Comparison of cerebral atrophy evaluated by MRI in Parkinson's disease and multiple system atrophy
Identifieur interne : 001B80 ( Istex/Corpus ); précédent : 001B79; suivant : 001B81Comparison of cerebral atrophy evaluated by MRI in Parkinson's disease and multiple system atrophy
Auteurs : F. Durif ; E. Albuisson ; B. Debilly ; J. F. Le Bas ; P. PollakSource :
- European Journal of Neurology [ 1351-5101 ] ; 1996-09.
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Abstract
Cerebral atrophy was evaluated in 31 patients with Parkinson's disease (PD) and 24 patients with clinically probable multiple system atrophy (MSA). Measurements of ventricular and brainstem areas, obtained from axial and sagittal MRI sections, were performed using a computer digitalizing system. Cortical and cerebellar atrophies were subjectively assessed. All measures were scored by one observer who was blind to the diagnosis (BD). Age, sex, levodopa dosage, baseline motor Parkinsonian disability (i.e. without levodopa treatment) and neuropsychological impairment were not significantly different between the two groups of patients. The total brainstem area (p < 0.001), the mesencephalon (p < 0.05) and the pons (p = 0.05) areas were significantly smaller in MSA as were the lobar (p < 0.05) and the vermian (p < 0.01) parts of the cerebellum. In the MSA group, significant correlations were observed between the brainstem area and items from the motor part of the Unified Parkinson's Disease Rating Scale (dysarthria, posture, arising from a chair), and between the cerebellar atrophy and the gait disturbance. A progressive discriminant analysis using radiologic variables correctly classified 79% of patients in their own diagnosis group with a significant difference (p = 0.01). From these results, it appears that MRI could help to differentiate MSA from PD, especially when MRI detects a severe infratentorial atrophy suggestive of MSA. However, brainstem and cerebellum atrophies are not sufficient criteria to differentiate MSA from PD because they lack both specificity and sensitivity.
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DOI: 10.1111/j.1468-1331.1996.tb00244.x
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ISTEX:97DB7DA0CD68CE737D88BF89689F2BB68CD27056Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of cerebral atrophy evaluated by MRI in Parkinson's disease and multiple system atrophy</title><author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F." last="Durif">F. Durif</name><affiliation><mods:affiliation>Department of Neurology, CHU Clermont‐Ferrand, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Clinique Neurologique, Hǒpital Fontmaure, avenue de Villars, 63407 Chamalières, France</mods:affiliation></affiliation></author><author><name sortKey="Albuisson, E" sort="Albuisson, E" uniqKey="Albuisson E" first="E." last="Albuisson">E. Albuisson</name><affiliation><mods:affiliation>Department of Biomathematics and Statistics, CHU Clermont‐Ferrand, France</mods:affiliation></affiliation></author><author><name sortKey="Debilly, B" sort="Debilly, B" uniqKey="Debilly B" first="B." last="Debilly">B. Debilly</name><affiliation><mods:affiliation>Department of Neurology, CHU Clermont‐Ferrand, France</mods:affiliation></affiliation></author><author><name sortKey="Le Bas, J F" sort="Le Bas, J F" uniqKey="Le Bas J" first="J. F." last="Le Bas">J. F. Le Bas</name><affiliation><mods:affiliation>Department of Magnetic Resonance Imaging, CHU Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><affiliation><mods:affiliation>Department of Neurology, CHU Grenoble, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:97DB7DA0CD68CE737D88BF89689F2BB68CD27056</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1111/j.1468-1331.1996.tb00244.x</idno><idno type="url">https://api.istex.fr/document/97DB7DA0CD68CE737D88BF89689F2BB68CD27056/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B80</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B80</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Comparison of cerebral atrophy evaluated by MRI in Parkinson's disease and multiple system atrophy</title><author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F." last="Durif">F. Durif</name><affiliation><mods:affiliation>Department of Neurology, CHU Clermont‐Ferrand, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Clinique Neurologique, Hǒpital Fontmaure, avenue de Villars, 63407 Chamalières, France</mods:affiliation></affiliation></author><author><name sortKey="Albuisson, E" sort="Albuisson, E" uniqKey="Albuisson E" first="E." last="Albuisson">E. Albuisson</name><affiliation><mods:affiliation>Department of Biomathematics and Statistics, CHU Clermont‐Ferrand, France</mods:affiliation></affiliation></author><author><name sortKey="Debilly, B" sort="Debilly, B" uniqKey="Debilly B" first="B." last="Debilly">B. Debilly</name><affiliation><mods:affiliation>Department of Neurology, CHU Clermont‐Ferrand, France</mods:affiliation></affiliation></author><author><name sortKey="Le Bas, J F" sort="Le Bas, J F" uniqKey="Le Bas J" first="J. F." last="Le Bas">J. F. Le Bas</name><affiliation><mods:affiliation>Department of Magnetic Resonance Imaging, CHU Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><affiliation><mods:affiliation>Department of Neurology, CHU Grenoble, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Neurology</title><idno type="ISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1996-09">1996-09</date><biblScope unit="volume">3</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="429">429</biblScope><biblScope unit="page" to="437">437</biblScope></imprint><idno type="ISSN">1351-5101</idno></series><idno type="istex">97DB7DA0CD68CE737D88BF89689F2BB68CD27056</idno><idno type="DOI">10.1111/j.1468-1331.1996.tb00244.x</idno><idno type="ArticleID">ENE244</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-5101</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebral atrophy</term><term>Discriminant analysis</term><term>Magnetic resonance imaging</term><term>Multiple system atrophy</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cerebral atrophy was evaluated in 31 patients with Parkinson's disease (PD) and 24 patients with clinically probable multiple system atrophy (MSA). Measurements of ventricular and brainstem areas, obtained from axial and sagittal MRI sections, were performed using a computer digitalizing system. Cortical and cerebellar atrophies were subjectively assessed. All measures were scored by one observer who was blind to the diagnosis (BD). Age, sex, levodopa dosage, baseline motor Parkinsonian disability (i.e. without levodopa treatment) and neuropsychological impairment were not significantly different between the two groups of patients. The total brainstem area (p < 0.001), the mesencephalon (p < 0.05) and the pons (p = 0.05) areas were significantly smaller in MSA as were the lobar (p < 0.05) and the vermian (p < 0.01) parts of the cerebellum. In the MSA group, significant correlations were observed between the brainstem area and items from the motor part of the Unified Parkinson's Disease Rating Scale (dysarthria, posture, arising from a chair), and between the cerebellar atrophy and the gait disturbance. A progressive discriminant analysis using radiologic variables correctly classified 79% of patients in their own diagnosis group with a significant difference (p = 0.01). From these results, it appears that MRI could help to differentiate MSA from PD, especially when MRI detects a severe infratentorial atrophy suggestive of MSA. However, brainstem and cerebellum atrophies are not sufficient criteria to differentiate MSA from PD because they lack both specificity and sensitivity.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>F. Durif</name><affiliations><json:string>Department of Neurology, CHU Clermont‐Ferrand, France</json:string><json:string>Clinique Neurologique, Hǒpital Fontmaure, avenue de Villars, 63407 Chamalières, France</json:string></affiliations></json:item><json:item><name>E. Albuisson</name><affiliations><json:string>Department of Biomathematics and Statistics, CHU Clermont‐Ferrand, France</json:string></affiliations></json:item><json:item><name>B. Debilly</name><affiliations><json:string>Department of Neurology, CHU Clermont‐Ferrand, France</json:string></affiliations></json:item><json:item><name>J.F. Le Bas</name><affiliations><json:string>Department of Magnetic Resonance Imaging, CHU Grenoble, France</json:string></affiliations></json:item><json:item><name>P. Pollak</name><affiliations><json:string>Department of Neurology, CHU Grenoble, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Multiple system atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Magnetic resonance imaging</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cerebral atrophy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Discriminant analysis</value></json:item></subject><articleId><json:string>ENE244</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Cerebral atrophy was evaluated in 31 patients with Parkinson's disease (PD) and 24 patients with clinically probable multiple system atrophy (MSA). Measurements of ventricular and brainstem areas, obtained from axial and sagittal MRI sections, were performed using a computer digitalizing system. Cortical and cerebellar atrophies were subjectively assessed. All measures were scored by one observer who was blind to the diagnosis (BD). Age, sex, levodopa dosage, baseline motor Parkinsonian disability (i.e. without levodopa treatment) and neuropsychological impairment were not significantly different between the two groups of patients. The total brainstem area (p > 0.001), the mesencephalon (p > 0.05) and the pons (p = 0.05) areas were significantly smaller in MSA as were the lobar (p > 0.05) and the vermian (p > 0.01) parts of the cerebellum. In the MSA group, significant correlations were observed between the brainstem area and items from the motor part of the Unified Parkinson's Disease Rating Scale (dysarthria, posture, arising from a chair), and between the cerebellar atrophy and the gait disturbance. A progressive discriminant analysis using radiologic variables correctly classified 79% of patients in their own diagnosis group with a significant difference (p = 0.01). From these results, it appears that MRI could help to differentiate MSA from PD, especially when MRI detects a severe infratentorial atrophy suggestive of MSA. 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Zimmerman</name></json:item><json:item><name>CA Fleming</name></json:item><json:item><name>BCP Lee</name></json:item><json:item><name>LA Saint‐Louis</name></json:item><json:item><name>MDF Deck</name></json:item></author><host><volume>146</volume><pages><last>450</last><first>443</first></pages><author></author><title>American Journal of Neuroradiology</title></host><title>Periventricular hyperintensity as seen by magnetic resonance: prevalence and significance</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>3</volume><publisherId><json:string>ENE</json:string></publisherId><pages><total>9</total><last>437</last><first>429</first></pages><issn><json:string>1351-5101</json:string></issn><issue>5</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1468-1331</json:string></eissn><title>European Journal of Neurology</title><doi><json:string>10.1111/(ISSN)1468-1331</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>1996</publicationDate><copyrightDate>1996</copyrightDate><doi><json:string>10.1111/j.1468-1331.1996.tb00244.x</json:string></doi><id>97DB7DA0CD68CE737D88BF89689F2BB68CD27056</id><score>0.21581993</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/97DB7DA0CD68CE737D88BF89689F2BB68CD27056/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/97DB7DA0CD68CE737D88BF89689F2BB68CD27056/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/97DB7DA0CD68CE737D88BF89689F2BB68CD27056/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Comparison of cerebral atrophy evaluated by MRI in Parkinson's disease and multiple system atrophy</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>1996 Lippincott Williams & Wilkins</p></availability><date>1996</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Comparison of cerebral atrophy evaluated by MRI in Parkinson's disease and multiple system atrophy</title><author xml:id="author-1"><persName><forename type="first">F.</forename><surname>Durif</surname></persName><affiliation>Department of Neurology, CHU Clermont‐Ferrand, France</affiliation><affiliation>Clinique Neurologique, Hǒpital Fontmaure, avenue de Villars, 63407 Chamalières, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">E.</forename><surname>Albuisson</surname></persName><affiliation>Department of Biomathematics and Statistics, CHU Clermont‐Ferrand, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">B.</forename><surname>Debilly</surname></persName><affiliation>Department of Neurology, CHU Clermont‐Ferrand, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">J.F.</forename><surname>Le Bas</surname></persName><affiliation>Department of Magnetic Resonance Imaging, CHU Grenoble, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">P.</forename><surname>Pollak</surname></persName><affiliation>Department of Neurology, CHU Grenoble, France</affiliation></author></analytic><monogr><title level="j">European Journal of Neurology</title><idno type="pISSN">1351-5101</idno><idno type="eISSN">1468-1331</idno><idno type="DOI">10.1111/(ISSN)1468-1331</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1996-09"></date><biblScope unit="volume">3</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="429">429</biblScope><biblScope unit="page" to="437">437</biblScope></imprint></monogr><idno type="istex">97DB7DA0CD68CE737D88BF89689F2BB68CD27056</idno><idno type="DOI">10.1111/j.1468-1331.1996.tb00244.x</idno><idno type="ArticleID">ENE244</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Cerebral atrophy was evaluated in 31 patients with Parkinson's disease (PD) and 24 patients with clinically probable multiple system atrophy (MSA). Measurements of ventricular and brainstem areas, obtained from axial and sagittal MRI sections, were performed using a computer digitalizing system. Cortical and cerebellar atrophies were subjectively assessed. All measures were scored by one observer who was blind to the diagnosis (BD). Age, sex, levodopa dosage, baseline motor Parkinsonian disability (i.e. without levodopa treatment) and neuropsychological impairment were not significantly different between the two groups of patients. The total brainstem area (p < 0.001), the mesencephalon (p < 0.05) and the pons (p = 0.05) areas were significantly smaller in MSA as were the lobar (p < 0.05) and the vermian (p < 0.01) parts of the cerebellum. In the MSA group, significant correlations were observed between the brainstem area and items from the motor part of the Unified Parkinson's Disease Rating Scale (dysarthria, posture, arising from a chair), and between the cerebellar atrophy and the gait disturbance. A progressive discriminant analysis using radiologic variables correctly classified 79% of patients in their own diagnosis group with a significant difference (p = 0.01). From these results, it appears that MRI could help to differentiate MSA from PD, especially when MRI detects a severe infratentorial atrophy suggestive of MSA. However, brainstem and cerebellum atrophies are not sufficient criteria to differentiate MSA from PD because they lack both specificity and sensitivity.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Parkinson's disease</term></item><item><term>Multiple system atrophy</term></item><item><term>Magnetic resonance imaging</term></item><item><term>Cerebral atrophy</term></item><item><term>Discriminant analysis</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/97DB7DA0CD68CE737D88BF89689F2BB68CD27056/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="09105"><doi origin="wiley">10.1111/ene.1996.3.issue-5</doi><numberingGroup><numbering type="journalVolume" number="3">3</numbering><numbering type="journalIssue" number="5">5</numbering></numberingGroup><coverDate startDate="1996-09">September 1996</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="3" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.1996.tb00244.x</doi><idGroup><id type="unit" value="ENE244"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="tocHeading1">Original Article</title></titleGroup><copyright>1996 Lippincott Williams & Wilkins</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.4.3 mode:FullText" date="2011-01-19"></event><event type="firstOnline" date="2011-01-20"></event><event type="publishedOnlineFinalForm" date="2011-01-20"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-17"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="429">429</numbering><numbering type="pageLast" number="437">437</numbering></numberingGroup><correspondenceTo>Clinique Neurologique, Hǒpital Fontmaure, avenue de Villars, 63407 Chamalières, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE244.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 19 January 1996; accepted 12 March 1996</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="37"></count><count type="linksCrossRef" number="6"></count></countGroup><titleGroup><title type="main">Comparison of cerebral atrophy evaluated by MRI in Parkinson's disease and multiple system atrophy</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>F.</givenNames><familyName>Durif</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>E.</givenNames><familyName>Albuisson</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>B.</givenNames><familyName>Debilly</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>J.F.</givenNames><familyNamePrefix>Le</familyNamePrefix><familyName>Bas</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>P.</givenNames><familyName>Pollak</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FR"><unparsedAffiliation>Department of Neurology, CHU Clermont‐Ferrand, France</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="FR"><unparsedAffiliation>Department of Biomathematics and Statistics, CHU Clermont‐Ferrand, France</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="FR"><unparsedAffiliation>Department of Magnetic Resonance Imaging, CHU Grenoble, France</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="FR"><unparsedAffiliation>Department of Neurology, CHU Grenoble, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">Parkinson's disease</keyword><keyword xml:id="k2">Multiple system atrophy</keyword><keyword xml:id="k3">Magnetic resonance imaging</keyword><keyword xml:id="k4">Cerebral atrophy</keyword><keyword xml:id="k5">Discriminant analysis</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Cerebral atrophy was evaluated in 31 patients with Parkinson's disease (PD) and 24 patients with clinically probable multiple system atrophy (MSA). Measurements of ventricular and brainstem areas, obtained from axial and sagittal MRI sections, were performed using a computer digitalizing system. Cortical and cerebellar atrophies were subjectively assessed. All measures were scored by one observer who was blind to the diagnosis (BD). Age, sex, levodopa dosage, baseline motor Parkinsonian disability (i.e. without levodopa treatment) and neuropsychological impairment were not significantly different between the two groups of patients. The total brainstem area (<i>p</i> < 0.001), the mesencephalon (<i>p</i> < 0.05) and the pons (<i>p</i> = 0.05) areas were significantly smaller in MSA as were the lobar (<i>p</i> < 0.05) and the vermian (<i>p</i> < 0.01) parts of the cerebellum. In the MSA group, significant correlations were observed between the brainstem area and items from the motor part of the Unified Parkinson's Disease Rating Scale (dysarthria, posture, arising from a chair), and between the cerebellar atrophy and the gait disturbance. A progressive discriminant analysis using radiologic variables correctly classified 79% of patients in their own diagnosis group with a significant difference (<i>p</i> = 0.01). From these results, it appears that MRI could help to differentiate MSA from PD, especially when MRI detects a severe infratentorial atrophy suggestive of MSA. However, brainstem and cerebellum atrophies are not sufficient criteria to differentiate MSA from PD because they lack both specificity and sensitivity.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Comparison of cerebral atrophy evaluated by MRI in Parkinson's disease and multiple system atrophy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Comparison of cerebral atrophy evaluated by MRI in Parkinson's disease and multiple system atrophy</title></titleInfo><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Durif</namePart><affiliation>Department of Neurology, CHU Clermont‐Ferrand, France</affiliation><affiliation>Clinique Neurologique, Hǒpital Fontmaure, avenue de Villars, 63407 Chamalières, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Albuisson</namePart><affiliation>Department of Biomathematics and Statistics, CHU Clermont‐Ferrand, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Debilly</namePart><affiliation>Department of Neurology, CHU Clermont‐Ferrand, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.F.</namePart><namePart type="family">Le Bas</namePart><affiliation>Department of Magnetic Resonance Imaging, CHU Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Pollak</namePart><affiliation>Department of Neurology, CHU Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1996-09</dateIssued><edition>Received 19 January 1996; accepted 12 March 1996</edition><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="references">37</extent></physicalDescription><abstract lang="en">Cerebral atrophy was evaluated in 31 patients with Parkinson's disease (PD) and 24 patients with clinically probable multiple system atrophy (MSA). Measurements of ventricular and brainstem areas, obtained from axial and sagittal MRI sections, were performed using a computer digitalizing system. Cortical and cerebellar atrophies were subjectively assessed. All measures were scored by one observer who was blind to the diagnosis (BD). Age, sex, levodopa dosage, baseline motor Parkinsonian disability (i.e. without levodopa treatment) and neuropsychological impairment were not significantly different between the two groups of patients. The total brainstem area (p < 0.001), the mesencephalon (p < 0.05) and the pons (p = 0.05) areas were significantly smaller in MSA as were the lobar (p < 0.05) and the vermian (p < 0.01) parts of the cerebellum. In the MSA group, significant correlations were observed between the brainstem area and items from the motor part of the Unified Parkinson's Disease Rating Scale (dysarthria, posture, arising from a chair), and between the cerebellar atrophy and the gait disturbance. A progressive discriminant analysis using radiologic variables correctly classified 79% of patients in their own diagnosis group with a significant difference (p = 0.01). From these results, it appears that MRI could help to differentiate MSA from PD, especially when MRI detects a severe infratentorial atrophy suggestive of MSA. However, brainstem and cerebellum atrophies are not sufficient criteria to differentiate MSA from PD because they lack both specificity and sensitivity.</abstract><subject lang="en"><genre>keywords</genre><topic>Parkinson's disease</topic><topic>Multiple system atrophy</topic><topic>Magnetic resonance imaging</topic><topic>Cerebral atrophy</topic><topic>Discriminant analysis</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>429</start><end>437</end><total>9</total></extent></part></relatedItem><identifier type="istex">97DB7DA0CD68CE737D88BF89689F2BB68CD27056</identifier><identifier type="DOI">10.1111/j.1468-1331.1996.tb00244.x</identifier><identifier type="ArticleID">ENE244</identifier><accessCondition type="use and reproduction" contentType="copyright">1996 Lippincott Williams & Wilkins</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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