Abnormal Development of Glutamatergic Synapses Afferent to Dopaminergic Neurons of the Pink1−/− Mouse Model of Parkinson’s Disease
Identifieur interne : 000366 ( Main/Exploration ); précédent : 000365; suivant : 000367Abnormal Development of Glutamatergic Synapses Afferent to Dopaminergic Neurons of the Pink1−/− Mouse Model of Parkinson’s Disease
Auteurs : Edouard Pearlstein [France] ; François J. Michel [France] ; Laurène Save [France] ; Diana C. Ferrari [France] ; Constance Hammond [France]Source :
- Frontiers in Cellular Neuroscience [ 1662-5102 ] ; 2016.
Abstract
In a preceding study, we showed that in adult pink1−/− mice, a monogenic animal model of Parkinson’s disease (PD), striatal neurons display aberrant electrical activities that precede the onset of overt clinical manifestations. Here, we tested the hypothesis that the maturation of dopaminergic (DA) neurons of the pink1−/− substantia nigra compacta (SNc) follows, from early stages on, a different developmental trajectory from age-matched wild type (wt) SNc DA neurons. We used immature (postnatal days P2–P10) and young adult (P30–P90) midbrain slices of pink1−/− mice expressing the green fluorescent protein in tyrosine hydroxylase (TH)-positive neurons. We report that the developmental sequence of N-Methyl-D-aspartic acid (NMDA) spontaneous excitatory postsynaptic currents (sEPSCs) is altered in pink1−/− SNc DA neurons, starting from shortly after birth. They lack the transient episode of high NMDA receptor-mediated neuronal activity characteristic of the immature stage of wt SNc DA neurons. The maturation of the membrane resistance of pink1−/− SNc DA neurons is also altered. Collectively, these observations suggest that electrical manifestations occurring shortly after birth in SNc DA neurons might lead to dysfunction in dopamine release and constitute an early pathogenic mechanism of PD.
Url:
DOI: 10.3389/fncel.2016.00168
PubMed: 27445695
PubMed Central: 4917553
Affiliations:
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Michel</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>UMR901, Aix-Marseille Université</institution><country>Marseille, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Neurobiologie de la Méditerranée (INMED), Inserm UMR 901</institution><country>Marseille, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Save, Laurene" sort="Save, Laurene" uniqKey="Save L" first="Laurène" last="Save">Laurène Save</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>UMR901, Aix-Marseille Université</institution><country>Marseille, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Neurobiologie de la Méditerranée (INMED), Inserm UMR 901</institution><country>Marseille, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Ferrari, Diana C" sort="Ferrari, Diana C" uniqKey="Ferrari D" first="Diana C." last="Ferrari">Diana C. Ferrari</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>UMR901, Aix-Marseille Université</institution><country>Marseille, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Neurobiologie de la Méditerranée (INMED), Inserm UMR 901</institution><country>Marseille, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author><author><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>UMR901, Aix-Marseille Université</institution><country>Marseille, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institut de Neurobiologie de la Méditerranée (INMED), Inserm UMR 901</institution><country>Marseille, France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea></wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Cellular Neuroscience</title><idno type="eISSN">1662-5102</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In a preceding study, we showed that in adult pink1<sup>−/−</sup> mice, a monogenic animal model of Parkinson’s disease (PD), striatal neurons display aberrant electrical activities that precede the onset of overt clinical manifestations. Here, we tested the hypothesis that the maturation of dopaminergic (DA) neurons of the pink1<sup>−/−</sup> substantia nigra compacta (SNc) follows, from early stages on, a different developmental trajectory from age-matched wild type (wt) SNc DA neurons. We used immature (postnatal days P2–P10) and young adult (P30–P90) midbrain slices of pink1<sup>−/−</sup> mice expressing the green fluorescent protein in tyrosine hydroxylase (TH)-positive neurons. We report that the developmental sequence of N-Methyl-D-aspartic acid (NMDA) spontaneous excitatory postsynaptic currents (sEPSCs) is altered in pink1<sup>−/−</sup> SNc DA neurons, starting from shortly after birth. They lack the transient episode of high NMDA receptor-mediated neuronal activity characteristic of the immature stage of wt SNc DA neurons. The maturation of the membrane resistance of pink1<sup>−/−</sup> SNc DA neurons is also altered. Collectively, these observations suggest that electrical manifestations occurring shortly after birth in SNc DA neurons might lead to dysfunction in dopamine release and constitute an early pathogenic mechanism of PD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ammari, R" uniqKey="Ammari R">R. Ammari</name></author><author><name sortKey="Lopez, C" uniqKey="Lopez C">C. Lopez</name></author><author><name sortKey="Fiorentino, H" uniqKey="Fiorentino H">H. Fiorentino</name></author><author><name sortKey="Gonon, F" uniqKey="Gonon F">F. Gonon</name></author><author><name sortKey="Hammond, C" uniqKey="Hammond C">C. Hammond</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Ari, Y" uniqKey="Ben Ari Y">Y. Ben-Ari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bentivoglio, A R" uniqKey="Bentivoglio A">A. R. 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Ferrari</name><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name><name sortKey="Hammond, Constance" sort="Hammond, Constance" uniqKey="Hammond C" first="Constance" last="Hammond">Constance Hammond</name><name sortKey="Michel, Francois J" sort="Michel, Francois J" uniqKey="Michel F" first="François J." last="Michel">François J. Michel</name><name sortKey="Michel, Francois J" sort="Michel, Francois J" uniqKey="Michel F" first="François J." last="Michel">François J. Michel</name><name sortKey="Pearlstein, Edouard" sort="Pearlstein, Edouard" uniqKey="Pearlstein E" first="Edouard" last="Pearlstein">Edouard Pearlstein</name><name sortKey="Save, Laurene" sort="Save, Laurene" uniqKey="Save L" first="Laurène" last="Save">Laurène Save</name><name sortKey="Save, Laurene" sort="Save, Laurene" uniqKey="Save L" first="Laurène" last="Save">Laurène Save</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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