Elusive roles for reactive astrocytes in neurodegenerative diseases
Identifieur interne : 000645 ( Main/Exploration ); précédent : 000644; suivant : 000646Elusive roles for reactive astrocytes in neurodegenerative diseases
Auteurs : Lucile Ben Haim [France] ; Maria-Angeles Carrillo-De Sauvage [France] ; Kelly Ceyzériat [France] ; Carole Escartin [France]Source :
- Frontiers in Cellular Neuroscience [ 1662-5102 ] ; 2015.
Abstract
Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory response. They become reactive in response to virtually all pathological situations in the brain such as axotomy, ischemia, infection, and neurodegenerative diseases (ND). Astrocyte reactivity was originally characterized by morphological changes (hypertrophy, remodeling of processes) and the overexpression of the intermediate filament glial fibrillary acidic protein (GFAP). However, it is unclear how the normal supportive functions of astrocytes are altered by their reactive state. In ND, in which neuronal dysfunction and astrocyte reactivity take place over several years or decades, the issue is even more complex and highly debated, with several conflicting reports published recently. In this review, we discuss studies addressing the contribution of reactive astrocytes to ND. We describe the molecular triggers leading to astrocyte reactivity during ND, examine how some key astrocyte functions may be enhanced or altered during the disease process, and discuss how astrocyte reactivity may globally affect ND progression. Finally we will consider the anticipated developments in this important field. With this review, we aim to show that the detailed study of reactive astrocytes may open new perspectives for ND.
Url:
DOI: 10.3389/fncel.2015.00278
PubMed: 26283915
PubMed Central: 4522610
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Astrocytes play crucial roles in the brain and are involved in the neuroinflammatory response. They become reactive in response to virtually all pathological situations in the brain such as axotomy, ischemia, infection, and neurodegenerative diseases (ND). Astrocyte reactivity was originally characterized by morphological changes (hypertrophy, remodeling of processes) and the overexpression of the intermediate filament glial fibrillary acidic protein (GFAP). However, it is unclear how the normal supportive functions of astrocytes are altered by their reactive state. In ND, in which neuronal dysfunction and astrocyte reactivity take place over several years or decades, the issue is even more complex and highly debated, with several conflicting reports published recently. In this review, we discuss studies addressing the contribution of reactive astrocytes to ND. We describe the molecular triggers leading to astrocyte reactivity during ND, examine how some key astrocyte functions may be enhanced or altered during the disease process, and discuss how astrocyte reactivity may globally affect ND progression. Finally we will consider the anticipated developments in this important field. With this review, we aim to show that the detailed study of reactive astrocytes may open new perspectives for ND.</p>
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<author><name sortKey="Zhu, A" uniqKey="Zhu A">A. Zhu</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yan, P" uniqKey="Yan P">P. Yan</name>
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<author><name sortKey="Hu, X" uniqKey="Hu X">X. Hu</name>
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<author><name sortKey="Cirrito, J R" uniqKey="Cirrito J">J. R. Cirrito</name>
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<affiliations><list><country><li>France</li>
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<tree><country name="France"><noRegion><name sortKey="Ben Haim, Lucile" sort="Ben Haim, Lucile" uniqKey="Ben Haim L" first="Lucile" last="Ben Haim">Lucile Ben Haim</name>
</noRegion>
<name sortKey="Ben Haim, Lucile" sort="Ben Haim, Lucile" uniqKey="Ben Haim L" first="Lucile" last="Ben Haim">Lucile Ben Haim</name>
<name sortKey="Carrillo De Sauvage, Maria Angeles" sort="Carrillo De Sauvage, Maria Angeles" uniqKey="Carrillo De Sauvage M" first="Maria-Angeles" last="Carrillo-De Sauvage">Maria-Angeles Carrillo-De Sauvage</name>
<name sortKey="Carrillo De Sauvage, Maria Angeles" sort="Carrillo De Sauvage, Maria Angeles" uniqKey="Carrillo De Sauvage M" first="Maria-Angeles" last="Carrillo-De Sauvage">Maria-Angeles Carrillo-De Sauvage</name>
<name sortKey="Ceyzeriat, Kelly" sort="Ceyzeriat, Kelly" uniqKey="Ceyzeriat K" first="Kelly" last="Ceyzériat">Kelly Ceyzériat</name>
<name sortKey="Ceyzeriat, Kelly" sort="Ceyzeriat, Kelly" uniqKey="Ceyzeriat K" first="Kelly" last="Ceyzériat">Kelly Ceyzériat</name>
<name sortKey="Escartin, Carole" sort="Escartin, Carole" uniqKey="Escartin C" first="Carole" last="Escartin">Carole Escartin</name>
<name sortKey="Escartin, Carole" sort="Escartin, Carole" uniqKey="Escartin C" first="Carole" last="Escartin">Carole Escartin</name>
</country>
</tree>
</affiliations>
</record>
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