Subthalamic nucleus influences spatial orientation in extrapersonal space
Identifieur interne : 002015 ( Istex/Corpus ); précédent : 002014; suivant : 002016Subthalamic nucleus influences spatial orientation in extrapersonal space
Auteurs : Karsten Witt ; Florian Kopper ; Günther Deuschl ; Paul KrackSource :
- Movement Disorders [ 0885-3185 ] ; 2006-03.
English descriptors
Abstract
While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extrapersonal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of L‐dopa. Patients were tested in a pseudorandomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extrapersonal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemispatial and hemimotor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extrapersonal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20728
Links to Exploration step
ISTEX:2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus influences spatial orientation in extrapersonal space</title>
<author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name>
<affiliation><mods:affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name>
<affiliation><mods:affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<affiliation><mods:affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>Department of Neurology, University Schleswig‐Holstein, Campus Kiel, Schittenhelmstrasse 10, D‐24105 Kiel, Germany</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5</idno>
<date when="2006" year="2006">2006</date>
<idno type="doi">10.1002/mds.20728</idno>
<idno type="url">https://api.istex.fr/document/2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002015</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002015</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Subthalamic nucleus influences spatial orientation in extrapersonal space</title>
<author><name sortKey="Witt, Karsten" sort="Witt, Karsten" uniqKey="Witt K" first="Karsten" last="Witt">Karsten Witt</name>
<affiliation><mods:affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name>
<affiliation><mods:affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name>
<affiliation><mods:affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>Department of Neurology, University Schleswig‐Holstein, Campus Kiel, Schittenhelmstrasse 10, D‐24105 Kiel, Germany</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation><mods:affiliation>Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2006-03">2006-03</date>
<biblScope unit="volume">21</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="354">354</biblScope>
<biblScope unit="page" to="361">361</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5</idno>
<idno type="DOI">10.1002/mds.20728</idno>
<idno type="ArticleID">MDS20728</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>deep brain stimulation</term>
<term>neglect</term>
<term>spatial orientation</term>
<term>subthalamic nucleus</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extrapersonal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of L‐dopa. Patients were tested in a pseudorandomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extrapersonal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemispatial and hemimotor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extrapersonal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere. © 2005 Movement Disorder Society</div>
</front>
</TEI>
<istex><corpusName>wiley</corpusName>
<author><json:item><name>Karsten Witt MD</name>
<affiliations><json:string>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</json:string>
</affiliations>
</json:item>
<json:item><name>Florian Kopper MD</name>
<affiliations><json:string>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</json:string>
</affiliations>
</json:item>
<json:item><name>Günther Deuschl MD</name>
<affiliations><json:string>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</json:string>
<json:string>Department of Neurology, University Schleswig‐Holstein, Campus Kiel, Schittenhelmstrasse 10, D‐24105 Kiel, Germany</json:string>
</affiliations>
</json:item>
<json:item><name>Paul Krack MD</name>
<affiliations><json:string>Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</json:string>
</affiliations>
</json:item>
</author>
<subject><json:item><lang><json:string>eng</json:string>
</lang>
<value>subthalamic nucleus</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>deep brain stimulation</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>spatial orientation</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>neglect</value>
</json:item>
</subject>
<articleId><json:string>MDS20728</json:string>
</articleId>
<language><json:string>eng</json:string>
</language>
<originalGenre><json:string>article</json:string>
</originalGenre>
<abstract>While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extrapersonal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of L‐dopa. Patients were tested in a pseudorandomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extrapersonal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemispatial and hemimotor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extrapersonal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere. © 2005 Movement Disorder Society</abstract>
<qualityIndicators><score>8</score>
<pdfVersion>1.3</pdfVersion>
<pdfPageSize>594 x 792 pts</pdfPageSize>
<refBibsNative>true</refBibsNative>
<abstractCharCount>1745</abstractCharCount>
<pdfWordCount>5082</pdfWordCount>
<pdfCharCount>32316</pdfCharCount>
<pdfPageCount>8</pdfPageCount>
<abstractWordCount>266</abstractWordCount>
</qualityIndicators>
<title>Subthalamic nucleus influences spatial orientation in extrapersonal space</title>
<refBibs><json:item><author><json:item><name>KM Heilman</name>
</json:item>
<json:item><name>D Bowers</name>
</json:item>
<json:item><name>RT Watson</name>
</json:item>
</author>
<host><volume>33</volume>
<pages><last>664</last>
<first>661</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Performance on hemispatial pointing task by patients with neglect syndrome</title>
</json:item>
<json:item><author><json:item><name>FS Leibovitch</name>
</json:item>
<json:item><name>SE Black</name>
</json:item>
<json:item><name>CB Caldwell</name>
</json:item>
<json:item><name>PL Ebert</name>
</json:item>
<json:item><name>LE Ehrlich</name>
</json:item>
<json:item><name>JP Szalai</name>
</json:item>
</author>
<host><volume>50</volume>
<pages><last>908</last>
<first>901</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Brain‐behavior correlations in hemispatial neglect using CT and SPECT: the Sunnybrook Stroke Study</title>
</json:item>
<json:item><author><json:item><name>G Vallar</name>
</json:item>
<json:item><name>D Perani</name>
</json:item>
</author>
<host><volume>24</volume>
<pages><last>622</last>
<first>609</first>
</pages>
<author></author>
<title>Neuropsychologia</title>
</host>
<title>The anatomy of unilateral neglect after right‐hemisphere stroke lesions: a clinical/CT‐scan correlation study in man</title>
</json:item>
<json:item><author><json:item><name>DJ Mort</name>
</json:item>
<json:item><name>P Malhotra</name>
</json:item>
<json:item><name>SK Mannan</name>
</json:item>
</author>
<host><volume>126</volume>
<pages><last>1997</last>
<first>1986</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>The anatomy of visual neglect</title>
</json:item>
<json:item><author><json:item><name>HO Karnath</name>
</json:item>
<json:item><name>S Ferber</name>
</json:item>
<json:item><name>M Himmelbach</name>
</json:item>
</author>
<host><volume>411</volume>
<pages><last>953</last>
<first>950</first>
</pages>
<author></author>
<title>Nature</title>
</host>
<title>Spatial awareness is a function of the temporal not the posterior parietal lobe</title>
</json:item>
<json:item><author><json:item><name>KM Heilman</name>
</json:item>
<json:item><name>E Valenstein</name>
</json:item>
</author>
<host><volume>22</volume>
<pages><last>664</last>
<first>660</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Frontal lobe neglect in man</title>
</json:item>
<json:item><author><json:item><name>KM Heilman</name>
</json:item>
<json:item><name>E Valenstein</name>
</json:item>
</author>
<host><volume>26</volume>
<pages><last>35</last>
<first>32</first>
</pages>
<author></author>
<title>Arch Neurol</title>
</host>
<title>Auditory neglect in man</title>
</json:item>
<json:item><author><json:item><name>M Husain</name>
</json:item>
<json:item><name>C Kennard</name>
</json:item>
</author>
<host><volume>243</volume>
<pages><last>657</last>
<first>652</first>
</pages>
<author></author>
<title>J Neurol</title>
</host>
<title>Visual neglect associated with frontal lobe infarction</title>
</json:item>
<json:item><author><json:item><name>MM Mesulam</name>
</json:item>
</author>
<host><volume>10</volume>
<pages><last>325</last>
<first>309</first>
</pages>
<author></author>
<title>Ann Neurol</title>
</host>
<title>A cortical network for directed attention and unilateral neglect</title>
</json:item>
<json:item><author><json:item><name>M Husain</name>
</json:item>
<json:item><name>JB Mattingley</name>
</json:item>
<json:item><name>C Rorden</name>
</json:item>
<json:item><name>C Kennard</name>
</json:item>
<json:item><name>J Driver</name>
</json:item>
</author>
<host><volume>123</volume>
<pages><last>1659</last>
<first>1643</first>
</pages>
<issue>Pt. 8</issue>
<author></author>
<title>Brain</title>
</host>
<title>Distinguishing sensory and motor biases in parietal and frontal neglect</title>
</json:item>
<json:item><author><json:item><name>AR Damasio</name>
</json:item>
<json:item><name>H Damasio</name>
</json:item>
<json:item><name>HC Chui</name>
</json:item>
</author>
<host><volume>18</volume>
<pages><last>132</last>
<first>123</first>
</pages>
<author></author>
<title>Neuropsychologia</title>
</host>
<title>Neglect following damage to frontal lobe or basal ganglia</title>
</json:item>
<json:item><author><json:item><name>D Perani</name>
</json:item>
<json:item><name>G Vallar</name>
</json:item>
<json:item><name>S Cappa</name>
</json:item>
<json:item><name>C Messa</name>
</json:item>
<json:item><name>F Fazio</name>
</json:item>
</author>
<host><volume>110</volume>
<pages><last>1229</last>
<first>1211</first>
</pages>
<issue>Pt. 5</issue>
<author></author>
<title>Brain</title>
</host>
<title>Aphasia and neglect after subcortical stroke: a clinical/cerebral perfusion correlation study</title>
</json:item>
<json:item><author><json:item><name>LR Caplan</name>
</json:item>
<json:item><name>JD Schmahmann</name>
</json:item>
<json:item><name>CS Kase</name>
</json:item>
</author>
<host><volume>47</volume>
<pages><last>143</last>
<first>133</first>
</pages>
<author></author>
<title>Arch Neurol</title>
</host>
<title>Caudate infarcts</title>
</json:item>
<json:item><author><json:item><name>GA Donnan</name>
</json:item>
<json:item><name>PF Bladin</name>
</json:item>
<json:item><name>SF Berkovic</name>
</json:item>
<json:item><name>WA Longley</name>
</json:item>
<json:item><name>MM Saling</name>
</json:item>
</author>
<host><volume>114</volume>
<pages><last>70</last>
<first>51</first>
</pages>
<issue>Pt. 1A</issue>
<author></author>
<title>Brain</title>
</host>
<title>The stroke syndrome of striatocapsular infarction</title>
</json:item>
<json:item><author><json:item><name>C Weiller</name>
</json:item>
<json:item><name>K Willmes</name>
</json:item>
<json:item><name>W Reiche</name>
</json:item>
</author>
<host><volume>116</volume>
<pages><last>1525</last>
<first>1509</first>
</pages>
<issue>Pt. 6</issue>
<author></author>
<title>Brain</title>
</host>
<title>The case of aphasia or neglect after striatocapsular infarction</title>
</json:item>
<json:item><author><json:item><name>E Kumral</name>
</json:item>
<json:item><name>D Evyapan</name>
</json:item>
<json:item><name>K Balkir</name>
</json:item>
</author>
<host><volume>30</volume>
<pages><last>108</last>
<first>100</first>
</pages>
<author></author>
<title>Stroke</title>
</host>
<title>Acute caudate vascular lesions</title>
</json:item>
<json:item><author><json:item><name>CS Chung</name>
</json:item>
<json:item><name>LR Caplan</name>
</json:item>
<json:item><name>Y Yamamoto</name>
</json:item>
</author>
<host><volume>123</volume>
<pages><last>1862</last>
<first>1850</first>
</pages>
<issue>Pt. 9</issue>
<author></author>
<title>Brain</title>
</host>
<title>Striatocapsular haemorrhage</title>
</json:item>
<json:item><author><json:item><name>HO Karnath</name>
</json:item>
<json:item><name>M Himmelbach</name>
</json:item>
<json:item><name>C Rorden</name>
</json:item>
</author>
<host><volume>125</volume>
<pages><last>360</last>
<first>350</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar</title>
</json:item>
<json:item><author><json:item><name>AE Hillis</name>
</json:item>
<json:item><name>RJ Wityk</name>
</json:item>
<json:item><name>PB Barker</name>
</json:item>
</author>
<host><volume>125</volume>
<pages><last>1104</last>
<first>1094</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>Subcortical aphasia and neglect in acute stroke: the role of cortical hypoperfusion</title>
</json:item>
<json:item><author><json:item><name>AE Hillis</name>
</json:item>
<json:item><name>RJ Wityk</name>
</json:item>
<json:item><name>PB Barker</name>
</json:item>
<json:item><name>JA Ulatowski</name>
</json:item>
<json:item><name>MA Jacobs</name>
</json:item>
</author>
<host><volume>34</volume>
<pages><last>2396</last>
<first>2392</first>
</pages>
<author></author>
<title>Stroke</title>
</host>
<title>Change in perfusion in acute nondominant hemisphere stroke may be better estimated by tests of hemispatial neglect than by the National Institutes of Health Stroke Scale</title>
</json:item>
<json:item><author><json:item><name>G Vallar</name>
</json:item>
<json:item><name>D Perani</name>
</json:item>
<json:item><name>SF Cappa</name>
</json:item>
<json:item><name>C Messa</name>
</json:item>
<json:item><name>GL Lenzi</name>
</json:item>
<json:item><name>F Fazio</name>
</json:item>
</author>
<host><volume>51</volume>
<pages><last>1276</last>
<first>1269</first>
</pages>
<author></author>
<title>J Neurol Neurosurg Psychiatry</title>
</host>
<title>Recovery from aphasia and neglect after subcortical stroke: neuropsychological and cerebral perfusion study</title>
</json:item>
<json:item><author><json:item><name>JM Henderson</name>
</json:item>
<json:item><name>LE Annett</name>
</json:item>
<json:item><name>LJ Ryan</name>
</json:item>
</author>
<host><volume>11</volume>
<pages><last>2757</last>
<first>2749</first>
</pages>
<author></author>
<title>Eur J Neurosci</title>
</host>
<title>Subthalamic nucleus lesions induce deficits as well as benefits in the hemiparkinsonian rat</title>
</json:item>
<json:item><author><json:item><name>JA Obeso</name>
</json:item>
<json:item><name>MC Rodriguez‐Oroz</name>
</json:item>
<json:item><name>M Rodriguez</name>
</json:item>
</author>
<host><volume>55</volume>
<pages><last>12</last>
<first>7</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Pathophysiologic basis of surgery for Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>H Bergman</name>
</json:item>
<json:item><name>T Wichmann</name>
</json:item>
<json:item><name>MR DeLong</name>
</json:item>
</author>
<host><volume>249</volume>
<pages><last>1438</last>
<first>1436</first>
</pages>
<author></author>
<title>Science</title>
</host>
<title>Reversal of experimental parkinsonism by lesions of the subthalamic nucleus</title>
</json:item>
<json:item><author><json:item><name>A Funkiewiez</name>
</json:item>
<json:item><name>C Ardouin</name>
</json:item>
<json:item><name>P Krack</name>
</json:item>
</author>
<host><volume>18</volume>
<pages><last>530</last>
<first>524</first>
</pages>
<author></author>
<title>Mov Disord</title>
</host>
<title>Acute psychotropic effects of bilateral subthalamic nucleus stimulation and levodopa in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>B Pillon</name>
</json:item>
<json:item><name>C Ardouin</name>
</json:item>
<json:item><name>P Damier</name>
</json:item>
</author>
<host><volume>55</volume>
<pages><last>418</last>
<first>411</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Neuropsychological changes between “OFF” and “ON” STN or GPi stimulation in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>U Schroeder</name>
</json:item>
<json:item><name>A Kuehler</name>
</json:item>
<json:item><name>B Haslinger</name>
</json:item>
</author>
<host><volume>125</volume>
<pages><last>2004</last>
<first>1995</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>Subthalamic nucleus stimulation affects striato–anterior cingulate cortex circuit in a response conflict task: a PET study</title>
</json:item>
<json:item><author><json:item><name>U Schroeder</name>
</json:item>
<json:item><name>A Kuehler</name>
</json:item>
<json:item><name>KW Lange</name>
</json:item>
</author>
<host><volume>54</volume>
<pages><last>450</last>
<first>445</first>
</pages>
<author></author>
<title>Ann Neurol</title>
</host>
<title>Subthalamic nucleus stimulation affects a frontotemporal network: a PET study</title>
</json:item>
<json:item><author><json:item><name>K Witt</name>
</json:item>
<json:item><name>U Pulkowski</name>
</json:item>
<json:item><name>J Herzog</name>
</json:item>
</author>
<host><volume>61</volume>
<pages><last>700</last>
<first>697</first>
</pages>
<author></author>
<title>Arch Neurol</title>
</host>
<title>Deep brain stimulation of the subthalamic nucleus improves cognitive flexibility but impairs response inhibition in Parkinson disease</title>
</json:item>
<json:item><author><json:item><name>F Schneider</name>
</json:item>
<json:item><name>U Habel</name>
</json:item>
<json:item><name>J Volkmann</name>
</json:item>
</author>
<host><volume>60</volume>
<pages><last>302</last>
<first>296</first>
</pages>
<author></author>
<title>Arch Gen Psychiatry</title>
</host>
<title>Deep brain stimulation of the subthalamic nucleus enhances emotional processing in Parkinson disease</title>
</json:item>
<json:item><author><json:item><name>Y Sakashita</name>
</json:item>
</author>
<host><volume>30</volume>
<pages><last>677</last>
<first>673</first>
</pages>
<author></author>
<title>Ann Neurol</title>
</host>
<title>Visual attentional disturbance with unilateral lesions in the basal ganglia and deep white matter</title>
</json:item>
<json:item><author><json:item><name>AJ Hughes</name>
</json:item>
<json:item><name>SE Daniel</name>
</json:item>
<json:item><name>L Kilford</name>
</json:item>
<json:item><name>AJ Lees</name>
</json:item>
</author>
<host><volume>55</volume>
<pages><last>184</last>
<first>181</first>
</pages>
<author></author>
<title>J Neurol Neurosurg Psychiatry</title>
</host>
<title>Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico‐pathological study of 100 cases</title>
</json:item>
<json:item><host><author></author>
<title>Mattis S.Dementia rating scale.Odessa, FL:Psychological Assessment Resources;1988.</title>
</host>
</json:item>
<json:item><author><json:item><name>M Annett</name>
</json:item>
</author>
<host><volume>61</volume>
<pages><last>321</last>
<first>303</first>
</pages>
<author></author>
<title>Br J Psychol</title>
</host>
<title>A classification of hand preference by association analysis</title>
</json:item>
<json:item><author><json:item><name>B Schrader</name>
</json:item>
<json:item><name>W Hamel</name>
</json:item>
<json:item><name>D Weinert</name>
</json:item>
<json:item><name>HM Mehdorn</name>
</json:item>
</author>
<host><volume>17</volume>
<pages><last>174</last>
<first>167</first>
</pages>
<author></author>
<title>Mov Disord</title>
</host>
<title>Documentation of electrode localisation</title>
</json:item>
<json:item><author><json:item><name>J Herzog</name>
</json:item>
<json:item><name>U Fietzek</name>
</json:item>
<json:item><name>W Hamel</name>
</json:item>
</author>
<host><volume>19</volume>
<pages><last>1054</last>
<first>1050</first>
</pages>
<author></author>
<title>Mov Disord</title>
</host>
<title>Most effective stimulation site in subthalamic deep brain stimulation for Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>JM Henderson</name>
</json:item>
<json:item><name>LE Annett</name>
</json:item>
<json:item><name>EM Torres</name>
</json:item>
<json:item><name>SB Dunnett</name>
</json:item>
</author>
<host><volume>10</volume>
<pages><last>698</last>
<first>689</first>
</pages>
<author></author>
<title>Eur J Neurosci</title>
</host>
<title>Behavioural effects of subthalamic nucleus lesions in the hemiparkinsonian marmoset (Callithrix jacchus)</title>
</json:item>
<json:item><author><json:item><name>D Grabli</name>
</json:item>
<json:item><name>K McCairn</name>
</json:item>
<json:item><name>EC Hirsch</name>
</json:item>
</author>
<host><volume>127</volume>
<pages><last>2054</last>
<first>2039</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>Behavioural disorders induced by external globus pallidus dysfunction in primates: I, behavioural study</title>
</json:item>
<json:item><author><json:item><name>AL Milton</name>
</json:item>
<json:item><name>JW Marshall</name>
</json:item>
<json:item><name>RM Cummings</name>
</json:item>
<json:item><name>HF Baker</name>
</json:item>
<json:item><name>RM Ridley</name>
</json:item>
</author>
<host><volume>150</volume>
<pages><last>63</last>
<first>55</first>
</pages>
<author></author>
<title>Behav Brain Res</title>
</host>
<title>Dissociation of hemi‐spatial and hemi‐motor impairments in a unilateral primate model of Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>T Wichmann</name>
</json:item>
<json:item><name>MR DeLong</name>
</json:item>
</author>
<host><volume>991</volume>
<pages><last>213</last>
<first>199</first>
</pages>
<author></author>
<title>Ann NY Acad Sci</title>
</host>
<title>Pathophysiology of Parkinson's disease: the MPTP primate model of the human disorder</title>
</json:item>
<json:item><author><json:item><name>L Garcia</name>
</json:item>
<json:item><name>J Audin</name>
</json:item>
<json:item><name>G D'Alessandro</name>
</json:item>
<json:item><name>B Bioulac</name>
</json:item>
<json:item><name>C Hammond</name>
</json:item>
</author>
<host><volume>23</volume>
<pages><last>8751</last>
<first>8743</first>
</pages>
<author></author>
<title>J Neurosci</title>
</host>
<title>Dual effect of high‐frequency stimulation on subthalamic neuron activity</title>
</json:item>
<json:item><author><json:item><name>S Starkstein</name>
</json:item>
<json:item><name>R Leiguarda</name>
</json:item>
<json:item><name>O Gershanik</name>
</json:item>
<json:item><name>M Berthier</name>
</json:item>
</author>
<host><volume>37</volume>
<pages><last>1764</last>
<first>1762</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Neuropsychological disturbances in hemiparkinson's disease</title>
</json:item>
<json:item><author><json:item><name>C Villardita</name>
</json:item>
<json:item><name>P Smirni</name>
</json:item>
<json:item><name>G Zappala</name>
</json:item>
</author>
<host><volume>40</volume>
<pages><last>739</last>
<first>737</first>
</pages>
<author></author>
<title>Arch Neurol</title>
</host>
<title>Visual neglect in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>G Ebersbach</name>
</json:item>
<json:item><name>T Trottenberg</name>
</json:item>
<json:item><name>H Hattig</name>
</json:item>
<json:item><name>L Schelosky</name>
</json:item>
<json:item><name>A Schrag</name>
</json:item>
<json:item><name>W Poewe</name>
</json:item>
</author>
<host><volume>119</volume>
<pages><last>87</last>
<first>79</first>
</pages>
<issue>Pt. 1</issue>
<author></author>
<title>Brain</title>
</host>
<title>Directional bias of initial visual exploration: a symptom of neglect in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>AC Lee</name>
</json:item>
<json:item><name>JP Harris</name>
</json:item>
<json:item><name>EA Atkinson</name>
</json:item>
<json:item><name>MS Fowler</name>
</json:item>
</author>
<host><volume>41</volume>
<pages><last>2686</last>
<first>2677</first>
</pages>
<author></author>
<title>Vision Res</title>
</host>
<title>Evidence from a line bisection task for visuospatial neglect in left hemiparkinson's disease</title>
</json:item>
<json:item><author><json:item><name>MM Mesulam</name>
</json:item>
</author>
<host><pages><last>168</last>
<first>125</first>
</pages>
<author></author>
<title>Principles of behavioral neurology</title>
</host>
<title>Attention, confusional states, and neglect</title>
</json:item>
<json:item><author><json:item><name>E Bisiach</name>
</json:item>
<json:item><name>G Geminiani</name>
</json:item>
<json:item><name>A Berti</name>
</json:item>
<json:item><name>ML Rusconi</name>
</json:item>
</author>
<host><volume>40</volume>
<pages><last>1281</last>
<first>1278</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Perceptual and premotor factors of unilateral neglect</title>
</json:item>
<json:item><author><json:item><name>KM Heilman</name>
</json:item>
<json:item><name>E Valenstein</name>
</json:item>
</author>
<host><volume>5</volume>
<pages><last>170</last>
<first>166</first>
</pages>
<author></author>
<title>Ann Neurol</title>
</host>
<title>Mechanisms underlying hemispatial neglect</title>
</json:item>
<json:item><author><json:item><name>JB Mattingley</name>
</json:item>
<json:item><name>M Husain</name>
</json:item>
<json:item><name>C Rorden</name>
</json:item>
<json:item><name>C Kennard</name>
</json:item>
<json:item><name>J Driver</name>
</json:item>
</author>
<host><volume>392</volume>
<pages><last>182</last>
<first>179</first>
</pages>
<author></author>
<title>Nature</title>
</host>
<title>Motor role of human inferior parietal lobe revealed in unilateral neglect patients</title>
</json:item>
<json:item><author><json:item><name>AC Nobre</name>
</json:item>
<json:item><name>GN Sebestyen</name>
</json:item>
<json:item><name>DR Gitelman</name>
</json:item>
<json:item><name>MM Mesulam</name>
</json:item>
<json:item><name>RS Frackowiak</name>
</json:item>
<json:item><name>CD Frith</name>
</json:item>
</author>
<host><volume>120</volume>
<pages><last>533</last>
<first>515</first>
</pages>
<issue>Pt. 3</issue>
<author></author>
<title>Brain</title>
</host>
<title>Functional localization of the system for visuospatial attention using positron emission tomography</title>
</json:item>
<json:item><author><json:item><name>C Hamani</name>
</json:item>
<json:item><name>JA Saint‐Cyr</name>
</json:item>
<json:item><name>J Fraser</name>
</json:item>
<json:item><name>M Kaplitt</name>
</json:item>
<json:item><name>AM Lozano</name>
</json:item>
</author>
<host><volume>127</volume>
<pages><last>20</last>
<first>4</first>
</pages>
<author></author>
<title>Brain</title>
</host>
<title>The subthalamic nucleus in the context of movement disorders</title>
</json:item>
<json:item><author><json:item><name>P Limousin</name>
</json:item>
<json:item><name>J Greene</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
<json:item><name>J Rothwell</name>
</json:item>
<json:item><name>AL Benabid</name>
</json:item>
<json:item><name>R Frackowiak</name>
</json:item>
</author>
<host><volume>42</volume>
<pages><last>291</last>
<first>283</first>
</pages>
<author></author>
<title>Ann Neurol</title>
</host>
<title>Changes in cerebral activity pattern due to subthalamic nucleus or internal pallidum stimulation in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>A Nambu</name>
</json:item>
<json:item><name>M Takada</name>
</json:item>
<json:item><name>M Inase</name>
</json:item>
<json:item><name>H Tokuno</name>
</json:item>
</author>
<host><volume>16</volume>
<pages><last>2683</last>
<first>2671</first>
</pages>
<author></author>
<title>J Neurosci</title>
</host>
<title>Dual somatotopical representations in the primate subthalamic nucleus: evidence for ordered but reversed body‐map transformations from the primary motor cortex and the supplementary motor area</title>
</json:item>
<json:item><author><json:item><name>M Matsumura</name>
</json:item>
<json:item><name>J Kojima</name>
</json:item>
<json:item><name>TW Gardiner</name>
</json:item>
<json:item><name>O Hikosaka</name>
</json:item>
</author>
<host><volume>67</volume>
<pages><last>1632</last>
<first>1615</first>
</pages>
<author></author>
<title>J Neurophysiol</title>
</host>
<title>Visual and oculomotor functions of monkey subthalamic nucleus</title>
</json:item>
<json:item><author><json:item><name>O Hikosaka</name>
</json:item>
<json:item><name>RH Wurtz</name>
</json:item>
</author>
<host><volume>49</volume>
<pages><last>1284</last>
<first>1268</first>
</pages>
<author></author>
<title>J Neurophysiol</title>
</host>
<title>Visual and oculomotor functions of monkey substantia nigra pars reticulata: III, memory‐contingent visual and saccade responses</title>
</json:item>
<json:item><author><json:item><name>O Hikosaka</name>
</json:item>
<json:item><name>RH Wurtz</name>
</json:item>
</author>
<host><volume>49</volume>
<pages><last>1267</last>
<first>1254</first>
</pages>
<author></author>
<title>J Neurophysiol</title>
</host>
<title>Visual and oculomotor functions of monkey substantia nigra pars reticulata: II, visual responses related to fixation of gaze</title>
</json:item>
<json:item><author><json:item><name>O Hikosaka</name>
</json:item>
<json:item><name>RH Wurtz</name>
</json:item>
</author>
<host><volume>53</volume>
<pages><last>308</last>
<first>292</first>
</pages>
<author></author>
<title>J Neurophysiol</title>
</host>
<title>Modification of saccadic eye movements by GABA‐related substances: II, effects of muscimol in monkey substantia nigra pars reticulata</title>
</json:item>
<json:item><author><json:item><name>O Hikosaka</name>
</json:item>
</author>
<host><volume>145</volume>
<pages><last>586</last>
<first>580</first>
</pages>
<author></author>
<title>Rev Neurol (Paris)</title>
</host>
<title>Role of basal ganglia in saccades</title>
</json:item>
<json:item><author><json:item><name>J Ventre</name>
</json:item>
<json:item><name>DS Zee</name>
</json:item>
<json:item><name>H Papageorgiou</name>
</json:item>
<json:item><name>S Reich</name>
</json:item>
</author>
<host><volume>115</volume>
<pages><last>1165</last>
<first>1147</first>
</pages>
<issue>Pt. 4</issue>
<author></author>
<title>Brain</title>
</host>
<title>Abnormalities of predictive saccades in hemi‐Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>P Sauleau</name>
</json:item>
<json:item><name>P Krack</name>
</json:item>
<json:item><name>C Tilikete</name>
</json:item>
<json:item><name>D Pelisson</name>
</json:item>
<json:item><name>A Vighetto</name>
</json:item>
<json:item><name>AL Benabid</name>
</json:item>
</author>
<host><volume>19</volume>
<pages><first>277</first>
</pages>
<issue>Suppl. 9</issue>
<author></author>
<title>Mov Disord</title>
</host>
<title>What is the role of the subthalamic nucleus in gaze orientation?</title>
</json:item>
<json:item><author><json:item><name>P Sauleau</name>
</json:item>
<json:item><name>C Tilikete</name>
</json:item>
<json:item><name>D Pelisson</name>
</json:item>
<json:item><name>V Alain</name>
</json:item>
<json:item><name>P Krack</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
</author>
<host><volume>19</volume>
<pages><first>277</first>
</pages>
<issue>Suppl. 9</issue>
<author></author>
<title>Mov Disord</title>
</host>
<title>Effects of deep brain stimulation of the subthalamic nucleus on oculocephalic movements in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>KM Heilman</name>
</json:item>
<json:item><name>RT Watson</name>
</json:item>
<json:item><name>E Valenstein</name>
</json:item>
</author>
<host><pages><last>336</last>
<first>279</first>
</pages>
<author></author>
<title>Clinical neuropsychology</title>
</host>
<title>Neglect and related disorders</title>
</json:item>
<json:item><author><json:item><name>KJ Meador</name>
</json:item>
<json:item><name>RT Watson</name>
</json:item>
<json:item><name>D Bowers</name>
</json:item>
<json:item><name>KM Heilman</name>
</json:item>
</author>
<host><volume>109</volume>
<pages><last>305</last>
<first>293</first>
</pages>
<issue>Pt. 2</issue>
<author></author>
<title>Brain</title>
</host>
<title>Hypometria with hemispatial and limb motor neglect</title>
</json:item>
</refBibs>
<genre><json:string>article</json:string>
</genre>
<host><volume>21</volume>
<publisherId><json:string>MDS</json:string>
</publisherId>
<pages><total>8</total>
<last>361</last>
<first>354</first>
</pages>
<issn><json:string>0885-3185</json:string>
</issn>
<issue>3</issue>
<subject><json:item><value>Research Article</value>
</json:item>
</subject>
<genre><json:string>journal</json:string>
</genre>
<language><json:string>unknown</json:string>
</language>
<eissn><json:string>1531-8257</json:string>
</eissn>
<title>Movement Disorders</title>
<doi><json:string>10.1002/(ISSN)1531-8257</json:string>
</doi>
</host>
<categories><wos><json:string>science</json:string>
<json:string>clinical neurology</json:string>
</wos>
<scienceMetrix><json:string>health sciences</json:string>
<json:string>clinical medicine</json:string>
<json:string>neurology & neurosurgery</json:string>
</scienceMetrix>
</categories>
<publicationDate>2006</publicationDate>
<copyrightDate>2006</copyrightDate>
<doi><json:string>10.1002/mds.20728</json:string>
</doi>
<id>2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5</id>
<score>0.1284209</score>
<fulltext><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/document/2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5/fulltext/pdf</uri>
</json:item>
<json:item><extension>zip</extension>
<original>false</original>
<mimetype>application/zip</mimetype>
<uri>https://api.istex.fr/document/2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5/fulltext/zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/document/2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Subthalamic nucleus influences spatial orientation in extrapersonal space</title>
</titleStmt>
<publicationStmt><authority>ISTEX</authority>
<publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<availability><p>Copyright © 2005 Movement Disorder Society</p>
</availability>
<date>2006</date>
</publicationStmt>
<sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Subthalamic nucleus influences spatial orientation in extrapersonal space</title>
<author xml:id="author-1"><persName><forename type="first">Karsten</forename>
<surname>Witt</surname>
</persName>
<roleName type="degree">MD</roleName>
<affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</affiliation>
</author>
<author xml:id="author-2"><persName><forename type="first">Florian</forename>
<surname>Kopper</surname>
</persName>
<roleName type="degree">MD</roleName>
<affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</affiliation>
</author>
<author xml:id="author-3"><persName><forename type="first">Günther</forename>
<surname>Deuschl</surname>
</persName>
<roleName type="degree">MD</roleName>
<affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</affiliation>
<affiliation>Department of Neurology, University Schleswig‐Holstein, Campus Kiel, Schittenhelmstrasse 10, D‐24105 Kiel, Germany</affiliation>
</author>
<author xml:id="author-4"><persName><forename type="first">Paul</forename>
<surname>Krack</surname>
</persName>
<roleName type="degree">MD</roleName>
<affiliation>Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</affiliation>
</author>
</analytic>
<monogr><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="pISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<idno type="DOI">10.1002/(ISSN)1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2006-03"></date>
<biblScope unit="volume">21</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="354">354</biblScope>
<biblScope unit="page" to="361">361</biblScope>
</imprint>
</monogr>
<idno type="istex">2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5</idno>
<idno type="DOI">10.1002/mds.20728</idno>
<idno type="ArticleID">MDS20728</idno>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><creation><date>2006</date>
</creation>
<langUsage><language ident="en">en</language>
</langUsage>
<abstract xml:lang="en"><p>While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extrapersonal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of L‐dopa. Patients were tested in a pseudorandomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extrapersonal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemispatial and hemimotor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extrapersonal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere. © 2005 Movement Disorder Society</p>
</abstract>
<textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head>
<item><term>subthalamic nucleus</term>
</item>
<item><term>deep brain stimulation</term>
</item>
<item><term>spatial orientation</term>
</item>
<item><term>neglect</term>
</item>
</list>
</keywords>
</textClass>
<textClass><keywords scheme="Journal Subject"><list><head>article-category</head>
<item><term>Research Article</term>
</item>
</list>
</keywords>
</textClass>
</profileDesc>
<revisionDesc><change when="2005-01-30">Received</change>
<change when="2005-07-11">Registration</change>
<change when="2006-03">Published</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><extension>txt</extension>
<original>false</original>
<mimetype>text/plain</mimetype>
<uri>https://api.istex.fr/document/2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5/fulltext/txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration>
<istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName>
<publisherLoc>Hoboken</publisherLoc>
</publisherInfo>
<doi registered="yes">10.1002/(ISSN)1531-8257</doi>
<issn type="print">0885-3185</issn>
<issn type="electronic">1531-8257</issn>
<idGroup><id type="product" value="MDS"></id>
</idGroup>
<titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title>
<title type="short">Mov. Disord.</title>
</titleGroup>
</publicationMeta>
<publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/mds.v21:3</doi>
<numberingGroup><numbering type="journalVolume" number="21">21</numbering>
<numbering type="journalIssue">3</numbering>
</numberingGroup>
<coverDate startDate="2006-03">March 2006</coverDate>
</publicationMeta>
<publicationMeta level="unit" type="article" position="110" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.20728</doi>
<idGroup><id type="unit" value="MDS20728"></id>
</idGroup>
<countGroup><count type="pageTotal" number="8"></count>
</countGroup>
<titleGroup><title type="articleCategory">Research Article</title>
<title type="tocHeading1">Research Articles</title>
</titleGroup>
<copyright ownership="thirdParty">Copyright © 2005 Movement Disorder Society</copyright>
<eventGroup><event type="manuscriptReceived" date="2005-01-30"></event>
<event type="manuscriptRevised" date="2005-05-26"></event>
<event type="manuscriptAccepted" date="2005-07-11"></event>
<event type="firstOnline" date="2005-10-06"></event>
<event type="publishedOnlineFinalForm" date="2006-03-09"></event>
<event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2005-10-06"></event>
<event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.2.9 mode:FullText" date="2014-02-21"></event>
<event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.2.9 mode:FullText" date="2014-02-21"></event>
<event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event>
</eventGroup>
<numberingGroup><numbering type="pageFirst">354</numbering>
<numbering type="pageLast">361</numbering>
</numberingGroup>
<correspondenceTo>Department of Neurology, University Schleswig‐Holstein, Campus Kiel, Schittenhelmstrasse 10, D‐24105 Kiel, Germany</correspondenceTo>
<linkGroup><link type="toTypesetVersion" href="file:MDS.MDS20728.pdf"></link>
</linkGroup>
</publicationMeta>
<contentMeta><countGroup><count type="figureTotal" number="2"></count>
<count type="tableTotal" number="2"></count>
<count type="referenceTotal" number="63"></count>
<count type="wordTotal" number="5592"></count>
</countGroup>
<titleGroup><title type="main" xml:lang="en">Subthalamic nucleus influences spatial orientation in extrapersonal space</title>
<title type="short" xml:lang="en">Subthalamic Nucleus</title>
</titleGroup>
<creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Karsten</givenNames>
<familyName>Witt</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Florian</givenNames>
<familyName>Kopper</familyName>
<degrees>MD</degrees>
</personName>
</creator>
<creator xml:id="au3" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Günther</givenNames>
<familyName>Deuschl</familyName>
<degrees>MD</degrees>
</personName>
<contactDetails><email normalForm="g.deuschl@neurologie.uni-kiel.de">g.deuschl@neurologie.uni‐kiel.de</email>
</contactDetails>
</creator>
<creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Paul</givenNames>
<familyName>Krack</familyName>
<degrees>MD</degrees>
</personName>
</creator>
</creators>
<affiliationGroup><affiliation xml:id="af1" countryCode="DE" type="organization"><unparsedAffiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</unparsedAffiliation>
</affiliation>
<affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</unparsedAffiliation>
</affiliation>
</affiliationGroup>
<keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">subthalamic nucleus</keyword>
<keyword xml:id="kwd2">deep brain stimulation</keyword>
<keyword xml:id="kwd3">spatial orientation</keyword>
<keyword xml:id="kwd4">neglect</keyword>
</keywordGroup>
<abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title>
<p>While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extrapersonal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of <sc>L</sc>
‐dopa. Patients were tested in a pseudorandomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extrapersonal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemispatial and hemimotor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extrapersonal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere. © 2005 Movement Disorder Society</p>
</abstract>
</abstractGroup>
</contentMeta>
</header>
</component>
</istex:document>
</istex:metadataXml>
<mods version="3.6"><titleInfo lang="en"><title>Subthalamic nucleus influences spatial orientation in extrapersonal space</title>
</titleInfo>
<titleInfo type="abbreviated" lang="en"><title>Subthalamic Nucleus</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>Subthalamic nucleus influences spatial orientation in extrapersonal space</title>
</titleInfo>
<name type="personal"><namePart type="given">Karsten</namePart>
<namePart type="family">Witt</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Florian</namePart>
<namePart type="family">Kopper</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Günther</namePart>
<namePart type="family">Deuschl</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Neurology, University Schleswig‐Holstein, Kiel, Germany</affiliation>
<affiliation>Department of Neurology, University Schleswig‐Holstein, Campus Kiel, Schittenhelmstrasse 10, D‐24105 Kiel, Germany</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Paul</namePart>
<namePart type="family">Krack</namePart>
<namePart type="termsOfAddress">MD</namePart>
<affiliation>Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, Grenoble, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="article" displayLabel="article"></genre>
<originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<place><placeTerm type="text">Hoboken</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2006-03</dateIssued>
<dateCaptured encoding="w3cdtf">2005-01-30</dateCaptured>
<dateValid encoding="w3cdtf">2005-07-11</dateValid>
<copyrightDate encoding="w3cdtf">2006</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription><internetMediaType>text/html</internetMediaType>
<extent unit="figures">2</extent>
<extent unit="tables">2</extent>
<extent unit="references">63</extent>
<extent unit="words">5592</extent>
</physicalDescription>
<abstract lang="en">While the role of frontal and parietal cortex in spatial orientation has been studied extensively, the contribution of the basal ganglia and especially the subthalamic nucleus to spatial orientation remains less clear. Here we use subthalamic nucleus (STN) deep brain stimulation (DBS) in Parkinson's disease (PD) as a reversible model of functional lesioning to evaluate the influence of the STN in extrapersonal space orientation. To this end, 12 PD patients were examined 1 year after implantation of DBS electrodes in the STN after overnight withdrawal of L‐dopa. Patients were tested in a pseudorandomized order while both stimulators, the right only, the left only, or no stimulator, were switched on. Patients performed line bisection and a reaction time task responding to stimuli of the middle, the left, and the right extrapersonal space. A separate assessment of the right and left hand responding to visual stimuli in each hemispace made it possible to distinguish hemispatial and hemimotor impairments. No asymmetries in space orientation were found when both stimulators were switched OFF, when both stimulators were switched ON, and when only the right stimulator was switched ON. When only the left subthalamic stimulation was switched ON, the reaction times of both hands to visual stimuli in the left extrapersonal hemispace increased significantly and the line bisection test showed a significant orientation to the right. These results lead to the conclusion that the STN and its cortical projections influence the network involved in visuospatial orientation. These patterns of symptoms of neglect demonstrate the influence of the STN on the attentional system of the nondominant hemisphere. © 2005 Movement Disorder Society</abstract>
<subject lang="en"><genre>keywords</genre>
<topic>subthalamic nucleus</topic>
<topic>deep brain stimulation</topic>
<topic>spatial orientation</topic>
<topic>neglect</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Movement Disorders</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Mov. Disord.</title>
</titleInfo>
<genre type="journal">journal</genre>
<subject><genre>article-category</genre>
<topic>Research Article</topic>
</subject>
<identifier type="ISSN">0885-3185</identifier>
<identifier type="eISSN">1531-8257</identifier>
<identifier type="DOI">10.1002/(ISSN)1531-8257</identifier>
<identifier type="PublisherID">MDS</identifier>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>21</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>3</number>
</detail>
<extent unit="pages"><start>354</start>
<end>361</end>
<total>8</total>
</extent>
</part>
</relatedItem>
<identifier type="istex">2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5</identifier>
<identifier type="DOI">10.1002/mds.20728</identifier>
<identifier type="ArticleID">MDS20728</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Copyright © 2005 Movement Disorder Society</accessCondition>
<recordInfo><recordContentSource>WILEY</recordContentSource>
<recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin>
</recordInfo>
</mods>
</metadata>
<serie></serie>
</istex>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002015 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 002015 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Istex |étape= Corpus |type= RBID |clé= ISTEX:2DD632BE40AA6A082F4CA17E355BAD73CE73E2C5 |texte= Subthalamic nucleus influences spatial orientation in extrapersonal space }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |