Current drug design to target the Semaphorin/Neuropilin/Plexin complexes
Identifieur interne : 000311 ( Main/Exploration ); précédent : 000310; suivant : 000312Current drug design to target the Semaphorin/Neuropilin/Plexin complexes
Auteurs : Lionel A. T. Meyer ; Justine Fritz ; Marie Pierdant-Mancera ; Dominique BagnardSource :
- Cell Adhesion & Migration [ 1933-6918 ] ; 2016.
Abstract
The Semaphorin/Neuropilin/Plexin (SNP) complexes control a wide range of biological processes. Consistently, activity deregulation of these complexes is associated with many diseases. The increasing knowledge on SNP had in turn validated these molecular complexes as novel therapeutic targets. Targeting SNP activities by small molecules, antibodies and peptides or by soluble semaphorins have been proposed as new therapeutic approach. This review is focusing on the latest demonstration of this potential and discusses some of the key questions that need to be addressed before translating SNP targeting into clinically relevant approaches.
Url:
DOI: 10.1080/19336918.2016.1261785
PubMed: 27906605
PubMed Central: 5160035
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Current drug design to target the Semaphorin/Neuropilin/Plexin complexes</title><author><name sortKey="Meyer, Lionel A T" sort="Meyer, Lionel A T" uniqKey="Meyer L" first="Lionel A. T." last="Meyer">Lionel A. T. Meyer</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author><author><name sortKey="Fritz, Justine" sort="Fritz, Justine" uniqKey="Fritz J" first="Justine" last="Fritz">Justine Fritz</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author><author><name sortKey="Pierdant Mancera, Marie" sort="Pierdant Mancera, Marie" uniqKey="Pierdant Mancera M" first="Marie" last="Pierdant-Mancera">Marie Pierdant-Mancera</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author><author><name sortKey="Bagnard, Dominique" sort="Bagnard, Dominique" uniqKey="Bagnard D" first="Dominique" last="Bagnard">Dominique Bagnard</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27906605</idno><idno type="pmc">5160035</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5160035</idno><idno type="RBID">PMC:5160035</idno><idno type="doi">10.1080/19336918.2016.1261785</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000919</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000919</idno><idno type="wicri:Area/Pmc/Curation">000915</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000915</idno><idno type="wicri:Area/Pmc/Checkpoint">000103</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000103</idno><idno type="wicri:Area/Ncbi/Merge">001B70</idno><idno type="wicri:Area/Ncbi/Curation">001B70</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B70</idno><idno type="wicri:doubleKey">1933-6918:2016:Meyer L:current:drug:design</idno><idno type="wicri:Area/Main/Merge">000313</idno><idno type="wicri:Area/Main/Curation">000311</idno><idno type="wicri:Area/Main/Exploration">000311</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Current drug design to target the Semaphorin/Neuropilin/Plexin complexes</title><author><name sortKey="Meyer, Lionel A T" sort="Meyer, Lionel A T" uniqKey="Meyer L" first="Lionel A. T." last="Meyer">Lionel A. T. Meyer</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author><author><name sortKey="Fritz, Justine" sort="Fritz, Justine" uniqKey="Fritz J" first="Justine" last="Fritz">Justine Fritz</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author><author><name sortKey="Pierdant Mancera, Marie" sort="Pierdant Mancera, Marie" uniqKey="Pierdant Mancera M" first="Marie" last="Pierdant-Mancera">Marie Pierdant-Mancera</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author><author><name sortKey="Bagnard, Dominique" sort="Bagnard, Dominique" uniqKey="Bagnard D" first="Dominique" last="Bagnard">Dominique Bagnard</name><affiliation><nlm:aff id="af0001"></nlm:aff></affiliation></author></analytic><series><title level="j">Cell Adhesion & Migration</title><idno type="ISSN">1933-6918</idno><idno type="eISSN">1933-6926</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><p>The Semaphorin/Neuropilin/Plexin (SNP) complexes control a wide range of biological processes. Consistently, activity deregulation of these complexes is associated with many diseases. The increasing knowledge on SNP had in turn validated these molecular complexes as novel therapeutic targets. Targeting SNP activities by small molecules, antibodies and peptides or by soluble semaphorins have been proposed as new therapeutic approach. This review is focusing on the latest demonstration of this potential and discusses some of the key questions that need to be addressed before translating SNP targeting into clinically relevant approaches.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Luo, Y" uniqKey="Luo Y">Y Luo</name></author><author><name sortKey="Raible, D" uniqKey="Raible D">D Raible</name></author><author><name sortKey="Raper, Ja" uniqKey="Raper J">JA Raper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roth, L" uniqKey="Roth L">L Roth</name></author><author><name sortKey="Koncina, E" uniqKey="Koncina E">E Koncina</name></author><author><name sortKey="Satkauskas, S" uniqKey="Satkauskas S">S Satkauskas</name></author><author><name sortKey="Cremel, G" uniqKey="Cremel G">G Crémel</name></author><author><name sortKey="Aunis, D" uniqKey="Aunis D">D Aunis</name></author><author><name sortKey="Bagnard, D" uniqKey="Bagnard 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sortKey="Garnier, N" uniqKey="Garnier N">N Garnier</name></author><author><name sortKey="Velazquez Quesada, I" uniqKey="Velazquez Quesada I">I Velázquez-Quesada</name></author><author><name sortKey="Hussenet, T" uniqKey="Hussenet T">T Hussenet</name></author><author><name sortKey="Aci Seche, S" uniqKey="Aci Seche S">S Aci-Sèche</name></author><author><name sortKey="Baumlin, N" uniqKey="Baumlin N">N Baumlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arpel, A" uniqKey="Arpel A">A Arpel</name></author><author><name sortKey="Gamper, C" uniqKey="Gamper C">C Gamper</name></author><author><name sortKey="C, Spenle" uniqKey="C S">Spenlé C</name></author><author><name sortKey="Fernandez, A" uniqKey="Fernandez A">A Fernandez</name></author><author><name sortKey="Jacob, L" uniqKey="Jacob L">L Jacob</name></author><author><name sortKey="Baumlin, N" uniqKey="Baumlin N">N Baumlin</name></author><author><name sortKey="Laquerriere, P" uniqKey="Laquerriere P">P Laquerriere</name></author><author><name sortKey="Orend, G" uniqKey="Orend G">G Orend</name></author><author><name sortKey="Cremel, G" uniqKey="Cremel G">G Crémel</name></author><author><name sortKey="Bagnard, D" uniqKey="Bagnard D">D Bagnard</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bagnard, Dominique" sort="Bagnard, Dominique" uniqKey="Bagnard D" first="Dominique" last="Bagnard">Dominique Bagnard</name><name sortKey="Fritz, Justine" sort="Fritz, Justine" uniqKey="Fritz J" first="Justine" last="Fritz">Justine Fritz</name><name sortKey="Meyer, Lionel A T" sort="Meyer, Lionel A T" uniqKey="Meyer L" first="Lionel A. T." last="Meyer">Lionel A. T. Meyer</name><name sortKey="Pierdant Mancera, Marie" sort="Pierdant Mancera, Marie" uniqKey="Pierdant Mancera M" first="Marie" last="Pierdant-Mancera">Marie Pierdant-Mancera</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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