Mixing pro- and antisaccades in patients with parkinsonian syndromes.
Identifieur interne : 002611 ( Main/Exploration ); précédent : 002610; suivant : 002612Mixing pro- and antisaccades in patients with parkinsonian syndromes.
Auteurs : S. Rivaud-Péchoux [France] ; M. Vidailhet ; J P Brandel ; B. GaymardSource :
- Brain : a journal of neurology [ 1460-2156 ] ; 2007.
English descriptors
- KwdEn :
- Aged, Basal Ganglia Diseases (physiopathology), Electrooculography (methods), Female, Fixation, Ocular (physiology), Humans, Male, Neurodegenerative Diseases (physiopathology), Neuropsychological Tests, Parkinson Disease (physiopathology), Reaction Time, Saccades (physiology), Supranuclear Palsy, Progressive (physiopathology), Task Performance and Analysis.
- MESH :
- methods : Electrooculography.
- physiology : Fixation, Ocular, Saccades.
- physiopathology : Basal Ganglia Diseases, Neurodegenerative Diseases, Parkinson Disease, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Male, Neuropsychological Tests, Reaction Time, Task Performance and Analysis.
Abstract
Prosaccades and antisaccades were investigated in three groups of patients with parkinsonian syndromes, Parkinson's disease, corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), and in a control group. Saccade tasks were performed in single-task blocks (i.e. either blocks of prosaccades or blocks of antisaccades) and in mixed-task blocks (i.e. in blocks of randomly interleaved pro- and antisaccades). Saccade latencies and directional errors (misdirected saccades) were analysed in each subject, and we concentrated more specifically on the comparison of error rates in single tasks and in repeated trials of mixed tasks (i.e. mixing costs). The performance of each group in single tasks was largely consistent with previous studies, with normal antisaccade error rates in Parkinson's disease and CBD patients and increased antisaccade error rates in PSP patients. In contrast, a double dissociation was observed in mixed tasks. Parkinson's disease and CBD patients showed a marked increase in prosaccade and antisaccade error rates in repeated trials of mixed tasks, illustrated by increased mixing costs, whereas PSP patients showed similar error rates in single and repeated trials of mixed tasks, i.e. normal mixing costs. These results demonstrate that: (i) antisaccade performances may be differentially affected in mixed tasks and single tasks; (ii) the region of the dorsolateral prefrontal cortex which is crucial for reflexive saccade inhibition does not seem to be involved in the additional processes required in mixed-task conditions; (iii) the study of interleaved pro- and antisaccades may increase the accuracy of the differential diagnosis between these parkinsonian syndromes.
DOI: 10.1093/brain/awl315
PubMed: 17124191
Affiliations:
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Vidailhet</name></author><author><name sortKey="Brandel, J P" sort="Brandel, J P" uniqKey="Brandel J" first="J P" last="Brandel">J P Brandel</name></author><author><name sortKey="Gaymard, B" sort="Gaymard, B" uniqKey="Gaymard B" first="B" last="Gaymard">B. 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Rivaud-Péchoux</name><affiliation wicri:level="3"><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale, Boulevard de l'Hôpital, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut National de la Santé et de la Recherche Médicale, Boulevard de l'Hôpital, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name></author><author><name sortKey="Brandel, J P" sort="Brandel, J P" uniqKey="Brandel J" first="J P" last="Brandel">J P Brandel</name></author><author><name sortKey="Gaymard, B" sort="Gaymard, B" uniqKey="Gaymard B" first="B" last="Gaymard">B. Gaymard</name></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno type="eISSN">1460-2156</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Basal Ganglia Diseases (physiopathology)</term><term>Electrooculography (methods)</term><term>Female</term><term>Fixation, Ocular (physiology)</term><term>Humans</term><term>Male</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (physiopathology)</term><term>Reaction Time</term><term>Saccades (physiology)</term><term>Supranuclear Palsy, Progressive (physiopathology)</term><term>Task Performance and Analysis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electrooculography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Fixation, Ocular</term><term>Saccades</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Neuropsychological Tests</term><term>Reaction Time</term><term>Task Performance and Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Prosaccades and antisaccades were investigated in three groups of patients with parkinsonian syndromes, Parkinson's disease, corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), and in a control group. Saccade tasks were performed in single-task blocks (i.e. either blocks of prosaccades or blocks of antisaccades) and in mixed-task blocks (i.e. in blocks of randomly interleaved pro- and antisaccades). Saccade latencies and directional errors (misdirected saccades) were analysed in each subject, and we concentrated more specifically on the comparison of error rates in single tasks and in repeated trials of mixed tasks (i.e. mixing costs). The performance of each group in single tasks was largely consistent with previous studies, with normal antisaccade error rates in Parkinson's disease and CBD patients and increased antisaccade error rates in PSP patients. In contrast, a double dissociation was observed in mixed tasks. Parkinson's disease and CBD patients showed a marked increase in prosaccade and antisaccade error rates in repeated trials of mixed tasks, illustrated by increased mixing costs, whereas PSP patients showed similar error rates in single and repeated trials of mixed tasks, i.e. normal mixing costs. These results demonstrate that: (i) antisaccade performances may be differentially affected in mixed tasks and single tasks; (ii) the region of the dorsolateral prefrontal cortex which is crucial for reflexive saccade inhibition does not seem to be involved in the additional processes required in mixed-task conditions; (iii) the study of interleaved pro- and antisaccades may increase the accuracy of the differential diagnosis between these parkinsonian syndromes.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><noCountry><name sortKey="Brandel, J P" sort="Brandel, J P" uniqKey="Brandel J" first="J P" last="Brandel">J P Brandel</name><name sortKey="Gaymard, B" sort="Gaymard, B" uniqKey="Gaymard B" first="B" last="Gaymard">B. Gaymard</name><name sortKey="Vidailhet, M" sort="Vidailhet, M" uniqKey="Vidailhet M" first="M" last="Vidailhet">M. Vidailhet</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Rivaud Pechoux, S" sort="Rivaud Pechoux, S" uniqKey="Rivaud Pechoux S" first="S" last="Rivaud-Péchoux">S. Rivaud-Péchoux</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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