SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans
Identifieur interne : 001E88 ( Main/Exploration ); précédent : 001E87; suivant : 001E89SMF-1, SMF-2 and SMF-3 DMT1 Orthologues Regulate and Are Regulated Differentially by Manganese Levels in C. elegans
Auteurs : Catherine Au [États-Unis] ; Alexandre Benedetto [États-Unis, Royaume-Uni] ; Joel Anderson [États-Unis] ; Arnaud Labrousse [France] ; Keith Erikson [États-Unis] ; Jonathan J. Ewbank [France] ; Michael Aschner [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Abstract
Manganese (Mn) is an essential metal that can exert toxic effects at high concentrations, eventually leading to Parkinsonism. A major transporter of Mn in mammals is the divalent-metal transporter (DMT1). We characterize here DMT1-like proteins in the nematode
Url:
DOI: 10.1371/journal.pone.0007792
PubMed: 19924247
PubMed Central: 2773845
Affiliations:
- France, Royaume-Uni, États-Unis
- Angleterre, Caroline du Nord, Grand Londres, Midi-Pyrénées, Occitanie (région administrative), Provence-Alpes-Côte d'Azur, Tennessee
- Londres, Marseille, Toulouse
- University College de Londres, Université de la Méditerranée
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Manganese (Mn) is an essential metal that can exert toxic effects at high concentrations, eventually leading to Parkinsonism. A major transporter of Mn in mammals is the divalent-metal transporter (DMT1). We characterize here DMT1-like proteins in the nematode <italic>C. elegans</italic>
, which regulate and are regulated by Mn and iron (Fe) content. We identified three new DMT1-like genes in <italic>C. elegans</italic>
: <italic>smf-1</italic>
, <italic>smf-2</italic>
and <italic>smf-3</italic>
. All three can functionally substitute for loss of their yeast orthologues in <italic>S. cerevisiae</italic>
. In the worm, deletion of <italic>smf-1</italic>
or <italic>smf-3</italic>
led to an increased Mn tolerance, while loss of <italic>smf-2</italic>
led to increased Mn sensitivity. <italic>smf</italic>
mRNA levels measured by QRT-PCR were up-regulated upon low Mn and down-regulated upon high Mn exposures. Translational GFP-fusions revealed that SMF-1 and SMF-3 strongly localize to partially overlapping apical regions of the gut epithelium, suggesting a differential role for SMF-1 and SMF-3 in Mn nutritional intake. Conversely, SMF-2 was detected in the marginal pharyngeal epithelium, possibly involved in metal-sensing. Analysis of metal content upon Mn exposure in <italic>smf</italic>
mutants revealed that SMF-3 is required for normal Mn uptake, while <italic>smf-1</italic>
was dispensable. Higher <italic>smf-2</italic>
mRNA levels correlated with higher Fe content, supporting a role for SMF-2 in Fe uptake. In <italic>smf-1</italic>
and <italic>smf-3</italic>
but not in <italic>smf-2</italic>
mutants, increased Mn exposure led to decreased Fe levels, suggesting that both metals compete for transport by SMF-2. Finally, SMF-3 was post-translationally and reversibly down-regulated following Mn-exposure. In sum, we unraveled a complex interplay of transcriptional and post-translational regulations of 3 DMT1-like transporters in two adjacent tissues, which regulate metal-content in <italic>C. elegans</italic>
.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Post, Je" uniqKey="Post J">JE Post</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saric, M" uniqKey="Saric M">M Saric</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wedler, Fc" uniqKey="Wedler F">FC Wedler</name>
</author>
<author><name sortKey="Denman, Rb" uniqKey="Denman R">RB Denman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Addess, Kj" uniqKey="Addess K">KJ Addess</name>
</author>
<author><name sortKey="Basilion, Jp" uniqKey="Basilion J">JP Basilion</name>
</author>
<author><name sortKey="Klausner, Rd" uniqKey="Klausner R">RD Klausner</name>
</author>
<author><name sortKey="Rouault, Ta" uniqKey="Rouault T">TA Rouault</name>
</author>
<author><name sortKey="Pardi, A" uniqKey="Pardi A">A Pardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aschner, M" uniqKey="Aschner M">M Aschner</name>
</author>
<author><name sortKey="Gannon, M" uniqKey="Gannon M">M Gannon</name>
</author>
<author><name sortKey="Kimelberg, Hk" uniqKey="Kimelberg H">HK Kimelberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fitsanakis, Va" uniqKey="Fitsanakis V">VA Fitsanakis</name>
</author>
<author><name sortKey="Aschner, M" uniqKey="Aschner M">M Aschner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liao, Sl" uniqKey="Liao S">SL Liao</name>
</author>
<author><name sortKey="Chen, Cj" uniqKey="Chen C">CJ Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Malecki, Ea" uniqKey="Malecki E">EA Malecki</name>
</author>
<author><name sortKey="Devenyi, Ag" uniqKey="Devenyi A">AG Devenyi</name>
</author>
<author><name sortKey="Beard, Jl" uniqKey="Beard J">JL Beard</name>
</author>
<author><name sortKey="Connor, Jr" uniqKey="Connor J">JR Connor</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prohaska, Jr" uniqKey="Prohaska J">JR Prohaska</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Takeda, A" uniqKey="Takeda A">A Takeda</name>
</author>
<author><name sortKey="Sotogaku, N" uniqKey="Sotogaku N">N Sotogaku</name>
</author>
<author><name sortKey="Oku, N" uniqKey="Oku N">N Oku</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aschner, M" uniqKey="Aschner M">M Aschner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aschner, M" uniqKey="Aschner M">M Aschner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aschner, M" uniqKey="Aschner M">M Aschner</name>
</author>
<author><name sortKey="Aschner, Jl" uniqKey="Aschner J">JL Aschner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, K" uniqKey="Thompson K">K Thompson</name>
</author>
<author><name sortKey="Molina, Rm" uniqKey="Molina R">RM Molina</name>
</author>
<author><name sortKey="Donaghey, T" uniqKey="Donaghey T">T Donaghey</name>
</author>
<author><name sortKey="Schwob, Je" uniqKey="Schwob J">JE Schwob</name>
</author>
<author><name sortKey="Brain, Jd" uniqKey="Brain J">JD Brain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dorman, Dc" uniqKey="Dorman D">DC Dorman</name>
</author>
<author><name sortKey="Mcmanus, Be" uniqKey="Mcmanus B">BE McManus</name>
</author>
<author><name sortKey="Parkinson, Cu" uniqKey="Parkinson C">CU Parkinson</name>
</author>
<author><name sortKey="Manuel, Ca" uniqKey="Manuel C">CA Manuel</name>
</author>
<author><name sortKey="Mcelveen, Am" uniqKey="Mcelveen A">AM McElveen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Calne, Db" uniqKey="Calne D">DB Calne</name>
</author>
<author><name sortKey="Chu, Ns" uniqKey="Chu N">NS Chu</name>
</author>
<author><name sortKey="Huang, Cc" uniqKey="Huang C">CC Huang</name>
</author>
<author><name sortKey="Lu, Cs" uniqKey="Lu C">CS Lu</name>
</author>
<author><name sortKey="Olanow, W" uniqKey="Olanow W">W Olanow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cersosimo, Mg" uniqKey="Cersosimo M">MG Cersosimo</name>
</author>
<author><name sortKey="Koller, Wc" uniqKey="Koller W">WC Koller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olanow, Cw" uniqKey="Olanow C">CW Olanow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pfeifer, Gd" uniqKey="Pfeifer G">GD Pfeifer</name>
</author>
<author><name sortKey="Roper, Jm" uniqKey="Roper J">JM Roper</name>
</author>
<author><name sortKey="Dorman, D" uniqKey="Dorman D">D Dorman</name>
</author>
<author><name sortKey="Lynam, Dr" uniqKey="Lynam D">DR Lynam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ressler, T" uniqKey="Ressler T">T Ressler</name>
</author>
<author><name sortKey="Wong, J" uniqKey="Wong J">J Wong</name>
</author>
<author><name sortKey="Roos, J" uniqKey="Roos J">J Roos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rollin, H" uniqKey="Rollin H">H Rollin</name>
</author>
<author><name sortKey="Mathee, A" uniqKey="Mathee A">A Mathee</name>
</author>
<author><name sortKey="Levin, J" uniqKey="Levin J">J Levin</name>
</author>
<author><name sortKey="Theodorou, P" uniqKey="Theodorou P">P Theodorou</name>
</author>
<author><name sortKey="Wewers, F" uniqKey="Wewers F">F Wewers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brown, Rc" uniqKey="Brown R">RC Brown</name>
</author>
<author><name sortKey="Lockwood, Ah" uniqKey="Lockwood A">AH Lockwood</name>
</author>
<author><name sortKey="Sonawane, Br" uniqKey="Sonawane B">BR Sonawane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dorsey, Er" uniqKey="Dorsey E">ER Dorsey</name>
</author>
<author><name sortKey="Constantinescu, R" uniqKey="Constantinescu R">R Constantinescu</name>
</author>
<author><name sortKey="Thompson, Jp" uniqKey="Thompson J">JP Thompson</name>
</author>
<author><name sortKey="Biglan, Km" uniqKey="Biglan K">KM Biglan</name>
</author>
<author><name sortKey="Holloway, Rg" uniqKey="Holloway R">RG Holloway</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mayeux, R" uniqKey="Mayeux R">R Mayeux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Murphy, Va" uniqKey="Murphy V">VA Murphy</name>
</author>
<author><name sortKey="Wadhwani, Kc" uniqKey="Wadhwani K">KC Wadhwani</name>
</author>
<author><name sortKey="Smith, Qr" uniqKey="Smith Q">QR Smith</name>
</author>
<author><name sortKey="Rapoport, Si" uniqKey="Rapoport S">SI Rapoport</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aschner, M" uniqKey="Aschner M">M Aschner</name>
</author>
<author><name sortKey="Gannon, M" uniqKey="Gannon M">M Gannon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rabin, O" uniqKey="Rabin O">O Rabin</name>
</author>
<author><name sortKey="Hegedus, L" uniqKey="Hegedus L">L Hegedus</name>
</author>
<author><name sortKey="Bourre, Jm" uniqKey="Bourre J">JM Bourre</name>
</author>
<author><name sortKey="Smith, Qr" uniqKey="Smith Q">QR Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Andrews, Nc" uniqKey="Andrews N">NC Andrews</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gruenheid, S" uniqKey="Gruenheid S">S Gruenheid</name>
</author>
<author><name sortKey="Cellier, M" uniqKey="Cellier M">M Cellier</name>
</author>
<author><name sortKey="Vidal, S" uniqKey="Vidal S">S Vidal</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vidal, S" uniqKey="Vidal S">S Vidal</name>
</author>
<author><name sortKey="Belouchi, Am" uniqKey="Belouchi A">AM Belouchi</name>
</author>
<author><name sortKey="Cellier, M" uniqKey="Cellier M">M Cellier</name>
</author>
<author><name sortKey="Beatty, B" uniqKey="Beatty B">B Beatty</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garrick, Md" uniqKey="Garrick M">MD Garrick</name>
</author>
<author><name sortKey="Dolan, Kg" uniqKey="Dolan K">KG Dolan</name>
</author>
<author><name sortKey="Horbinski, C" uniqKey="Horbinski C">C Horbinski</name>
</author>
<author><name sortKey="Ghio, Aj" uniqKey="Ghio A">AJ Ghio</name>
</author>
<author><name sortKey="Higgins, D" uniqKey="Higgins D">D Higgins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gunshin, H" uniqKey="Gunshin H">H Gunshin</name>
</author>
<author><name sortKey="Mackenzie, B" uniqKey="Mackenzie B">B Mackenzie</name>
</author>
<author><name sortKey="Berger, Uv" uniqKey="Berger U">UV Berger</name>
</author>
<author><name sortKey="Gunshin, Y" uniqKey="Gunshin Y">Y Gunshin</name>
</author>
<author><name sortKey="Romero, Mf" uniqKey="Romero M">MF Romero</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Forbes, Jr" uniqKey="Forbes J">JR Forbes</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Knopfel, M" uniqKey="Knopfel M">M Knopfel</name>
</author>
<author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name>
</author>
<author><name sortKey="Garrick, Md" uniqKey="Garrick M">MD Garrick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cellier, M" uniqKey="Cellier M">M Cellier</name>
</author>
<author><name sortKey="Prive, G" uniqKey="Prive G">G Prive</name>
</author>
<author><name sortKey="Belouchi, A" uniqKey="Belouchi A">A Belouchi</name>
</author>
<author><name sortKey="Kwan, T" uniqKey="Kwan T">T Kwan</name>
</author>
<author><name sortKey="Rodrigues, V" uniqKey="Rodrigues V">V Rodrigues</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Su, Ma" uniqKey="Su M">MA Su</name>
</author>
<author><name sortKey="Trenor, Cc" uniqKey="Trenor C">CC Trenor</name>
</author>
<author><name sortKey="Fleming, Jc" uniqKey="Fleming J">JC Fleming</name>
</author>
<author><name sortKey="Fleming, Md" uniqKey="Fleming M">MD Fleming</name>
</author>
<author><name sortKey="Andrews, Nc" uniqKey="Andrews N">NC Andrews</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beaumont, C" uniqKey="Beaumont C">C Beaumont</name>
</author>
<author><name sortKey="Delaunay, J" uniqKey="Delaunay J">J Delaunay</name>
</author>
<author><name sortKey="Hetet, G" uniqKey="Hetet G">G Hetet</name>
</author>
<author><name sortKey="Grandchamp, B" uniqKey="Grandchamp B">B Grandchamp</name>
</author>
<author><name sortKey="De Montalembert, M" uniqKey="De Montalembert M">M de Montalembert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Iolascon, A" uniqKey="Iolascon A">A Iolascon</name>
</author>
<author><name sortKey="D Apolito, M" uniqKey="D Apolito M">M d'Apolito</name>
</author>
<author><name sortKey="Servedio, V" uniqKey="Servedio V">V Servedio</name>
</author>
<author><name sortKey="Cimmino, F" uniqKey="Cimmino F">F Cimmino</name>
</author>
<author><name sortKey="Piga, A" uniqKey="Piga A">A Piga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lam Yuk Tseung, S" uniqKey="Lam Yuk Tseung S">S Lam-Yuk-Tseung</name>
</author>
<author><name sortKey="Camaschella, C" uniqKey="Camaschella C">C Camaschella</name>
</author>
<author><name sortKey="Iolascon, A" uniqKey="Iolascon A">A Iolascon</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lam Yuk Tseung, S" uniqKey="Lam Yuk Tseung S">S Lam-Yuk-Tseung</name>
</author>
<author><name sortKey="Mathieu, M" uniqKey="Mathieu M">M Mathieu</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mims, Mp" uniqKey="Mims M">MP Mims</name>
</author>
<author><name sortKey="Prchal, Jt" uniqKey="Prchal J">JT Prchal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Priwitzerova, M" uniqKey="Priwitzerova M">M Priwitzerova</name>
</author>
<author><name sortKey="Nie, G" uniqKey="Nie G">G Nie</name>
</author>
<author><name sortKey="Sheftel, Ad" uniqKey="Sheftel A">AD Sheftel</name>
</author>
<author><name sortKey="Pospisilova, D" uniqKey="Pospisilova D">D Pospisilova</name>
</author>
<author><name sortKey="Divoky, V" uniqKey="Divoky V">V Divoky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Pl" uniqKey="Lee P">PL Lee</name>
</author>
<author><name sortKey="Gelbart, T" uniqKey="Gelbart T">T Gelbart</name>
</author>
<author><name sortKey="West, C" uniqKey="West C">C West</name>
</author>
<author><name sortKey="Halloran, C" uniqKey="Halloran C">C Halloran</name>
</author>
<author><name sortKey="Beutler, E" uniqKey="Beutler E">E Beutler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, Wh" uniqKey="Huang W">WH Huang</name>
</author>
<author><name sortKey="Lin, Jl" uniqKey="Lin J">JL Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canonne Hergaux, F" uniqKey="Canonne Hergaux F">F Canonne-Hergaux</name>
</author>
<author><name sortKey="Gruenheid, S" uniqKey="Gruenheid S">S Gruenheid</name>
</author>
<author><name sortKey="Ponka, P" uniqKey="Ponka P">P Ponka</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fleming, Md" uniqKey="Fleming M">MD Fleming</name>
</author>
<author><name sortKey="Andrews, Nc" uniqKey="Andrews N">NC Andrews</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Courville, P" uniqKey="Courville P">P Courville</name>
</author>
<author><name sortKey="Chaloupka, R" uniqKey="Chaloupka R">R Chaloupka</name>
</author>
<author><name sortKey="Cellier, Mf" uniqKey="Cellier M">MF Cellier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tabuchi, M" uniqKey="Tabuchi M">M Tabuchi</name>
</author>
<author><name sortKey="Yoshimori, T" uniqKey="Yoshimori T">T Yoshimori</name>
</author>
<author><name sortKey="Yamaguchi, K" uniqKey="Yamaguchi K">K Yamaguchi</name>
</author>
<author><name sortKey="Yoshida, T" uniqKey="Yoshida T">T Yoshida</name>
</author>
<author><name sortKey="Kishi, F" uniqKey="Kishi F">F Kishi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gruenheid, S" uniqKey="Gruenheid S">S Gruenheid</name>
</author>
<author><name sortKey="Canonne Hergaux, F" uniqKey="Canonne Hergaux F">F Canonne-Hergaux</name>
</author>
<author><name sortKey="Gauthier, S" uniqKey="Gauthier S">S Gauthier</name>
</author>
<author><name sortKey="Hackam, Dj" uniqKey="Hackam D">DJ Hackam</name>
</author>
<author><name sortKey="Grinstein, S" uniqKey="Grinstein S">S Grinstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kannurpatti, Ss" uniqKey="Kannurpatti S">SS Kannurpatti</name>
</author>
<author><name sortKey="Joshi, Pg" uniqKey="Joshi P">PG Joshi</name>
</author>
<author><name sortKey="Joshi, Nb" uniqKey="Joshi N">NB Joshi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Touret, N" uniqKey="Touret N">N Touret</name>
</author>
<author><name sortKey="Furuya, W" uniqKey="Furuya W">W Furuya</name>
</author>
<author><name sortKey="Forbes, J" uniqKey="Forbes J">J Forbes</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
<author><name sortKey="Grinstein, S" uniqKey="Grinstein S">S Grinstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eide, Dj" uniqKey="Eide D">DJ Eide</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Supek, F" uniqKey="Supek F">F Supek</name>
</author>
<author><name sortKey="Supekova, L" uniqKey="Supekova L">L Supekova</name>
</author>
<author><name sortKey="Nelson, H" uniqKey="Nelson H">H Nelson</name>
</author>
<author><name sortKey="Nelson, N" uniqKey="Nelson N">N Nelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cohen, A" uniqKey="Cohen A">A Cohen</name>
</author>
<author><name sortKey="Nelson, H" uniqKey="Nelson H">H Nelson</name>
</author>
<author><name sortKey="Nelson, N" uniqKey="Nelson N">N Nelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Portnoy, Me" uniqKey="Portnoy M">ME Portnoy</name>
</author>
<author><name sortKey="Jensen, Lt" uniqKey="Jensen L">LT Jensen</name>
</author>
<author><name sortKey="Culotta, Vc" uniqKey="Culotta V">VC Culotta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Portnoy, Me" uniqKey="Portnoy M">ME Portnoy</name>
</author>
<author><name sortKey="Liu, Xf" uniqKey="Liu X">XF Liu</name>
</author>
<author><name sortKey="Culotta, Vc" uniqKey="Culotta V">VC Culotta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luk, Ee" uniqKey="Luk E">EE Luk</name>
</author>
<author><name sortKey="Culotta, Vc" uniqKey="Culotta V">VC Culotta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pinner, E" uniqKey="Pinner E">E Pinner</name>
</author>
<author><name sortKey="Gruenheid, S" uniqKey="Gruenheid S">S Gruenheid</name>
</author>
<author><name sortKey="Raymond, M" uniqKey="Raymond M">M Raymond</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, Jd" uniqKey="Thompson J">JD Thompson</name>
</author>
<author><name sortKey="Gibson, Tj" uniqKey="Gibson T">TJ Gibson</name>
</author>
<author><name sortKey="Plewniak, F" uniqKey="Plewniak F">F Plewniak</name>
</author>
<author><name sortKey="Jeanmougin, F" uniqKey="Jeanmougin F">F Jeanmougin</name>
</author>
<author><name sortKey="Higgins, Dg" uniqKey="Higgins D">DG Higgins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, Jd" uniqKey="Thompson J">JD Thompson</name>
</author>
<author><name sortKey="Higgins, Dg" uniqKey="Higgins D">DG Higgins</name>
</author>
<author><name sortKey="Gibson, Tj" uniqKey="Gibson T">TJ Gibson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brenner, S" uniqKey="Brenner S">S Brenner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mello, Cc" uniqKey="Mello C">CC Mello</name>
</author>
<author><name sortKey="Kramer, Jm" uniqKey="Kramer J">JM Kramer</name>
</author>
<author><name sortKey="Stinchcomb, D" uniqKey="Stinchcomb D">D Stinchcomb</name>
</author>
<author><name sortKey="Ambros, V" uniqKey="Ambros V">V Ambros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hoogewijs, D" uniqKey="Hoogewijs D">D Hoogewijs</name>
</author>
<author><name sortKey="Houthoofd, K" uniqKey="Houthoofd K">K Houthoofd</name>
</author>
<author><name sortKey="Matthijssens, F" uniqKey="Matthijssens F">F Matthijssens</name>
</author>
<author><name sortKey="Vandesompele, J" uniqKey="Vandesompele J">J Vandesompele</name>
</author>
<author><name sortKey="Vanfleteren, Jr" uniqKey="Vanfleteren J">JR Vanfleteren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liegeois, S" uniqKey="Liegeois S">S Liegeois</name>
</author>
<author><name sortKey="Benedetto, A" uniqKey="Benedetto A">A Benedetto</name>
</author>
<author><name sortKey="Michaux, G" uniqKey="Michaux G">G Michaux</name>
</author>
<author><name sortKey="Belliard, G" uniqKey="Belliard G">G Belliard</name>
</author>
<author><name sortKey="Labouesse, M" uniqKey="Labouesse M">M Labouesse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, Fk" uniqKey="Nelson F">FK Nelson</name>
</author>
<author><name sortKey="Riddle, Dl" uniqKey="Riddle D">DL Riddle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Au, C" uniqKey="Au C">C Au</name>
</author>
<author><name sortKey="Benedetto, A" uniqKey="Benedetto A">A Benedetto</name>
</author>
<author><name sortKey="Aschner, M" uniqKey="Aschner M">M Aschner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garrick, Md" uniqKey="Garrick M">MD Garrick</name>
</author>
<author><name sortKey="Singleton, St" uniqKey="Singleton S">ST Singleton</name>
</author>
<author><name sortKey="Vargas, F" uniqKey="Vargas F">F Vargas</name>
</author>
<author><name sortKey="Kuo, Hc" uniqKey="Kuo H">HC Kuo</name>
</author>
<author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roth, Ja" uniqKey="Roth J">JA Roth</name>
</author>
<author><name sortKey="Feng, L" uniqKey="Feng L">L Feng</name>
</author>
<author><name sortKey="Dolan, Kg" uniqKey="Dolan K">KG Dolan</name>
</author>
<author><name sortKey="Lis, A" uniqKey="Lis A">A Lis</name>
</author>
<author><name sortKey="Garrick, Md" uniqKey="Garrick M">MD Garrick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thompson, K" uniqKey="Thompson K">K Thompson</name>
</author>
<author><name sortKey="Molina, R" uniqKey="Molina R">R Molina</name>
</author>
<author><name sortKey="Donaghey, T" uniqKey="Donaghey T">T Donaghey</name>
</author>
<author><name sortKey="Brain, Jd" uniqKey="Brain J">JD Brain</name>
</author>
<author><name sortKey="Wessling Resnick, M" uniqKey="Wessling Resnick M">M Wessling-Resnick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mackenzie, B" uniqKey="Mackenzie B">B Mackenzie</name>
</author>
<author><name sortKey="Takanaga, H" uniqKey="Takanaga H">H Takanaga</name>
</author>
<author><name sortKey="Hubert, N" uniqKey="Hubert N">N Hubert</name>
</author>
<author><name sortKey="Rolfs, A" uniqKey="Rolfs A">A Rolfs</name>
</author>
<author><name sortKey="Hediger, Ma" uniqKey="Hediger M">MA Hediger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Piccinelli, P" uniqKey="Piccinelli P">P Piccinelli</name>
</author>
<author><name sortKey="Samuelsson, T" uniqKey="Samuelsson T">T Samuelsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Eguez, L" uniqKey="Eguez L">L Eguez</name>
</author>
<author><name sortKey="Chung, Ys" uniqKey="Chung Y">YS Chung</name>
</author>
<author><name sortKey="Kuchibhatla, A" uniqKey="Kuchibhatla A">A Kuchibhatla</name>
</author>
<author><name sortKey="Paidhungat, M" uniqKey="Paidhungat M">M Paidhungat</name>
</author>
<author><name sortKey="Garrett, S" uniqKey="Garrett S">S Garrett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Xf" uniqKey="Liu X">XF Liu</name>
</author>
<author><name sortKey="Culotta, Vc" uniqKey="Culotta V">VC Culotta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jensen, Lt" uniqKey="Jensen L">LT Jensen</name>
</author>
<author><name sortKey="Ajua Alemanji, M" uniqKey="Ajua Alemanji M">M Ajua-Alemanji</name>
</author>
<author><name sortKey="Culotta, Vc" uniqKey="Culotta V">VC Culotta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Albertson, Dg" uniqKey="Albertson D">DG Albertson</name>
</author>
<author><name sortKey="Thomson, Jn" uniqKey="Thomson J">JN Thomson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bansal, Sk" uniqKey="Bansal S">SK Bansal</name>
</author>
<author><name sortKey="Murthy, Rc" uniqKey="Murthy R">RC Murthy</name>
</author>
<author><name sortKey="Chandra, Sv" uniqKey="Chandra S">SV Chandra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steinberg, Sf" uniqKey="Steinberg S">SF Steinberg</name>
</author>
<author><name sortKey="Chow, Yk" uniqKey="Chow Y">YK Chow</name>
</author>
<author><name sortKey="Bilezikian, Jp" uniqKey="Bilezikian J">JP Bilezikian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mango, Se" uniqKey="Mango S">SE Mango</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burdo, Jr" uniqKey="Burdo J">JR Burdo</name>
</author>
<author><name sortKey="Menzies, Sl" uniqKey="Menzies S">SL Menzies</name>
</author>
<author><name sortKey="Simpson, Ia" uniqKey="Simpson I">IA Simpson</name>
</author>
<author><name sortKey="Garrick, Lm" uniqKey="Garrick L">LM Garrick</name>
</author>
<author><name sortKey="Garrick, Md" uniqKey="Garrick M">MD Garrick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canonne Hergaux, F" uniqKey="Canonne Hergaux F">F Canonne-Hergaux</name>
</author>
<author><name sortKey="Gruenheid, S" uniqKey="Gruenheid S">S Gruenheid</name>
</author>
<author><name sortKey="Govoni, G" uniqKey="Govoni G">G Govoni</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mulero, V" uniqKey="Mulero V">V Mulero</name>
</author>
<author><name sortKey="Searle, S" uniqKey="Searle S">S Searle</name>
</author>
<author><name sortKey="Blackwell, Jm" uniqKey="Blackwell J">JM Blackwell</name>
</author>
<author><name sortKey="Brock, Jh" uniqKey="Brock J">JH Brock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Searle, S" uniqKey="Searle S">S Searle</name>
</author>
<author><name sortKey="Bright, Na" uniqKey="Bright N">NA Bright</name>
</author>
<author><name sortKey="Roach, Ti" uniqKey="Roach T">TI Roach</name>
</author>
<author><name sortKey="Atkinson, Pg" uniqKey="Atkinson P">PG Atkinson</name>
</author>
<author><name sortKey="Barton, Ch" uniqKey="Barton C">CH Barton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guven, K" uniqKey="Guven K">K Guven</name>
</author>
<author><name sortKey="Deveci, E" uniqKey="Deveci E">E Deveci</name>
</author>
<author><name sortKey="Akba, O" uniqKey="Akba O">O Akba</name>
</author>
<author><name sortKey="Onen, A" uniqKey="Onen A">A Onen</name>
</author>
<author><name sortKey="De Pomerai, D" uniqKey="De Pomerai D">D de Pomerai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponnapakkam, T" uniqKey="Ponnapakkam T">T Ponnapakkam</name>
</author>
<author><name sortKey="Iszard, M" uniqKey="Iszard M">M Iszard</name>
</author>
<author><name sortKey="Henry Sam, G" uniqKey="Henry Sam G">G Henry-Sam</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canonne Hergaux, F" uniqKey="Canonne Hergaux F">F Canonne-Hergaux</name>
</author>
<author><name sortKey="Gros, P" uniqKey="Gros P">P Gros</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mackenzie, B" uniqKey="Mackenzie B">B Mackenzie</name>
</author>
<author><name sortKey="Garrick, Md" uniqKey="Garrick M">MD Garrick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Salazar, J" uniqKey="Salazar J">J Salazar</name>
</author>
<author><name sortKey="Mena, N" uniqKey="Mena N">N Mena</name>
</author>
<author><name sortKey="Hunot, S" uniqKey="Hunot S">S Hunot</name>
</author>
<author><name sortKey="Prigent, A" uniqKey="Prigent A">A Prigent</name>
</author>
<author><name sortKey="Alvarez Fischer, D" uniqKey="Alvarez Fischer D">D Alvarez-Fischer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Song, N" uniqKey="Song N">N Song</name>
</author>
<author><name sortKey="Xie, J" uniqKey="Xie J">J Xie</name>
</author>
<author><name sortKey="Jiang, H" uniqKey="Jiang H">H Jiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liegeois, S" uniqKey="Liegeois S">S Liegeois</name>
</author>
<author><name sortKey="Benedetto, A" uniqKey="Benedetto A">A Benedetto</name>
</author>
<author><name sortKey="Garnier, Jm" uniqKey="Garnier J">JM Garnier</name>
</author>
<author><name sortKey="Schwab, Y" uniqKey="Schwab Y">Y Schwab</name>
</author>
<author><name sortKey="Labouesse, M" uniqKey="Labouesse M">M Labouesse</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nelson, N" uniqKey="Nelson N">N Nelson</name>
</author>
<author><name sortKey="Harvey, Wr" uniqKey="Harvey W">WR Harvey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Techau, Me" uniqKey="Techau M">ME Techau</name>
</author>
<author><name sortKey="Valdez Taubas, J" uniqKey="Valdez Taubas J">J Valdez-Taubas</name>
</author>
<author><name sortKey="Popoff, Jf" uniqKey="Popoff J">JF Popoff</name>
</author>
<author><name sortKey="Francis, R" uniqKey="Francis R">R Francis</name>
</author>
<author><name sortKey="Seaman, M" uniqKey="Seaman M">M Seaman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, Yt" uniqKey="Lin Y">YT Lin</name>
</author>
<author><name sortKey="Hoang, H" uniqKey="Hoang H">H Hoang</name>
</author>
<author><name sortKey="Hsieh, Si" uniqKey="Hsieh S">SI Hsieh</name>
</author>
<author><name sortKey="Rangel, N" uniqKey="Rangel N">N Rangel</name>
</author>
<author><name sortKey="Foster, Al" uniqKey="Foster A">AL Foster</name>
</author>
</analytic>
</biblStruct>
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</TEI>
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<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Caroline du Nord</li>
<li>Grand Londres</li>
<li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Tennessee</li>
</region>
<settlement><li>Londres</li>
<li>Marseille</li>
<li>Toulouse</li>
</settlement>
<orgName><li>University College de Londres</li>
<li>Université de la Méditerranée</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Au, Catherine" sort="Au, Catherine" uniqKey="Au C" first="Catherine" last="Au">Catherine Au</name>
</region>
<name sortKey="Anderson, Joel" sort="Anderson, Joel" uniqKey="Anderson J" first="Joel" last="Anderson">Joel Anderson</name>
<name sortKey="Aschner, Michael" sort="Aschner, Michael" uniqKey="Aschner M" first="Michael" last="Aschner">Michael Aschner</name>
<name sortKey="Aschner, Michael" sort="Aschner, Michael" uniqKey="Aschner M" first="Michael" last="Aschner">Michael Aschner</name>
<name sortKey="Aschner, Michael" sort="Aschner, Michael" uniqKey="Aschner M" first="Michael" last="Aschner">Michael Aschner</name>
<name sortKey="Au, Catherine" sort="Au, Catherine" uniqKey="Au C" first="Catherine" last="Au">Catherine Au</name>
<name sortKey="Benedetto, Alexandre" sort="Benedetto, Alexandre" uniqKey="Benedetto A" first="Alexandre" last="Benedetto">Alexandre Benedetto</name>
<name sortKey="Benedetto, Alexandre" sort="Benedetto, Alexandre" uniqKey="Benedetto A" first="Alexandre" last="Benedetto">Alexandre Benedetto</name>
<name sortKey="Erikson, Keith" sort="Erikson, Keith" uniqKey="Erikson K" first="Keith" last="Erikson">Keith Erikson</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Benedetto, Alexandre" sort="Benedetto, Alexandre" uniqKey="Benedetto A" first="Alexandre" last="Benedetto">Alexandre Benedetto</name>
</region>
</country>
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</region>
<name sortKey="Ewbank, Jonathan J" sort="Ewbank, Jonathan J" uniqKey="Ewbank J" first="Jonathan J." last="Ewbank">Jonathan J. Ewbank</name>
<name sortKey="Ewbank, Jonathan J" sort="Ewbank, Jonathan J" uniqKey="Ewbank J" first="Jonathan J." last="Ewbank">Jonathan J. Ewbank</name>
<name sortKey="Ewbank, Jonathan J" sort="Ewbank, Jonathan J" uniqKey="Ewbank J" first="Jonathan J." last="Ewbank">Jonathan J. Ewbank</name>
<name sortKey="Labrousse, Arnaud" sort="Labrousse, Arnaud" uniqKey="Labrousse A" first="Arnaud" last="Labrousse">Arnaud Labrousse</name>
<name sortKey="Labrousse, Arnaud" sort="Labrousse, Arnaud" uniqKey="Labrousse A" first="Arnaud" last="Labrousse">Arnaud Labrousse</name>
<name sortKey="Labrousse, Arnaud" sort="Labrousse, Arnaud" uniqKey="Labrousse A" first="Arnaud" last="Labrousse">Arnaud Labrousse</name>
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</record>
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