Functional MRI exploration of combined hand and speech movements in Parkinson’s disease
Identifieur interne : 001580 ( Main/Exploration ); précédent : 001579; suivant : 001581Functional MRI exploration of combined hand and speech movements in Parkinson’s disease
Auteurs : Serge Pinto [France] ; Laura Mancini [Royaume-Uni] ; Marjan Jahanshahi [Royaume-Uni] ; John S. Thornton [Royaume-Uni] ; Elina Tripoliti [Royaume-Uni] ; Tarek A. Yousry [Royaume-Uni] ; Patricia Limousin [Royaume-Uni]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2011.
English descriptors
- KwdEn :
- Acoustic Stimulation, Adult, Aged, Brain (blood supply), Brain (pathology), Brain (physiopathology), Brain Mapping, Female, Functional Laterality, Hand (physiopathology), Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging (methods), Male, Middle Aged, Movement (physiology), Neuropsychological Tests, Oxygen (blood), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Photic Stimulation, Psychomotor Performance (physiology), Speech.
- MESH :
- chemical , blood : Oxygen.
- blood supply : Brain.
- methods : Magnetic Resonance Imaging.
- pathology : Brain, Parkinson Disease.
- physiology : Movement, Psychomotor Performance.
- physiopathology : Brain, Hand, Parkinson Disease.
- Acoustic Stimulation, Adult, Aged, Brain Mapping, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, Photic Stimulation, Speech.
Abstract
Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson’s disease (PD) in which patients have specific difficulties performing 2 movements simultaneously. In 9 unmedicated PD patients and fifteen healthy control subjects, externally-cued tasks (hand movement, speech production and combined hand movement and speech production) were performed twice in a random order and fMRI detected cerebral activations compared to rest. F-statistics tested within-group (significant activations at p-values < 0.05, FWE corrected), between-group and between-task comparisons (regional activations significant at p-values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In PD patients, only activations underlying HM were observed during the combined task. We interpreted this phenomenon as the patients’ potential inability to recruit facilitatory activations while performing2 movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (hand movement) in comparison with the other (speech production). Our observation could also reflect the inability of PD patients to intrinsically engage the motor coordination necessary to perform a combined task.
Url:
DOI: 10.1002/mds.23799
PubMed: 21714000
PubMed Central: 3184369
Affiliations:
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xml:lang="fr">France</country><wicri:regionArea> Laboratoire Parole et Langage, 5 avenue Pasteur, BP80975, F-13604 Aix-en-Provence Cedex 1</wicri:regionArea><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-en-Provence</settlement></placeName></affiliation></author><author><name sortKey="Mancini, Laura" sort="Mancini, Laura" uniqKey="Mancini L" first="Laura" last="Mancini">Laura Mancini</name><affiliation wicri:level="1"><nlm:aff id="A2"> Queen Square Imaging Centre, 8-11 Queen Square, London WC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Queen Square Imaging Centre, 8-11 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Trust, Queen Square, LondonWC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Trust, Queen Square, LondonWC1N 3BG</wicri:regionArea><wicri:noRegion>LondonWC1N 3BG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4"> Academic Neuroradiological Unit, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Academic Neuroradiological Unit, Institute of Neurology, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="1"><nlm:aff id="A5"> Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London WC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Thornton, John S" sort="Thornton, John S" uniqKey="Thornton J" first="John S." last="Thornton">John S. Thornton</name><affiliation wicri:level="1"><nlm:aff id="A3"> Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Trust, Queen Square, LondonWC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Trust, Queen Square, LondonWC1N 3BG</wicri:regionArea><wicri:noRegion>LondonWC1N 3BG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4"> Academic Neuroradiological Unit, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Academic Neuroradiological Unit, Institute of Neurology, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Tripoliti, Elina" sort="Tripoliti, Elina" uniqKey="Tripoliti E" first="Elina" last="Tripoliti">Elina Tripoliti</name><affiliation wicri:level="1"><nlm:aff id="A5"> Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London WC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name><affiliation wicri:level="1"><nlm:aff id="A2"> Queen Square Imaging Centre, 8-11 Queen Square, London WC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Queen Square Imaging Centre, 8-11 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A3"> Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Trust, Queen Square, LondonWC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Trust, Queen Square, LondonWC1N 3BG</wicri:regionArea><wicri:noRegion>LondonWC1N 3BG</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="A4"> Academic Neuroradiological Unit, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Academic Neuroradiological Unit, Institute of Neurology, Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author><author><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name><affiliation wicri:level="1"><nlm:aff id="A5"> Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London WC1N 3BG, United Kingdom</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea> Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, 33 Queen Square, London WC1N 3BG</wicri:regionArea><wicri:noRegion>London WC1N 3BG</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acoustic Stimulation</term><term>Adult</term><term>Aged</term><term>Brain (blood supply)</term><term>Brain (pathology)</term><term>Brain (physiopathology)</term><term>Brain Mapping</term><term>Female</term><term>Functional Laterality</term><term>Hand (physiopathology)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Neuropsychological Tests</term><term>Oxygen (blood)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Photic Stimulation</term><term>Psychomotor Performance (physiology)</term><term>Speech</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Hand</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Acoustic Stimulation</term><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Functional Laterality</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Photic Stimulation</term><term>Speech</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Among the repertoire of motor functions, although hand movement and speech production tasks have been investigated widely by functional neuroimaging, paradigms combining both movements have been studied less so. Such paradigms are of particular interest in Parkinson’s disease (PD) in which patients have specific difficulties performing 2 movements simultaneously. In 9 unmedicated PD patients and fifteen healthy control subjects, externally-cued tasks (hand movement, speech production and combined hand movement and speech production) were performed twice in a random order and fMRI detected cerebral activations compared to rest. F-statistics tested within-group (significant activations at p-values < 0.05, FWE corrected), between-group and between-task comparisons (regional activations significant at p-values < 0.001, uncorrected, with cluster size > 10 voxels). For control subjects the combined task activations comprised the sum of those obtained during hand movement and speech production performed separately, reflecting the neural correlates of performing movements sharing similar programming modalities. In PD patients, only activations underlying HM were observed during the combined task. We interpreted this phenomenon as the patients’ potential inability to recruit facilitatory activations while performing2 movements simultaneously. This lost capacity could be related to a functional prioritization of one movement (hand movement) in comparison with the other (speech production). Our observation could also reflect the inability of PD patients to intrinsically engage the motor coordination necessary to perform a combined task.</p></div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Aix-en-Provence</li></settlement></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Pinto, Serge" sort="Pinto, Serge" uniqKey="Pinto S" first="Serge" last="Pinto">Serge Pinto</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Mancini, Laura" sort="Mancini, Laura" uniqKey="Mancini L" first="Laura" last="Mancini">Laura Mancini</name></noRegion><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name><name sortKey="Mancini, Laura" sort="Mancini, Laura" uniqKey="Mancini L" first="Laura" last="Mancini">Laura Mancini</name><name sortKey="Mancini, Laura" sort="Mancini, Laura" uniqKey="Mancini L" first="Laura" last="Mancini">Laura Mancini</name><name sortKey="Thornton, John S" sort="Thornton, John S" uniqKey="Thornton J" first="John S." last="Thornton">John S. Thornton</name><name sortKey="Thornton, John S" sort="Thornton, John S" uniqKey="Thornton J" first="John S." last="Thornton">John S. Thornton</name><name sortKey="Tripoliti, Elina" sort="Tripoliti, Elina" uniqKey="Tripoliti E" first="Elina" last="Tripoliti">Elina Tripoliti</name><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name><name sortKey="Yousry, Tarek A" sort="Yousry, Tarek A" uniqKey="Yousry T" first="Tarek A." last="Yousry">Tarek A. Yousry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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