ParkinsonFranceV1, Main, Exploration, bibRecord, 003C02

Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey

Identifieur interne : 003C02 ( Main/Exploration ); précédent : 003C01; suivant : 003C03

Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey

Auteurs : C. Imbert [France] ; E. Bezard [France] ; S. Guitraud [France] ; T. Boraud [France] ; C. E. Gross [France]

Source :

Journal of neuroscience methods [ 0165-0270 ] ; 2000.

RBID : Pascal:00-0266798

Descripteurs français

Pascal (Inist)
- Echelle évaluation, Méthode mesure, Modèle animal, Parkinson maladie, Etude comparative, Récepteur dopaminergique, Agoniste, Animal, Macaca fascicularis, Cercopithecidae.

English descriptors

KwdEn :
- Agonist, Animal, Animal model, Comparative study, Dopamine receptor, Evaluation scale, Macaca fascicularis, Measurement method, Parkinson disease.

Abstract

The most valuable model of Parkinson's disease available at present is the primate model treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), frequently used to study response to new drugs or surgical treatments. The evaluation of such therapies requires clinical rating scales which measure precisely motor behaviour in both normal and parkinsonian monkeys. It is obvious that such evaluation can only be valid if parallel studies are carried out under similar experimental conditions with well-defined objective criteria. Hence the need to compare and assess the different rating scales in use if we want to be able to compare the results of clinical studies. In order to give rise to some fresh thinking on the necessity of a certain uniformity of assessment, this study compares eight clinical rating scales and considers their capacity to express in quantitative terms both the severity of MPTP intoxication in five cynomolgus monkeys and the alleviation afforded by levodopa. None of the eight scales reaches all the criteria despite the Kurlan scale would appear as an interesting working basis for a further consensual definition of a worldwide used parkinsonian monkey clinical rating scale.

Affiliations:

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Le document en format XML

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	La maladie de Parkinson en France (serveur d'exploration)
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Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey

Comparison of eight clinical rating scales used for the assessment of MPTP-induced parkinsonism in the Macaque monkey

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri