Handwriting in patients with Parkinson disease: effect of L-dopa and stimulation of the sub-thalamic nucleus on motor anticipation.
Identifieur interne : 001574 ( Main/Exploration ); précédent : 001573; suivant : 001575Handwriting in patients with Parkinson disease: effect of L-dopa and stimulation of the sub-thalamic nucleus on motor anticipation.
Auteurs : Christel Bidet-Ildei [France] ; Pierre Pollak ; Sonia Kandel ; Valérie Fraix ; Jean-Pierre OrliaguetSource :
- Human movement science [ 1872-7646 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Anticipation, Psychological (drug effects), Anticipation, Psychological (physiology), Antiparkinson Agents (therapeutic use), Attention (drug effects), Attention (physiology), Computer Graphics, Deep Brain Stimulation, Female, Handwriting, Humans, Levodopa (therapeutic use), Male, Middle Aged, Neurologic Examination (drug effects), Parkinson Disease (diagnosis), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Reaction Time (drug effects), Reaction Time (physiology), Reference Values, Subthalamic Nucleus (physiology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- diagnosis : Parkinson Disease.
- drug effects : Anticipation, Psychological, Attention, Neurologic Examination, Psychomotor Performance, Reaction Time.
- drug therapy : Parkinson Disease.
- physiology : Anticipation, Psychological, Attention, Psychomotor Performance, Reaction Time, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- Adult, Computer Graphics, Deep Brain Stimulation, Female, Handwriting, Humans, Male, Middle Aged, Reference Values.
Abstract
The present research focused on how patients with Parkinson's disease (PD) produce handwriting sequences. PD patients who were on/off medication or deep brain stimulation treatments had to write lll and lln trigrams. We evaluated their ability to anticipate on-line the last letter in the trigram. The results revealed that in PD patients, contrary to healthy participants, the percentage of time taken by the down-stroke of the second l did not vary as a function of the spatial constraints of the following letter (l or n). In other words, the handwriting of the PD patients did not exhibit any sign of motor anticipation. However, under treatment, PD patients exhibited similar results to healthy participants despite no improvement in movement variability. Taken together these results do not seem consistent with the hypothesis that PD patients do not anticipate future movements because of their movement variability. They are more in agreement with theories that postulate that PD patients have a general deficit in the parallel processing of the components of a motor sequence.
DOI: 10.1016/j.humov.2010.08.008
PubMed: 21339012
Affiliations:
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Grenoble Cedex 9, France. christel.bidet@univ-poitiers.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Psychologie et NeuroCognition, CNRS UMR 5105, BP47, 38040 Grenoble Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></author><author><name sortKey="Kandel, Sonia" sort="Kandel, Sonia" uniqKey="Kandel S" first="Sonia" last="Kandel">Sonia Kandel</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Orliaguet, Jean Pierre" sort="Orliaguet, Jean Pierre" uniqKey="Orliaguet J" first="Jean-Pierre" last="Orliaguet">Jean-Pierre Orliaguet</name></author></analytic><series><title level="j">Human movement science</title><idno type="eISSN">1872-7646</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anticipation, Psychological (drug effects)</term><term>Anticipation, Psychological (physiology)</term><term>Antiparkinson Agents (therapeutic use)</term><term>Attention (drug effects)</term><term>Attention (physiology)</term><term>Computer Graphics</term><term>Deep Brain Stimulation</term><term>Female</term><term>Handwriting</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination (drug effects)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (drug effects)</term><term>Psychomotor Performance (physiology)</term><term>Reaction Time (drug effects)</term><term>Reaction Time (physiology)</term><term>Reference Values</term><term>Subthalamic Nucleus (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Anticipation, Psychological</term><term>Attention</term><term>Neurologic Examination</term><term>Psychomotor Performance</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Anticipation, Psychological</term><term>Attention</term><term>Psychomotor Performance</term><term>Reaction Time</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Computer Graphics</term><term>Deep Brain Stimulation</term><term>Female</term><term>Handwriting</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present research focused on how patients with Parkinson's disease (PD) produce handwriting sequences. PD patients who were on/off medication or deep brain stimulation treatments had to write lll and lln trigrams. We evaluated their ability to anticipate on-line the last letter in the trigram. The results revealed that in PD patients, contrary to healthy participants, the percentage of time taken by the down-stroke of the second l did not vary as a function of the spatial constraints of the following letter (l or n). In other words, the handwriting of the PD patients did not exhibit any sign of motor anticipation. However, under treatment, PD patients exhibited similar results to healthy participants despite no improvement in movement variability. Taken together these results do not seem consistent with the hypothesis that PD patients do not anticipate future movements because of their movement variability. They are more in agreement with theories that postulate that PD patients have a general deficit in the parallel processing of the components of a motor sequence.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement></list><tree><noCountry><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name><name sortKey="Kandel, Sonia" sort="Kandel, Sonia" uniqKey="Kandel S" first="Sonia" last="Kandel">Sonia Kandel</name><name sortKey="Orliaguet, Jean Pierre" sort="Orliaguet, Jean Pierre" uniqKey="Orliaguet J" first="Jean-Pierre" last="Orliaguet">Jean-Pierre Orliaguet</name><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Bidet Ildei, Christel" sort="Bidet Ildei, Christel" uniqKey="Bidet Ildei C" first="Christel" last="Bidet-Ildei">Christel Bidet-Ildei</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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