Identification of Protein Interfaces between α-Synuclein, the Principal Component of Lewy Bodies in Parkinson Disease, and the Molecular Chaperones Human Hsc70 and the Yeast Ssa1p*

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Identification of Protein Interfaces between α-Synuclein, the Principal Component of Lewy Bodies in Parkinson Disease, and the Molecular Chaperones Human Hsc70 and the Yeast Ssa1p*

Auteurs : Virginie Redeker ; Samantha Pemberton ; Willy Bienvenut [France] ; Luc Bousset ; Ronald Melki

Source :

• The Journal of Biological Chemistry [ 0021-9258 ] ; 2012.

RBID : PMC:3463349

English descriptors

• KwdEn :
  • Adenosine Triphosphatases (chemistry), Adenosine Triphosphatases (genetics), Adenosine Triphosphatases (metabolism), HSC70 Heat-Shock Proteins (chemistry), HSC70 Heat-Shock Proteins (genetics), HSC70 Heat-Shock Proteins (metabolism), HSP70 Heat-Shock Proteins (chemistry), HSP70 Heat-Shock Proteins (genetics), HSP70 Heat-Shock Proteins (metabolism), Humans, Lewy Bodies (chemistry), Lewy Bodies (genetics), Lewy Bodies (metabolism), Parkinson Disease (drug therapy), Parkinson Disease (genetics), Parkinson Disease (metabolism), Peptides (chemistry), Peptides (genetics), Peptides (metabolism), Peptides (therapeutic use), Protein Binding, Protein Engineering (methods), Protein Structure, Tertiary, Saccharomyces cerevisiae (chemistry), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (chemistry), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Solubility, alpha-Synuclein (chemistry), alpha-Synuclein (genetics), alpha-Synuclein (metabolism).
• MESH :
  • chemical , chemistry : Adenosine Triphosphatases, HSC70 Heat-Shock Proteins, HSP70 Heat-Shock Proteins, Peptides, Saccharomyces cerevisiae Proteins, alpha-Synuclein.
  • chemical , genetics : Adenosine Triphosphatases, HSC70 Heat-Shock Proteins, HSP70 Heat-Shock Proteins, Peptides, Saccharomyces cerevisiae Proteins, alpha-Synuclein.
  • chemical , metabolism : Adenosine Triphosphatases, HSC70 Heat-Shock Proteins, HSP70 Heat-Shock Proteins, Peptides, Saccharomyces cerevisiae Proteins, alpha-Synuclein.
  • chemistry : Lewy Bodies, Saccharomyces cerevisiae.
  • drug therapy : Parkinson Disease.
  • genetics : Lewy Bodies, Parkinson Disease, Saccharomyces cerevisiae.
  • metabolism : Lewy Bodies, Parkinson Disease, Saccharomyces cerevisiae.
  • methods : Protein Engineering.
  • chemical , therapeutic use : Peptides.
  • Humans, Protein Binding, Protein Structure, Tertiary, Solubility.

Abstract

Url:

• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3463349
• https://hal.archives-ouvertes.fr/hal-01183065

DOI: 10.1074/jbc.M112.387530
PubMed: 22843682
PubMed Central: 3463349

Affiliations:

• France
• Île-de-France
• Gif-sur-Yvette

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