Interaction of noradrenergic pharmacological manipulation and subthalamic stimulation on movement initiation control in Parkinson's disease.
Identifieur interne : 005981 ( Main/Curation ); précédent : 005980; suivant : 005982Interaction of noradrenergic pharmacological manipulation and subthalamic stimulation on movement initiation control in Parkinson's disease.
Auteurs : Marion Albares [France] ; Stéphane Thobois [France] ; Emilie Favre [France] ; Emmanuel Broussolle [France] ; Gustavo Polo [France] ; Philippe Domenech [France] ; Philippe Boulinguez [France] ; Bénédicte Ballanger [France]Source :
- Brain stimulation [ 1876-4754 ]
English descriptors
- KwdEn :
- Adrenergic alpha-2 Receptor Agonists (therapeutic use), Aged, Clonidine (therapeutic use), Combined Modality Therapy (methods), Deep Brain Stimulation, Female, Humans, Male, Middle Aged, Movement (drug effects), Movement (physiology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Psychomotor Performance (drug effects), Psychomotor Performance (physiology), Reaction Time (drug effects), Subthalamic Nucleus (physiology).
- MESH :
- chemical , therapeutic use : Adrenergic alpha-2 Receptor Agonists, Clonidine.
- drug effects : Movement, Psychomotor Performance, Reaction Time.
- drug therapy : Parkinson Disease.
- methods : Combined Modality Therapy.
- physiology : Movement, Psychomotor Performance, Subthalamic Nucleus.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Deep Brain Stimulation, Female, Humans, Male, Middle Aged.
Abstract
Slowness in movement initiation (akinesia) is a cardinal feature of Parkinson's disease (PD), which is still poorly understood. Notably, akinesia is restored by subthalamic nucleus deep brain stimulation (STN-DBS) but not fully reversed by current dopaminergic treatments. It was recently suggested that this disorder is of executive nature (related to inhibitory control of response) and of non-dopaminergic origin (possibly noradrenergic).
DOI: 10.1016/j.brs.2014.09.002
PubMed: 25284704
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pubmed:25284704Le document en format XML
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<series><title level="j">Brain stimulation</title>
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<front><div type="abstract" xml:lang="en">Slowness in movement initiation (akinesia) is a cardinal feature of Parkinson's disease (PD), which is still poorly understood. Notably, akinesia is restored by subthalamic nucleus deep brain stimulation (STN-DBS) but not fully reversed by current dopaminergic treatments. It was recently suggested that this disorder is of executive nature (related to inhibitory control of response) and of non-dopaminergic origin (possibly noradrenergic).</div>
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