Assessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium
Identifieur interne : 001F56 ( Main/Exploration ); précédent : 001F55; suivant : 001F57Assessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium
Auteurs : Irina Alafuzoff [Finlande, Suède] ; Dietmar R. Thal [Allemagne] ; Thomas Arzberger [Allemagne] ; Nenad Bogdanovic [Suède] ; Safa Al-Sarraj [Royaume-Uni] ; Istvan Bodi [Royaume-Uni] ; Susan Boluda [Espagne] ; Orso Bugiani [Italie] ; Charles Duyckaerts [France] ; Ellen Gelpi [Espagne] ; Stephen Gentleman [Royaume-Uni] ; Giorgio Giaccone [Italie] ; Manuel Graeber [Royaume-Uni] ; Tibor Hortobagyi [Royaume-Uni] ; Romana Höftberger [Autriche] ; Paul Ince [Royaume-Uni] ; James W. Ironside [Royaume-Uni] ; Nikolaos Kavantzas [Grèce] ; Andrew King [Royaume-Uni] ; Penelope Korkolopoulou [Grèce] ; Gábor G. Kovács [Autriche] ; David Meyronet [France] ; Camelia Monoranu [Allemagne] ; Tatjana Nilsson [Suède] ; Piero Parchi [Italie] ; Efstratios Patsouris [Grèce] ; Maria Pikkarainen [Finlande] ; Tamas Revesz [Royaume-Uni] ; Annemieke Rozemuller [Pays-Bas] ; Danielle Seilhean [France] ; Walter Schulz-Schaeffer [Allemagne] ; Nathalie Streichenberger [France] ; Stephen B. Wharton [Royaume-Uni] ; Hans Kretzschmar [Allemagne]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 2009.
Abstract
β-Amyloid (Aβ) related pathology shows a range of lesions which differ both qualitatively and quantitatively. Pathologists, to date, mainly focused on the assessment of both of these aspects but attempts to correlate the findings with clinical phenotypes are not convincing. It has been recently proposed in the same way as ι and α synuclein related lesions, also Aβ related pathology may follow a temporal evolution, i.e. distinct phases, characterized by a step-wise involvement of different brain-regions. Twenty-six independent observers reached an 81% absolute agreement while assessing the phase of Aβ, i.e. phase 1 = deposition of Aβ exclusively in neocortex, phase 2 = additionally in allocortex, phase 3 = additionally in diencephalon, phase 4 = additionally in brainstem, and phase 5 = additionally in cerebellum. These high agreement rates were reached when at least six brain regions were evaluated. Likewise, a high agreement (93%) was reached while assessing the absence/presence of cerebral amyloid angiopathy (CAA) and the type of CAA (74%) while examining the six brain regions. Of note, most of observers failed to detect capillary CAA when it was only mild and focal and thus instead of type 1, type 2 CAA was diagnosed. In conclusion, a reliable assessment of Aβ phase and presence/absence of CAA was achieved by a total of 26 observers who examined a standardized set of blocks taken from only six anatomical regions, applying commercially available reagents and by assessing them as instructed. Thus, one may consider rating of Aβ-phases as a diagnostic tool while analyzing subjects with suspected Alzheimer’s disease (AD). Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the Aβ phase in AD is feasible even in large scale retrospective studies.
Url:
DOI: 10.1007/s00401-009-0485-4
PubMed: 19184666
PubMed Central: 2910889
Affiliations:
- Allemagne, Autriche, Espagne, Finlande, France, Grèce, Italie, Pays-Bas, Royaume-Uni, Suède
- Angleterre, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Basse-Saxe, Bavière, Catalogne, District de Basse-Franconie, District de Haute-Bavière, District de Tübingen, East Middle Sweden, Grand Londres, Hollande-Septentrionale, Lombardie, Rhône-Alpes, Svealand, Vienne (Autriche), Écosse, Émilie-Romagne, Île-de-France
- Amsterdam, Barcelone, Bologne, Göttingen, Londres, Lyon, Milan, Munich, Paris, Ulm, Uppsala, Vienne (Autriche), Wurtzbourg, Édimbourg
- Université Louis-et-Maximilien de Munich, Université Pierre-et-Marie-Curie, Université d'Ulm, Université d'Uppsala, Université d'Édimbourg, Université de Barcelone, Université de Bologne, Université de Wurtzbourg
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Le document en format XML
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<wicri:regionArea>Department of Pathology, Western General Hospital, University of Edinburgh, Edinburgh</wicri:regionArea>
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<author><name sortKey="King, Andrew" sort="King, Andrew" uniqKey="King A" first="Andrew" last="King">Andrew King</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Monoranu, Camelia" sort="Monoranu, Camelia" uniqKey="Monoranu C" first="Camelia" last="Monoranu">Camelia Monoranu</name>
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<author><name sortKey="Nilsson, Tatjana" sort="Nilsson, Tatjana" uniqKey="Nilsson T" first="Tatjana" last="Nilsson">Tatjana Nilsson</name>
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<author><name sortKey="Pikkarainen, Maria" sort="Pikkarainen, Maria" uniqKey="Pikkarainen M" first="Maria" last="Pikkarainen">Maria Pikkarainen</name>
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<author><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name>
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<author><name sortKey="Rozemuller, Annemieke" sort="Rozemuller, Annemieke" uniqKey="Rozemuller A" first="Annemieke" last="Rozemuller">Annemieke Rozemuller</name>
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<author><name sortKey="Seilhean, Danielle" sort="Seilhean, Danielle" uniqKey="Seilhean D" first="Danielle" last="Seilhean">Danielle Seilhean</name>
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<author><name sortKey="Schulz Schaeffer, Walter" sort="Schulz Schaeffer, Walter" uniqKey="Schulz Schaeffer W" first="Walter" last="Schulz-Schaeffer">Walter Schulz-Schaeffer</name>
<affiliation wicri:level="3"><nlm:aff id="Aff6">Georg-August-Universitaet Goettingen, Göttingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Georg-August-Universitaet Goettingen, Göttingen</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Streichenberger, Nathalie" sort="Streichenberger, Nathalie" uniqKey="Streichenberger N" first="Nathalie" last="Streichenberger">Nathalie Streichenberger</name>
<affiliation wicri:level="3"><nlm:aff id="Aff14">Université Lyon 1 faculté de médecine Laennec, Centre de Neuropathologie et Pathologie Est. Bron Lyon, Hospices Civils de Lyon, Universite de Lyon, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lyon 1 faculté de médecine Laennec, Centre de Neuropathologie et Pathologie Est. Bron Lyon, Hospices Civils de Lyon, Universite de Lyon, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wharton, Stephen B" sort="Wharton, Stephen B" uniqKey="Wharton S" first="Stephen B." last="Wharton">Stephen B. Wharton</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18">Neuroscience Section, University of Sheffield, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neuroscience Section, University of Sheffield, Sheffield</wicri:regionArea>
<wicri:noRegion>Sheffield</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kretzschmar, Hans" sort="Kretzschmar, Hans" uniqKey="Kretzschmar H" first="Hans" last="Kretzschmar">Hans Kretzschmar</name>
<affiliation wicri:level="4"><nlm:aff id="Aff16">Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessment of β-amyloid deposits in human brain: a study of the BrainNet Europe Consortium</title>
<author><name sortKey="Alafuzoff, Irina" sort="Alafuzoff, Irina" uniqKey="Alafuzoff I" first="Irina" last="Alafuzoff">Irina Alafuzoff</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8">Department of Clinical Medicine, Section of Neuropathology, Unit of Neurology, Kuopio University, PO Box 1627, 70211 Kuopio, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Clinical Medicine, Section of Neuropathology, Unit of Neurology, Kuopio University, PO Box 1627, 70211 Kuopio</wicri:regionArea>
<wicri:noRegion>70211 Kuopio</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="Aff9">Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName><settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thal, Dietmar R" sort="Thal, Dietmar R" uniqKey="Thal D" first="Dietmar R." last="Thal">Dietmar R. Thal</name>
<affiliation wicri:level="4"><nlm:aff id="Aff20">Laboratory for Neuropathology, Institute of Pathology, University of Ulm, Ulm, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Laboratory for Neuropathology, Institute of Pathology, University of Ulm, Ulm</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
<orgName type="university">Université d'Ulm</orgName>
</affiliation>
</author>
<author><name sortKey="Arzberger, Thomas" sort="Arzberger, Thomas" uniqKey="Arzberger T" first="Thomas" last="Arzberger">Thomas Arzberger</name>
<affiliation wicri:level="4"><nlm:aff id="Aff16">Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Bogdanovic, Nenad" sort="Bogdanovic, Nenad" uniqKey="Bogdanovic N" first="Nenad" last="Bogdanovic">Nenad Bogdanovic</name>
<affiliation wicri:level="1"><nlm:aff id="Aff7">Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge</wicri:regionArea>
<wicri:noRegion>Huddinge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Al Sarraj, Safa" sort="Al Sarraj, Safa" uniqKey="Al Sarraj S" first="Safa" last="Al-Sarraj">Safa Al-Sarraj</name>
<affiliation wicri:level="3"><nlm:aff id="Aff11">Department of Clinical Neuropathology, London Institute of Psychiatry, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuropathology, London Institute of Psychiatry, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bodi, Istvan" sort="Bodi, Istvan" uniqKey="Bodi I" first="Istvan" last="Bodi">Istvan Bodi</name>
<affiliation wicri:level="3"><nlm:aff id="Aff11">Department of Clinical Neuropathology, London Institute of Psychiatry, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuropathology, London Institute of Psychiatry, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Boluda, Susan" sort="Boluda, Susan" uniqKey="Boluda S" first="Susan" last="Boluda">Susan Boluda</name>
<affiliation wicri:level="4"><nlm:aff id="Aff3">Institut de Neuropatologia, Universitat de Barcelona, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut de Neuropatologia, Universitat de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
<orgName type="university">Université de Barcelone</orgName>
</affiliation>
</author>
<author><name sortKey="Bugiani, Orso" sort="Bugiani, Orso" uniqKey="Bugiani O" first="Orso" last="Bugiani">Orso Bugiani</name>
<affiliation wicri:level="3"><nlm:aff id="Aff15">Fondazione Istituto Neurologico Carlo Besta, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione Istituto Neurologico Carlo Besta, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name>
<affiliation wicri:level="4"><nlm:aff id="Aff17">Laboratorie Escourolle, Assisstance Publique des Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratorie Escourolle, Assisstance Publique des Hopitaux de Paris, Universite Pierre et Marie Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author><name sortKey="Gelpi, Ellen" sort="Gelpi, Ellen" uniqKey="Gelpi E" first="Ellen" last="Gelpi">Ellen Gelpi</name>
<affiliation wicri:level="4"><nlm:aff id="Aff3">Institut de Neuropatologia, Universitat de Barcelona, Barcelona, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Institut de Neuropatologia, Universitat de Barcelona, Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
<orgName type="university">Université de Barcelone</orgName>
</affiliation>
</author>
<author><name sortKey="Gentleman, Stephen" sort="Gentleman, Stephen" uniqKey="Gentleman S" first="Stephen" last="Gentleman">Stephen Gentleman</name>
<affiliation wicri:level="3"><nlm:aff id="Aff10">Department of Neuropathology, Imperial College, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Neuropathology, Imperial College, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giaccone, Giorgio" sort="Giaccone, Giorgio" uniqKey="Giaccone G" first="Giorgio" last="Giaccone">Giorgio Giaccone</name>
<affiliation wicri:level="3"><nlm:aff id="Aff15">Fondazione Istituto Neurologico Carlo Besta, Milan, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Fondazione Istituto Neurologico Carlo Besta, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Graeber, Manuel" sort="Graeber, Manuel" uniqKey="Graeber M" first="Manuel" last="Graeber">Manuel Graeber</name>
<affiliation wicri:level="3"><nlm:aff id="Aff13">The Athenaeum, Pall Mall, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Athenaeum, Pall Mall, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobagyi">Tibor Hortobagyi</name>
<affiliation wicri:level="3"><nlm:aff id="Aff11">Department of Clinical Neuropathology, London Institute of Psychiatry, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuropathology, London Institute of Psychiatry, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hoftberger, Romana" sort="Hoftberger, Romana" uniqKey="Hoftberger R" first="Romana" last="Höftberger">Romana Höftberger</name>
<affiliation wicri:level="3"><nlm:aff id="Aff21">Institute of Neurology, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute of Neurology, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ince, Paul" sort="Ince, Paul" uniqKey="Ince P" first="Paul" last="Ince">Paul Ince</name>
<affiliation wicri:level="1"><nlm:aff id="Aff19">Neuropathology, Royal Hallamshire Hospital, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neuropathology, Royal Hallamshire Hospital, Sheffield</wicri:regionArea>
<wicri:noRegion>Sheffield</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ironside, James W" sort="Ironside, James W" uniqKey="Ironside J" first="James W." last="Ironside">James W. Ironside</name>
<affiliation wicri:level="4"><nlm:aff id="Aff5">Department of Pathology, Western General Hospital, University of Edinburgh, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Pathology, Western General Hospital, University of Edinburgh, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université d'Édimbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Kavantzas, Nikolaos" sort="Kavantzas, Nikolaos" uniqKey="Kavantzas N" first="Nikolaos" last="Kavantzas">Nikolaos Kavantzas</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Pathology, National and Capodistrian University of Athens, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Pathology, National and Capodistrian University of Athens, Athens</wicri:regionArea>
<wicri:noRegion>Athens</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="King, Andrew" sort="King, Andrew" uniqKey="King A" first="Andrew" last="King">Andrew King</name>
<affiliation wicri:level="3"><nlm:aff id="Aff11">Department of Clinical Neuropathology, London Institute of Psychiatry, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Neuropathology, London Institute of Psychiatry, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Korkolopoulou, Penelope" sort="Korkolopoulou, Penelope" uniqKey="Korkolopoulou P" first="Penelope" last="Korkolopoulou">Penelope Korkolopoulou</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Pathology, National and Capodistrian University of Athens, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Pathology, National and Capodistrian University of Athens, Athens</wicri:regionArea>
<wicri:noRegion>Athens</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kovacs, Gabor G" sort="Kovacs, Gabor G" uniqKey="Kovacs G" first="Gábor G." last="Kovács">Gábor G. Kovács</name>
<affiliation wicri:level="3"><nlm:aff id="Aff21">Institute of Neurology, Medical University of Vienna, Vienna, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute of Neurology, Medical University of Vienna, Vienna</wicri:regionArea>
<placeName><settlement type="city">Vienne (Autriche)</settlement>
<region nuts="2" type="province">Vienne (Autriche)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meyronet, David" sort="Meyronet, David" uniqKey="Meyronet D" first="David" last="Meyronet">David Meyronet</name>
<affiliation wicri:level="3"><nlm:aff id="Aff14">Université Lyon 1 faculté de médecine Laennec, Centre de Neuropathologie et Pathologie Est. Bron Lyon, Hospices Civils de Lyon, Universite de Lyon, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lyon 1 faculté de médecine Laennec, Centre de Neuropathologie et Pathologie Est. Bron Lyon, Hospices Civils de Lyon, Universite de Lyon, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Monoranu, Camelia" sort="Monoranu, Camelia" uniqKey="Monoranu C" first="Camelia" last="Monoranu">Camelia Monoranu</name>
<affiliation wicri:level="4"><nlm:aff id="Aff22">Pathologisches Institut der Universität Würzburg, Abteilung für Neuropathologie, Würzburg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Pathologisches Institut der Universität Würzburg, Abteilung für Neuropathologie, Würzburg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Basse-Franconie</region>
<settlement type="city">Wurtzbourg</settlement>
</placeName>
<orgName type="university">Université de Wurtzbourg</orgName>
</affiliation>
</author>
<author><name sortKey="Nilsson, Tatjana" sort="Nilsson, Tatjana" uniqKey="Nilsson T" first="Tatjana" last="Nilsson">Tatjana Nilsson</name>
<affiliation wicri:level="1"><nlm:aff id="Aff7">Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska Institutet, Huddinge</wicri:regionArea>
<wicri:noRegion>Huddinge</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Parchi, Piero" sort="Parchi, Piero" uniqKey="Parchi P" first="Piero" last="Parchi">Piero Parchi</name>
<affiliation wicri:level="4"><nlm:aff id="Aff4">Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna</wicri:regionArea>
<orgName type="university">Université de Bologne</orgName>
<placeName><settlement type="city">Bologne</settlement>
<region nuts="2" type="region">Émilie-Romagne</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Patsouris, Efstratios" sort="Patsouris, Efstratios" uniqKey="Patsouris E" first="Efstratios" last="Patsouris">Efstratios Patsouris</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Pathology, National and Capodistrian University of Athens, Athens, Greece</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Department of Pathology, National and Capodistrian University of Athens, Athens</wicri:regionArea>
<wicri:noRegion>Athens</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pikkarainen, Maria" sort="Pikkarainen, Maria" uniqKey="Pikkarainen M" first="Maria" last="Pikkarainen">Maria Pikkarainen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8">Department of Clinical Medicine, Section of Neuropathology, Unit of Neurology, Kuopio University, PO Box 1627, 70211 Kuopio, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Clinical Medicine, Section of Neuropathology, Unit of Neurology, Kuopio University, PO Box 1627, 70211 Kuopio</wicri:regionArea>
<wicri:noRegion>70211 Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Revesz, Tamas" sort="Revesz, Tamas" uniqKey="Revesz T" first="Tamas" last="Revesz">Tamas Revesz</name>
<affiliation wicri:level="3"><nlm:aff id="Aff12">Queen Square Brain Bank, UCL Institute of Neurology, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Queen Square Brain Bank, UCL Institute of Neurology, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rozemuller, Annemieke" sort="Rozemuller, Annemieke" uniqKey="Rozemuller A" first="Annemieke" last="Rozemuller">Annemieke Rozemuller</name>
<affiliation wicri:level="3"><nlm:aff id="Aff1">Netherlands Brain Bank, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Brain Bank, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seilhean, Danielle" sort="Seilhean, Danielle" uniqKey="Seilhean D" first="Danielle" last="Seilhean">Danielle Seilhean</name>
<affiliation wicri:level="4"><nlm:aff id="Aff17">Laboratorie Escourolle, Assisstance Publique des Hopitaux de Paris, Universite Pierre et Marie Curie, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratorie Escourolle, Assisstance Publique des Hopitaux de Paris, Universite Pierre et Marie Curie, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
<orgName type="university">Université Pierre-et-Marie-Curie</orgName>
</affiliation>
</author>
<author><name sortKey="Schulz Schaeffer, Walter" sort="Schulz Schaeffer, Walter" uniqKey="Schulz Schaeffer W" first="Walter" last="Schulz-Schaeffer">Walter Schulz-Schaeffer</name>
<affiliation wicri:level="3"><nlm:aff id="Aff6">Georg-August-Universitaet Goettingen, Göttingen, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Georg-August-Universitaet Goettingen, Göttingen</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Streichenberger, Nathalie" sort="Streichenberger, Nathalie" uniqKey="Streichenberger N" first="Nathalie" last="Streichenberger">Nathalie Streichenberger</name>
<affiliation wicri:level="3"><nlm:aff id="Aff14">Université Lyon 1 faculté de médecine Laennec, Centre de Neuropathologie et Pathologie Est. Bron Lyon, Hospices Civils de Lyon, Universite de Lyon, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lyon 1 faculté de médecine Laennec, Centre de Neuropathologie et Pathologie Est. Bron Lyon, Hospices Civils de Lyon, Universite de Lyon, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wharton, Stephen B" sort="Wharton, Stephen B" uniqKey="Wharton S" first="Stephen B." last="Wharton">Stephen B. Wharton</name>
<affiliation wicri:level="1"><nlm:aff id="Aff18">Neuroscience Section, University of Sheffield, Sheffield, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Neuroscience Section, University of Sheffield, Sheffield</wicri:regionArea>
<wicri:noRegion>Sheffield</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kretzschmar, Hans" sort="Kretzschmar, Hans" uniqKey="Kretzschmar H" first="Hans" last="Kretzschmar">Hans Kretzschmar</name>
<affiliation wicri:level="4"><nlm:aff id="Aff16">Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Centre for Neuropathology and Prion Research, Ludwig-Maximilians-University, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université Louis-et-Maximilien de Munich</orgName>
</affiliation>
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</analytic>
<series><title level="j">Acta Neuropathologica</title>
<idno type="ISSN">0001-6322</idno>
<idno type="eISSN">1432-0533</idno>
<imprint><date when="2009">2009</date>
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<front><div type="abstract" xml:lang="en"><p>β-Amyloid (Aβ) related pathology shows a range of lesions which differ both qualitatively and quantitatively. Pathologists, to date, mainly focused on the assessment of both of these aspects but attempts to correlate the findings with clinical phenotypes are not convincing. It has been recently proposed in the same way as ι and α synuclein related lesions, also Aβ related pathology may follow a temporal evolution, i.e. distinct phases, characterized by a step-wise involvement of different brain-regions. Twenty-six independent observers reached an 81% absolute agreement while assessing the phase of Aβ, i.e. phase 1 = deposition of Aβ exclusively in neocortex, phase 2 = additionally in allocortex, phase 3 = additionally in diencephalon, phase 4 = additionally in brainstem, and phase 5 = additionally in cerebellum. These high agreement rates were reached when at least six brain regions were evaluated. Likewise, a high agreement (93%) was reached while assessing the absence/presence of cerebral amyloid angiopathy (CAA) and the type of CAA (74%) while examining the six brain regions. Of note, most of observers failed to detect capillary CAA when it was only mild and focal and thus instead of type 1, type 2 CAA was diagnosed. In conclusion, a reliable assessment of Aβ phase and presence/absence of CAA was achieved by a total of 26 observers who examined a standardized set of blocks taken from only six anatomical regions, applying commercially available reagents and by assessing them as instructed. Thus, one may consider rating of Aβ-phases as a diagnostic tool while analyzing subjects with suspected Alzheimer’s disease (AD). Because most of these blocks are currently routinely sampled by the majority of laboratories, assessment of the Aβ phase in AD is feasible even in large scale retrospective studies.</p>
</div>
</front>
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<li>Espagne</li>
<li>Finlande</li>
<li>France</li>
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<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suède</li>
</country>
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<li>Bade-Wurtemberg</li>
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<li>Catalogne</li>
<li>District de Basse-Franconie</li>
<li>District de Haute-Bavière</li>
<li>District de Tübingen</li>
<li>East Middle Sweden</li>
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<li>Svealand</li>
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<li>Émilie-Romagne</li>
<li>Île-de-France</li>
</region>
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<li>Milan</li>
<li>Munich</li>
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</settlement>
<orgName><li>Université Louis-et-Maximilien de Munich</li>
<li>Université Pierre-et-Marie-Curie</li>
<li>Université d'Ulm</li>
<li>Université d'Uppsala</li>
<li>Université d'Édimbourg</li>
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<name sortKey="Pikkarainen, Maria" sort="Pikkarainen, Maria" uniqKey="Pikkarainen M" first="Maria" last="Pikkarainen">Maria Pikkarainen</name>
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<country name="Suède"><region name="Svealand"><name sortKey="Alafuzoff, Irina" sort="Alafuzoff, Irina" uniqKey="Alafuzoff I" first="Irina" last="Alafuzoff">Irina Alafuzoff</name>
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<name sortKey="Bogdanovic, Nenad" sort="Bogdanovic, Nenad" uniqKey="Bogdanovic N" first="Nenad" last="Bogdanovic">Nenad Bogdanovic</name>
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<name sortKey="Bodi, Istvan" sort="Bodi, Istvan" uniqKey="Bodi I" first="Istvan" last="Bodi">Istvan Bodi</name>
<name sortKey="Gentleman, Stephen" sort="Gentleman, Stephen" uniqKey="Gentleman S" first="Stephen" last="Gentleman">Stephen Gentleman</name>
<name sortKey="Graeber, Manuel" sort="Graeber, Manuel" uniqKey="Graeber M" first="Manuel" last="Graeber">Manuel Graeber</name>
<name sortKey="Hortobagyi, Tibor" sort="Hortobagyi, Tibor" uniqKey="Hortobagyi T" first="Tibor" last="Hortobagyi">Tibor Hortobagyi</name>
<name sortKey="Ince, Paul" sort="Ince, Paul" uniqKey="Ince P" first="Paul" last="Ince">Paul Ince</name>
<name sortKey="Ironside, James W" sort="Ironside, James W" uniqKey="Ironside J" first="James W." last="Ironside">James W. Ironside</name>
<name sortKey="King, Andrew" sort="King, Andrew" uniqKey="King A" first="Andrew" last="King">Andrew King</name>
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<name sortKey="Wharton, Stephen B" sort="Wharton, Stephen B" uniqKey="Wharton S" first="Stephen B." last="Wharton">Stephen B. Wharton</name>
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<name sortKey="Gelpi, Ellen" sort="Gelpi, Ellen" uniqKey="Gelpi E" first="Ellen" last="Gelpi">Ellen Gelpi</name>
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<name sortKey="Giaccone, Giorgio" sort="Giaccone, Giorgio" uniqKey="Giaccone G" first="Giorgio" last="Giaccone">Giorgio Giaccone</name>
<name sortKey="Parchi, Piero" sort="Parchi, Piero" uniqKey="Parchi P" first="Piero" last="Parchi">Piero Parchi</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Duyckaerts, Charles" sort="Duyckaerts, Charles" uniqKey="Duyckaerts C" first="Charles" last="Duyckaerts">Charles Duyckaerts</name>
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<name sortKey="Meyronet, David" sort="Meyronet, David" uniqKey="Meyronet D" first="David" last="Meyronet">David Meyronet</name>
<name sortKey="Seilhean, Danielle" sort="Seilhean, Danielle" uniqKey="Seilhean D" first="Danielle" last="Seilhean">Danielle Seilhean</name>
<name sortKey="Streichenberger, Nathalie" sort="Streichenberger, Nathalie" uniqKey="Streichenberger N" first="Nathalie" last="Streichenberger">Nathalie Streichenberger</name>
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<country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Hoftberger, Romana" sort="Hoftberger, Romana" uniqKey="Hoftberger R" first="Romana" last="Höftberger">Romana Höftberger</name>
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<name sortKey="Kovacs, Gabor G" sort="Kovacs, Gabor G" uniqKey="Kovacs G" first="Gábor G." last="Kovács">Gábor G. Kovács</name>
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<country name="Grèce"><noRegion><name sortKey="Kavantzas, Nikolaos" sort="Kavantzas, Nikolaos" uniqKey="Kavantzas N" first="Nikolaos" last="Kavantzas">Nikolaos Kavantzas</name>
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<name sortKey="Korkolopoulou, Penelope" sort="Korkolopoulou, Penelope" uniqKey="Korkolopoulou P" first="Penelope" last="Korkolopoulou">Penelope Korkolopoulou</name>
<name sortKey="Patsouris, Efstratios" sort="Patsouris, Efstratios" uniqKey="Patsouris E" first="Efstratios" last="Patsouris">Efstratios Patsouris</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Rozemuller, Annemieke" sort="Rozemuller, Annemieke" uniqKey="Rozemuller A" first="Annemieke" last="Rozemuller">Annemieke Rozemuller</name>
</region>
</country>
</tree>
</affiliations>
</record>
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