Neurochemical mechanisms induced by high frequency stimulation of the subthalamic nucleus: Increase of extracellular striatal glutamate and GABA in normal and hemiparkinsonian rats
Identifieur interne : 003245 ( Main/Exploration ); précédent : 003244; suivant : 003246Neurochemical mechanisms induced by high frequency stimulation of the subthalamic nucleus: Increase of extracellular striatal glutamate and GABA in normal and hemiparkinsonian rats
Auteurs : Nicolas Bruet [France] ; Francois Windels [France] ; Carole Carcenac [France] ; Claude Feuerstein [France] ; Anne Bertrand [France] ; Annie Poupard [France] ; Marc Savasta [France]Source :
- Journal of neuropathology and experimental neurology [ 0022-3069 ] ; 2003.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
High frequency stimulation (HFS) (130 Hz) of the subthalamic nucleus (STN) provides beneficial effects in patients suffering from severe parkinsonism, but the mechanisms underlying these clinical results remain to be clarified. To date, very little is known concerning the effects of STN-HFS on neurochemical transmission in the different basal ganglia nuclei and in particular the striatum. This study examines the effects of STN-HFS in intact and hemiparkinsonian rats on extracellular striatal glutamate (Glu) and GABA levels by means of intracerebral microdialysis. Unilateral STN-HFS was found to induce a significant bilateral increase of striatal Glu and GABA both in intact and in dopamine-lesioned animals. In intact rats, these increases were reversed by local administration of the Dl antagonist SCH 23390, but were potentiated by the D2 antagonist sulpiride. Potentiation was also observed after local administration of both D1 and D2 antagonists whose amplitude was similar to that measured in hemiparkinsonian rats. These data furnish the first evidence that STN-HFS influences striatal amino-acid transmission and that this influence is modulated by dopamine. They provide evidence that the effects of STN-HFS are not only restricted to the direct STN targets, but also involve adaptive changes within other structures of the basal ganglia circuitry.
Affiliations:
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Fourier</orgName></affiliation></author><author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Bertrand, Anne" sort="Bertrand, Anne" uniqKey="Bertrand A" first="Anne" last="Bertrand">Anne Bertrand</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Poupard, Annie" sort="Poupard, Annie" uniqKey="Poupard A" first="Annie" last="Poupard">Annie Poupard</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno><imprint><date when="2003">2003</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>GABA</term><term>Glutamate</term><term>High frequency</term><term>Liquid chromatography</term><term>Microdialysis</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>Rat</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Haute fréquence</term><term>Noyau sousthalamique</term><term>Système nerveux pathologie</term><term>Glutamate</term><term>GABA</term><term>Animal</term><term>Rat</term><term>Chromatographie phase liquide</term><term>Microdialyse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High frequency stimulation (HFS) (130 Hz) of the subthalamic nucleus (STN) provides beneficial effects in patients suffering from severe parkinsonism, but the mechanisms underlying these clinical results remain to be clarified. To date, very little is known concerning the effects of STN-HFS on neurochemical transmission in the different basal ganglia nuclei and in particular the striatum. This study examines the effects of STN-HFS in intact and hemiparkinsonian rats on extracellular striatal glutamate (Glu) and GABA levels by means of intracerebral microdialysis. Unilateral STN-HFS was found to induce a significant bilateral increase of striatal Glu and GABA both in intact and in dopamine-lesioned animals. In intact rats, these increases were reversed by local administration of the Dl antagonist SCH 23390, but were potentiated by the D2 antagonist sulpiride. Potentiation was also observed after local administration of both D1 and D2 antagonists whose amplitude was similar to that measured in hemiparkinsonian rats. These data furnish the first evidence that STN-HFS influences striatal amino-acid transmission and that this influence is modulated by dopamine. They provide evidence that the effects of STN-HFS are not only restricted to the direct STN targets, but also involve adaptive changes within other structures of the basal ganglia circuitry.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement><orgName><li>Université Joseph Fourier</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Bruet, Nicolas" sort="Bruet, Nicolas" uniqKey="Bruet N" first="Nicolas" last="Bruet">Nicolas Bruet</name></region><name sortKey="Bertrand, Anne" sort="Bertrand, Anne" uniqKey="Bertrand A" first="Anne" last="Bertrand">Anne Bertrand</name><name sortKey="Carcenac, Carole" sort="Carcenac, Carole" uniqKey="Carcenac C" first="Carole" last="Carcenac">Carole Carcenac</name><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name><name sortKey="Poupard, Annie" sort="Poupard, Annie" uniqKey="Poupard A" first="Annie" last="Poupard">Annie Poupard</name><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><name sortKey="Windels, Francois" sort="Windels, Francois" uniqKey="Windels F" first="Francois" last="Windels">Francois Windels</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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