ParkinsonFranceV1, Main, Curation, bibRecord, 003257

Heart rate variability and Parkinson's disease severity

Identifieur interne : 003257 ( Main/Curation ); précédent : 003256; suivant : 003258

Heart rate variability and Parkinson's disease severity

Auteurs : D. Devos [France] ; M. Kroumova [France] ; R. Bordet [France] ; H. Vodougnon [France] ; J. D. Guieu [France] ; C. Libersa [France] ; A. Destee [France]

Source :

Journal of neural transmission [ 0300-9564 ] ; 2003.

RBID : Pascal:04-0220992

Descripteurs français

Pascal (Inist)
- Rythme cardiaque, Système nerveux autonome, Parkinson maladie.

English descriptors

KwdEn :
- Autonomic Nervous System Diseases (diagnosis), Autonomic Nervous System Diseases (etiology), Autonomic Nervous System Diseases (physiopathology), Autonomic nervous system, Cardiovascular System (physiopathology), Chronobiology Disorders (diagnosis), Chronobiology Disorders (etiology), Chronobiology Disorders (physiopathology), Disease Progression, Female, Heart Rate (drug effects), Heart Rate (physiology), Heart rate, Humans, Hypokinesia (complications), Hypokinesia (drug therapy), Hypokinesia (physiopathology), Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Surveys and Questionnaires, Sympathetic Nervous System (physiopathology), Up-Regulation (drug effects), Up-Regulation (physiology), Vagus Nerve (physiopathology).
MESH :
- chemical , therapeutic use : Levodopa.
- complications : Hypokinesia, Parkinson Disease.
- diagnosis : Autonomic Nervous System Diseases, Chronobiology Disorders.
- drug effects : Heart Rate, Up-Regulation.
- drug therapy : Hypokinesia, Parkinson Disease.
- etiology : Autonomic Nervous System Diseases, Chronobiology Disorders.
- physiology : Heart Rate, Up-Regulation.
- physiopathology : Autonomic Nervous System Diseases, Cardiovascular System, Chronobiology Disorders, Hypokinesia, Parkinson Disease, Sympathetic Nervous System, Vagus Nerve.
- Disease Progression, Female, Humans, Male, Middle Aged, Surveys and Questionnaires.

Abstract

Heart rate variability (HRV) decrease in Parkinson's disease (PD) could only be a consequence of reduce motor activity besides of being a marker of cardiovascular dysautonomia. Under continuously recorded and standardised motor activity, we studied thirty patients compared to controls in 3 PD stages: group I: less than 2 year-evolution, slight impaired without L-dopa; group II: mildly impaired with L-dopa; group III: advanced PD with motor complications. No difference was observed between group I and controls. The diurnal low frequency power (LF) and the ratio of LF/high frequency (HF) power decreased in groups II and III. The nocturnal vagal indicators: HF power and pNN50 were decreased in group III. Those parameters were correlated with Off-drug-motor handicap, suggesting an evolutive HRV decrease with disease severity but not with On-drug-motor activity. The low LF despite the higher motor activity in group III, due to dyskinesias, suggested a defective cardiovascular up-regulation.

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autonomic Nervous System Diseases (diagnosis)</term>
<term>Autonomic Nervous System Diseases (etiology)</term>
<term>Autonomic Nervous System Diseases (physiopathology)</term>
<term>Autonomic nervous system</term>
<term>Cardiovascular System (physiopathology)</term>
<term>Chronobiology Disorders (diagnosis)</term>
<term>Chronobiology Disorders (etiology)</term>
<term>Chronobiology Disorders (physiopathology)</term>
<term>Disease Progression</term>
<term>Female</term>
<term>Heart Rate (drug effects)</term>
<term>Heart Rate (physiology)</term>
<term>Heart rate</term>
<term>Humans</term>
<term>Hypokinesia (complications)</term>
<term>Hypokinesia (drug therapy)</term>
<term>Hypokinesia (physiopathology)</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Surveys and Questionnaires</term>
<term>Sympathetic Nervous System (physiopathology)</term>
<term>Up-Regulation (drug effects)</term>
<term>Up-Regulation (physiology)</term>
<term>Vagus Nerve (physiopathology)</term>
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<term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Autonomic Nervous System Diseases</term>
<term>Chronobiology Disorders</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Heart Rate</term>
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<keywords scheme="MESH" xml:lang="en"><term>Disease Progression</term>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Surveys and Questionnaires</term>
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<term>Système nerveux autonome</term>
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<front><div type="abstract" xml:lang="en">Heart rate variability (HRV) decrease in Parkinson's disease (PD) could only be a consequence of reduce motor activity besides of being a marker of cardiovascular dysautonomia. Under continuously recorded and standardised motor activity, we studied thirty patients compared to controls in 3 PD stages: group I: less than 2 year-evolution, slight impaired without L-dopa; group II: mildly impaired with L-dopa; group III: advanced PD with motor complications. No difference was observed between group I and controls. The diurnal low frequency power (LF) and the ratio of LF/high frequency (HF) power decreased in groups II and III. The nocturnal vagal indicators: HF power and pNN50 were decreased in group III. Those parameters were correlated with Off-drug-motor handicap, suggesting an evolutive HRV decrease with disease severity but not with On-drug-motor activity. The low LF despite the higher motor activity in group III, due to dyskinesias, suggested a defective cardiovascular up-regulation.</div>
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<series><title level="j" type="main">Journal of neural transmission</title>
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<front><div type="abstract" xml:lang="en">Heart rate variability (HRV) decrease in Parkinson's disease (PD) could only be a consequence of reduce motor activity besides of being a marker of cardiovascular dysautonomia. Under continuously recorded and standardised motor activity, we studied thirty patients compared to controls in 3 PD stages: group I: less than 2 year-evolution, slight impaired without L-dopa; group II: mildly impaired with L-dopa; group III: advanced PD with motor complications. No difference was observed between group I and controls. The diurnal low frequency power (LF) and the ratio of LF/high frequency (HF) power decreased in groups II and III. The nocturnal vagal indicators: HF power and pNN50 were decreased in group III. Those parameters were correlated with Off-drug-motor handicap, suggesting an evolutive HRV decrease with disease severity but not with On-drug-motor activity. The low LF despite the higher motor activity in group III, due to dyskinesias, suggested a defective cardiovascular up-regulation.</div>
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<front><div type="abstract" xml:lang="en">Heart rate variability (HRV) decrease in Parkinson's disease (PD) could only be a consequence of reduce motor activity besides of being a marker of cardiovascular dysautonomia. Under continuously recorded and standardised motor activity, we studied thirty patients compared to controls in 3 PD stages: group I: less than 2 year-evolution, slight impaired without L-dopa; group II: mildly impaired with L-dopa; group III: advanced PD with motor complications. No difference was observed between group I and controls. The diurnal low frequency power (LF) and the ratio of LF/high frequency (HF) power decreased in groups II and III. The nocturnal vagal indicators: HF power and pNN50 were decreased in group III. Those parameters were correlated with Off-drug-motor handicap, suggesting an evolutive HRV decrease with disease severity but not with On-drug-motor activity. The low LF despite the higher motor activity in group III, due to dyskinesias, suggested a defective cardiovascular up-regulation.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Heart rate variability and Parkinson's disease severity

Heart rate variability and Parkinson's disease severity

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