Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.
Identifieur interne : 000931 ( Main/Exploration ); précédent : 000930; suivant : 000932Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.
Auteurs : Stéphane Palfi [France] ; Jean Marc Gurruchaga [France] ; G Scott Ralph [Royaume-Uni] ; Helene Lepetit [France] ; Sonia Lavisse [France] ; Philip C. Buttery [Royaume-Uni] ; Colin Watts [Royaume-Uni] ; James Miskin [Royaume-Uni] ; Michelle Kelleher [Royaume-Uni] ; Sarah Deeley [Royaume-Uni] ; Hirokazu Iwamuro [France] ; Jean Pascal Lefaucheur [France] ; Claire Thiriez [France] ; Gilles Fenelon [France] ; Cherry Lucas [Royaume-Uni] ; Pierre Brugières [France] ; Inanna Gabriel [France] ; Kou Abhay [France] ; Xavier Drouot [France] ; Naoki Tani [France] ; Aurelie Kas [France] ; Bijan Ghaleh [France] ; Philippe Le Corvoisier [France] ; Patrice Dolphin [France] ; David P. Breen [Royaume-Uni] ; Sarah Mason [Royaume-Uni] ; Natalie Valle Guzman [Royaume-Uni] ; Nicholas D. Mazarakis [Royaume-Uni] ; Pippa A. Radcliffe [Royaume-Uni] ; Richard Harrop [Royaume-Uni] ; Susan M. Kingsman [Royaume-Uni] ; Olivier Rascol [France] ; Stuart Naylor [Royaume-Uni] ; Roger A. Barker [Royaume-Uni] ; Philippe Hantraye [France] ; Philippe Remy [France] ; Pierre Cesaro [France] ; Kyriacos A. Mitrophanous [Royaume-Uni]Source :
- Lancet (London, England) [ 1474-547X ] ; 2014.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (adverse effects), Dopa Decarboxylase (genetics), Dopamine (biosynthesis), Dopaminergic Neurons (metabolism), Dopaminergic Neurons (virology), Follow-Up Studies, GTP Cyclohydrolase (administration & dosage), GTP Cyclohydrolase (adverse effects), GTP Cyclohydrolase (genetics), Genetic Therapy (adverse effects), Genetic Therapy (methods), Genetic Vectors (administration & dosage), Genetic Vectors (adverse effects), Humans, Infectious Anemia Virus, Equine (genetics), Injections, Intralesional, Male, Middle Aged, Parkinson Disease (therapy), Putamen, Transfection (methods), Transgenes (genetics), Tyrosine 3-Monooxygenase (administration & dosage), Tyrosine 3-Monooxygenase (adverse effects), Tyrosine 3-Monooxygenase (genetics).
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, GTP Cyclohydrolase, Tyrosine 3-Monooxygenase.
- chemical , adverse effects : Antiparkinson Agents, GTP Cyclohydrolase, Tyrosine 3-Monooxygenase.
- chemical , biosynthesis : Dopamine.
- chemical , genetics : Dopa Decarboxylase, GTP Cyclohydrolase, Tyrosine 3-Monooxygenase.
- administration & dosage : Genetic Vectors.
- adverse effects : Genetic Therapy, Genetic Vectors.
- genetics : Infectious Anemia Virus, Equine, Transgenes.
- metabolism : Dopaminergic Neurons.
- methods : Genetic Therapy, Transfection.
- therapy : Parkinson Disease.
- virology : Dopaminergic Neurons.
- Aged, Follow-Up Studies, Humans, Injections, Intralesional, Male, Middle Aged, Putamen.
Abstract
Parkinson's disease is typically treated with oral dopamine replacement therapies; however, long-term treatment leads to motor complications and, occasionally, impulse control disorders caused by intermittent stimulation of dopamine receptors and off-target effects, respectively. We aimed to assess the safety, tolerability, and efficacy of bilateral, intrastriatal delivery of ProSavin, a lentiviral vector-based gene therapy aimed at restoring local and continuous dopamine production in patients with advanced Parkinson's disease.
DOI: 10.1016/S0140-6736(13)61939-X
PubMed: 24412048
Affiliations:
- France, Royaume-Uni
- Angleterre, Grand Londres, Midi-Pyrénées, Occitanie (région administrative), Oxfordshire, Île-de-France
- Créteil, Londres, Oxford, Toulouse
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000591
- to stream PubMed, to step Curation: 000571
- to stream PubMed, to step Checkpoint: 000571
- to stream Ncbi, to step Merge: 001305
- to stream Ncbi, to step Curation: 001305
- to stream Ncbi, to step Checkpoint: 001305
- to stream Main, to step Merge: 000941
- to stream Main, to step Curation: 000931
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.</title><author><name sortKey="Palfi, Stephane" sort="Palfi, Stephane" uniqKey="Palfi S" first="Stéphane" last="Palfi">Stéphane Palfi</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France. Electronic address: stephane.palfi@hmn.aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Gurruchaga, Jean Marc" sort="Gurruchaga, Jean Marc" uniqKey="Gurruchaga J" first="Jean Marc" last="Gurruchaga">Jean Marc Gurruchaga</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Ralph, G Scott" sort="Ralph, G Scott" uniqKey="Ralph G" first="G Scott" last="Ralph">G Scott Ralph</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Lepetit, Helene" sort="Lepetit, Helene" uniqKey="Lepetit H" first="Helene" last="Lepetit">Helene Lepetit</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Lavisse, Sonia" sort="Lavisse, Sonia" uniqKey="Lavisse S" first="Sonia" last="Lavisse">Sonia Lavisse</name><affiliation wicri:level="1"><nlm:affiliation>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Buttery, Philip C" sort="Buttery, Philip C" uniqKey="Buttery P" first="Philip C" last="Buttery">Philip C. Buttery</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Watts, Colin" sort="Watts, Colin" uniqKey="Watts C" first="Colin" last="Watts">Colin Watts</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Miskin, James" sort="Miskin, James" uniqKey="Miskin J" first="James" last="Miskin">James Miskin</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kelleher, Michelle" sort="Kelleher, Michelle" uniqKey="Kelleher M" first="Michelle" last="Kelleher">Michelle Kelleher</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Deeley, Sarah" sort="Deeley, Sarah" uniqKey="Deeley S" first="Sarah" last="Deeley">Sarah Deeley</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Iwamuro, Hirokazu" sort="Iwamuro, Hirokazu" uniqKey="Iwamuro H" first="Hirokazu" last="Iwamuro">Hirokazu Iwamuro</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Lefaucheur, Jean Pascal" sort="Lefaucheur, Jean Pascal" uniqKey="Lefaucheur J" first="Jean Pascal" last="Lefaucheur">Jean Pascal Lefaucheur</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Thiriez, Claire" sort="Thiriez, Claire" uniqKey="Thiriez C" first="Claire" last="Thiriez">Claire Thiriez</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Fenelon, Gilles" sort="Fenelon, Gilles" uniqKey="Fenelon G" first="Gilles" last="Fenelon">Gilles Fenelon</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; INSERM U955, E01, Institut de Recherche Biomédicale, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; INSERM U955, E01, Institut de Recherche Biomédicale, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Lucas, Cherry" sort="Lucas, Cherry" uniqKey="Lucas C" first="Cherry" last="Lucas">Cherry Lucas</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Brugieres, Pierre" sort="Brugieres, Pierre" uniqKey="Brugieres P" first="Pierre" last="Brugières">Pierre Brugières</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Gabriel, Inanna" sort="Gabriel, Inanna" uniqKey="Gabriel I" first="Inanna" last="Gabriel">Inanna Gabriel</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Abhay, Kou" sort="Abhay, Kou" uniqKey="Abhay K" first="Kou" last="Abhay">Kou Abhay</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Drouot, Xavier" sort="Drouot, Xavier" uniqKey="Drouot X" first="Xavier" last="Drouot">Xavier Drouot</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Tani, Naoki" sort="Tani, Naoki" uniqKey="Tani N" first="Naoki" last="Tani">Naoki Tani</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Kas, Aurelie" sort="Kas, Aurelie" uniqKey="Kas A" first="Aurelie" last="Kas">Aurelie Kas</name><affiliation wicri:level="1"><nlm:affiliation>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Ghaleh, Bijan" sort="Ghaleh, Bijan" uniqKey="Ghaleh B" first="Bijan" last="Ghaleh">Bijan Ghaleh</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Le Corvoisier, Philippe" sort="Le Corvoisier, Philippe" uniqKey="Le Corvoisier P" first="Philippe" last="Le Corvoisier">Philippe Le Corvoisier</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Dolphin, Patrice" sort="Dolphin, Patrice" uniqKey="Dolphin P" first="Patrice" last="Dolphin">Patrice Dolphin</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Breen, David P" sort="Breen, David P" uniqKey="Breen D" first="David P" last="Breen">David P. Breen</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Mason, Sarah" sort="Mason, Sarah" uniqKey="Mason S" first="Sarah" last="Mason">Sarah Mason</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Guzman, Natalie Valle" sort="Guzman, Natalie Valle" uniqKey="Guzman N" first="Natalie Valle" last="Guzman">Natalie Valle Guzman</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Mazarakis, Nicholas D" sort="Mazarakis, Nicholas D" uniqKey="Mazarakis N" first="Nicholas D" last="Mazarakis">Nicholas D. Mazarakis</name><affiliation wicri:level="3"><nlm:affiliation>Gene Therapy, Centre of Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Faculty of Medicine, Hammersmith Hospital Campus, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Gene Therapy, Centre of Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Faculty of Medicine, Hammersmith Hospital Campus, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Radcliffe, Pippa A" sort="Radcliffe, Pippa A" uniqKey="Radcliffe P" first="Pippa A" last="Radcliffe">Pippa A. Radcliffe</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Harrop, Richard" sort="Harrop, Richard" uniqKey="Harrop R" first="Richard" last="Harrop">Richard Harrop</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kingsman, Susan M" sort="Kingsman, Susan M" uniqKey="Kingsman S" first="Susan M" last="Kingsman">Susan M. Kingsman</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="3"><nlm:affiliation>CIC9302 and UMR 825, INSERM and Department of Pharmacology and Neurosciences, University Hospital and University of Toulouse III, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIC9302 and UMR 825, INSERM and Department of Pharmacology and Neurosciences, University Hospital and University of Toulouse III, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Naylor, Stuart" sort="Naylor, Stuart" uniqKey="Naylor S" first="Stuart" last="Naylor">Stuart Naylor</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A" last="Barker">Roger A. Barker</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name><affiliation wicri:level="1"><nlm:affiliation>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Cesaro">Pierre Cesaro</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; INSERM U955, E01, Institut de Recherche Biomédicale, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; INSERM U955, E01, Institut de Recherche Biomédicale, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Mitrophanous, Kyriacos A" sort="Mitrophanous, Kyriacos A" uniqKey="Mitrophanous K" first="Kyriacos A" last="Mitrophanous">Kyriacos A. Mitrophanous</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24412048</idno><idno type="pmid">24412048</idno><idno type="doi">10.1016/S0140-6736(13)61939-X</idno><idno type="wicri:Area/PubMed/Corpus">000591</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000591</idno><idno type="wicri:Area/PubMed/Curation">000571</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000571</idno><idno type="wicri:Area/PubMed/Checkpoint">000571</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000571</idno><idno type="wicri:Area/Ncbi/Merge">001305</idno><idno type="wicri:Area/Ncbi/Curation">001305</idno><idno type="wicri:Area/Ncbi/Checkpoint">001305</idno><idno type="wicri:Area/Main/Merge">000941</idno><idno type="wicri:Area/Main/Curation">000931</idno><idno type="wicri:Area/Main/Exploration">000931</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.</title><author><name sortKey="Palfi, Stephane" sort="Palfi, Stephane" uniqKey="Palfi S" first="Stéphane" last="Palfi">Stéphane Palfi</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France. Electronic address: stephane.palfi@hmn.aphp.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Gurruchaga, Jean Marc" sort="Gurruchaga, Jean Marc" uniqKey="Gurruchaga J" first="Jean Marc" last="Gurruchaga">Jean Marc Gurruchaga</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Ralph, G Scott" sort="Ralph, G Scott" uniqKey="Ralph G" first="G Scott" last="Ralph">G Scott Ralph</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Lepetit, Helene" sort="Lepetit, Helene" uniqKey="Lepetit H" first="Helene" last="Lepetit">Helene Lepetit</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Lavisse, Sonia" sort="Lavisse, Sonia" uniqKey="Lavisse S" first="Sonia" last="Lavisse">Sonia Lavisse</name><affiliation wicri:level="1"><nlm:affiliation>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Buttery, Philip C" sort="Buttery, Philip C" uniqKey="Buttery P" first="Philip C" last="Buttery">Philip C. Buttery</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Watts, Colin" sort="Watts, Colin" uniqKey="Watts C" first="Colin" last="Watts">Colin Watts</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Miskin, James" sort="Miskin, James" uniqKey="Miskin J" first="James" last="Miskin">James Miskin</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kelleher, Michelle" sort="Kelleher, Michelle" uniqKey="Kelleher M" first="Michelle" last="Kelleher">Michelle Kelleher</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Deeley, Sarah" sort="Deeley, Sarah" uniqKey="Deeley S" first="Sarah" last="Deeley">Sarah Deeley</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Iwamuro, Hirokazu" sort="Iwamuro, Hirokazu" uniqKey="Iwamuro H" first="Hirokazu" last="Iwamuro">Hirokazu Iwamuro</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Lefaucheur, Jean Pascal" sort="Lefaucheur, Jean Pascal" uniqKey="Lefaucheur J" first="Jean Pascal" last="Lefaucheur">Jean Pascal Lefaucheur</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Thiriez, Claire" sort="Thiriez, Claire" uniqKey="Thiriez C" first="Claire" last="Thiriez">Claire Thiriez</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Fenelon, Gilles" sort="Fenelon, Gilles" uniqKey="Fenelon G" first="Gilles" last="Fenelon">Gilles Fenelon</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; INSERM U955, E01, Institut de Recherche Biomédicale, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; INSERM U955, E01, Institut de Recherche Biomédicale, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Lucas, Cherry" sort="Lucas, Cherry" uniqKey="Lucas C" first="Cherry" last="Lucas">Cherry Lucas</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Brugieres, Pierre" sort="Brugieres, Pierre" uniqKey="Brugieres P" first="Pierre" last="Brugières">Pierre Brugières</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Gabriel, Inanna" sort="Gabriel, Inanna" uniqKey="Gabriel I" first="Inanna" last="Gabriel">Inanna Gabriel</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Abhay, Kou" sort="Abhay, Kou" uniqKey="Abhay K" first="Kou" last="Abhay">Kou Abhay</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Drouot, Xavier" sort="Drouot, Xavier" uniqKey="Drouot X" first="Xavier" last="Drouot">Xavier Drouot</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Tani, Naoki" sort="Tani, Naoki" uniqKey="Tani N" first="Naoki" last="Tani">Naoki Tani</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Kas, Aurelie" sort="Kas, Aurelie" uniqKey="Kas A" first="Aurelie" last="Kas">Aurelie Kas</name><affiliation wicri:level="1"><nlm:affiliation>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Ghaleh, Bijan" sort="Ghaleh, Bijan" uniqKey="Ghaleh B" first="Bijan" last="Ghaleh">Bijan Ghaleh</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Le Corvoisier, Philippe" sort="Le Corvoisier, Philippe" uniqKey="Le Corvoisier P" first="Philippe" last="Le Corvoisier">Philippe Le Corvoisier</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Dolphin, Patrice" sort="Dolphin, Patrice" uniqKey="Dolphin P" first="Patrice" last="Dolphin">Patrice Dolphin</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Breen, David P" sort="Breen, David P" uniqKey="Breen D" first="David P" last="Breen">David P. Breen</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Mason, Sarah" sort="Mason, Sarah" uniqKey="Mason S" first="Sarah" last="Mason">Sarah Mason</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Guzman, Natalie Valle" sort="Guzman, Natalie Valle" uniqKey="Guzman N" first="Natalie Valle" last="Guzman">Natalie Valle Guzman</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Mazarakis, Nicholas D" sort="Mazarakis, Nicholas D" uniqKey="Mazarakis N" first="Nicholas D" last="Mazarakis">Nicholas D. Mazarakis</name><affiliation wicri:level="3"><nlm:affiliation>Gene Therapy, Centre of Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Faculty of Medicine, Hammersmith Hospital Campus, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Gene Therapy, Centre of Neuroinflammation and Neurodegeneration, Division of Brain Sciences, Faculty of Medicine, Hammersmith Hospital Campus, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Radcliffe, Pippa A" sort="Radcliffe, Pippa A" uniqKey="Radcliffe P" first="Pippa A" last="Radcliffe">Pippa A. Radcliffe</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Harrop, Richard" sort="Harrop, Richard" uniqKey="Harrop R" first="Richard" last="Harrop">Richard Harrop</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Kingsman, Susan M" sort="Kingsman, Susan M" uniqKey="Kingsman S" first="Susan M" last="Kingsman">Susan M. Kingsman</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><affiliation wicri:level="3"><nlm:affiliation>CIC9302 and UMR 825, INSERM and Department of Pharmacology and Neurosciences, University Hospital and University of Toulouse III, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CIC9302 and UMR 825, INSERM and Department of Pharmacology and Neurosciences, University Hospital and University of Toulouse III, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Naylor, Stuart" sort="Naylor, Stuart" uniqKey="Naylor S" first="Stuart" last="Naylor">Stuart Naylor</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A" last="Barker">Roger A. Barker</name><affiliation wicri:level="1"><nlm:affiliation>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>John van Geest Centre for Brain Repair and Addenbrooke's Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name><affiliation wicri:level="1"><nlm:affiliation>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; CEA, DSV I(2)BM, MIRCen and CNRS URA2210, Fontenay-aux-Roses</wicri:regionArea><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion><wicri:noRegion>Fontenay-aux-Roses</wicri:noRegion></affiliation></author><author><name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Cesaro">Pierre Cesaro</name><affiliation wicri:level="3"><nlm:affiliation>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; INSERM U955, E01, Institut de Recherche Biomédicale, Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Groupe Hospitalier Henri-Mondor, DHU PePsy, UF Neurochirurgie Fonctionnelle, Neurologie, Neurophysiologie, Anesthésie, Centre d'Investigation Clinique 006, Plateforme de Ressources Biologiques, Créteil, France; Université Paris 12, Faculté de Médecine, Créteil, France; INSERM U955, E01, Institut de Recherche Biomédicale, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Mitrophanous, Kyriacos A" sort="Mitrophanous, Kyriacos A" uniqKey="Mitrophanous K" first="Kyriacos A" last="Mitrophanous">Kyriacos A. Mitrophanous</name><affiliation wicri:level="3"><nlm:affiliation>Oxford BioMedica, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford BioMedica, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (administration & dosage)</term><term>Antiparkinson Agents (adverse effects)</term><term>Dopa Decarboxylase (genetics)</term><term>Dopamine (biosynthesis)</term><term>Dopaminergic Neurons (metabolism)</term><term>Dopaminergic Neurons (virology)</term><term>Follow-Up Studies</term><term>GTP Cyclohydrolase (administration & dosage)</term><term>GTP Cyclohydrolase (adverse effects)</term><term>GTP Cyclohydrolase (genetics)</term><term>Genetic Therapy (adverse effects)</term><term>Genetic Therapy (methods)</term><term>Genetic Vectors (administration & dosage)</term><term>Genetic Vectors (adverse effects)</term><term>Humans</term><term>Infectious Anemia Virus, Equine (genetics)</term><term>Injections, Intralesional</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (therapy)</term><term>Putamen</term><term>Transfection (methods)</term><term>Transgenes (genetics)</term><term>Tyrosine 3-Monooxygenase (administration & dosage)</term><term>Tyrosine 3-Monooxygenase (adverse effects)</term><term>Tyrosine 3-Monooxygenase (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiparkinson Agents</term><term>GTP Cyclohydrolase</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>GTP Cyclohydrolase</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Dopa Decarboxylase</term><term>GTP Cyclohydrolase</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Genetic Vectors</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Genetic Therapy</term><term>Genetic Vectors</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Infectious Anemia Virus, Equine</term><term>Transgenes</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dopaminergic Neurons</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genetic Therapy</term><term>Transfection</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Dopaminergic Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Follow-Up Studies</term><term>Humans</term><term>Injections, Intralesional</term><term>Male</term><term>Middle Aged</term><term>Putamen</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Parkinson's disease is typically treated with oral dopamine replacement therapies; however, long-term treatment leads to motor complications and, occasionally, impulse control disorders caused by intermittent stimulation of dopamine receptors and off-target effects, respectively. We aimed to assess the safety, tolerability, and efficacy of bilateral, intrastriatal delivery of ProSavin, a lentiviral vector-based gene therapy aimed at restoring local and continuous dopamine production in patients with advanced Parkinson's disease.</div></front></TEI><affiliations><list><country><li>France</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li><li>Oxfordshire</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Londres</li><li>Oxford</li><li>Toulouse</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Palfi, Stephane" sort="Palfi, Stephane" uniqKey="Palfi S" first="Stéphane" last="Palfi">Stéphane Palfi</name></region><name sortKey="Abhay, Kou" sort="Abhay, Kou" uniqKey="Abhay K" first="Kou" last="Abhay">Kou Abhay</name><name sortKey="Brugieres, Pierre" sort="Brugieres, Pierre" uniqKey="Brugieres P" first="Pierre" last="Brugières">Pierre Brugières</name><name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Cesaro">Pierre Cesaro</name><name sortKey="Dolphin, Patrice" sort="Dolphin, Patrice" uniqKey="Dolphin P" first="Patrice" last="Dolphin">Patrice Dolphin</name><name sortKey="Drouot, Xavier" sort="Drouot, Xavier" uniqKey="Drouot X" first="Xavier" last="Drouot">Xavier Drouot</name><name sortKey="Fenelon, Gilles" sort="Fenelon, Gilles" uniqKey="Fenelon G" first="Gilles" last="Fenelon">Gilles Fenelon</name><name sortKey="Gabriel, Inanna" sort="Gabriel, Inanna" uniqKey="Gabriel I" first="Inanna" last="Gabriel">Inanna Gabriel</name><name sortKey="Ghaleh, Bijan" sort="Ghaleh, Bijan" uniqKey="Ghaleh B" first="Bijan" last="Ghaleh">Bijan Ghaleh</name><name sortKey="Gurruchaga, Jean Marc" sort="Gurruchaga, Jean Marc" uniqKey="Gurruchaga J" first="Jean Marc" last="Gurruchaga">Jean Marc Gurruchaga</name><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name><name sortKey="Iwamuro, Hirokazu" sort="Iwamuro, Hirokazu" uniqKey="Iwamuro H" first="Hirokazu" last="Iwamuro">Hirokazu Iwamuro</name><name sortKey="Kas, Aurelie" sort="Kas, Aurelie" uniqKey="Kas A" first="Aurelie" last="Kas">Aurelie Kas</name><name sortKey="Lavisse, Sonia" sort="Lavisse, Sonia" uniqKey="Lavisse S" first="Sonia" last="Lavisse">Sonia Lavisse</name><name sortKey="Le Corvoisier, Philippe" sort="Le Corvoisier, Philippe" uniqKey="Le Corvoisier P" first="Philippe" last="Le Corvoisier">Philippe Le Corvoisier</name><name sortKey="Lefaucheur, Jean Pascal" sort="Lefaucheur, Jean Pascal" uniqKey="Lefaucheur J" first="Jean Pascal" last="Lefaucheur">Jean Pascal Lefaucheur</name><name sortKey="Lepetit, Helene" sort="Lepetit, Helene" uniqKey="Lepetit H" first="Helene" last="Lepetit">Helene Lepetit</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name><name sortKey="Tani, Naoki" sort="Tani, Naoki" uniqKey="Tani N" first="Naoki" last="Tani">Naoki Tani</name><name sortKey="Thiriez, Claire" sort="Thiriez, Claire" uniqKey="Thiriez C" first="Claire" last="Thiriez">Claire Thiriez</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ralph, G Scott" sort="Ralph, G Scott" uniqKey="Ralph G" first="G Scott" last="Ralph">G Scott Ralph</name></region><name sortKey="Barker, Roger A" sort="Barker, Roger A" uniqKey="Barker R" first="Roger A" last="Barker">Roger A. Barker</name><name sortKey="Breen, David P" sort="Breen, David P" uniqKey="Breen D" first="David P" last="Breen">David P. Breen</name><name sortKey="Buttery, Philip C" sort="Buttery, Philip C" uniqKey="Buttery P" first="Philip C" last="Buttery">Philip C. Buttery</name><name sortKey="Deeley, Sarah" sort="Deeley, Sarah" uniqKey="Deeley S" first="Sarah" last="Deeley">Sarah Deeley</name><name sortKey="Guzman, Natalie Valle" sort="Guzman, Natalie Valle" uniqKey="Guzman N" first="Natalie Valle" last="Guzman">Natalie Valle Guzman</name><name sortKey="Harrop, Richard" sort="Harrop, Richard" uniqKey="Harrop R" first="Richard" last="Harrop">Richard Harrop</name><name sortKey="Kelleher, Michelle" sort="Kelleher, Michelle" uniqKey="Kelleher M" first="Michelle" last="Kelleher">Michelle Kelleher</name><name sortKey="Kingsman, Susan M" sort="Kingsman, Susan M" uniqKey="Kingsman S" first="Susan M" last="Kingsman">Susan M. Kingsman</name><name sortKey="Lucas, Cherry" sort="Lucas, Cherry" uniqKey="Lucas C" first="Cherry" last="Lucas">Cherry Lucas</name><name sortKey="Mason, Sarah" sort="Mason, Sarah" uniqKey="Mason S" first="Sarah" last="Mason">Sarah Mason</name><name sortKey="Mazarakis, Nicholas D" sort="Mazarakis, Nicholas D" uniqKey="Mazarakis N" first="Nicholas D" last="Mazarakis">Nicholas D. Mazarakis</name><name sortKey="Miskin, James" sort="Miskin, James" uniqKey="Miskin J" first="James" last="Miskin">James Miskin</name><name sortKey="Mitrophanous, Kyriacos A" sort="Mitrophanous, Kyriacos A" uniqKey="Mitrophanous K" first="Kyriacos A" last="Mitrophanous">Kyriacos A. Mitrophanous</name><name sortKey="Naylor, Stuart" sort="Naylor, Stuart" uniqKey="Naylor S" first="Stuart" last="Naylor">Stuart Naylor</name><name sortKey="Radcliffe, Pippa A" sort="Radcliffe, Pippa A" uniqKey="Radcliffe P" first="Pippa A" last="Radcliffe">Pippa A. Radcliffe</name><name sortKey="Watts, Colin" sort="Watts, Colin" uniqKey="Watts C" first="Colin" last="Watts">Colin Watts</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000931 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000931 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:24412048
|texte= Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24412048" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |