ParkinsonFranceV1, Main, Curation, bibRecord, 003996

Preservation of midbrain catecholaminergic neurons in very old human subjects

Identifieur interne : 003996 ( Main/Curation ); précédent : 003995; suivant : 003997

Preservation of midbrain catecholaminergic neurons in very old human subjects

Auteurs : N. Kubis ; B. A. Faucheux ; G. Ransmayr [Autriche] ; P. Damier ; C. Duyckaerts ; D. Henin ; B. Forette ; Y. Le Charpentier [France] ; J.-J. Hauw ; Yves Agid [France] ; E. C. Hirsch

Source :

Brain [ 0006-8950 ] ; 2000-02.

RBID : ISTEX:58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147

Descripteurs français

Pascal (Inist)
- Adulte, Age, Analyse quantitative, Evolution, Immunohistochimie, Neurone catécholaminergique, Personne âgée, Physiologie, Sénescence, Tronc cérébral, Tyrosine 3-monooxygenase.
Wicri :
- topic : Adulte, Analyse quantitative, Personne âgée.

English descriptors

KwdEn :
- A8 = peri- and retro-rubral catecholaminergic cell group A8, AChE = acetylcholinesterase, Adult, Age, Aged, Aged, 80 and over, Aging (physiology), Brain Stem (pathology), Brain stem, CGS = central grey substance, Catecholaminergic neuron, Catecholamines (physiology), Cell Death, Elderly, Evolution, Female, Humans, Immunohistochemistry, LC = locus coeruleus, Male, Middle Aged, Neurons (metabolism), Neurons (pathology), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Physiology, Quantitative analysis, SNpc = substantia nigra pars compacta, Senescence, TH = tyrosine hydroxylase, Tyrosine 3-monooxygenase, VTA = ventral tegmental area, ageing, human, substantia nigra, tyrosine hydroxylase.
MESH :
- chemical , physiology : Catecholamines.
- metabolism : Neurons.
- pathology : Brain Stem, Neurons, Parkinson Disease.
- physiology : Aging.
- physiopathology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Cell Death, Female, Humans, Immunohistochemistry, Male, Middle Aged.

Abstract

Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the midbrain, yet the cause of this neuronal loss is still unknown. It has been hypothesized that Parkinson's disease could be the consequence of accelerated ageing. In order to reveal a possible common process during ageing and Parkinson's disease neurodegeneration, catecholaminergic neurons of five anatomical regions of the brainstem (substantia nigra, central grey substance, ventral tegmental area, peri- and retrorubral area, and locus coeruleus) have been quantified using immunohistochemical staining for tyrosine hydroxylase (TH) on regularly spaced sections, between the rostral and caudal poles of the mesencephalon and in the rostral pole of the pons, in post-mortem samples of 21 control subjects who died at ages 44–110 years. No statistically significant loss of TH positive neurons was observed in the older subjects, either in the substantia nigra or in the other midbrain regions that are known to degenerate to a lesser degree in Parkinson's disease. Furthermore, in the later regions no neuronal loss was observed from age 44 to 80 years, indicating that this result is not dependent on the inclusion of `supernormal' very old people. These results suggest that from age 44 to 110 years, ageing in control adults is not, or is scarcely, accompanied by catecholaminergic cell loss in the midbrain and hence Parkinson's disease is probably not caused by an acceleration of a degenerative process during ageing.

Url:

https://api.istex.fr/document/58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147/fulltext/pdf

DOI: 10.1093/brain/123.2.366

Links toward previous steps (curation, corpus...)

to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002315
to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :002313
to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001088
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004046
to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001420
to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :000018
to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001185
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :004222
to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001347
to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001306
to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001306
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000086
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000086
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000086
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :003E82

Links to Exploration step

ISTEX:58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147

Curation

No country items

N. Kubis

<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>

B. A. Faucheux

<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>

P. Damier

<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>

C. Duyckaerts

<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>

D. Henin

<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>

B. Forette

<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>

J.-J. Hauw

<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>

Yves Agid

<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>

E. C. Hirsch

<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preservation of midbrain catecholaminergic neurons in very old human subjects</title>
<author><name sortKey="Kubis, N" sort="Kubis, N" uniqKey="Kubis N" first="N." last="Kubis">N. Kubis</name>
</author>
<author><name sortKey="Faucheux, B A" sort="Faucheux, B A" uniqKey="Faucheux B" first="B. A." last="Faucheux">B. A. Faucheux</name>
</author>
<author><name sortKey="Ransmayr, G" sort="Ransmayr, G" uniqKey="Ransmayr G" first="G." last="Ransmayr">G. Ransmayr</name>
</author>
<author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name>
</author>
<author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C." last="Duyckaerts">C. Duyckaerts</name>
</author>
<author><name sortKey="Henin, D" sort="Henin, D" uniqKey="Henin D" first="D." last="Henin">D. Henin</name>
</author>
<author><name sortKey="Forette, B" sort="Forette, B" uniqKey="Forette B" first="B." last="Forette">B. Forette</name>
</author>
<author><name sortKey="Le Charpentier, Y" sort="Le Charpentier, Y" uniqKey="Le Charpentier Y" first="Y." last="Le Charpentier">Y. Le Charpentier</name>
</author>
<author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J.-J." last="Hauw">J.-J. Hauw</name>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1093/brain/123.2.366</idno>
<idno type="url">https://api.istex.fr/document/58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002315</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002315</idno>
<idno type="wicri:Area/Istex/Curation">002313</idno>
<idno type="wicri:Area/Istex/Checkpoint">001088</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001088</idno>
<idno type="wicri:doubleKey">0006-8950:2000:Kubis N:preservation:of:midbrain</idno>
<idno type="wicri:Area/Main/Merge">004046</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:00-0094542</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001420</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000018</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001185</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001185</idno>
<idno type="wicri:doubleKey">0006-8950:2000:Kubis N:preservation:of:midbrain</idno>
<idno type="wicri:Area/Main/Merge">004222</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:10648443</idno>
<idno type="wicri:Area/PubMed/Corpus">001347</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001347</idno>
<idno type="wicri:Area/PubMed/Curation">001306</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001306</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001306</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001306</idno>
<idno type="wicri:Area/Ncbi/Merge">000086</idno>
<idno type="wicri:Area/Ncbi/Curation">000086</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000086</idno>
<idno type="wicri:doubleKey">0006-8950:2000:Kubis N:preservation:of:midbrain</idno>
<idno type="wicri:Area/Main/Merge">003E82</idno>
<idno type="wicri:Area/Main/Curation">003996</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Preservation of midbrain catecholaminergic neurons in very old human subjects</title>
<author><name sortKey="Kubis, N" sort="Kubis, N" uniqKey="Kubis N" first="N." last="Kubis">N. Kubis</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Faucheux, B A" sort="Faucheux, B A" uniqKey="Faucheux B" first="B. A." last="Faucheux">B. A. Faucheux</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ransmayr, G" sort="Ransmayr, G" uniqKey="Ransmayr G" first="G." last="Ransmayr">G. Ransmayr</name>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Universität Klinik für Neurologie, Innsbrück</wicri:regionArea>
<wicri:noRegion>Innsbrück</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C." last="Duyckaerts">C. Duyckaerts</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Henin, D" sort="Henin, D" uniqKey="Henin D" first="D." last="Henin">D. Henin</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Forette, B" sort="Forette, B" uniqKey="Forette B" first="B." last="Forette">B. Forette</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Le Charpentier, Y" sort="Le Charpentier, Y" uniqKey="Le Charpentier Y" first="Y." last="Le Charpentier">Y. Le Charpentier</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Anatomo-Pathologie, Hôpital de la Pitié, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J.-J." last="Hauw">J.-J. Hauw</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain</title>
<title level="j" type="abbrev">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="2000-02">2000-02</date>
<biblScope unit="volume">123</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="366">366</biblScope>
<biblScope unit="page" to="373">373</biblScope>
</imprint>
<idno type="ISSN">0006-8950</idno>
</series>
<idno type="istex">58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147</idno>
<idno type="DOI">10.1093/brain/123.2.366</idno>
<idno type="PII">1460-2156</idno>
<idno type="local">1230366</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A8 = peri- and retro-rubral catecholaminergic cell group A8</term>
<term>AChE = acetylcholinesterase</term>
<term>Adult</term>
<term>Age</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging (physiology)</term>
<term>Brain Stem (pathology)</term>
<term>Brain stem</term>
<term>CGS = central grey substance</term>
<term>Catecholaminergic neuron</term>
<term>Catecholamines (physiology)</term>
<term>Cell Death</term>
<term>Elderly</term>
<term>Evolution</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>LC = locus coeruleus</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurons (metabolism)</term>
<term>Neurons (pathology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Physiology</term>
<term>Quantitative analysis</term>
<term>SNpc = substantia nigra pars compacta</term>
<term>Senescence</term>
<term>TH = tyrosine hydroxylase</term>
<term>Tyrosine 3-monooxygenase</term>
<term>VTA = ventral tegmental area</term>
<term>ageing</term>
<term>human</term>
<term>substantia nigra</term>
<term>tyrosine hydroxylase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Catecholamines</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Stem</term>
<term>Neurons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cell Death</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adulte</term>
<term>Age</term>
<term>Analyse quantitative</term>
<term>Evolution</term>
<term>Immunohistochimie</term>
<term>Neurone catécholaminergique</term>
<term>Personne âgée</term>
<term>Physiologie</term>
<term>Sénescence</term>
<term>Tronc cérébral</term>
<term>Tyrosine 3-monooxygenase</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term>
<term>Analyse quantitative</term>
<term>Personne âgée</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the midbrain, yet the cause of this neuronal loss is still unknown. It has been hypothesized that Parkinson's disease could be the consequence of accelerated ageing. In order to reveal a possible common process during ageing and Parkinson's disease neurodegeneration, catecholaminergic neurons of five anatomical regions of the brainstem (substantia nigra, central grey substance, ventral tegmental area, peri- and retrorubral area, and locus coeruleus) have been quantified using immunohistochemical staining for tyrosine hydroxylase (TH) on regularly spaced sections, between the rostral and caudal poles of the mesencephalon and in the rostral pole of the pons, in post-mortem samples of 21 control subjects who died at ages 44–110 years. No statistically significant loss of TH positive neurons was observed in the older subjects, either in the substantia nigra or in the other midbrain regions that are known to degenerate to a lesser degree in Parkinson's disease. Furthermore, in the later regions no neuronal loss was observed from age 44 to 80 years, indicating that this result is not dependent on the inclusion of `supernormal' very old people. These results suggest that from age 44 to 110 years, ageing in control adults is not, or is scarcely, accompanied by catecholaminergic cell loss in the midbrain and hence Parkinson's disease is probably not caused by an acceleration of a degenerative process during ageing.</div>
</front>
</TEI>
<double idat="0006-8950:2000:Kubis N:preservation:of:midbrain"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Preservation of midbrain catecholaminergic neurons in very old human subjects</title>
<author><name sortKey="Kubis, N" sort="Kubis, N" uniqKey="Kubis N" first="N." last="Kubis">N. Kubis</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Faucheux, B A" sort="Faucheux, B A" uniqKey="Faucheux B" first="B. A." last="Faucheux">B. A. Faucheux</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ransmayr, G" sort="Ransmayr, G" uniqKey="Ransmayr G" first="G." last="Ransmayr">G. Ransmayr</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Universität Klinik für Neurologie</s1>
<s2>Innsbrück</s2>
<s3>AUT</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Universität Klinik für Neurologie</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C." last="Duyckaerts">C. Duyckaerts</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratoire de Neuropathologie R. Escourolle, INSERM U360, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>Laboratoire de Neuropathologie R. Escourolle, INSERM U360, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Henin, D" sort="Henin, D" uniqKey="Henin D" first="D." last="Henin">D. Henin</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Service d'Anatomo-Pathologie, Hôpital Bichat</s1>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital Bichat</wicri:noRegion>
<wicri:noRegion>Service d'Anatomo-Pathologie, Hôpital Bichat</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Forette, B" sort="Forette, B" uniqKey="Forette B" first="B." last="Forette">B. Forette</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Service de Gériatrie, Hôpital Sainte-Périne</s1>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital Sainte-Périne</wicri:noRegion>
<wicri:noRegion>Service de Gériatrie, Hôpital Sainte-Périne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Le Charpentier, Y" sort="Le Charpentier, Y" uniqKey="Le Charpentier Y" first="Y." last="Le Charpentier">Y. Le Charpentier</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Service d'Anatomo-Pathologie, Hôpital de la Pitié</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J.-J." last="Hauw">J.-J. Hauw</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratoire de Neuropathologie R. Escourolle, INSERM U360, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>Laboratoire de Neuropathologie R. Escourolle, INSERM U360, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">00-0094542</idno>
<date when="2000">2000</date>
<idno type="stanalyst">PASCAL 00-0094542 INIST</idno>
<idno type="RBID">Pascal:00-0094542</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001420</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000018</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001185</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001185</idno>
<idno type="wicri:doubleKey">0006-8950:2000:Kubis N:preservation:of:midbrain</idno>
<idno type="wicri:Area/Main/Merge">004222</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Preservation of midbrain catecholaminergic neurons in very old human subjects</title>
<author><name sortKey="Kubis, N" sort="Kubis, N" uniqKey="Kubis N" first="N." last="Kubis">N. Kubis</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Faucheux, B A" sort="Faucheux, B A" uniqKey="Faucheux B" first="B. A." last="Faucheux">B. A. Faucheux</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ransmayr, G" sort="Ransmayr, G" uniqKey="Ransmayr G" first="G." last="Ransmayr">G. Ransmayr</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Universität Klinik für Neurologie</s1>
<s2>Innsbrück</s2>
<s3>AUT</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Universität Klinik für Neurologie</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C." last="Duyckaerts">C. Duyckaerts</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratoire de Neuropathologie R. Escourolle, INSERM U360, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>Laboratoire de Neuropathologie R. Escourolle, INSERM U360, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Henin, D" sort="Henin, D" uniqKey="Henin D" first="D." last="Henin">D. Henin</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Service d'Anatomo-Pathologie, Hôpital Bichat</s1>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital Bichat</wicri:noRegion>
<wicri:noRegion>Service d'Anatomo-Pathologie, Hôpital Bichat</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Forette, B" sort="Forette, B" uniqKey="Forette B" first="B." last="Forette">B. Forette</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Service de Gériatrie, Hôpital Sainte-Périne</s1>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital Sainte-Périne</wicri:noRegion>
<wicri:noRegion>Service de Gériatrie, Hôpital Sainte-Périne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Le Charpentier, Y" sort="Le Charpentier, Y" uniqKey="Le Charpentier Y" first="Y." last="Le Charpentier">Y. Le Charpentier</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Service d'Anatomo-Pathologie, Hôpital de la Pitié</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J.-J." last="Hauw">J.-J. Hauw</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Laboratoire de Neuropathologie R. Escourolle, INSERM U360, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>Laboratoire de Neuropathologie R. Escourolle, INSERM U360, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>INSERM U289, Hôpital de la Salpêtrière</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Hôpital de la Salpêtrière</wicri:noRegion>
<wicri:noRegion>INSERM U289, Hôpital de la Salpêtrière</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Brain</title>
<title level="j" type="abbreviated">Brain</title>
<idno type="ISSN">0006-8950</idno>
<imprint><date when="2000">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Brain</title>
<title level="j" type="abbreviated">Brain</title>
<idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age</term>
<term>Brain stem</term>
<term>Catecholaminergic neuron</term>
<term>Elderly</term>
<term>Evolution</term>
<term>Immunohistochemistry</term>
<term>Physiology</term>
<term>Quantitative analysis</term>
<term>Senescence</term>
<term>Tyrosine 3-monooxygenase</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Sénescence</term>
<term>Age</term>
<term>Neurone catécholaminergique</term>
<term>Analyse quantitative</term>
<term>Tronc cérébral</term>
<term>Immunohistochimie</term>
<term>Tyrosine 3-monooxygenase</term>
<term>Physiologie</term>
<term>Evolution</term>
<term>Adulte</term>
<term>Personne âgée</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Analyse quantitative</term>
<term>Adulte</term>
<term>Personne âgée</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the midbrain, yet the cause of this neuronal loss is still unknown. It has been hypothesized that Parkinson's disease could be the consequence of accelerated ageing. In order to reveal a possible common process during ageing and Parkinson's disease neurodegeneration, catecholaminergic neurons of five anatomical regions of the brainstem (substantia nigra, central grey substance, ventral tegmental area, periand retrorubral area, and locus coeruleus) have been quantified using immunohistochemical staining for tyrosine hydroxylase (TH) on regularly spaced sections, between the rostral and caudal poles of the mesencephalon and in the rostral pole of the pons, in post-mortem samples of 21 control subjects who died at ages 44-110 years. No statistically significant loss of TH positive neurons was observed in the older subjects, either in the substantia nigra or in the other midbrain regions that are known to degenerate to a lesser degree in Parkinson's disease. Furthermore, in the later regions no neuronal loss was observed from age 44 to 80 years, indicating that this result is not dependent on the inclusion of 'supernormal' very old people. These results suggest that from age 44 to 110 years, ageing in control adults is not, or is scarcely, accompanied by catecholaminergic cell loss in the midbrain and hence Parkinson's disease is probably not caused by an acceleration of a degenerative process during ageing.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preservation of midbrain catecholaminergic neurons in very old human subjects</title>
<author><name sortKey="Kubis, N" sort="Kubis, N" uniqKey="Kubis N" first="N." last="Kubis">N. Kubis</name>
</author>
<author><name sortKey="Faucheux, B A" sort="Faucheux, B A" uniqKey="Faucheux B" first="B. A." last="Faucheux">B. A. Faucheux</name>
</author>
<author><name sortKey="Ransmayr, G" sort="Ransmayr, G" uniqKey="Ransmayr G" first="G." last="Ransmayr">G. Ransmayr</name>
</author>
<author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name>
</author>
<author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C." last="Duyckaerts">C. Duyckaerts</name>
</author>
<author><name sortKey="Henin, D" sort="Henin, D" uniqKey="Henin D" first="D." last="Henin">D. Henin</name>
</author>
<author><name sortKey="Forette, B" sort="Forette, B" uniqKey="Forette B" first="B." last="Forette">B. Forette</name>
</author>
<author><name sortKey="Le Charpentier, Y" sort="Le Charpentier, Y" uniqKey="Le Charpentier Y" first="Y." last="Le Charpentier">Y. Le Charpentier</name>
</author>
<author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J.-J." last="Hauw">J.-J. Hauw</name>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1093/brain/123.2.366</idno>
<idno type="url">https://api.istex.fr/document/58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002315</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002315</idno>
<idno type="wicri:Area/Istex/Curation">002313</idno>
<idno type="wicri:Area/Istex/Checkpoint">001088</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001088</idno>
<idno type="wicri:doubleKey">0006-8950:2000:Kubis N:preservation:of:midbrain</idno>
<idno type="wicri:Area/Main/Merge">004046</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Preservation of midbrain catecholaminergic neurons in very old human subjects</title>
<author><name sortKey="Kubis, N" sort="Kubis, N" uniqKey="Kubis N" first="N." last="Kubis">N. Kubis</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Faucheux, B A" sort="Faucheux, B A" uniqKey="Faucheux B" first="B. A." last="Faucheux">B. A. Faucheux</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ransmayr, G" sort="Ransmayr, G" uniqKey="Ransmayr G" first="G." last="Ransmayr">G. Ransmayr</name>
<affiliation wicri:level="1"><country xml:lang="fr">Autriche</country>
<wicri:regionArea>Universität Klinik für Neurologie, Innsbrück</wicri:regionArea>
<wicri:noRegion>Innsbrück</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C." last="Duyckaerts">C. Duyckaerts</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Henin, D" sort="Henin, D" uniqKey="Henin D" first="D." last="Henin">D. Henin</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Forette, B" sort="Forette, B" uniqKey="Forette B" first="B." last="Forette">B. Forette</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Le Charpentier, Y" sort="Le Charpentier, Y" uniqKey="Le Charpentier Y" first="Y." last="Le Charpentier">Y. Le Charpentier</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Service d'Anatomo-Pathologie, Hôpital de la Pitié, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J.-J." last="Hauw">J.-J. Hauw</name>
<affiliation><wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y." last="Agid">Yves Agid</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E. C." last="Hirsch">E. C. Hirsch</name>
<affiliation><wicri:noCountry code="no comma">INSERM U289 and</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain</title>
<title level="j" type="abbrev">Brain</title>
<idno type="ISSN">0006-8950</idno>
<idno type="eISSN">1460-2156</idno>
<imprint><publisher>Oxford University Press</publisher>
<date type="published" when="2000-02">2000-02</date>
<biblScope unit="volume">123</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="366">366</biblScope>
<biblScope unit="page" to="373">373</biblScope>
</imprint>
<idno type="ISSN">0006-8950</idno>
</series>
<idno type="istex">58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147</idno>
<idno type="DOI">10.1093/brain/123.2.366</idno>
<idno type="PII">1460-2156</idno>
<idno type="local">1230366</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0006-8950</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A8 = peri- and retro-rubral catecholaminergic cell group A8</term>
<term>AChE = acetylcholinesterase</term>
<term>CGS = central grey substance</term>
<term>LC = locus coeruleus</term>
<term>SNpc = substantia nigra pars compacta</term>
<term>TH = tyrosine hydroxylase</term>
<term>VTA = ventral tegmental area</term>
<term>ageing</term>
<term>human</term>
<term>substantia nigra</term>
<term>tyrosine hydroxylase</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the midbrain, yet the cause of this neuronal loss is still unknown. It has been hypothesized that Parkinson's disease could be the consequence of accelerated ageing. In order to reveal a possible common process during ageing and Parkinson's disease neurodegeneration, catecholaminergic neurons of five anatomical regions of the brainstem (substantia nigra, central grey substance, ventral tegmental area, peri- and retrorubral area, and locus coeruleus) have been quantified using immunohistochemical staining for tyrosine hydroxylase (TH) on regularly spaced sections, between the rostral and caudal poles of the mesencephalon and in the rostral pole of the pons, in post-mortem samples of 21 control subjects who died at ages 44–110 years. No statistically significant loss of TH positive neurons was observed in the older subjects, either in the substantia nigra or in the other midbrain regions that are known to degenerate to a lesser degree in Parkinson's disease. Furthermore, in the later regions no neuronal loss was observed from age 44 to 80 years, indicating that this result is not dependent on the inclusion of `supernormal' very old people. These results suggest that from age 44 to 110 years, ageing in control adults is not, or is scarcely, accompanied by catecholaminergic cell loss in the midbrain and hence Parkinson's disease is probably not caused by an acceleration of a degenerative process during ageing.</div>
</front>
</TEI>
</ISTEX>
<PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Preservation of midbrain catecholaminergic neurons in very old human subjects.</title>
<author><name sortKey="Kubis, N" sort="Kubis, N" uniqKey="Kubis N" first="N" last="Kubis">N. Kubis</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U289 Hôpital de la Salpêtrière, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U289 Hôpital de la Salpêtrière, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Faucheux, B A" sort="Faucheux, B A" uniqKey="Faucheux B" first="B A" last="Faucheux">B A Faucheux</name>
</author>
<author><name sortKey="Ransmayr, G" sort="Ransmayr, G" uniqKey="Ransmayr G" first="G" last="Ransmayr">G. Ransmayr</name>
</author>
<author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P" last="Damier">P. Damier</name>
</author>
<author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C" last="Duyckaerts">C. Duyckaerts</name>
</author>
<author><name sortKey="Henin, D" sort="Henin, D" uniqKey="Henin D" first="D" last="Henin">D. Henin</name>
</author>
<author><name sortKey="Forette, B" sort="Forette, B" uniqKey="Forette B" first="B" last="Forette">B. Forette</name>
</author>
<author><name sortKey="Le Charpentier, Y" sort="Le Charpentier, Y" uniqKey="Le Charpentier Y" first="Y" last="Le Charpentier">Y. Le Charpentier</name>
</author>
<author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J J" last="Hauw">J J Hauw</name>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E C" last="Hirsch">E C Hirsch</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2000">2000</date>
<idno type="RBID">pubmed:10648443</idno>
<idno type="pmid">10648443</idno>
<idno type="wicri:Area/PubMed/Corpus">001347</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001347</idno>
<idno type="wicri:Area/PubMed/Curation">001306</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001306</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001306</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001306</idno>
<idno type="wicri:Area/Ncbi/Merge">000086</idno>
<idno type="wicri:Area/Ncbi/Curation">000086</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000086</idno>
<idno type="wicri:doubleKey">0006-8950:2000:Kubis N:preservation:of:midbrain</idno>
<idno type="wicri:Area/Main/Merge">003E82</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Preservation of midbrain catecholaminergic neurons in very old human subjects.</title>
<author><name sortKey="Kubis, N" sort="Kubis, N" uniqKey="Kubis N" first="N" last="Kubis">N. Kubis</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM U289 Hôpital de la Salpêtrière, Paris, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U289 Hôpital de la Salpêtrière, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Faucheux, B A" sort="Faucheux, B A" uniqKey="Faucheux B" first="B A" last="Faucheux">B A Faucheux</name>
</author>
<author><name sortKey="Ransmayr, G" sort="Ransmayr, G" uniqKey="Ransmayr G" first="G" last="Ransmayr">G. Ransmayr</name>
</author>
<author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P" last="Damier">P. Damier</name>
</author>
<author><name sortKey="Duyckaerts, C" sort="Duyckaerts, C" uniqKey="Duyckaerts C" first="C" last="Duyckaerts">C. Duyckaerts</name>
</author>
<author><name sortKey="Henin, D" sort="Henin, D" uniqKey="Henin D" first="D" last="Henin">D. Henin</name>
</author>
<author><name sortKey="Forette, B" sort="Forette, B" uniqKey="Forette B" first="B" last="Forette">B. Forette</name>
</author>
<author><name sortKey="Le Charpentier, Y" sort="Le Charpentier, Y" uniqKey="Le Charpentier Y" first="Y" last="Le Charpentier">Y. Le Charpentier</name>
</author>
<author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J J" last="Hauw">J J Hauw</name>
</author>
<author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
</placeName>
<orgName type="hospital" n="4">Hôpital de la Salpêtrière</orgName>
</affiliation>
</author>
<author><name sortKey="Hirsch, E C" sort="Hirsch, E C" uniqKey="Hirsch E" first="E C" last="Hirsch">E C Hirsch</name>
</author>
</analytic>
<series><title level="j">Brain : a journal of neurology</title>
<idno type="ISSN">0006-8950</idno>
<imprint><date when="2000" type="published">2000</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging (physiology)</term>
<term>Brain Stem (pathology)</term>
<term>Catecholamines (physiology)</term>
<term>Cell Death</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neurons (metabolism)</term>
<term>Neurons (pathology)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Catecholamines</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain Stem</term>
<term>Neurons</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cell Death</term>
<term>Female</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Male</term>
<term>Middle Aged</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Parkinson's disease is characterized by a progressive degeneration of dopaminergic neurons in the midbrain, yet the cause of this neuronal loss is still unknown. It has been hypothesized that Parkinson's disease could be the consequence of accelerated ageing. In order to reveal a possible common process during ageing and Parkinson's disease neurodegeneration, catecholaminergic neurons of five anatomical regions of the brainstem (substantia nigra, central grey substance, ventral tegmental area, peri- and retrorubral area, and locus coeruleus) have been quantified using immunohistochemical staining for tyrosine hydroxylase (TH) on regularly spaced sections, between the rostral and caudal poles of the mesencephalon and in the rostral pole of the pons, in post-mortem samples of 21 control subjects who died at ages 44-110 years. No statistically significant loss of TH positive neurons was observed in the older subjects, either in the substantia nigra or in the other midbrain regions that are known to degenerate to a lesser degree in Parkinson's disease. Furthermore, in the later regions no neuronal loss was observed from age 44 to 80 years, indicating that this result is not dependent on the inclusion of 'supernormal' very old people. These results suggest that from age 44 to 110 years, ageing in control adults is not, or is scarcely, accompanied by catecholaminergic cell loss in the midbrain and hence Parkinson's disease is probably not caused by an acceleration of a degenerative process during ageing.</div>
</front>
</TEI>
</PubMed>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003996 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 003996 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     ISTEX:58AD85E646F93D5D47E891CD8CBB2ED4C4CBF147
   |texte=   Preservation of midbrain catecholaminergic neurons in very old human subjects
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Preservation of midbrain catecholaminergic neurons in very old human subjects

Preservation of midbrain catecholaminergic neurons in very old human subjects

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Curation

No country items

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri