Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus
Identifieur interne : 002C34 ( Main/Exploration ); précédent : 002C33; suivant : 002C35Methylazoxymethanol acetate does not fully block cell genesis in the young and aged dentate gyrus
Auteurs : David Dupret [France] ; Marie-Françoise Montaron [France] ; Elodie Drapeau [France] ; Catherine Aurousseau [France] ; Michel Le Moal [France] ; Pier-Vincenzo Piazza [France] ; Djoher Nora Abrous [France]Source :
- European Journal of Neuroscience [ 0953-816X ] ; 2005-08.
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Abstract
During adulthood, new neurons are continuously added to the mammalian dentate gyrus (DG). An increasing number of studies have correlated changes in rates of dentate neurogenesis with memory abilities. One study based on subchronic treatment with the toxin methylazoxymethanol acetate (MAM) has provided causal evidence that neurogenesis is involved in hippocampal‐dependent trace conditioning. In contrast, spatial learning is not impaired following MAM treatment. We hypothesized that this was due to the small residual number of new cells produced following MAM treatment. In the present experiment, we attempted to achieve a higher level of reduction of adult‐generated cells following MAM treatment in young and aged rats. We found only a partial reduction of adult‐generated cells in the DG. More importantly, independently of the age of the animals, MAM treatment at a dose necessary to reduce neurogenesis altered the overall health of the animals. In conclusion, the behavioural results obtained following subchronic treatment with high doses of MAM in adulthood must be interpreted with extreme caution.
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DOI: 10.1111/j.1460-9568.2005.04262.x
Affiliations:
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An increasing number of studies have correlated changes in rates of dentate neurogenesis with memory abilities. One study based on subchronic treatment with the toxin methylazoxymethanol acetate (MAM) has provided causal evidence that neurogenesis is involved in hippocampal‐dependent trace conditioning. In contrast, spatial learning is not impaired following MAM treatment. We hypothesized that this was due to the small residual number of new cells produced following MAM treatment. In the present experiment, we attempted to achieve a higher level of reduction of adult‐generated cells following MAM treatment in young and aged rats. We found only a partial reduction of adult‐generated cells in the DG. More importantly, independently of the age of the animals, MAM treatment at a dose necessary to reduce neurogenesis altered the overall health of the animals. In conclusion, the behavioural results obtained following subchronic treatment with high doses of MAM in adulthood must be interpreted with extreme caution.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li></settlement></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Dupret, David" sort="Dupret, David" uniqKey="Dupret D" first="David" last="Dupret">David Dupret</name></region><name sortKey="Abrous, Djoher Nora" sort="Abrous, Djoher Nora" uniqKey="Abrous D" first="Djoher Nora" last="Abrous">Djoher Nora Abrous</name><name sortKey="Aurousseau, Catherine" sort="Aurousseau, Catherine" uniqKey="Aurousseau C" first="Catherine" last="Aurousseau">Catherine Aurousseau</name><name sortKey="Drapeau, Elodie" sort="Drapeau, Elodie" uniqKey="Drapeau E" first="Elodie" last="Drapeau">Elodie Drapeau</name><name sortKey="Le Moal, Michel" sort="Le Moal, Michel" uniqKey="Le Moal M" first="Michel" last="Le Moal">Michel Le Moal</name><name sortKey="Montaron, Marie Rancoise" sort="Montaron, Marie Rancoise" uniqKey="Montaron M" first="Marie-Françoise" last="Montaron">Marie-Françoise Montaron</name><name sortKey="Piazza, Pier Incenzo" sort="Piazza, Pier Incenzo" uniqKey="Piazza P" first="Pier-Vincenzo" last="Piazza">Pier-Vincenzo Piazza</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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