Behavioural effects of genetically engineered cells releasing DOPA and dopamine after intracerebral grafting in a rat model of Parkinson's disease
Identifieur interne : 005003 ( Main/Curation ); précédent : 005002; suivant : 005004Behavioural effects of genetically engineered cells releasing DOPA and dopamine after intracerebral grafting in a rat model of Parkinson's disease
Auteurs : P. Horellou [France] ; C. Lundberg ; B. Le Bourdelles ; K. Wictorin ; P. Brundin ; P. Kalen ; A. Björklund ; J. MalletSource :
- Journal de physiologie : (Paris) [ 0021-7948 ] ; 1991.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Animal, Animals, Catechols (metabolism), Corpus Striatum (metabolism), Corpus Striatum (transplantation), Degenerative disease, Dihydroxyphenylalanine (pharmacokinetics), Dihydroxyphenylalanine (pharmacology), Disease Models, Animal, Dopamine (pharmacokinetics), Dopamine (pharmacology), Dopaminergic transmission, Experimental disease, Genetic Engineering, Graft surgical, Motor Activity (drug effects), Nervous system diseases, Parkinson Disease (genetics), Parkinson Disease (metabolism), Parkinson Disease (surgery), Parkinson disease, Rat, Rats, Treatment, Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : Catechols, Tyrosine 3-Monooxygenase.
- drug effects : Motor Activity.
- genetics : Parkinson Disease.
- metabolism : Corpus Striatum, Parkinson Disease.
- chemical , pharmacokinetics : Dihydroxyphenylalanine, Dopamine.
- chemical , pharmacology : Dihydroxyphenylalanine, Dopamine.
- surgery : Parkinson Disease.
- transplantation : Corpus Striatum.
- Animals, Disease Models, Animal, Genetic Engineering, Rats.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001B36
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :001515
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001A19
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :005A69
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001809
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001768
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001768
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000634
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000634
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000634
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :005916
Links to Exploration step
Pascal:92-0280542Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Behavioural effects of genetically engineered cells releasing DOPA and dopamine after intracerebral grafting in a rat model of Parkinson's disease</title>
<author><name sortKey="Horellou, P" sort="Horellou, P" uniqKey="Horellou P" first="P." last="Horellou">P. Horellou</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CNRS</s1>
<s2>Gif-sur-Yvette 91198</s2>
<s3>FRA</s3>
<sZ>1 aut., 3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundberg, C" sort="Lundberg, C" uniqKey="Lundberg C" first="C." last="Lundberg">C. Lundberg</name>
</author>
<author><name sortKey="Le Bourdelles, B" sort="Le Bourdelles, B" uniqKey="Le Bourdelles B" first="B." last="Le Bourdelles">B. Le Bourdelles</name>
</author>
<author><name sortKey="Wictorin, K" sort="Wictorin, K" uniqKey="Wictorin K" first="K." last="Wictorin">K. Wictorin</name>
</author>
<author><name sortKey="Brundin, P" sort="Brundin, P" uniqKey="Brundin P" first="P." last="Brundin">P. Brundin</name>
</author>
<author><name sortKey="Kalen, P" sort="Kalen, P" uniqKey="Kalen P" first="P." last="Kalen">P. Kalen</name>
</author>
<author><name sortKey="Bjorklund, A" sort="Bjorklund, A" uniqKey="Bjorklund A" first="A." last="Björklund">A. Björklund</name>
</author>
<author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">92-0280542</idno>
<date when="1991">1991</date>
<idno type="stanalyst">PASCAL 92-0280542 INIST</idno>
<idno type="RBID">Pascal:92-0280542</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001B36</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001515</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001A19</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001A19</idno>
<idno type="wicri:doubleKey">0021-7948:1991:Horellou P:behavioural:effects:of</idno>
<idno type="wicri:Area/Main/Merge">005A69</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:1687823</idno>
<idno type="wicri:Area/PubMed/Corpus">001809</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001809</idno>
<idno type="wicri:Area/PubMed/Curation">001768</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001768</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001768</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001768</idno>
<idno type="wicri:Area/Ncbi/Merge">000634</idno>
<idno type="wicri:Area/Ncbi/Curation">000634</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000634</idno>
<idno type="wicri:doubleKey">0021-7948:1991:Horellou P:behavioural:effects:of</idno>
<idno type="wicri:Area/Main/Merge">005916</idno>
<idno type="wicri:Area/Main/Curation">005003</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Behavioural effects of genetically engineered cells releasing DOPA and dopamine after intracerebral grafting in a rat model of Parkinson's disease</title>
<author><name sortKey="Horellou, P" sort="Horellou, P" uniqKey="Horellou P" first="P." last="Horellou">P. Horellou</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CNRS</s1>
<s2>Gif-sur-Yvette 91198</s2>
<s3>FRA</s3>
<sZ>1 aut., 3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundberg, C" sort="Lundberg, C" uniqKey="Lundberg C" first="C." last="Lundberg">C. Lundberg</name>
</author>
<author><name sortKey="Le Bourdelles, B" sort="Le Bourdelles, B" uniqKey="Le Bourdelles B" first="B." last="Le Bourdelles">B. Le Bourdelles</name>
</author>
<author><name sortKey="Wictorin, K" sort="Wictorin, K" uniqKey="Wictorin K" first="K." last="Wictorin">K. Wictorin</name>
</author>
<author><name sortKey="Brundin, P" sort="Brundin, P" uniqKey="Brundin P" first="P." last="Brundin">P. Brundin</name>
</author>
<author><name sortKey="Kalen, P" sort="Kalen, P" uniqKey="Kalen P" first="P." last="Kalen">P. Kalen</name>
</author>
<author><name sortKey="Bjorklund, A" sort="Bjorklund, A" uniqKey="Bjorklund A" first="A." last="Björklund">A. Björklund</name>
</author>
<author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name>
</author>
</analytic>
<series><title level="j" type="main">Journal de physiologie : (Paris)</title>
<title level="j" type="abbreviated">J. physiol. : (Paris)</title>
<idno type="ISSN">0021-7948</idno>
<imprint><date when="1991">1991</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal de physiologie : (Paris)</title>
<title level="j" type="abbreviated">J. physiol. : (Paris)</title>
<idno type="ISSN">0021-7948</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Animals</term>
<term>Catechols (metabolism)</term>
<term>Corpus Striatum (metabolism)</term>
<term>Corpus Striatum (transplantation)</term>
<term>Degenerative disease</term>
<term>Dihydroxyphenylalanine (pharmacokinetics)</term>
<term>Dihydroxyphenylalanine (pharmacology)</term>
<term>Disease Models, Animal</term>
<term>Dopamine (pharmacokinetics)</term>
<term>Dopamine (pharmacology)</term>
<term>Dopaminergic transmission</term>
<term>Experimental disease</term>
<term>Genetic Engineering</term>
<term>Graft surgical</term>
<term>Motor Activity (drug effects)</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson disease</term>
<term>Rat</term>
<term>Rats</term>
<term>Treatment</term>
<term>Tyrosine 3-Monooxygenase (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catechols</term>
<term>Tyrosine 3-Monooxygenase</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Dihydroxyphenylalanine</term>
<term>Dopamine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dihydroxyphenylalanine</term>
<term>Dopamine</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Corpus Striatum</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Genetic Engineering</term>
<term>Rats</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Rat</term>
<term>Parkinson maladie</term>
<term>Maladie dégénérative</term>
<term>Système nerveux pathologie</term>
<term>Traitement</term>
<term>Greffe</term>
<term>Animal</term>
<term>Pathologie expérimentale</term>
<term>Transmission dopaminergique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
</TEI>
<double idat="0021-7948:1991:Horellou P:behavioural:effects:of"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Behavioural effects of genetically engineered cells releasing DOPA and dopamine after intracerebral grafting in a rat model of Parkinson's disease</title>
<author><name sortKey="Horellou, P" sort="Horellou, P" uniqKey="Horellou P" first="P." last="Horellou">P. Horellou</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CNRS</s1>
<s2>Gif-sur-Yvette 91198</s2>
<s3>FRA</s3>
<sZ>1 aut., 3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundberg, C" sort="Lundberg, C" uniqKey="Lundberg C" first="C." last="Lundberg">C. Lundberg</name>
</author>
<author><name sortKey="Le Bourdelles, B" sort="Le Bourdelles, B" uniqKey="Le Bourdelles B" first="B." last="Le Bourdelles">B. Le Bourdelles</name>
</author>
<author><name sortKey="Wictorin, K" sort="Wictorin, K" uniqKey="Wictorin K" first="K." last="Wictorin">K. Wictorin</name>
</author>
<author><name sortKey="Brundin, P" sort="Brundin, P" uniqKey="Brundin P" first="P." last="Brundin">P. Brundin</name>
</author>
<author><name sortKey="Kalen, P" sort="Kalen, P" uniqKey="Kalen P" first="P." last="Kalen">P. Kalen</name>
</author>
<author><name sortKey="Bjorklund, A" sort="Bjorklund, A" uniqKey="Bjorklund A" first="A." last="Björklund">A. Björklund</name>
</author>
<author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">92-0280542</idno>
<date when="1991">1991</date>
<idno type="stanalyst">PASCAL 92-0280542 INIST</idno>
<idno type="RBID">Pascal:92-0280542</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001B36</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001515</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001A19</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001A19</idno>
<idno type="wicri:doubleKey">0021-7948:1991:Horellou P:behavioural:effects:of</idno>
<idno type="wicri:Area/Main/Merge">005A69</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Behavioural effects of genetically engineered cells releasing DOPA and dopamine after intracerebral grafting in a rat model of Parkinson's disease</title>
<author><name sortKey="Horellou, P" sort="Horellou, P" uniqKey="Horellou P" first="P." last="Horellou">P. Horellou</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CNRS</s1>
<s2>Gif-sur-Yvette 91198</s2>
<s3>FRA</s3>
<sZ>1 aut., 3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region" nuts="2">Île-de-France</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundberg, C" sort="Lundberg, C" uniqKey="Lundberg C" first="C." last="Lundberg">C. Lundberg</name>
</author>
<author><name sortKey="Le Bourdelles, B" sort="Le Bourdelles, B" uniqKey="Le Bourdelles B" first="B." last="Le Bourdelles">B. Le Bourdelles</name>
</author>
<author><name sortKey="Wictorin, K" sort="Wictorin, K" uniqKey="Wictorin K" first="K." last="Wictorin">K. Wictorin</name>
</author>
<author><name sortKey="Brundin, P" sort="Brundin, P" uniqKey="Brundin P" first="P." last="Brundin">P. Brundin</name>
</author>
<author><name sortKey="Kalen, P" sort="Kalen, P" uniqKey="Kalen P" first="P." last="Kalen">P. Kalen</name>
</author>
<author><name sortKey="Bjorklund, A" sort="Bjorklund, A" uniqKey="Bjorklund A" first="A." last="Björklund">A. Björklund</name>
</author>
<author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J." last="Mallet">J. Mallet</name>
</author>
</analytic>
<series><title level="j" type="main">Journal de physiologie : (Paris)</title>
<title level="j" type="abbreviated">J. physiol. : (Paris)</title>
<idno type="ISSN">0021-7948</idno>
<imprint><date when="1991">1991</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal de physiologie : (Paris)</title>
<title level="j" type="abbreviated">J. physiol. : (Paris)</title>
<idno type="ISSN">0021-7948</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Degenerative disease</term>
<term>Dopaminergic transmission</term>
<term>Experimental disease</term>
<term>Graft surgical</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Rat</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Rat</term>
<term>Parkinson maladie</term>
<term>Maladie dégénérative</term>
<term>Système nerveux pathologie</term>
<term>Traitement</term>
<term>Greffe</term>
<term>Animal</term>
<term>Pathologie expérimentale</term>
<term>Transmission dopaminergique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Behavioural effects of genetically engineered cells releasing dopa and dopamine after intracerebral grafting in a rat model of Parkinson's disease.</title>
<author><name sortKey="Horellou, P" sort="Horellou, P" uniqKey="Horellou P" first="P" last="Horellou">P. Horellou</name>
<affiliation wicri:level="3"><nlm:affiliation>LNBCM, CNRS, Gif-sur-Yvette, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LNBCM, CNRS, Gif-sur-Yvette</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Gif-sur-Yvette</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundberg, C" sort="Lundberg, C" uniqKey="Lundberg C" first="C" last="Lundberg">C. Lundberg</name>
</author>
<author><name sortKey="Le Bourdelles, B" sort="Le Bourdelles, B" uniqKey="Le Bourdelles B" first="B" last="Le Bourdellès">B. Le Bourdellès</name>
</author>
<author><name sortKey="Wictorin, K" sort="Wictorin, K" uniqKey="Wictorin K" first="K" last="Wictorin">K. Wictorin</name>
</author>
<author><name sortKey="Brundin, P" sort="Brundin, P" uniqKey="Brundin P" first="P" last="Brundin">P. Brundin</name>
</author>
<author><name sortKey="Kalen, P" sort="Kalen, P" uniqKey="Kalen P" first="P" last="Kalén">P. Kalén</name>
</author>
<author><name sortKey="Bjorklund, A" sort="Bjorklund, A" uniqKey="Bjorklund A" first="A" last="Björklund">A. Björklund</name>
</author>
<author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J" last="Mallet">J. Mallet</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1991">1991</date>
<idno type="RBID">pubmed:1687823</idno>
<idno type="pmid">1687823</idno>
<idno type="wicri:Area/PubMed/Corpus">001809</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001809</idno>
<idno type="wicri:Area/PubMed/Curation">001768</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001768</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001768</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001768</idno>
<idno type="wicri:Area/Ncbi/Merge">000634</idno>
<idno type="wicri:Area/Ncbi/Curation">000634</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000634</idno>
<idno type="wicri:doubleKey">0021-7948:1991:Horellou P:behavioural:effects:of</idno>
<idno type="wicri:Area/Main/Merge">005916</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Behavioural effects of genetically engineered cells releasing dopa and dopamine after intracerebral grafting in a rat model of Parkinson's disease.</title>
<author><name sortKey="Horellou, P" sort="Horellou, P" uniqKey="Horellou P" first="P" last="Horellou">P. Horellou</name>
<affiliation wicri:level="3"><nlm:affiliation>LNBCM, CNRS, Gif-sur-Yvette, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>LNBCM, CNRS, Gif-sur-Yvette</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Gif-sur-Yvette</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lundberg, C" sort="Lundberg, C" uniqKey="Lundberg C" first="C" last="Lundberg">C. Lundberg</name>
</author>
<author><name sortKey="Le Bourdelles, B" sort="Le Bourdelles, B" uniqKey="Le Bourdelles B" first="B" last="Le Bourdellès">B. Le Bourdellès</name>
</author>
<author><name sortKey="Wictorin, K" sort="Wictorin, K" uniqKey="Wictorin K" first="K" last="Wictorin">K. Wictorin</name>
</author>
<author><name sortKey="Brundin, P" sort="Brundin, P" uniqKey="Brundin P" first="P" last="Brundin">P. Brundin</name>
</author>
<author><name sortKey="Kalen, P" sort="Kalen, P" uniqKey="Kalen P" first="P" last="Kalén">P. Kalén</name>
</author>
<author><name sortKey="Bjorklund, A" sort="Bjorklund, A" uniqKey="Bjorklund A" first="A" last="Björklund">A. Björklund</name>
</author>
<author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J" last="Mallet">J. Mallet</name>
</author>
</analytic>
<series><title level="j">Journal de physiologie</title>
<idno type="ISSN">0021-7948</idno>
<imprint><date when="1991" type="published">1991</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Catechols (metabolism)</term>
<term>Corpus Striatum (metabolism)</term>
<term>Corpus Striatum (transplantation)</term>
<term>Dihydroxyphenylalanine (pharmacokinetics)</term>
<term>Dihydroxyphenylalanine (pharmacology)</term>
<term>Disease Models, Animal</term>
<term>Dopamine (pharmacokinetics)</term>
<term>Dopamine (pharmacology)</term>
<term>Genetic Engineering</term>
<term>Motor Activity (drug effects)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (surgery)</term>
<term>Rats</term>
<term>Tyrosine 3-Monooxygenase (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Catechols</term>
<term>Tyrosine 3-Monooxygenase</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Dihydroxyphenylalanine</term>
<term>Dopamine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dihydroxyphenylalanine</term>
<term>Dopamine</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Corpus Striatum</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Disease Models, Animal</term>
<term>Genetic Engineering</term>
<term>Rats</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The relative importance of synaptic versus paracrine dopamine transmission for the occurrence of functional effects following intrastriatal grafting is not fully established. In the present study we grafted cell lines, expressing the form I of human tyrosine hydroxylase after infection with a recombinant retrovirus and selection in tyrosine-free-medium, to the denervated striatum in order to analyse the extent to which extracellular dopamine levels can be restored and the effect of a diffuse release of dopamine on motor impairement in a rat model of Parkinson's disease. In petri dish, the modified fibroblast cells (NIH.3T3) release DOPA constitutively whereas the modified endocrine cells (RIN) store and release dopamine in a regulated way. Interestingly, in denervated striatum, grafts of modified fibroblast cells produce DOPA which was efficiently converted into dopamine by the host striatal tissue. In the grafted striatum, both fibroblast and endocrine cells restore subnormal levels of diffuse release of dopamine which is notably unaffected and stimulated, respectively, by high concentration of potassium, in connection with the in vitro properties of the grafted cells. The intrastriatal grafts of modified cells partially reversed the apomorphine-induced but not the amphetamine-induced motor asymmetry. We discuss the implications of these results in the context of Parkinson disease.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005003 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 005003 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Curation |type= RBID |clé= Pascal:92-0280542 |texte= Behavioural effects of genetically engineered cells releasing DOPA and dopamine after intracerebral grafting in a rat model of Parkinson's disease }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |