Neurodegenerative disorders: the role of peroxynitrite.
Identifieur interne : 003C46 ( Main/Exploration ); précédent : 003C45; suivant : 003C47Neurodegenerative disorders: the role of peroxynitrite.
Auteurs : F. Torreilles [France] ; S. Salman-Tabcheh ; M. Guérin ; J. TorreillesSource :
- Brain research. Brain research reviews ; 1999.
English descriptors
- KwdEn :
- Alzheimer Disease (physiopathology), Animals, Central Nervous System (physiopathology), Humans, Inflammation, Motor Neuron Disease (physiopathology), Multiple Sclerosis (physiopathology), Neurodegenerative Diseases (pathology), Neurodegenerative Diseases (physiopathology), Neurons (pathology), Neurons (physiology), Nitrates (physiology), Oxidants, Parkinson Disease (physiopathology).
- MESH :
- chemical , physiology : Nitrates.
- pathology : Neurodegenerative Diseases, Neurons.
- physiology : Neurons.
- physiopathology : Alzheimer Disease, Central Nervous System, Motor Neuron Disease, Multiple Sclerosis, Neurodegenerative Diseases, Parkinson Disease.
- Animals, Humans, Inflammation, Oxidants.
Abstract
Inflammatory reaction is thought to be an important contributor to neuronal damage in neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and the parkinsonism dementia complex of Guam. Among the toxic agents released in brain tissues by activated cells, we focus attention in this review on peroxynitrite, the product of the reaction between nitric oxide (NO) and superoxide. Peroxynitrite is a strong oxidizing and nitrating agent which can react with all classes of biomolecules. In the CNS it can be generated by microglial cells activated by pro-inflammatory cytokines or beta-amyloid peptide (beta-A) and by neurons in three different situations: hyperactivity of glutamate neurotransmission, mitochondrial dysfunction and depletion of L-arginine or tetrahydrobiopterin. The first two situations correspond to cellular responses to an initial neuronal injury and the peroxynitrite formed only exacerbates the inflammatory process, whereas in the third situation the peroxynitrite generated directly contributes to the initiation of the neurodegenerative process.
PubMed: 10525172
Affiliations:
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Le document en format XML
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Salman-Tabcheh</name></author><author><name sortKey="Guerin, M" sort="Guerin, M" uniqKey="Guerin M" first="M" last="Guérin">M. Guérin</name></author><author><name sortKey="Torreilles, J" sort="Torreilles, J" uniqKey="Torreilles J" first="J" last="Torreilles">J. Torreilles</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:10525172</idno><idno type="pmid">10525172</idno><idno type="wicri:Area/PubMed/Corpus">001386</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001386</idno><idno type="wicri:Area/PubMed/Curation">001345</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001345</idno><idno type="wicri:Area/PubMed/Checkpoint">001345</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001345</idno><idno type="wicri:Area/Ncbi/Merge">000070</idno><idno type="wicri:Area/Ncbi/Curation">000070</idno><idno type="wicri:Area/Ncbi/Checkpoint">000070</idno><idno type="wicri:Area/Main/Merge">004336</idno><idno type="wicri:Area/Main/Curation">003C46</idno><idno type="wicri:Area/Main/Exploration">003C46</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neurodegenerative disorders: the role of peroxynitrite.</title><author><name sortKey="Torreilles, F" sort="Torreilles, F" uniqKey="Torreilles F" first="F" last="Torreilles">F. Torreilles</name><affiliation wicri:level="3"><nlm:affiliation>CNRS UMR 9921 UFR Pharmacie, 15 av. Charles Flahault, 34060, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS UMR 9921 UFR Pharmacie, 15 av. Charles Flahault, 34060, Montpellier</wicri:regionArea><placeName><region type="region" nuts="2">Occitanie (région administrative)</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Salman Tabcheh, S" sort="Salman Tabcheh, S" uniqKey="Salman Tabcheh S" first="S" last="Salman-Tabcheh">S. Salman-Tabcheh</name></author><author><name sortKey="Guerin, M" sort="Guerin, M" uniqKey="Guerin M" first="M" last="Guérin">M. Guérin</name></author><author><name sortKey="Torreilles, J" sort="Torreilles, J" uniqKey="Torreilles J" first="J" last="Torreilles">J. Torreilles</name></author></analytic><series><title level="j">Brain research. Brain research reviews</title><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (physiopathology)</term><term>Animals</term><term>Central Nervous System (physiopathology)</term><term>Humans</term><term>Inflammation</term><term>Motor Neuron Disease (physiopathology)</term><term>Multiple Sclerosis (physiopathology)</term><term>Neurodegenerative Diseases (pathology)</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Neurons (pathology)</term><term>Neurons (physiology)</term><term>Nitrates (physiology)</term><term>Oxidants</term><term>Parkinson Disease (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Nitrates</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neurodegenerative Diseases</term><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term><term>Central Nervous System</term><term>Motor Neuron Disease</term><term>Multiple Sclerosis</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Inflammation</term><term>Oxidants</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Inflammatory reaction is thought to be an important contributor to neuronal damage in neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and the parkinsonism dementia complex of Guam. Among the toxic agents released in brain tissues by activated cells, we focus attention in this review on peroxynitrite, the product of the reaction between nitric oxide (NO) and superoxide. Peroxynitrite is a strong oxidizing and nitrating agent which can react with all classes of biomolecules. In the CNS it can be generated by microglial cells activated by pro-inflammatory cytokines or beta-amyloid peptide (beta-A) and by neurons in three different situations: hyperactivity of glutamate neurotransmission, mitochondrial dysfunction and depletion of L-arginine or tetrahydrobiopterin. The first two situations correspond to cellular responses to an initial neuronal injury and the peroxynitrite formed only exacerbates the inflammatory process, whereas in the third situation the peroxynitrite generated directly contributes to the initiation of the neurodegenerative process.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li></region><settlement><li>Montpellier</li></settlement></list><tree><noCountry><name sortKey="Guerin, M" sort="Guerin, M" uniqKey="Guerin M" first="M" last="Guérin">M. Guérin</name><name sortKey="Salman Tabcheh, S" sort="Salman Tabcheh, S" uniqKey="Salman Tabcheh S" first="S" last="Salman-Tabcheh">S. Salman-Tabcheh</name><name sortKey="Torreilles, J" sort="Torreilles, J" uniqKey="Torreilles J" first="J" last="Torreilles">J. Torreilles</name></noCountry><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Torreilles, F" sort="Torreilles, F" uniqKey="Torreilles F" first="F" last="Torreilles">F. Torreilles</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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