ParkinsonFranceV1, Main, Exploration, bibRecord, 002519

Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver

Identifieur interne : 002519 ( Main/Exploration ); précédent : 002518; suivant : 002520

Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver

Auteurs : C. Cavin [Suisse] ; M. Marin-Kuan [Suisse] ; S. Langouët [France] ; C. Bezencon [Suisse] ; G. Guignard [Suisse] ; C. Verguet [Suisse] ; D. Piguet [Suisse] ; D. Holzh User [Suisse] ; R. Cornaz [Suisse] ; B. Schilter [Suisse]

Source :

Food and chemical toxicology [ 0278-6915 ] ; 2008.

RBID : Pascal:08-0285055

Descripteurs français

Pascal (Inist)
- Défense organisme, Toxicité, Activité biologique, Mécanisme action, Prévention, Café, Foie, Facteur transcription, Erythrocyte, Glutathione transferase, Cytochrome P450.
Wicri :
- topic : Café.

English descriptors

KwdEn :
- Biological activity, Coffee, Cytochrome P450, Glutathione transferase, Liver, Mechanism of action, Organism defense, Prevention, Red blood cell, Toxicity, Transcription factor.
mix :
- Chemoprotection, Coffee, Cytochromes P450, Glutathione S-transferases, Mechanisms, Nuclear factor-erythroid 2 p45-related factor 2.

Abstract

Coffee consumption has been associated with a significant decrease in the risk of developing chronic diseases such as Parkinson disease, diabetes type-2 and several types of cancers (e.g. colon, liver). In the present study, a coffee-dependent induction of enzymes involved in xenobiotic detoxification processes was observed in rat liver and primary hepatocytes. In addition, coffee was found to induce the mRNA and protein expression of enzymes involved in cellular antioxidant defenses. These inductions were correlated with the activation of the Nrf2 transcription factor as shown using an ARE-reporter luciferase assay. The induction of detoxifying enzymes GSTs and AKR is compatible with a protection against both genotoxicity and cytotoxicity of aflatoxin B1 (AFB₁). This hypothesis was confirmed in in vitro and ex vivo test systems, where coffee reduced both AFB₁-DNA and protein adducts. Interestingly, coffee was also found to inhibit cytochrome CYP1A1/2, indicating that other mechanisms different from a stimulation of detoxification may also play a significant role in the chemoprotective effects of coffee. Further investigations in either human liver cell line and primary hepatocytes indicated that the chemoprotective effects of coffee against AFB₁ genotoxicity are likely to be of relevance for humans. These data strongly suggest that coffee may protect against the adverse effects of AFB₁. In addition, the coffee-mediated stimulation of the Nrf2-ARE pathway resulting in increased endogenous defense mechanisms against electrophilic but also oxidative insults further support that coffee may be associated with a protection against various types of chemical stresses.

Url:

https://hal.archives-ouvertes.fr/hal-00677698

Affiliations:

Le document en format XML

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<term>Liver</term>
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<term>Café</term>
<term>Foie</term>
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<term>Glutathione S-transferases</term>
<term>Mechanisms</term>
<term>Nuclear factor-erythroid 2 p45-related factor 2</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Coffee consumption has been associated with a significant decrease in the risk of developing chronic diseases such as Parkinson disease, diabetes type-2 and several types of cancers (e.g. colon, liver). In the present study, a coffee-dependent induction of enzymes involved in xenobiotic detoxification processes was observed in rat liver and primary hepatocytes. In addition, coffee was found to induce the mRNA and protein expression of enzymes involved in cellular antioxidant defenses. These inductions were correlated with the activation of the Nrf2 transcription factor as shown using an ARE-reporter luciferase assay. The induction of detoxifying enzymes GSTs and AKR is compatible with a protection against both genotoxicity and cytotoxicity of aflatoxin B1 (AFB<sub>1</sub>
). This hypothesis was confirmed in in vitro and ex vivo test systems, where coffee reduced both AFB<sub>1</sub>
-DNA and protein adducts. Interestingly, coffee was also found to inhibit cytochrome CYP1A1/2, indicating that other mechanisms different from a stimulation of detoxification may also play a significant role in the chemoprotective effects of coffee. Further investigations in either human liver cell line and primary hepatocytes indicated that the chemoprotective effects of coffee against AFB<sub>1</sub>
 genotoxicity are likely to be of relevance for humans. These data strongly suggest that coffee may protect against the adverse effects of AFB<sub>1</sub>
. In addition, the coffee-mediated stimulation of the Nrf2-ARE pathway resulting in increased endogenous defense mechanisms against electrophilic but also oxidative insults further support that coffee may be associated with a protection against various types of chemical stresses.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Suisse</li>
</country>
<region><li>Canton de Vaud</li>
<li>Région Bretagne</li>
</region>
<settlement><li>Lausanne</li>
<li>Rennes</li>
</settlement>
</list>
<tree><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Cavin, C" sort="Cavin, C" uniqKey="Cavin C" first="C." last="Cavin">C. Cavin</name>
</region>
<name sortKey="Bezencon, C" sort="Bezencon, C" uniqKey="Bezencon C" first="C." last="Bezencon">C. Bezencon</name>
<name sortKey="Cornaz, R" sort="Cornaz, R" uniqKey="Cornaz R" first="R." last="Cornaz">R. Cornaz</name>
<name sortKey="Guignard, G" sort="Guignard, G" uniqKey="Guignard G" first="G." last="Guignard">G. Guignard</name>
<name sortKey="Holzh User, D" sort="Holzh User, D" uniqKey="Holzh User D" first="D." last="Holzh User">D. Holzh User</name>
<name sortKey="Marin Kuan, M" sort="Marin Kuan, M" uniqKey="Marin Kuan M" first="M." last="Marin-Kuan">M. Marin-Kuan</name>
<name sortKey="Piguet, D" sort="Piguet, D" uniqKey="Piguet D" first="D." last="Piguet">D. Piguet</name>
<name sortKey="Schilter, B" sort="Schilter, B" uniqKey="Schilter B" first="B." last="Schilter">B. Schilter</name>
<name sortKey="Verguet, C" sort="Verguet, C" uniqKey="Verguet C" first="C." last="Verguet">C. Verguet</name>
</country>
<country name="France"><region name="Région Bretagne"><name sortKey="Langouet, S" sort="Langouet, S" uniqKey="Langouet S" first="S." last="Langouët">S. Langouët</name>
</region>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson en France (serveur d'exploration)

Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver

Induction of Nrf2-mediated cellular defenses and alteration of phase I activities as mechanisms of chemoprotective effects of coffee in the liver

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	La maladie de Parkinson en France (serveur d'exploration)
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