The enhanced oral response to the 5-HT2 agonist Ro 60-0175 in parkinsonian rats involves the entopeduncular nucleus: electrophysiological correlates
Identifieur interne : 000F46 ( Main/Exploration ); précédent : 000F45; suivant : 000F47The enhanced oral response to the 5-HT2 agonist Ro 60-0175 in parkinsonian rats involves the entopeduncular nucleus: electrophysiological correlates
Auteurs : M. Lagière [France] ; S. Navailles [France] ; L. Mignon [États-Unis] ; A. Roumegous [France] ; M.-F. Chesselet [États-Unis] ; P. De Deurwaerdère [France]Source :
- Experimental brain research [ 0014-4819 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Administration, Oral, Agonist, Animal, Animals, Basal Ganglia (drug effects), Basal Ganglia (metabolism), Basal ganglion, Corpus Striatum (drug effects), Corpus Striatum (metabolism), Disease Models, Animal, Electrophysiological Phenomena (physiology), Electrophysiology, Entopeduncular Nucleus (drug effects), Entopeduncular Nucleus (metabolism), Ethylamines (administration & dosage), Ethylamines (pharmacology), Globus Pallidus (drug effects), Globus Pallidus (metabolism), Indoles (administration & dosage), Indoles (pharmacology), Male, Neurons (drug effects), Oxidopamine, Parkinson Disease (drug therapy), Parkinson Disease (metabolism), Parkinson disease, Rat, Rats, Rats, Sprague-Dawley, Serotonin, Serotonin (metabolism), Serotonin 5-HT2 Receptor Agonists (administration & dosage), Serotonin 5-HT2 Receptor Agonists (pharmacology), Substantia Nigra (drug effects), Substantia Nigra (metabolism).
- MESH :
- chemical , administration & dosage : Ethylamines, Indoles, Serotonin 5-HT2 Receptor Agonists.
- drug effects : Basal Ganglia, Corpus Striatum, Entopeduncular Nucleus, Globus Pallidus, Neurons, Substantia Nigra.
- drug therapy : Parkinson Disease.
- metabolism : Basal Ganglia, Corpus Striatum, Entopeduncular Nucleus, Globus Pallidus, Parkinson Disease, Serotonin, Substantia Nigra.
- chemical , pharmacology : Ethylamines, Indoles, Serotonin 5-HT2 Receptor Agonists.
- physiology : Electrophysiological Phenomena.
- Administration, Oral, Animals, Disease Models, Animal, Male, Rats, Rats, Sprague-Dawley.
Abstract
Lesions of nigrostriatal dopaminergic neurons as seen in Parkinson's disease (PD) increase orofacial responses to serotonergic (5-HT) agonists in rodents. Although this response to 5-HT agonists has been related to aberrant signalling in the basal ganglia, a group a subcortical structures involved in the control of motor behaviours, it deserves additional studies with respect to the specific loci involved. Using measurements of orofacial activity, as well as single-cell recordings in vivo, we have studied the role of the entopeduncular nucleus (EPN; equivalent to the internal globus pallidus of primates), an output structure of basal ganglia, in the hypersensitized responses to a 5-HT agonist in sham- or unilaterally dopamine-depleted rats. Intra-EPN injections of Ro 60-0175 (0.3 and 1 μg/100 nl) promoted robust oral movements in 6-OHDA rats without affecting oral activity in sham-depleted rats. Peripheral administration of Ro 60-0175 (3 mg/kg ip) decreased EPN neuronal firing rate in 6-OHDA rats compared to sham-depleted rats. Such an effect was also observed when the agonist (0.2 μg/20 nl) was locally applied onto EPN neurons. These data demonstrate the contribution of EPN to hypersensitized responses to 5-HT agonists in a rat model of PD.
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Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Lesions of nigrostriatal dopaminergic neurons as seen in Parkinson's disease (PD) increase orofacial responses to serotonergic (5-HT) agonists in rodents. Although this response to 5-HT agonists has been related to aberrant signalling in the basal ganglia, a group a subcortical structures involved in the control of motor behaviours, it deserves additional studies with respect to the specific loci involved. Using measurements of orofacial activity, as well as single-cell recordings in vivo, we have studied the role of the entopeduncular nucleus (EPN; equivalent to the internal globus pallidus of primates), an output structure of basal ganglia, in the hypersensitized responses to a 5-HT agonist in sham- or unilaterally dopamine-depleted rats. Intra-EPN injections of Ro 60-0175 (0.3 and 1 μg/100 nl) promoted robust oral movements in 6-OHDA rats without affecting oral activity in sham-depleted rats. Peripheral administration of Ro 60-0175 (3 mg/kg ip) decreased EPN neuronal firing rate in 6-OHDA rats compared to sham-depleted rats. Such an effect was also observed when the agonist (0.2 μg/20 nl) was locally applied onto EPN neurons. These data demonstrate the contribution of EPN to hypersensitized responses to 5-HT agonists in a rat model of PD.</div>
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