Differential involvement of anterior and posterior cingulate cortices in spatial discriminative learning in a T-maze in mice
Identifieur interne : 001D56 ( Istex/Corpus ); précédent : 001D55; suivant : 001D57Differential involvement of anterior and posterior cingulate cortices in spatial discriminative learning in a T-maze in mice
Auteurs : Martine Meunier ; Robert Jaffard ; Claude DestradeSource :
- Behavioural Brain Research [ 0166-4328 ] ; 1991.
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- KwdEn :
Abstract
The contribution of the anterior and posterior cingulate cortical areas to spatial learning and memory was examined in mice using a behavioral paradigm based on a spatial discrimination task in a T-maze. Multiple injections of small amounts of ibotenic acid were used to produce fiber-sparing lesions of either the anterior (ACC) or the posterior (PCC) cingulate area. Mice with ACC lesions, though learning the initial acquisition and first reversal of the discrimination at about the normal rate, were impaired during the subsequent four reversal sessions. In contrast to control mice, they failed to improve their performance from the first to the last session. Nevertheless, when later required to repeatedly learn the same discrimination over several days (repetitive testing), animals with ACC lesions no longer exhibited any learning deficit. The converse pattern of results was found in mice with PCC lesions. These animals performed much more poorly than control animals during the acquisition and first reversal of the discrimination, but displayed remarkable improvement over the subsequent four reversal sessions, gradually overcoming their initial impairment. However, when later submitted to repetitive testing, these animals again showed a substantial learning deficit. Neither ACC nor PCC cingulate lesions significantly affected the animals' retention capacities as measured by single test-trials over a 24-h interval. Yet, mice with PCC lesions were retarded in reversal learning after a long intersession interval (10 days), indicating that PCC, but not ACC, lesions did interfere with some long-term retention processes. These results imply that the ACC, as a part of the medial frontal cortex, may play a crucial role in temporally ordering a series of spatial responses, whereas the PCC seems to contribute to the formation and retention of each individual spatial response, probably by transmitting information from limbic structures such as the anterior thalamus and hippocampal formation to posterior neocortical association areas.
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DOI: 10.1016/S0166-4328(05)80018-X
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<front><div type="abstract" xml:lang="en">The contribution of the anterior and posterior cingulate cortical areas to spatial learning and memory was examined in mice using a behavioral paradigm based on a spatial discrimination task in a T-maze. Multiple injections of small amounts of ibotenic acid were used to produce fiber-sparing lesions of either the anterior (ACC) or the posterior (PCC) cingulate area. Mice with ACC lesions, though learning the initial acquisition and first reversal of the discrimination at about the normal rate, were impaired during the subsequent four reversal sessions. In contrast to control mice, they failed to improve their performance from the first to the last session. Nevertheless, when later required to repeatedly learn the same discrimination over several days (repetitive testing), animals with ACC lesions no longer exhibited any learning deficit. The converse pattern of results was found in mice with PCC lesions. These animals performed much more poorly than control animals during the acquisition and first reversal of the discrimination, but displayed remarkable improvement over the subsequent four reversal sessions, gradually overcoming their initial impairment. However, when later submitted to repetitive testing, these animals again showed a substantial learning deficit. Neither ACC nor PCC cingulate lesions significantly affected the animals' retention capacities as measured by single test-trials over a 24-h interval. Yet, mice with PCC lesions were retarded in reversal learning after a long intersession interval (10 days), indicating that PCC, but not ACC, lesions did interfere with some long-term retention processes. These results imply that the ACC, as a part of the medial frontal cortex, may play a crucial role in temporally ordering a series of spatial responses, whereas the PCC seems to contribute to the formation and retention of each individual spatial response, probably by transmitting information from limbic structures such as the anterior thalamus and hippocampal formation to posterior neocortical association areas.</div>
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<sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Differential involvement of anterior and posterior cingulate cortices in spatial discriminative learning in a T-maze in mice</title>
<author xml:id="author-1"><persName><forename type="first">Martine</forename>
<surname>Meunier</surname>
</persName>
<note type="biography">Present address: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, U.S.A.</note>
<affiliation>Present address: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, U.S.A.</affiliation>
<affiliation>Laboratoire de Psychophysiologie, Université de Bordeaux I, URA CNRS 339, Talence (France)</affiliation>
</author>
<author xml:id="author-2"><persName><forename type="first">Robert</forename>
<surname>Jaffard</surname>
</persName>
<affiliation>Laboratoire de Psychophysiologie, Université de Bordeaux I, URA CNRS 339, Talence (France)</affiliation>
</author>
<author xml:id="author-3"><persName><forename type="first">Claude</forename>
<surname>Destrade</surname>
</persName>
<note type="correspondence"><p>Correspondence: C. Destrade, Laboratoire de Psychophysiologie,avenue des Facultés, 33405 Talence Cedex, France. Fax: (33) 56-37-07-27.</p>
</note>
<affiliation>Laboratoire de Psychophysiologie, Université de Bordeaux I, URA CNRS 339, Talence (France)</affiliation>
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<abstract xml:lang="en"><p>The contribution of the anterior and posterior cingulate cortical areas to spatial learning and memory was examined in mice using a behavioral paradigm based on a spatial discrimination task in a T-maze. Multiple injections of small amounts of ibotenic acid were used to produce fiber-sparing lesions of either the anterior (ACC) or the posterior (PCC) cingulate area. Mice with ACC lesions, though learning the initial acquisition and first reversal of the discrimination at about the normal rate, were impaired during the subsequent four reversal sessions. In contrast to control mice, they failed to improve their performance from the first to the last session. Nevertheless, when later required to repeatedly learn the same discrimination over several days (repetitive testing), animals with ACC lesions no longer exhibited any learning deficit. The converse pattern of results was found in mice with PCC lesions. These animals performed much more poorly than control animals during the acquisition and first reversal of the discrimination, but displayed remarkable improvement over the subsequent four reversal sessions, gradually overcoming their initial impairment. However, when later submitted to repetitive testing, these animals again showed a substantial learning deficit. Neither ACC nor PCC cingulate lesions significantly affected the animals' retention capacities as measured by single test-trials over a 24-h interval. Yet, mice with PCC lesions were retarded in reversal learning after a long intersession interval (10 days), indicating that PCC, but not ACC, lesions did interfere with some long-term retention processes. These results imply that the ACC, as a part of the medial frontal cortex, may play a crucial role in temporally ordering a series of spatial responses, whereas the PCC seems to contribute to the formation and retention of each individual spatial response, probably by transmitting information from limbic structures such as the anterior thalamus and hippocampal formation to posterior neocortical association areas.</p>
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<head><ce:title>Differential involvement of anterior and posterior cingulate cortices in spatial discriminative learning in a T-maze in mice</ce:title>
<ce:author-group><ce:author><ce:given-name>Martine</ce:given-name>
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<ce:author><ce:given-name>Claude</ce:given-name>
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</ce:affiliation>
<ce:correspondence id="cor1"><ce:label>**</ce:label>
<ce:text><ce:italic>Correspondence:</ce:italic>
C. Destrade, Laboratoire de Psychophysiologie,avenue des Facultés, 33405 Talence Cedex, France. Fax: (33) 56-37-07-27.</ce:text>
</ce:correspondence>
<ce:footnote id="fn1"><ce:label>*</ce:label>
<ce:note-para>Present address: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, U.S.A.</ce:note-para>
</ce:footnote>
</ce:author-group>
<ce:date-received day="11" month="2" year="1991"></ce:date-received>
<ce:date-revised day="18" month="3" year="1991"></ce:date-revised>
<ce:date-accepted day="5" month="4" year="1991"></ce:date-accepted>
<ce:abstract id="ab1" class="author" xml:lang="en"><ce:abstract-sec><ce:simple-para>The contribution of the anterior and posterior cingulate cortical areas to spatial learning and memory was examined in mice using a behavioral paradigm based on a spatial discrimination task in a T-maze. Multiple injections of small amounts of ibotenic acid were used to produce fiber-sparing lesions of either the anterior (ACC) or the posterior (PCC) cingulate area. Mice with ACC lesions, though learning the initial acquisition and first reversal of the discrimination at about the normal rate, were impaired during the subsequent four reversal sessions. In contrast to control mice, they failed to improve their performance from the first to the last session. Nevertheless, when later required to repeatedly learn the same discrimination over several days (repetitive testing), animals with ACC lesions no longer exhibited any learning deficit. The converse pattern of results was found in mice with PCC lesions. These animals performed much more poorly than control animals during the acquisition and first reversal of the discrimination, but displayed remarkable improvement over the subsequent four reversal sessions, gradually overcoming their initial impairment. However, when later submitted to repetitive testing, these animals again showed a substantial learning deficit. Neither ACC nor PCC cingulate lesions significantly affected the animals' retention capacities as measured by single test-trials over a 24-h interval. Yet, mice with PCC lesions were retarded in reversal learning after a long intersession interval (10 days), indicating that PCC, but not ACC, lesions did interfere with some long-term retention processes. These results imply that the ACC, as a part of the medial frontal cortex, may play a crucial role in temporally ordering a series of spatial responses, whereas the PCC seems to contribute to the formation and retention of each individual spatial response, probably by transmitting information from limbic structures such as the anterior thalamus and hippocampal formation to posterior neocortical association areas.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:keywords class="keyword" xml:lang="en"><ce:section-title>Key words</ce:section-title>
<ce:keyword><ce:text>Medial cortex</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Limbic system</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Neurotoxic lesion</ce:text>
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<ce:keyword><ce:text>Reversal learning</ce:text>
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<ce:keyword><ce:text>Spatial memory</ce:text>
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<ce:keyword><ce:text>T-maze</ce:text>
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<ce:keyword><ce:text>Rodent</ce:text>
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<mods version="3.6"><titleInfo lang="en"><title>Differential involvement of anterior and posterior cingulate cortices in spatial discriminative learning in a T-maze in mice</title>
</titleInfo>
<titleInfo type="alternative" lang="en" contentType="CDATA"><title>Differential involvement of anterior and posterior cingulate cortices in spatial discriminative learning in a T-maze in mice</title>
</titleInfo>
<name type="personal"><namePart type="given">Martine</namePart>
<namePart type="family">Meunier</namePart>
<affiliation>Laboratoire de Psychophysiologie, Université de Bordeaux I, URA CNRS 339, Talence (France)</affiliation>
<description>Present address: Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD, U.S.A.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Robert</namePart>
<namePart type="family">Jaffard</namePart>
<affiliation>Laboratoire de Psychophysiologie, Université de Bordeaux I, URA CNRS 339, Talence (France)</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Claude</namePart>
<namePart type="family">Destrade</namePart>
<affiliation>Laboratoire de Psychophysiologie, Université de Bordeaux I, URA CNRS 339, Talence (France)</affiliation>
<description>Correspondence: C. Destrade, Laboratoire de Psychophysiologie,avenue des Facultés, 33405 Talence Cedex, France. Fax: (33) 56-37-07-27.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
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<typeOfResource>text</typeOfResource>
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<dateIssued encoding="w3cdtf">1991</dateIssued>
<dateModified encoding="w3cdtf">1991-03-18</dateModified>
<copyrightDate encoding="w3cdtf">1991</copyrightDate>
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<abstract lang="en">The contribution of the anterior and posterior cingulate cortical areas to spatial learning and memory was examined in mice using a behavioral paradigm based on a spatial discrimination task in a T-maze. Multiple injections of small amounts of ibotenic acid were used to produce fiber-sparing lesions of either the anterior (ACC) or the posterior (PCC) cingulate area. Mice with ACC lesions, though learning the initial acquisition and first reversal of the discrimination at about the normal rate, were impaired during the subsequent four reversal sessions. In contrast to control mice, they failed to improve their performance from the first to the last session. Nevertheless, when later required to repeatedly learn the same discrimination over several days (repetitive testing), animals with ACC lesions no longer exhibited any learning deficit. The converse pattern of results was found in mice with PCC lesions. These animals performed much more poorly than control animals during the acquisition and first reversal of the discrimination, but displayed remarkable improvement over the subsequent four reversal sessions, gradually overcoming their initial impairment. However, when later submitted to repetitive testing, these animals again showed a substantial learning deficit. Neither ACC nor PCC cingulate lesions significantly affected the animals' retention capacities as measured by single test-trials over a 24-h interval. Yet, mice with PCC lesions were retarded in reversal learning after a long intersession interval (10 days), indicating that PCC, but not ACC, lesions did interfere with some long-term retention processes. These results imply that the ACC, as a part of the medial frontal cortex, may play a crucial role in temporally ordering a series of spatial responses, whereas the PCC seems to contribute to the formation and retention of each individual spatial response, probably by transmitting information from limbic structures such as the anterior thalamus and hippocampal formation to posterior neocortical association areas.</abstract>
<subject lang="en"><genre>Key words</genre>
<topic>Medial cortex</topic>
<topic>Limbic system</topic>
<topic>Neurotoxic lesion</topic>
<topic>Reversal learning</topic>
<topic>Spatial memory</topic>
<topic>T-maze</topic>
<topic>Rodent</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Behavioural Brain Research</title>
</titleInfo>
<titleInfo type="abbreviated"><title>BBR</title>
</titleInfo>
<genre type="journal">journal</genre>
<originInfo><dateIssued encoding="w3cdtf">19910829</dateIssued>
</originInfo>
<identifier type="ISSN">0166-4328</identifier>
<identifier type="PII">S0166-4328(05)X8015-9</identifier>
<part><date>19910829</date>
<detail type="volume"><number>44</number>
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<detail type="issue"><number>2</number>
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<extent unit="pages"><start>133</start>
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<identifier type="DOI">10.1016/S0166-4328(05)80018-X</identifier>
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<identifier type="ArticleID">0580018X</identifier>
<accessCondition type="use and reproduction" contentType="copyright">©1991 Elsevier Science Publishers B.V. All rights reserved</accessCondition>
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<recordOrigin>Elsevier Science Publishers B.V. All rights reserved, ©1991</recordOrigin>
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