High-frequency stimulation of the globus pallidus internalis in Parkinson's disease : a study of seven cases
Identifieur interne : 004435 ( Main/Curation ); précédent : 004434; suivant : 004436High-frequency stimulation of the globus pallidus internalis in Parkinson's disease : a study of seven cases
Auteurs : C. Gross [France] ; A. Rougier ; D. Guehl ; T. Boraud ; J. Julien ; B. BioulacSource :
- Journal of neurosurgery [ 0022-3085 ] ; 1997.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Case study, Disease Progression, Dyskinesia, Dyskinesia, Drug-Induced (etiology), Electric Stimulation Therapy (instrumentation), Electric Stimulation Therapy (methods), Electrodes, Electrodes, Implanted, Follow up study, Follow-Up Studies, Gait (physiology), Globus Pallidus (physiopathology), Globus Pallidus (surgery), High frequency, Humans, Hypokinesia, Hypokinesia (surgery), Hypokinesia (therapy), Implanted, Instrumental stimulation, Instrumentation therapy, Levodopa (adverse effects), Male, Middle Aged, Movement Disorders (therapy), Muscle Rigidity (surgery), Muscle Rigidity (therapy), Pallidum, Parkinson Disease (etiology), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Parkinson Disease (therapy), Parkinson disease, Speech Disorders (therapy), Stereotaxic Techniques, Stiffness, Thalamic Nuclei (physiopathology), Treatment Outcome, Tremor (therapy), Young adult.
- MESH :
- chemical , adverse effects : Levodopa.
- etiology : Dyskinesia, Drug-Induced, Parkinson Disease.
- instrumentation : Electric Stimulation Therapy.
- methods : Electric Stimulation Therapy.
- physiology : Gait.
- physiopathology : Globus Pallidus, Parkinson Disease, Thalamic Nuclei.
- surgery : Globus Pallidus, Hypokinesia, Muscle Rigidity, Parkinson Disease.
- therapy : Hypokinesia, Movement Disorders, Muscle Rigidity, Parkinson Disease, Speech Disorders, Tremor.
- Adult, Disease Progression, Electrodes, Implanted, Follow-Up Studies, Humans, Male, Middle Aged, Stereotaxic Techniques, Treatment Outcome.
Abstract
The effectiveness of ventroposterolateral pallidotomy in the treatment of akinesia and rigidity is not a new discovery and agrees with recent investigations into the pathogenesis of Parkinson's disease, which highlight the role played by the unbridled activity of the subthalamic nucleus (STN) and the consequent overactivity of the globus pallidus internalis (GPi). Because high-frequency stimulation can reversibly incapacitate a nerve structure, we applied stimulation to the same target. Seven patients suffering from severe Parkinson's disease (Stages III-V on the Hoehn and Yahr scale) and. particularly, bradykinesia, rigidity, and levodopa-induced dyskinesias underwent unilateral electrode implantation in the posteroventral GPi. Follow-up evaluation using the regular Unified Parkinson's Disease Rating Scale has been conducted for I year in all seven patients, 2 years in five of them, and 3 years in one. In all cases high-frequency stimulation has alleviated akinesia and rigidity and has generally improved gait and speech disturbances. In some cases tremor was attenuated. In a similar manner, the authors observed a marked diminution in levodopa-induced dyskinesias. This could be an excellent primary therapy for younger patients exhibiting severe bradykinesia. rigidity, and levodopa-induced dyskinesias, which would allow therapists to keep ventroposterolateral pallidotomy in reserve as a second weapon.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001671
- to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :001975
- to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001574
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004C76
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001513
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001472
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001472
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :001E82
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :001E82
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001E82
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004A24
Links to Exploration step
Pascal:97-0506440Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">High-frequency stimulation of the globus pallidus internalis in Parkinson's disease : a study of seven cases</title>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C." last="Gross">C. Gross</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Neurophysiologie, Université Victor Segalen Bordeaux II</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Pellegrin</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, Hôpital du Haut Lévèque</s1>
<s2>Pessac</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Hôpital du Haut Lévèque</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rougier, A" sort="Rougier, A" uniqKey="Rougier A" first="A." last="Rougier">A. Rougier</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D." last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T." last="Boraud">T. Boraud</name>
</author>
<author><name sortKey="Julien, J" sort="Julien, J" uniqKey="Julien J" first="J." last="Julien">J. Julien</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B." last="Bioulac">B. Bioulac</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">97-0506440</idno>
<date when="1997">1997</date>
<idno type="stanalyst">PASCAL 97-0506440 INIST</idno>
<idno type="RBID">Pascal:97-0506440</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001671</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001975</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001574</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001574</idno>
<idno type="wicri:doubleKey">0022-3085:1997:Gross C:high:frequency:stimulation</idno>
<idno type="wicri:Area/Main/Merge">004C76</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:9322838</idno>
<idno type="wicri:Area/PubMed/Corpus">001513</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001513</idno>
<idno type="wicri:Area/PubMed/Curation">001472</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001472</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001472</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001472</idno>
<idno type="wicri:Area/Ncbi/Merge">001E82</idno>
<idno type="wicri:Area/Ncbi/Curation">001E82</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001E82</idno>
<idno type="wicri:doubleKey">0022-3085:1997:Gross C:high:frequency:stimulation</idno>
<idno type="wicri:Area/Main/Merge">004A24</idno>
<idno type="wicri:Area/Main/Curation">004435</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">High-frequency stimulation of the globus pallidus internalis in Parkinson's disease : a study of seven cases</title>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C." last="Gross">C. Gross</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Neurophysiologie, Université Victor Segalen Bordeaux II</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Pellegrin</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, Hôpital du Haut Lévèque</s1>
<s2>Pessac</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Hôpital du Haut Lévèque</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rougier, A" sort="Rougier, A" uniqKey="Rougier A" first="A." last="Rougier">A. Rougier</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D." last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T." last="Boraud">T. Boraud</name>
</author>
<author><name sortKey="Julien, J" sort="Julien, J" uniqKey="Julien J" first="J." last="Julien">J. Julien</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B." last="Bioulac">B. Bioulac</name>
</author>
</analytic>
<series><title level="j" type="main">Journal of neurosurgery</title>
<title level="j" type="abbreviated">J. neurosurg.</title>
<idno type="ISSN">0022-3085</idno>
<imprint><date when="1997">1997</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of neurosurgery</title>
<title level="j" type="abbreviated">J. neurosurg.</title>
<idno type="ISSN">0022-3085</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Case study</term>
<term>Disease Progression</term>
<term>Dyskinesia</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Electric Stimulation Therapy (instrumentation)</term>
<term>Electric Stimulation Therapy (methods)</term>
<term>Electrodes</term>
<term>Electrodes, Implanted</term>
<term>Follow up study</term>
<term>Follow-Up Studies</term>
<term>Gait (physiology)</term>
<term>Globus Pallidus (physiopathology)</term>
<term>Globus Pallidus (surgery)</term>
<term>High frequency</term>
<term>Humans</term>
<term>Hypokinesia</term>
<term>Hypokinesia (surgery)</term>
<term>Hypokinesia (therapy)</term>
<term>Implanted</term>
<term>Instrumental stimulation</term>
<term>Instrumentation therapy</term>
<term>Levodopa (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Movement Disorders (therapy)</term>
<term>Muscle Rigidity (surgery)</term>
<term>Muscle Rigidity (therapy)</term>
<term>Pallidum</term>
<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson Disease (therapy)</term>
<term>Parkinson disease</term>
<term>Speech Disorders (therapy)</term>
<term>Stereotaxic Techniques</term>
<term>Stiffness</term>
<term>Thalamic Nuclei (physiopathology)</term>
<term>Treatment Outcome</term>
<term>Tremor (therapy)</term>
<term>Young adult</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electric Stimulation Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gait</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term>
<term>Parkinson Disease</term>
<term>Thalamic Nuclei</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term>
<term>Hypokinesia</term>
<term>Muscle Rigidity</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hypokinesia</term>
<term>Movement Disorders</term>
<term>Muscle Rigidity</term>
<term>Parkinson Disease</term>
<term>Speech Disorders</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Disease Progression</term>
<term>Electrodes, Implanted</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Stereotaxic Techniques</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Dyskinésie</term>
<term>Hypokinésie</term>
<term>Rigidité</term>
<term>Stimulation instrumentale</term>
<term>Haute fréquence</term>
<term>Pallidum</term>
<term>Electrode</term>
<term>Implanté</term>
<term>Traitement instrumental</term>
<term>Etude longitudinale</term>
<term>Etude cas</term>
<term>Adulte jeune</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The effectiveness of ventroposterolateral pallidotomy in the treatment of akinesia and rigidity is not a new discovery and agrees with recent investigations into the pathogenesis of Parkinson's disease, which highlight the role played by the unbridled activity of the subthalamic nucleus (STN) and the consequent overactivity of the globus pallidus internalis (GPi). Because high-frequency stimulation can reversibly incapacitate a nerve structure, we applied stimulation to the same target. Seven patients suffering from severe Parkinson's disease (Stages III-V on the Hoehn and Yahr scale) and. particularly, bradykinesia, rigidity, and levodopa-induced dyskinesias underwent unilateral electrode implantation in the posteroventral GPi. Follow-up evaluation using the regular Unified Parkinson's Disease Rating Scale has been conducted for I year in all seven patients, 2 years in five of them, and 3 years in one. In all cases high-frequency stimulation has alleviated akinesia and rigidity and has generally improved gait and speech disturbances. In some cases tremor was attenuated. In a similar manner, the authors observed a marked diminution in levodopa-induced dyskinesias. This could be an excellent primary therapy for younger patients exhibiting severe bradykinesia. rigidity, and levodopa-induced dyskinesias, which would allow therapists to keep ventroposterolateral pallidotomy in reserve as a second weapon.</div>
</front>
</TEI>
<double idat="0022-3085:1997:Gross C:high:frequency:stimulation"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">High-frequency stimulation of the globus pallidus internalis in Parkinson's disease : a study of seven cases</title>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C." last="Gross">C. Gross</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Neurophysiologie, Université Victor Segalen Bordeaux II</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Pellegrin</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, Hôpital du Haut Lévèque</s1>
<s2>Pessac</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Hôpital du Haut Lévèque</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rougier, A" sort="Rougier, A" uniqKey="Rougier A" first="A." last="Rougier">A. Rougier</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D." last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T." last="Boraud">T. Boraud</name>
</author>
<author><name sortKey="Julien, J" sort="Julien, J" uniqKey="Julien J" first="J." last="Julien">J. Julien</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B." last="Bioulac">B. Bioulac</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">97-0506440</idno>
<date when="1997">1997</date>
<idno type="stanalyst">PASCAL 97-0506440 INIST</idno>
<idno type="RBID">Pascal:97-0506440</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001671</idno>
<idno type="wicri:Area/PascalFrancis/Curation">001975</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001574</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001574</idno>
<idno type="wicri:doubleKey">0022-3085:1997:Gross C:high:frequency:stimulation</idno>
<idno type="wicri:Area/Main/Merge">004C76</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">High-frequency stimulation of the globus pallidus internalis in Parkinson's disease : a study of seven cases</title>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C." last="Gross">C. Gross</name>
<affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Laboratoire de Neurophysiologie, Université Victor Segalen Bordeaux II</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Service de Neurochirurgie, Hôpital Pellegrin</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Service de Neurologie, Hôpital du Haut Lévèque</s1>
<s2>Pessac</s2>
<s3>FRA</s3>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Hôpital du Haut Lévèque</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rougier, A" sort="Rougier, A" uniqKey="Rougier A" first="A." last="Rougier">A. Rougier</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D." last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T." last="Boraud">T. Boraud</name>
</author>
<author><name sortKey="Julien, J" sort="Julien, J" uniqKey="Julien J" first="J." last="Julien">J. Julien</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B." last="Bioulac">B. Bioulac</name>
</author>
</analytic>
<series><title level="j" type="main">Journal of neurosurgery</title>
<title level="j" type="abbreviated">J. neurosurg.</title>
<idno type="ISSN">0022-3085</idno>
<imprint><date when="1997">1997</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of neurosurgery</title>
<title level="j" type="abbreviated">J. neurosurg.</title>
<idno type="ISSN">0022-3085</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Case study</term>
<term>Dyskinesia</term>
<term>Electrodes</term>
<term>Follow up study</term>
<term>High frequency</term>
<term>Hypokinesia</term>
<term>Implanted</term>
<term>Instrumental stimulation</term>
<term>Instrumentation therapy</term>
<term>Pallidum</term>
<term>Parkinson disease</term>
<term>Stiffness</term>
<term>Young adult</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Dyskinésie</term>
<term>Hypokinésie</term>
<term>Rigidité</term>
<term>Stimulation instrumentale</term>
<term>Haute fréquence</term>
<term>Pallidum</term>
<term>Electrode</term>
<term>Implanté</term>
<term>Traitement instrumental</term>
<term>Etude longitudinale</term>
<term>Etude cas</term>
<term>Adulte jeune</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The effectiveness of ventroposterolateral pallidotomy in the treatment of akinesia and rigidity is not a new discovery and agrees with recent investigations into the pathogenesis of Parkinson's disease, which highlight the role played by the unbridled activity of the subthalamic nucleus (STN) and the consequent overactivity of the globus pallidus internalis (GPi). Because high-frequency stimulation can reversibly incapacitate a nerve structure, we applied stimulation to the same target. Seven patients suffering from severe Parkinson's disease (Stages III-V on the Hoehn and Yahr scale) and. particularly, bradykinesia, rigidity, and levodopa-induced dyskinesias underwent unilateral electrode implantation in the posteroventral GPi. Follow-up evaluation using the regular Unified Parkinson's Disease Rating Scale has been conducted for I year in all seven patients, 2 years in five of them, and 3 years in one. In all cases high-frequency stimulation has alleviated akinesia and rigidity and has generally improved gait and speech disturbances. In some cases tremor was attenuated. In a similar manner, the authors observed a marked diminution in levodopa-induced dyskinesias. This could be an excellent primary therapy for younger patients exhibiting severe bradykinesia. rigidity, and levodopa-induced dyskinesias, which would allow therapists to keep ventroposterolateral pallidotomy in reserve as a second weapon.</div>
</front>
</TEI>
</INIST>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High-frequency stimulation of the globus pallidus internalis in Parkinson's disease: a study of seven cases.</title>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C" last="Gross">C. Gross</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Neurophysiologie, Université Victor Segalen Bordeaux II, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Neurophysiologie, Université Victor Segalen Bordeaux II</wicri:regionArea>
<wicri:noRegion>Université Victor Segalen Bordeaux II</wicri:noRegion>
<wicri:noRegion>Université Victor Segalen Bordeaux II</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rougier, A" sort="Rougier, A" uniqKey="Rougier A" first="A" last="Rougier">A. Rougier</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T" last="Boraud">T. Boraud</name>
</author>
<author><name sortKey="Julien, J" sort="Julien, J" uniqKey="Julien J" first="J" last="Julien">J. Julien</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1997">1997</date>
<idno type="RBID">pubmed:9322838</idno>
<idno type="pmid">9322838</idno>
<idno type="doi">10.3171/jns.1997.87.4.0491</idno>
<idno type="wicri:Area/PubMed/Corpus">001513</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001513</idno>
<idno type="wicri:Area/PubMed/Curation">001472</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001472</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001472</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001472</idno>
<idno type="wicri:Area/Ncbi/Merge">001E82</idno>
<idno type="wicri:Area/Ncbi/Curation">001E82</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001E82</idno>
<idno type="wicri:doubleKey">0022-3085:1997:Gross C:high:frequency:stimulation</idno>
<idno type="wicri:Area/Main/Merge">004A24</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">High-frequency stimulation of the globus pallidus internalis in Parkinson's disease: a study of seven cases.</title>
<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C" last="Gross">C. Gross</name>
<affiliation wicri:level="1"><nlm:affiliation>Laboratoire de Neurophysiologie, Université Victor Segalen Bordeaux II, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Neurophysiologie, Université Victor Segalen Bordeaux II</wicri:regionArea>
<wicri:noRegion>Université Victor Segalen Bordeaux II</wicri:noRegion>
<wicri:noRegion>Université Victor Segalen Bordeaux II</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rougier, A" sort="Rougier, A" uniqKey="Rougier A" first="A" last="Rougier">A. Rougier</name>
</author>
<author><name sortKey="Guehl, D" sort="Guehl, D" uniqKey="Guehl D" first="D" last="Guehl">D. Guehl</name>
</author>
<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T" last="Boraud">T. Boraud</name>
</author>
<author><name sortKey="Julien, J" sort="Julien, J" uniqKey="Julien J" first="J" last="Julien">J. Julien</name>
</author>
<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
</author>
</analytic>
<series><title level="j">Journal of neurosurgery</title>
<idno type="ISSN">0022-3085</idno>
<imprint><date when="1997" type="published">1997</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Disease Progression</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Electric Stimulation Therapy (instrumentation)</term>
<term>Electric Stimulation Therapy (methods)</term>
<term>Electrodes, Implanted</term>
<term>Follow-Up Studies</term>
<term>Gait (physiology)</term>
<term>Globus Pallidus (physiopathology)</term>
<term>Globus Pallidus (surgery)</term>
<term>Humans</term>
<term>Hypokinesia (surgery)</term>
<term>Hypokinesia (therapy)</term>
<term>Levodopa (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Movement Disorders (therapy)</term>
<term>Muscle Rigidity (surgery)</term>
<term>Muscle Rigidity (therapy)</term>
<term>Parkinson Disease (etiology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (surgery)</term>
<term>Parkinson Disease (therapy)</term>
<term>Speech Disorders (therapy)</term>
<term>Stereotaxic Techniques</term>
<term>Thalamic Nuclei (physiopathology)</term>
<term>Treatment Outcome</term>
<term>Tremor (therapy)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electric Stimulation Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation Therapy</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gait</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Globus Pallidus</term>
<term>Parkinson Disease</term>
<term>Thalamic Nuclei</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Globus Pallidus</term>
<term>Hypokinesia</term>
<term>Muscle Rigidity</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Hypokinesia</term>
<term>Movement Disorders</term>
<term>Muscle Rigidity</term>
<term>Parkinson Disease</term>
<term>Speech Disorders</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Disease Progression</term>
<term>Electrodes, Implanted</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Stereotaxic Techniques</term>
<term>Treatment Outcome</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The effectiveness of ventroposterolateral pallidotomy in the treatment of akinesia and rigidity is not a new discovery and agrees with recent investigations into the pathogenesis of Parkinson's disease, which highlight the role played by the unbridled activity of the subthalamic nucleus (STN) and the consequent overactivity of the globus pallidus internalis (GPi). Because high-frequency stimulation can reversibly incapacitate a nerve structure, we applied stimulation to the same target. Seven patients suffering from severe Parkinson's disease (Stages III-V on the Hoehn and Yahr scale) and, particularly, bradykinesia, rigidity, and levodopa-induced dyskinesias underwent unilateral electrode implantation in the posteroventral GPi. Follow-up evaluation using the regular Unified Parkinson's Disease Rating Scale has been conducted for 1 year in all seven patients, 2 years in five of them, and 3 years in one. In all cases high-frequency stimulation has alleviated akinesia and rigidity and has generally improved gait and speech disturbances. In some cases tremor was attenuated. In a similar manner, the authors observed a marked diminution in levodopa-induced dyskinesias. This could be an excellent primary therapy for younger patients exhibiting severe bradykinesia, rigidity, and levodopa-induced dyskinesias, which would allow therapists to keep ventroposterolateral pallidotomy in reserve as a second weapon.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004435 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 004435 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Main |étape= Curation |type= RBID |clé= Pascal:97-0506440 |texte= High-frequency stimulation of the globus pallidus internalis in Parkinson's disease : a study of seven cases }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |