Mechanism of Alzheimer's disease: Arguments for a neurotransmitter-aluminium complex implication
Identifieur interne : 000E60 ( Istex/Curation ); précédent : 000E59; suivant : 000E61Mechanism of Alzheimer's disease: Arguments for a neurotransmitter-aluminium complex implication
Auteurs : Roger Deloncle [France] ; Olivier Guillard [France]Source :
- Neurochemical Research [ 0364-3190 ] ; 1990-12-01.
Abstract
Abstract: The authors are convinced that in Alzheimer's disease, as in Down's syndrome and Guam-Parkinson dementia, one may find an alteration in blood brain barrier transfer and a resultant imbalance in mineral metabolism. Metals, such as aluminium, which in vivo yield stable complexes with aspartic and glutamic acids act as previously been clearly shown with glutamic acid; they cross the blood brain barrier, and are deposited in the brain. The authors explain how amyloid protein or neurofibrillary tangles could well be produced by aluminium complex formation. Whithin the brain, in the form precisely of aluminium complex,l-glutamic acid is consequently unable to detoxify ammonia from neurons and to produce L-glutamin. Accumulation of ammonia is subsequently responsible for the neuronal death, affecting each and every neurotransmitter system.
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DOI: 10.1007/BF01208586
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mechanism of Alzheimer's disease: Arguments for a neurotransmitter-aluminium complex implication</title><author><name sortKey="Deloncle, Roger" sort="Deloncle, Roger" uniqKey="Deloncle R" first="Roger" last="Deloncle">Roger Deloncle</name><affiliation wicri:level="1"><mods:affiliation>Bio-Inorganic Chemistry Laboratory, Faculty of Pharmacy, 2 Bis Boulevard Tonnellé, 37042, Tours, (FRANCE)</mods:affiliation><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Bio-Inorganic Chemistry Laboratory, Faculty of Pharmacy, 2 Bis Boulevard Tonnellé, 37042, Tours</wicri:regionArea></affiliation></author><author><name sortKey="Guillard, Olivier" sort="Guillard, Olivier" uniqKey="Guillard O" first="Olivier" last="Guillard">Olivier Guillard</name><affiliation wicri:level="1"><mods:affiliation>Departments of Biochemistry and Pharmacology, Faculty of Medicine, 34 Rue du Jardin des Plantes, 86034, Poitiers, (FRANCE)</mods:affiliation><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Departments of Biochemistry and Pharmacology, Faculty of Medicine, 34 Rue du Jardin des Plantes, 86034, Poitiers</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:28D68F1F3036C591EAFD69CB13D3215466B2DE2D</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1007/BF01208586</idno><idno type="url">https://api.istex.fr/document/28D68F1F3036C591EAFD69CB13D3215466B2DE2D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000E62</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000E62</idno><idno type="wicri:Area/Istex/Curation">000E60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Mechanism of Alzheimer's disease: Arguments for a neurotransmitter-aluminium complex implication</title><author><name sortKey="Deloncle, Roger" sort="Deloncle, Roger" uniqKey="Deloncle R" first="Roger" last="Deloncle">Roger Deloncle</name><affiliation wicri:level="1"><mods:affiliation>Bio-Inorganic Chemistry Laboratory, Faculty of Pharmacy, 2 Bis Boulevard Tonnellé, 37042, Tours, (FRANCE)</mods:affiliation><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Bio-Inorganic Chemistry Laboratory, Faculty of Pharmacy, 2 Bis Boulevard Tonnellé, 37042, Tours</wicri:regionArea></affiliation></author><author><name sortKey="Guillard, Olivier" sort="Guillard, Olivier" uniqKey="Guillard O" first="Olivier" last="Guillard">Olivier Guillard</name><affiliation wicri:level="1"><mods:affiliation>Departments of Biochemistry and Pharmacology, Faculty of Medicine, 34 Rue du Jardin des Plantes, 86034, Poitiers, (FRANCE)</mods:affiliation><country xml:lang="fr" wicri:curation="lc">France</country><wicri:regionArea>Departments of Biochemistry and Pharmacology, Faculty of Medicine, 34 Rue du Jardin des Plantes, 86034, Poitiers</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Neurochemical Research</title><title level="j" type="abbrev">Neurochem Res</title><idno type="ISSN">0364-3190</idno><idno type="eISSN">1573-6903</idno><imprint><publisher>Kluwer Academic Publishers-Plenum Publishers</publisher><pubPlace>New York</pubPlace><date type="published" when="1990-12-01">1990-12-01</date><biblScope unit="volume">15</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1239">1239</biblScope><biblScope unit="page" to="1245">1245</biblScope></imprint><idno type="ISSN">0364-3190</idno></series><idno type="istex">28D68F1F3036C591EAFD69CB13D3215466B2DE2D</idno><idno type="DOI">10.1007/BF01208586</idno><idno type="ArticleID">BF01208586</idno><idno type="ArticleID">Art14</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-3190</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The authors are convinced that in Alzheimer's disease, as in Down's syndrome and Guam-Parkinson dementia, one may find an alteration in blood brain barrier transfer and a resultant imbalance in mineral metabolism. Metals, such as aluminium, which in vivo yield stable complexes with aspartic and glutamic acids act as previously been clearly shown with glutamic acid; they cross the blood brain barrier, and are deposited in the brain. The authors explain how amyloid protein or neurofibrillary tangles could well be produced by aluminium complex formation. Whithin the brain, in the form precisely of aluminium complex,l-glutamic acid is consequently unable to detoxify ammonia from neurons and to produce L-glutamin. Accumulation of ammonia is subsequently responsible for the neuronal death, affecting each and every neurotransmitter system.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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