RANDOMIZED, DOUBLE‐BLIND TRIAL OF EXIFONE VERSUS COGNITIVE PROBLEMS IN PARKINSON'S DISEASE
Identifieur interne : 000837 ( Istex/Curation ); précédent : 000836; suivant : 000838RANDOMIZED, DOUBLE‐BLIND TRIAL OF EXIFONE VERSUS COGNITIVE PROBLEMS IN PARKINSON'S DISEASE
Auteurs : H. Allain ; J. Denmat ; D. Bentue-Ferrer [France] ; D. Milon [France] ; P. Pignol ; J. M. Reymann [France] ; D. Pape [France] ; O. Sabouraud ; J. Van Den Driessche [France]Source :
- Fundamental & Clinical Pharmacology [ 0767-3981 ] ; 1988-01-02.
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Abstract
Summary— Exifone is a novel substance of the benzophenone group that possesses potent scavenging properties. Initial findings demonstrate beneficial effects on age‐related cognitive disorders. In this double‐blind clinical trial versus placebo, the efficacy of 2 dosages (600 and 1200 mg/d) was evaluated with regard to Parkinson's disease (PD)‐related cognitive disorders, for which there is increasing suspicion of a free‐radicals origin. Despite disparities between the treatment groups as assessed by validated scales and subtests, and a considerable placebo effect on main parameters, both dose levels of exifone produced statistically significant improvement of the cognitive items most commonly impaired by PD: immediate recall, naming of objects presented, spatiotemporal orientation, and calculation. These properties suggest a new slot for exifone in the range of therapeutics available.
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DOI: 10.1111/j.1472-8206.1988.tb00615.x
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H. Allain<affiliation><mods:affiliation>Service de Neurologie, Hôpital de Pontchaillou, rue Henri‐Le‐Guillou, 35043 Rennes</mods:affiliation><wicri:noCountry code="subField">Rennes</wicri:noCountry></affiliation><affiliation><mods:affiliation>Laboratoire de Psychologie clinique, Université de Haute Bretagne, avenue Gaston‐Berger, 35043 Rennes</mods:affiliation><wicri:noCountry code="subField">Rennes</wicri:noCountry></affiliation><affiliation><mods:affiliation>Laboratoire de Psychologie clinique, Université de Haute Bretagne, avenue Gaston‐Berger, 35043 Rennes</mods:affiliation><wicri:noCountry code="subField">Rennes</wicri:noCountry></affiliation><affiliation><mods:affiliation>Service de Neurologie, Hôpital de Pontchaillou, rue Henri‐Le‐Guillou, 35043 Rennes</mods:affiliation><wicri:noCountry code="subField">Rennes</wicri:noCountry></affiliation>Le document en format XML
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Allain</name><affiliation><mods:affiliation>Service de Neurologie, Hôpital de Pontchaillou, rue Henri‐Le‐Guillou, 35043 Rennes</mods:affiliation><wicri:noCountry code="subField">Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Denmat, J" sort="Denmat, J" uniqKey="Denmat J" first="J." last="Denmat">J. Denmat</name><affiliation><mods:affiliation>Laboratoire de Psychologie clinique, Université de Haute Bretagne, avenue Gaston‐Berger, 35043 Rennes</mods:affiliation><wicri:noCountry code="subField">Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Bentue Errer, D" sort="Bentue Errer, D" uniqKey="Bentue Errer D" first="D." last="Bentue-Ferrer">D. Bentue-Ferrer</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Pharmacologie expérimental et clinique, Faculté de Médecine, avenue du Pr. 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Pignol</name><affiliation><mods:affiliation>Laboratoire de Psychologie clinique, Université de Haute Bretagne, avenue Gaston‐Berger, 35043 Rennes</mods:affiliation><wicri:noCountry code="subField">Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Reymann, J M" sort="Reymann, J M" uniqKey="Reymann J" first="J. M." last="Reymann">J. M. Reymann</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Pharmacologie expérimental et clinique, Faculté de Médecine, avenue du Pr. Léon‐Bernard, 35043 Rennes, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie expérimental et clinique, Faculté de Médecine, avenue du Pr. Léon‐Bernard, 35043 Rennes</wicri:regionArea></affiliation></author><author><name sortKey="Pape, D" sort="Pape, D" uniqKey="Pape D" first="D." last="Pape">D. Pape</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Pharmacologie expérimental et clinique, Faculté de Médecine, avenue du Pr. Léon‐Bernard, 35043 Rennes, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie expérimental et clinique, Faculté de Médecine, avenue du Pr. Léon‐Bernard, 35043 Rennes</wicri:regionArea></affiliation></author><author><name sortKey="Sabouraud, O" sort="Sabouraud, O" uniqKey="Sabouraud O" first="O." last="Sabouraud">O. Sabouraud</name><affiliation><mods:affiliation>Service de Neurologie, Hôpital de Pontchaillou, rue Henri‐Le‐Guillou, 35043 Rennes</mods:affiliation><wicri:noCountry code="subField">Rennes</wicri:noCountry></affiliation></author><author><name sortKey="Van Den Driessche, J" sort="Van Den Driessche, J" uniqKey="Van Den Driessche J" first="J." last="Van Den Driessche">J. Van Den Driessche</name><affiliation wicri:level="1"><mods:affiliation>Laboratoire de Pharmacologie expérimental et clinique, Faculté de Médecine, avenue du Pr. Léon‐Bernard, 35043 Rennes, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacologie expérimental et clinique, Faculté de Médecine, avenue du Pr. Léon‐Bernard, 35043 Rennes</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Fundamental & Clinical Pharmacology</title><idno type="ISSN">0767-3981</idno><idno type="eISSN">1472-8206</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1988-01-02">1988-01-02</date><biblScope unit="volume">2</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="12">12</biblScope></imprint><idno type="ISSN">0767-3981</idno></series><idno type="istex">84F2F1543A791709C683DA93A475948E9D199661</idno><idno type="DOI">10.1111/j.1472-8206.1988.tb00615.x</idno><idno type="ArticleID">FCP615</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0767-3981</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>benzophenone</term><term>cognitive problems</term><term>exifone</term><term>memory</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Summary— Exifone is a novel substance of the benzophenone group that possesses potent scavenging properties. Initial findings demonstrate beneficial effects on age‐related cognitive disorders. In this double‐blind clinical trial versus placebo, the efficacy of 2 dosages (600 and 1200 mg/d) was evaluated with regard to Parkinson's disease (PD)‐related cognitive disorders, for which there is increasing suspicion of a free‐radicals origin. Despite disparities between the treatment groups as assessed by validated scales and subtests, and a considerable placebo effect on main parameters, both dose levels of exifone produced statistically significant improvement of the cognitive items most commonly impaired by PD: immediate recall, naming of objects presented, spatiotemporal orientation, and calculation. These properties suggest a new slot for exifone in the range of therapeutics available.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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