ParkinsonFranceV1, Main, Exploration, bibRecord, 000020

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial.

Identifieur interne : 000020 ( Main/Exploration ); précédent : 000019; suivant : 000021

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial.

Auteurs : Andrew J. Lees [Royaume-Uni] ; Joaquim Ferreira [Portugal] ; Olivier Rascol [France] ; Werner Poewe [Autriche] ; José-Francisco Rocha [Portugal] ; Michelle Mccrory [Irlande (pays)] ; Patricio Soares-Da-Silva [Portugal]

Source :

JAMA neurology [ 2168-6157 ] ; 2017.

RBID : pubmed:28027332

Abstract

Catechol O-methyltransferase (COMT) inhibitors are an established treatment for end-of-dose motor fluctuations associated with levodopa therapy in patients with Parkinson disease (PD). Current COMT inhibitors carry a high risk for toxic effects to hepatic cells or show moderate improvement. Opicapone was designed to be effective without the adverse effects.

DOI: 10.1001/jamaneurol.2016.4703
PubMed: 28027332

Affiliations:

Le document en format XML

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La maladie de Parkinson en France (serveur d'exploration)

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial.

Opicapone as Adjunct to Levodopa Therapy in Patients With Parkinson Disease and Motor Fluctuations: A Randomized Clinical Trial.

Source :

Abstract

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	La maladie de Parkinson en France (serveur d'exploration)
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