RANDOMIZED, DOUBLE‐BLIND TRIAL OF EXIFONE VERSUS COGNITIVE PROBLEMS IN PARKINSON'S DISEASE
Identifieur interne : 000837 ( Istex/Curation ); précédent : 000836; suivant : 000838RANDOMIZED, DOUBLE‐BLIND TRIAL OF EXIFONE VERSUS COGNITIVE PROBLEMS IN PARKINSON'S DISEASE
Auteurs : H. Allain ; J. Denmat ; D. Bentue-Ferrer [France] ; D. Milon [France] ; P. Pignol ; J. M. Reymann [France] ; D. Pape [France] ; O. Sabouraud ; J. Van Den Driessche [France]Source :
- Fundamental & Clinical Pharmacology [ 0767-3981 ] ; 1988-01-02.
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- KwdEn :
Abstract
Summary— Exifone is a novel substance of the benzophenone group that possesses potent scavenging properties. Initial findings demonstrate beneficial effects on age‐related cognitive disorders. In this double‐blind clinical trial versus placebo, the efficacy of 2 dosages (600 and 1200 mg/d) was evaluated with regard to Parkinson's disease (PD)‐related cognitive disorders, for which there is increasing suspicion of a free‐radicals origin. Despite disparities between the treatment groups as assessed by validated scales and subtests, and a considerable placebo effect on main parameters, both dose levels of exifone produced statistically significant improvement of the cognitive items most commonly impaired by PD: immediate recall, naming of objects presented, spatiotemporal orientation, and calculation. These properties suggest a new slot for exifone in the range of therapeutics available.
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DOI: 10.1111/j.1472-8206.1988.tb00615.x
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H. Allain<affiliation><mods:affiliation>Service de Neurologie, Hôpital de Pontchaillou, rue Henri‐Le‐Guillou, 35043 Rennes</mods:affiliation>
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<affiliation><mods:affiliation>Laboratoire de Psychologie clinique, Université de Haute Bretagne, avenue Gaston‐Berger, 35043 Rennes</mods:affiliation>
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Le document en format XML
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<front><div type="abstract">Summary— Exifone is a novel substance of the benzophenone group that possesses potent scavenging properties. Initial findings demonstrate beneficial effects on age‐related cognitive disorders. In this double‐blind clinical trial versus placebo, the efficacy of 2 dosages (600 and 1200 mg/d) was evaluated with regard to Parkinson's disease (PD)‐related cognitive disorders, for which there is increasing suspicion of a free‐radicals origin. Despite disparities between the treatment groups as assessed by validated scales and subtests, and a considerable placebo effect on main parameters, both dose levels of exifone produced statistically significant improvement of the cognitive items most commonly impaired by PD: immediate recall, naming of objects presented, spatiotemporal orientation, and calculation. These properties suggest a new slot for exifone in the range of therapeutics available.</div>
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