Association between early-onset Parkinson's disease and mutations in the Parkin gene
Identifieur interne : 003C09 ( Main/Exploration ); précédent : 003C08; suivant : 003C10Association between early-onset Parkinson's disease and mutations in the Parkin gene
Auteurs : C. B. Lücking [France] ; A. Dürr [France] ; V. Bonifati [Italie] ; J. Vaughan [Royaume-Uni] ; G. De Michele [Italie] ; T. Gasser [Allemagne] ; B. S. Harhangi [Pays-Bas] ; G. Meco [Italie] ; P. Denefle [France] ; N. W. Wood [Royaume-Uni] ; Yves Agid [France] ; A. Brice [France]Source :
- The New England journal of medicine [ 0028-4793 ] ; 2000.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Background Mutations in the parkin gene have recently been identified in patients with early-onset Parkinson's disease, but the frequency of the mutations and the associated phenotype have not been assessed in a large series of patients. Methods We studied 73 families in which at least one of the affected family members was affected at or before the age of 45 years and had parents who were not affected, as well as 100 patients with isolated Parkinson's disease that began at or before the age of 45 years. All subjects were screened for mutations in the parkin gene with use of a semiquantitative polymerase-chain-reaction assay that simultaneously amplified several exons. We sequenced the coding exons in a subgroup of patients. We also compared the clinical features of patients with parkin mutations and those without mutations. Results Among the families with early-onset Parkinson's disease, 36 (49 percent) had parkin mutations. The age at onset ranged from 7 to 58 years. Among the patients with isolated Parkinson's disease, mutations were detected in 10 of 13 patients (77 percent) with an age at onset of 20 years or younger, but in only 2 of 64 patients (3 percent) with an age at onset of more than 30 years. The mean (±SD) age at onset in the patients with parkin mutations was younger than that in those without mutations (32±11 vs. 42± 11 years, P<0.001), and they were more likely to have symmetric involvement and dystonia at onset, to have hyperreflexia at onset or later, to have a good response to levodopa therapy, and to have levodopa-induced dyskinesias during treatment. Nineteen different rearrangements of exons (deletions and multiplications) and 16 different point mutations were detected. Conclusions Mutations in the parkin gene are a major cause of early-onset autosomal recessive familial Parkinson's disease and isolated juvenile-onset Parkinson's disease (at or before the age of 20 years). Accurate diagnosis of these cases cannot be based only on the clinical manifestations of the disease.
Affiliations:
- Allemagne, France, Italie, Pays-Bas, Royaume-Uni
- Angleterre, Bavière, District de Haute-Bavière, Grand Londres, Hollande-Méridionale, Latium, Île-de-France
- Londres, Munich, Paris, Rome, Rotterdam, Évry (Essonne)
- Hôpital de la Salpêtrière
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001379
- to stream PascalFrancis, to step Curation: 000059
- to stream PascalFrancis, to step Checkpoint: 001240
- to stream Main, to step Merge: 004277
- to stream Main, to step Curation: 003C09
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Association between early-onset Parkinson's disease and mutations in the Parkin gene</title>
<author><name sortKey="Lucking, C B" sort="Lucking, C B" uniqKey="Lucking C" first="C. B." last="Lücking">C. B. Lücking</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM Unité 289, Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Durr, A" sort="Durr, A" uniqKey="Durr A" first="A." last="Dürr">A. Dürr</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM Unité 289, Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonifati, V" sort="Bonifati, V" uniqKey="Bonifati V" first="V." last="Bonifati">V. Bonifati</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Dipartimento di Scienze Neurologiche, University La Sapienza</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vaughan, J" sort="Vaughan, J" uniqKey="Vaughan J" first="J." last="Vaughan">J. Vaughan</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Michele, G" sort="De Michele, G" uniqKey="De Michele G" first="G." last="De Michele">G. De Michele</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Dipartimento di Scienze Neurologiche, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T." last="Gasser">T. Gasser</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universität</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harhangi, B S" sort="Harhangi, B S" uniqKey="Harhangi B" first="B. S." last="Harhangi">B. S. Harhangi</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Epidemiology and Biostatistics, Erasmus University Medical School</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meco, G" sort="Meco, G" uniqKey="Meco G" first="G." last="Meco">G. Meco</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Dipartimento di Scienze Neurologiche, University La Sapienza</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Denefle, P" sort="Denefle, P" uniqKey="Denefle P" first="P." last="Denefle">P. Denefle</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Evry Genomics Center, Aventis Pharma France</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wood, N W" sort="Wood, N W" uniqKey="Wood N" first="N. W." last="Wood">N. W. Wood</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM Unité 289, Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A." last="Brice">A. Brice</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM Unité 289, Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">00-0276372</idno>
<date when="2000">2000</date>
<idno type="stanalyst">PASCAL 00-0276372 INIST</idno>
<idno type="RBID">Pascal:00-0276372</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001379</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000059</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001240</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001240</idno>
<idno type="wicri:doubleKey">0028-4793:2000:Lucking C:association:between:early</idno>
<idno type="wicri:Area/Main/Merge">004277</idno>
<idno type="wicri:Area/Main/Curation">003C09</idno>
<idno type="wicri:Area/Main/Exploration">003C09</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association between early-onset Parkinson's disease and mutations in the Parkin gene</title>
<author><name sortKey="Lucking, C B" sort="Lucking, C B" uniqKey="Lucking C" first="C. B." last="Lücking">C. B. Lücking</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM Unité 289, Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Durr, A" sort="Durr, A" uniqKey="Durr A" first="A." last="Dürr">A. Dürr</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM Unité 289, Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonifati, V" sort="Bonifati, V" uniqKey="Bonifati V" first="V." last="Bonifati">V. Bonifati</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Dipartimento di Scienze Neurologiche, University La Sapienza</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vaughan, J" sort="Vaughan, J" uniqKey="Vaughan J" first="J." last="Vaughan">J. Vaughan</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Michele, G" sort="De Michele, G" uniqKey="De Michele G" first="G." last="De Michele">G. De Michele</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Dipartimento di Scienze Neurologiche, University Federico II</s1>
<s2>Naples</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<wicri:noRegion>Naples</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T." last="Gasser">T. Gasser</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians Universität</s1>
<s2>Munich</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harhangi, B S" sort="Harhangi, B S" uniqKey="Harhangi B" first="B. S." last="Harhangi">B. S. Harhangi</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Epidemiology and Biostatistics, Erasmus University Medical School</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meco, G" sort="Meco, G" uniqKey="Meco G" first="G." last="Meco">G. Meco</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Dipartimento di Scienze Neurologiche, University La Sapienza</s1>
<s2>Rome</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Italie</country>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Denefle, P" sort="Denefle, P" uniqKey="Denefle P" first="P." last="Denefle">P. Denefle</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Evry Genomics Center, Aventis Pharma France</s1>
<s2>Evry</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Évry (Essonne)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wood, N W" sort="Wood, N W" uniqKey="Wood N" first="N. W." last="Wood">N. W. Wood</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Neurology</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM Unité 289, Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A." last="Brice">A. Brice</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>INSERM Unité 289, Hôpital de la Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
<imprint><date when="2000">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The New England journal of medicine</title>
<title level="j" type="abbreviated">N. Engl. j. med.</title>
<idno type="ISSN">0028-4793</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical form</term>
<term>Comparative study</term>
<term>Early</term>
<term>Etiopathogenesis</term>
<term>Family study</term>
<term>Human</term>
<term>Mutation</term>
<term>Onset time</term>
<term>Parkinson disease</term>
<term>Phenotype</term>
<term>Polymerase chain reaction</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Précoce</term>
<term>Temps établissement</term>
<term>Mutation</term>
<term>Réaction chaîne polymérase</term>
<term>Forme clinique</term>
<term>Phénotype</term>
<term>Etude comparative</term>
<term>Etiopathogénie</term>
<term>Homme</term>
<term>Etude familiale</term>
<term>Gène parkin</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background Mutations in the parkin gene have recently been identified in patients with early-onset Parkinson's disease, but the frequency of the mutations and the associated phenotype have not been assessed in a large series of patients. Methods We studied 73 families in which at least one of the affected family members was affected at or before the age of 45 years and had parents who were not affected, as well as 100 patients with isolated Parkinson's disease that began at or before the age of 45 years. All subjects were screened for mutations in the parkin gene with use of a semiquantitative polymerase-chain-reaction assay that simultaneously amplified several exons. We sequenced the coding exons in a subgroup of patients. We also compared the clinical features of patients with parkin mutations and those without mutations. Results Among the families with early-onset Parkinson's disease, 36 (49 percent) had parkin mutations. The age at onset ranged from 7 to 58 years. Among the patients with isolated Parkinson's disease, mutations were detected in 10 of 13 patients (77 percent) with an age at onset of 20 years or younger, but in only 2 of 64 patients (3 percent) with an age at onset of more than 30 years. The mean (±SD) age at onset in the patients with parkin mutations was younger than that in those without mutations (32±11 vs. 42± 11 years, P<0.001), and they were more likely to have symmetric involvement and dystonia at onset, to have hyperreflexia at onset or later, to have a good response to levodopa therapy, and to have levodopa-induced dyskinesias during treatment. Nineteen different rearrangements of exons (deletions and multiplications) and 16 different point mutations were detected. Conclusions Mutations in the parkin gene are a major cause of early-onset autosomal recessive familial Parkinson's disease and isolated juvenile-onset Parkinson's disease (at or before the age of 20 years). Accurate diagnosis of these cases cannot be based only on the clinical manifestations of the disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Bavière</li>
<li>District de Haute-Bavière</li>
<li>Grand Londres</li>
<li>Hollande-Méridionale</li>
<li>Latium</li>
<li>Île-de-France</li>
</region>
<settlement><li>Londres</li>
<li>Munich</li>
<li>Paris</li>
<li>Rome</li>
<li>Rotterdam</li>
<li>Évry (Essonne)</li>
</settlement>
<orgName><li>Hôpital de la Salpêtrière</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Lucking, C B" sort="Lucking, C B" uniqKey="Lucking C" first="C. B." last="Lücking">C. B. Lücking</name>
</region>
<name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<name sortKey="Brice, A" sort="Brice, A" uniqKey="Brice A" first="A." last="Brice">A. Brice</name>
<name sortKey="Denefle, P" sort="Denefle, P" uniqKey="Denefle P" first="P." last="Denefle">P. Denefle</name>
<name sortKey="Durr, A" sort="Durr, A" uniqKey="Durr A" first="A." last="Dürr">A. Dürr</name>
</country>
<country name="Italie"><region name="Latium"><name sortKey="Bonifati, V" sort="Bonifati, V" uniqKey="Bonifati V" first="V." last="Bonifati">V. Bonifati</name>
</region>
<name sortKey="De Michele, G" sort="De Michele, G" uniqKey="De Michele G" first="G." last="De Michele">G. De Michele</name>
<name sortKey="Meco, G" sort="Meco, G" uniqKey="Meco G" first="G." last="Meco">G. Meco</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Vaughan, J" sort="Vaughan, J" uniqKey="Vaughan J" first="J." last="Vaughan">J. Vaughan</name>
</region>
<name sortKey="Wood, N W" sort="Wood, N W" uniqKey="Wood N" first="N. W." last="Wood">N. W. Wood</name>
</country>
<country name="Allemagne"><region name="Bavière"><name sortKey="Gasser, T" sort="Gasser, T" uniqKey="Gasser T" first="T." last="Gasser">T. Gasser</name>
</region>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Harhangi, B S" sort="Harhangi, B S" uniqKey="Harhangi B" first="B. S." last="Harhangi">B. S. Harhangi</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003C09 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003C09 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Exploration |type= RBID |clé= Pascal:00-0276372 |texte= Association between early-onset Parkinson's disease and mutations in the Parkin gene }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |