Acute interactions between l-DOPA and the neurotoxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine in mice
Identifieur interne : 003E45 ( Main/Curation ); précédent : 003E44; suivant : 003E46Acute interactions between l-DOPA and the neurotoxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine in mice
Auteurs : C. Cleren [France] ; C. Vilpoux [France] ; N. Dourmap [France] ; J.-J Bonnet [France] ; J. Costentin [France]Source :
- Brain Research [ 0006-8993 ] ; 1999.
English descriptors
- KwdEn :
Abstract
We have compared the effects of an i.p. pretreatment with l-DOPA (200 mg/kg) associated with benserazide (25 mg/kg) on neurotoxic effects of either 6-hydroxydopamine (6-OHDA) (50 μg, 10 μl per mouse) or 1-methyl-4-phenylpyridinium (MPP+) (17.5 μg, 10 μl per mouse). The striatal dopamine (DA) content, the vesicular monoamine transporter (VMAT2) density, as well as the hypothalamic norepinephrine (NE) content were measured 8 days after treatments. The l-DOPA–benserazide pretreatment worsened by 65% the 6-OHDA-induced depletion in striatal DA. On the contrary, it reduced by 42% the MPP+-induced depletion in striatal DA and by 54% the MPP+-induced decrease in VMAT2 density. It was noticed that the l-DOPA–benserazide pretreatment did not modify the marked decrease in hypothalamic NE content induced by 6-OHDA.
Url:
DOI: 10.1016/S0006-8993(99)01420-1
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A22
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :000A20
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001374
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004566
Links to Exploration step
ISTEX:2261F2F057DD049066721F2292C82F897D06F833Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Acute interactions between l-DOPA and the neurotoxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine in mice</title><author><name sortKey="Cleren, C" sort="Cleren, C" uniqKey="Cleren C" first="C" last="Cleren">C. Cleren</name></author><author><name sortKey="Vilpoux, C" sort="Vilpoux, C" uniqKey="Vilpoux C" first="C" last="Vilpoux">C. Vilpoux</name></author><author><name sortKey="Dourmap, N" sort="Dourmap, N" uniqKey="Dourmap N" first="N" last="Dourmap">N. Dourmap</name></author><author><name sortKey="Bonnet, J J" sort="Bonnet, J J" uniqKey="Bonnet J" first="J.-J" last="Bonnet">J.-J Bonnet</name></author><author><name sortKey="Costentin, J" sort="Costentin, J" uniqKey="Costentin J" first="J" last="Costentin">J. Costentin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2261F2F057DD049066721F2292C82F897D06F833</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0006-8993(99)01420-1</idno><idno type="url">https://api.istex.fr/document/2261F2F057DD049066721F2292C82F897D06F833/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000A22</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000A22</idno><idno type="wicri:Area/Istex/Curation">000A20</idno><idno type="wicri:Area/Istex/Checkpoint">001374</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001374</idno><idno type="wicri:doubleKey">0006-8993:1999:Cleren C:acute:interactions:between</idno><idno type="wicri:Area/Main/Merge">004566</idno><idno type="wicri:Area/Main/Curation">003E45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Acute interactions between l-DOPA and the neurotoxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine in mice</title><author><name sortKey="Cleren, C" sort="Cleren, C" uniqKey="Cleren C" first="C" last="Cleren">C. Cleren</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unité de Neuropsychopharmacologie Expérimentale, UPRES-A CNRS 6036, IFRMP N° 23, Site universitaire du Madrillet, Avenue de l'Université, 76800 Saint-Etienne du Rouvray</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Saint-Etienne du Rouvray</settlement></placeName></affiliation></author><author><name sortKey="Vilpoux, C" sort="Vilpoux, C" uniqKey="Vilpoux C" first="C" last="Vilpoux">C. Vilpoux</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unité de Neuropsychopharmacologie Expérimentale, UPRES-A CNRS 6036, IFRMP N° 23, Site universitaire du Madrillet, Avenue de l'Université, 76800 Saint-Etienne du Rouvray</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Saint-Etienne du Rouvray</settlement></placeName></affiliation></author><author><name sortKey="Dourmap, N" sort="Dourmap, N" uniqKey="Dourmap N" first="N" last="Dourmap">N. Dourmap</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unité de Neuropsychopharmacologie Expérimentale, UPRES-A CNRS 6036, IFRMP N° 23, Site universitaire du Madrillet, Avenue de l'Université, 76800 Saint-Etienne du Rouvray</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Saint-Etienne du Rouvray</settlement></placeName></affiliation></author><author><name sortKey="Bonnet, J J" sort="Bonnet, J J" uniqKey="Bonnet J" first="J.-J" last="Bonnet">J.-J Bonnet</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unité de Neuropsychopharmacologie Expérimentale, UPRES-A CNRS 6036, IFRMP N° 23, Site universitaire du Madrillet, Avenue de l'Université, 76800 Saint-Etienne du Rouvray</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Saint-Etienne du Rouvray</settlement></placeName></affiliation></author><author><name sortKey="Costentin, J" sort="Costentin, J" uniqKey="Costentin J" first="J" last="Costentin">J. Costentin</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unité de Neuropsychopharmacologie Expérimentale, UPRES-A CNRS 6036, IFRMP N° 23, Site universitaire du Madrillet, Avenue de l'Université, 76800 Saint-Etienne du Rouvray</wicri:regionArea><placeName><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region><settlement type="city">Saint-Etienne du Rouvray</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">830</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="314">314</biblScope><biblScope unit="page" to="319">319</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">2261F2F057DD049066721F2292C82F897D06F833</idno><idno type="DOI">10.1016/S0006-8993(99)01420-1</idno><idno type="PII">S0006-8993(99)01420-1</idno><idno type="ArticleID">15555</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenylpyridinium</term><term>6-Hydroxydopamine</term><term>Hypothalamic noradrenergic neuron</term><term>Neurotoxicity</term><term>Nigro-striatal dopaminergic neuron</term><term>Vesicular monoamine transporter type 2</term><term>l-DOPA</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have compared the effects of an i.p. pretreatment with l-DOPA (200 mg/kg) associated with benserazide (25 mg/kg) on neurotoxic effects of either 6-hydroxydopamine (6-OHDA) (50 μg, 10 μl per mouse) or 1-methyl-4-phenylpyridinium (MPP+) (17.5 μg, 10 μl per mouse). The striatal dopamine (DA) content, the vesicular monoamine transporter (VMAT2) density, as well as the hypothalamic norepinephrine (NE) content were measured 8 days after treatments. The l-DOPA–benserazide pretreatment worsened by 65% the 6-OHDA-induced depletion in striatal DA. On the contrary, it reduced by 42% the MPP+-induced depletion in striatal DA and by 54% the MPP+-induced decrease in VMAT2 density. It was noticed that the l-DOPA–benserazide pretreatment did not modify the marked decrease in hypothalamic NE content induced by 6-OHDA.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003E45 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 003E45 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:2261F2F057DD049066721F2292C82F897D06F833
|texte= Acute interactions between l-DOPA and the neurotoxic effects of 1-methyl-4-phenylpyridinium or 6-hydroxydopamine in mice
}}
| This area was generated with Dilib version V0.6.29. |  |