resulting in 50% inhibition)=0.9±0.3 μM) and dose-dependently antagonized ouabain-stimulated [³H]dopamine release, the effect being observed at low concentrations. Tetrodotoxin (1 μM) and nomifensine (10 μM) also abolished ouabain-induced [³H]dopamine release. Blockade of glutamate receptors with dizocilpine (1 μM) and 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione (YM-90K; 10 μM), alone or in combination, was without effect. Incubation of striatal slices with 50 μM La³⁺, which blocks voltage-dependent calcium channels, did not inhibit [³H]dopamine release induced by ouabain. The potent effects of riluzole observed in this model are probably related to its ability to block voltage-dependent sodium channels. The consequences of this activity are critically discussed in relation to the protective action of riluzole previously reported in various models of Parkinson's disease and other neurodegenerative disorders.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 001555
to stream PascalFrancis, to step Curation: 001A90
to stream PascalFrancis, to step Checkpoint: 001428
to stream Main, to step Merge: 004932
to stream Main, to step Curation: 004143

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Ouabain-induced increase in dopamine release from mouse striatal slices is antagonized by riluzole</title>
<author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A." last="Boireau">A. Boireau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Rhône-Poulenc Rorer S. A., Centre de Recherche de Vitry-Alfortville, 13, quai Jules Guesde BP 14</s1>
<s2>94403 Vitry-sur-Seine</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Vitry-sur-Seine</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meunier, M" sort="Meunier, M" uniqKey="Meunier M" first="M." last="Meunier">M. Meunier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Rhône-Poulenc Rorer S. A., Centre de Recherche de Vitry-Alfortville, 13, quai Jules Guesde BP 14</s1>
<s2>94403 Vitry-sur-Seine</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Vitry-sur-Seine</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Imperato, A" sort="Imperato, A" uniqKey="Imperato A" first="A." last="Imperato">A. Imperato</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Rhône-Poulenc Rorer S. A., Centre de Recherche de Vitry-Alfortville, 13, quai Jules Guesde BP 14</s1>
<s2>94403 Vitry-sur-Seine</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Vitry-sur-Seine</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">99-0043435</idno>
<date when="1998">1998</date>
<idno type="stanalyst">PASCAL 99-0043435 INIST</idno>
<idno type="RBID">Pascal:99-0043435</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001555</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001A90</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001428</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001428</idno>
<idno type="wicri:doubleKey">0022-3573:1998:Boireau A:ouabain:induced:increase</idno>
<idno type="wicri:Area/Main/Merge">004932</idno>
<idno type="wicri:Area/Main/Curation">004143</idno>
<idno type="wicri:Area/Main/Exploration">004143</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Ouabain-induced increase in dopamine release from mouse striatal slices is antagonized by riluzole</title>
<author><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A." last="Boireau">A. Boireau</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Rhône-Poulenc Rorer S. A., Centre de Recherche de Vitry-Alfortville, 13, quai Jules Guesde BP 14</s1>
<s2>94403 Vitry-sur-Seine</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Vitry-sur-Seine</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meunier, M" sort="Meunier, M" uniqKey="Meunier M" first="M." last="Meunier">M. Meunier</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Rhône-Poulenc Rorer S. A., Centre de Recherche de Vitry-Alfortville, 13, quai Jules Guesde BP 14</s1>
<s2>94403 Vitry-sur-Seine</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Vitry-sur-Seine</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Imperato, A" sort="Imperato, A" uniqKey="Imperato A" first="A." last="Imperato">A. Imperato</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Rhône-Poulenc Rorer S. A., Centre de Recherche de Vitry-Alfortville, 13, quai Jules Guesde BP 14</s1>
<s2>94403 Vitry-sur-Seine</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Vitry-sur-Seine</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of pharmacy and pharmacology</title>
<title level="j" type="abbreviated">J. pharm. pharmacol.</title>
<idno type="ISSN">0022-3573</idno>
<imprint><date when="1998">1998</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of pharmacy and pharmacology</title>
<title level="j" type="abbreviated">J. pharm. pharmacol.</title>
<idno type="ISSN">0022-3573</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Anticonvulsant</term>
<term>Benzothiazole</term>
<term>Biological activity</term>
<term>Calcium</term>
<term>Calcium antagonist</term>
<term>Catecholamine</term>
<term>Central nervous system</term>
<term>Corpus striatum</term>
<term>Dopamine</term>
<term>In vitro</term>
<term>Ionic channel</term>
<term>Mechanism of action</term>
<term>Mouse</term>
<term>Neuroprotective agent</term>
<term>Neurotransmitter</term>
<term>Psychotropic</term>
<term>Riluzole</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Riluzole</term>
<term>Anticonvulsivant</term>
<term>Psychotrope</term>
<term>Activité biologique</term>
<term>Mécanisme action</term>
<term>Animal</term>
<term>Souris</term>
<term>Système nerveux central</term>
<term>Corps strié</term>
<term>In vitro</term>
<term>Dopamine</term>
<term>Catécholamine</term>
<term>Neurotransmetteur</term>
<term>Antagoniste calcium</term>
<term>Neuroprotecteur</term>
<term>Canal ionique</term>
<term>Calcium</term>
<term>Benzothiazole</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Calcium</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We have examined the effects of riluzole, a neuroprotective drug which stabilizes voltage-dependent sodium channels in their inactivated state and inhibits the release of glutamate in-vivo and in-vitro, on the release of newly taken up [<sup>3</sup>
H]dopamine induced by ouabain, a potent and selective inhibitor of Na<sup>+</sup>
/K<sup>+</sup>
-ATPase in mouse striatal slices in-vitro. Riluzole potently (IC50 (concentration resulting in 50% inhibition)=0.9±0.3 μM) and dose-dependently antagonized ouabain-stimulated [<sup>3</sup>
H]dopamine release, the effect being observed at low concentrations. Tetrodotoxin (1 μM) and nomifensine (10 μM) also abolished ouabain-induced [<sup>3</sup>
H]dopamine release. Blockade of glutamate receptors with dizocilpine (1 μM) and 6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione (YM-90K; 10 μM), alone or in combination, was without effect. Incubation of striatal slices with 50 μM La<sup>3+</sup>
, which blocks voltage-dependent calcium channels, did not inhibit [<sup>3</sup>
H]dopamine release induced by ouabain. The potent effects of riluzole observed in this model are probably related to its ability to block voltage-dependent sodium channels. The consequences of this activity are critically discussed in relation to the protective action of riluzole previously reported in various models of Parkinson's disease and other neurodegenerative disorders.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Vitry-sur-Seine</li>
</settlement>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Boireau, A" sort="Boireau, A" uniqKey="Boireau A" first="A." last="Boireau">A. Boireau</name>
</region>
<name sortKey="Imperato, A" sort="Imperato, A" uniqKey="Imperato A" first="A." last="Imperato">A. Imperato</name>
<name sortKey="Meunier, M" sort="Meunier, M" uniqKey="Meunier M" first="M." last="Meunier">M. Meunier</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004143 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004143 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:99-0043435
   |texte=   Ouabain-induced increase in dopamine release from mouse striatal slices is antagonized by riluzole
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Ouabain-induced increase in dopamine release from mouse striatal slices is antagonized by riluzole

Ouabain-induced increase in dopamine release from mouse striatal slices is antagonized by riluzole

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri