A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation.
Identifieur interne : 000723 ( Main/Exploration ); précédent : 000722; suivant : 000724A preoperative metabolic marker of parkinsonian apathy following subthalamic nucleus stimulation.
Auteurs : Aude Gesquière-Dando [France] ; Eric Guedj [France] ; Anderson Loundou [France] ; Romain Carron [France] ; Tatiana Witjas [France] ; Frédérique Fluchère [France] ; Marie Delfini [France] ; Laura Mundler [France] ; Jean Regis [France] ; Jean-Philippe Azulay [France] ; Alexandre Eusebio [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Apathy (physiology), Brain (diagnostic imaging), Brain (drug effects), Brain (metabolism), Deep Brain Stimulation, Female, Fluorodeoxyglucose F18 (pharmacokinetics), Humans, Image Processing, Computer-Assisted, Logistic Models, Male, Middle Aged, Parkinsonian Disorders (diagnostic imaging), Parkinsonian Disorders (metabolism), Parkinsonian Disorders (therapy), Positron-Emission Tomography, Subthalamic Nucleus (physiology), Treatment Outcome.
- MESH :
- chemical , pharmacokinetics : Fluorodeoxyglucose F18.
- diagnostic imaging : Brain, Parkinsonian Disorders.
- drug effects : Brain.
- metabolism : Brain, Parkinsonian Disorders.
- physiology : Apathy, Subthalamic Nucleus.
- therapy : Parkinsonian Disorders.
- Aged, Deep Brain Stimulation, Female, Humans, Image Processing, Computer-Assisted, Logistic Models, Male, Middle Aged, Positron-Emission Tomography, Treatment Outcome.
Abstract
Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) has been associated with the development of postoperative apathy. Debate on the causes of postoperative apathy continues, and the dominant hypothesis is that stimulation or dopaminergic drug reductions are causal in its development. We hypothesized that a preoperative predisposition to apathy also could exist. To this end, we sought to identify a preoperative metabolic pattern using [(18)]Fluorodeoxyglucose Positron Emission Tomography (PET), which could be associated with the occurrence of postoperative apathy after STN-DBS for PD.
DOI: 10.1002/mds.26349
PubMed: 26228098
Affiliations:
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Le document en format XML
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sort="Guedj, Eric" uniqKey="Guedj E" first="Eric" last="Guedj">Eric Guedj</name><affiliation wicri:level="4"><nlm:affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Loundou, Anderson" sort="Loundou, Anderson" uniqKey="Loundou A" first="Anderson" last="Loundou">Anderson Loundou</name><affiliation wicri:level="3"><nlm:affiliation>APHM, CHU Timone, Unité d'Aide méthodologique à la Recherche Clinique et Epidémiologique, DRRC, Marseille, 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sort="Fluchere, Frederique" uniqKey="Fluchere F" first="Frédérique" last="Fluchère">Frédérique Fluchère</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Delfini, Marie" sort="Delfini, Marie" uniqKey="Delfini M" first="Marie" last="Delfini">Marie Delfini</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Mundler, Laura" sort="Mundler, Laura" uniqKey="Mundler L" first="Laura" last="Mundler">Laura Mundler</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region 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d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation 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of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Guedj, Eric" sort="Guedj, Eric" uniqKey="Guedj E" first="Eric" last="Guedj">Eric Guedj</name><affiliation wicri:level="4"><nlm:affiliation>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut de Neurosciences de la Timone UMR 7289, Aix Marseille Université, CNRS, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Loundou, Anderson" sort="Loundou, Anderson" uniqKey="Loundou A" first="Anderson" last="Loundou">Anderson Loundou</name><affiliation wicri:level="3"><nlm:affiliation>APHM, CHU Timone, Unité d'Aide méthodologique à la Recherche Clinique et Epidémiologique, DRRC, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Unité d'Aide méthodologique à la Recherche Clinique et Epidémiologique, DRRC, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Carron, Romain" sort="Carron, Romain" uniqKey="Carron R" first="Romain" last="Carron">Romain Carron</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Fluchere, Frederique" sort="Fluchere, Frederique" uniqKey="Fluchere F" first="Frédérique" last="Fluchère">Frédérique Fluchère</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Delfini, Marie" sort="Delfini, Marie" uniqKey="Delfini M" first="Marie" last="Delfini">Marie Delfini</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Mundler, Laura" sort="Mundler, Laura" uniqKey="Mundler L" first="Laura" last="Mundler">Laura Mundler</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Regis, Jean" sort="Regis, Jean" uniqKey="Regis J" first="Jean" last="Regis">Jean Regis</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Functional and Stereotactic Neurosurgery, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author><author><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><affiliation wicri:level="4"><nlm:affiliation>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>APHM, CHU Timone, Department of Neurology and Movement Disorders, Aix Marseille Université, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName><orgName type="university">Université d'Aix-Marseille</orgName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Apathy (physiology)</term><term>Brain (diagnostic imaging)</term><term>Brain (drug effects)</term><term>Brain (metabolism)</term><term>Deep Brain Stimulation</term><term>Female</term><term>Fluorodeoxyglucose F18 (pharmacokinetics)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Parkinsonian Disorders (diagnostic imaging)</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (therapy)</term><term>Positron-Emission Tomography</term><term>Subthalamic Nucleus (physiology)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apathy</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Positron-Emission Tomography</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) has been associated with the development of postoperative apathy. Debate on the causes of postoperative apathy continues, and the dominant hypothesis is that stimulation or dopaminergic drug reductions are causal in its development. We hypothesized that a preoperative predisposition to apathy also could exist. To this end, we sought to identify a preoperative metabolic pattern using [(18)]Fluorodeoxyglucose Positron Emission Tomography (PET), which could be associated with the occurrence of postoperative apathy after STN-DBS for PD.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Marseille</li></settlement><orgName><li>Université d'Aix-Marseille</li></orgName></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Gesquiere Dando, Aude" sort="Gesquiere Dando, Aude" uniqKey="Gesquiere Dando A" first="Aude" last="Gesquière-Dando">Aude Gesquière-Dando</name></region><name sortKey="Azulay, Jean Philippe" sort="Azulay, Jean Philippe" uniqKey="Azulay J" first="Jean-Philippe" last="Azulay">Jean-Philippe Azulay</name><name sortKey="Carron, Romain" sort="Carron, Romain" uniqKey="Carron R" first="Romain" last="Carron">Romain Carron</name><name sortKey="Delfini, Marie" sort="Delfini, Marie" uniqKey="Delfini M" first="Marie" last="Delfini">Marie Delfini</name><name sortKey="Eusebio, Alexandre" sort="Eusebio, Alexandre" uniqKey="Eusebio A" first="Alexandre" last="Eusebio">Alexandre Eusebio</name><name sortKey="Fluchere, Frederique" sort="Fluchere, Frederique" uniqKey="Fluchere F" first="Frédérique" last="Fluchère">Frédérique Fluchère</name><name sortKey="Guedj, Eric" sort="Guedj, Eric" uniqKey="Guedj E" first="Eric" last="Guedj">Eric Guedj</name><name sortKey="Loundou, Anderson" sort="Loundou, Anderson" uniqKey="Loundou A" first="Anderson" last="Loundou">Anderson Loundou</name><name sortKey="Mundler, Laura" sort="Mundler, Laura" uniqKey="Mundler L" first="Laura" last="Mundler">Laura Mundler</name><name sortKey="Regis, Jean" sort="Regis, Jean" uniqKey="Regis J" first="Jean" last="Regis">Jean Regis</name><name sortKey="Witjas, Tatiana" sort="Witjas, Tatiana" uniqKey="Witjas T" first="Tatiana" last="Witjas">Tatiana Witjas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26228098" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |