Apomorphine-induced relief of the akinetic-rigid syndrome and early median nerve somatosensory evoked potentials (SEPs) in Parkinson's disease.
Identifieur interne : 005A06 ( Main/Curation ); précédent : 005A05; suivant : 005A07Apomorphine-induced relief of the akinetic-rigid syndrome and early median nerve somatosensory evoked potentials (SEPs) in Parkinson's disease.
Auteurs : F. Mauguière [France] ; E. Broussolle ; J. IsnardSource :
- Electroencephalography and clinical neurophysiology [ 0013-4694 ]
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Apomorphine (therapeutic use), Brain (physiopathology), Brain Mapping, Electric Stimulation, Electroencephalography, Evoked Potentials, Somatosensory (physiology), Female, Humans, Male, Median Nerve (physiopathology), Middle Aged, Movement Disorders (drug therapy), Movement Disorders (etiology), Movement Disorders (physiopathology), Muscle Rigidity (drug therapy), Muscle Rigidity (etiology), Muscle Rigidity (physiopathology), Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Reaction Time (physiology), Syndrome.
- MESH :
- chemical , therapeutic use : Apomorphine.
- complications : Parkinson Disease.
- drug therapy : Movement Disorders, Muscle Rigidity, Parkinson Disease.
- etiology : Movement Disorders, Muscle Rigidity.
- physiology : Evoked Potentials, Somatosensory, Reaction Time.
- physiopathology : Brain, Median Nerve, Movement Disorders, Muscle Rigidity, Parkinson Disease.
- Aged, Analysis of Variance, Brain Mapping, Electric Stimulation, Electroencephalography, Female, Humans, Male, Middle Aged, Syndrome.
Abstract
Among early cortical median nerve SEPs the frontal N30 potential is known to show amplitude reduction during execution of voluntary movements and to be abnormally reduced in parkinsonian patients. However, it is not clear whether N30 abnormalities are related to the severity of motor disability in Parkinson's disease. To address this question we studied median nerve SEPs, using a 16-channel montage, in 7 patients chronically treated with subcutaneous (s.c.) injections of apomorphine hydrochloride for spontaneous "on-off" motor fluctuations. We observed no significant changes in the latency, amplitude or scalp topography of early SEPs when comparing traces and maps obtained in the "off" condition and during the "on" phase induced by s.c. injection of apomorphine. The absence of any SEP changes, despite a clear-cut relief of the akinetic-rigid syndrome, suggests that early cortical SEPs, and in particular the frontal N30 potential, at least when recorded in a subject at rest, are not usable as an objective means to assess the severity or the fluctuations of motor disability in Parkinson's disease.
PubMed: 7688279
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pubmed:7688279Le document en format XML
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<term>Parkinson Disease (physiopathology)</term>
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<front><div type="abstract" xml:lang="en">Among early cortical median nerve SEPs the frontal N30 potential is known to show amplitude reduction during execution of voluntary movements and to be abnormally reduced in parkinsonian patients. However, it is not clear whether N30 abnormalities are related to the severity of motor disability in Parkinson's disease. To address this question we studied median nerve SEPs, using a 16-channel montage, in 7 patients chronically treated with subcutaneous (s.c.) injections of apomorphine hydrochloride for spontaneous "on-off" motor fluctuations. We observed no significant changes in the latency, amplitude or scalp topography of early SEPs when comparing traces and maps obtained in the "off" condition and during the "on" phase induced by s.c. injection of apomorphine. The absence of any SEP changes, despite a clear-cut relief of the akinetic-rigid syndrome, suggests that early cortical SEPs, and in particular the frontal N30 potential, at least when recorded in a subject at rest, are not usable as an objective means to assess the severity or the fluctuations of motor disability in Parkinson's disease.</div>
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