Stabilization and enhancement of interleukin-2 in vitro bioactivity by new carriers: supramolecular biovectors
Identifieur interne : 000F10 ( Istex/Curation ); précédent : 000F09; suivant : 000F11Stabilization and enhancement of interleukin-2 in vitro bioactivity by new carriers: supramolecular biovectors
Auteurs : Nathalie Castignolles [France] ; Didier Betbeder [France] ; Karim Ioualalen [France] ; Otto Merten [France] ; Claude Leclerc [France] ; Daniel Samain [France] ; Pierre Perrin [France]Source :
- Vaccine [ 0264-410X ] ; 1994.
Abstract
Human recombinant interleukin-2 can be associated and released from supramolecular biovectors (SMBVs), consisting of particles made of polymerized polysaccharides. The particles are substituted with phosphate residues and contain bound lipid molecules (palmitic acid) buried near their surfaces. The association of IL-2 with SMBVs modifies its in vitro bioactivity. SMBVs prolong the growth of IL-2-dependent cells, enhance IL-2 proliferative activity and restore the activity of impaired IL-2. These properties mainly depend on the presence of lipids linked to the SMBV and on both the degree of acylation and the SMBV:IL-2 ratio. SMBVs are therefore good candidates for the stabilization and enhancement of the biological activity of IL-2.
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DOI: 10.1016/0264-410X(94)90150-3
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supramolecular biovectors (SMBVs), consisting of particles made of polymerized polysaccharides. The particles are substituted with phosphate residues and contain bound lipid molecules (palmitic acid) buried near their surfaces. The association of IL-2 with SMBVs modifies its in vitro bioactivity. SMBVs prolong the growth of IL-2-dependent cells, enhance IL-2 proliferative activity and restore the activity of impaired IL-2. These properties mainly depend on the presence of lipids linked to the SMBV and on both the degree of acylation and the SMBV:IL-2 ratio. SMBVs are therefore good candidates for the stabilization and enhancement of the biological activity of IL-2.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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