Procedural learning and striatofrontal dysfunction in Parkinson's disease
Identifieur interne : 001B54 ( Istex/Corpus ); précédent : 001B53; suivant : 001B55Procedural learning and striatofrontal dysfunction in Parkinson's disease
Auteurs : Marie Sarazin ; Bernard Deweer ; Angela Merkl ; Natalia Von Poser ; Bernard Pillon ; Bruno DuboisSource :
- Movement Disorders [ 0885-3185 ] ; 2002-03.
English descriptors
- KwdEn :
Abstract
The neural basis of procedural learning remains controversial. We further analyzed procedural learning in nondemented patients with Parkinson's disease (PD) according to the specific demands of the tasks and the severity of striatal and frontal lobe dysfunction. In the first experiment, the performance of 20 nondemented PD patients and matched normal control subjects was studied in two procedural learning tasks, rotor pursuit and mirror reading, that differ in terms of motor and cognitive involvement. A second experiment further assessed the relationship between learning in mirror reading and executive functions in a new group of 15 nondemented PD patients. In rotor pursuit, PD patients significantly progressed across the first sessions, although their asymptotic performance was inferior to that of controls. In mirror reading, both experiments showed substantial learning in PD patients considered as a group. However, subsequent analyses allowed us to distinguish PD patients without executive dysfunction, whose learning was normal, from PD patients with executive dysfunction, whose learning was severely impaired. These results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task. © 2002 Movement Disorder Society.
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DOI: 10.1002/mds.10018
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ISTEX:65C6C06C7A3D7DF7919BDB290EE55475BC1FE9CBLe document en format XML
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France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM E 007 and Centre de Neuropsychologie, Fédération de Neurologie, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Deweer, Bernard" sort="Deweer, Bernard" uniqKey="Deweer B" first="Bernard" last="Deweer">Bernard Deweer</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Merkl, Angela" sort="Merkl, Angela" uniqKey="Merkl A" first="Angela" last="Merkl">Angela Merkl</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Von Poser, Natalia" sort="Von Poser, Natalia" uniqKey="Von Poser N" first="Natalia" last="Von Poser">Natalia Von Poser</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Pillon, Bernard" sort="Pillon, Bernard" uniqKey="Pillon B" first="Bernard" last="Pillon">Bernard Pillon</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name><affiliation><mods:affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-03">2002-03</date><biblScope unit="volume">17</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="265">265</biblScope><biblScope unit="page" to="273">273</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">65C6C06C7A3D7DF7919BDB290EE55475BC1FE9CB</idno><idno type="DOI">10.1002/mds.10018</idno><idno type="ArticleID">MDS10018</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>executive functions</term><term>mirror reading</term><term>procedural learning</term><term>striatofrontal circuits</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The neural basis of procedural learning remains controversial. We further analyzed procedural learning in nondemented patients with Parkinson's disease (PD) according to the specific demands of the tasks and the severity of striatal and frontal lobe dysfunction. In the first experiment, the performance of 20 nondemented PD patients and matched normal control subjects was studied in two procedural learning tasks, rotor pursuit and mirror reading, that differ in terms of motor and cognitive involvement. A second experiment further assessed the relationship between learning in mirror reading and executive functions in a new group of 15 nondemented PD patients. In rotor pursuit, PD patients significantly progressed across the first sessions, although their asymptotic performance was inferior to that of controls. In mirror reading, both experiments showed substantial learning in PD patients considered as a group. However, subsequent analyses allowed us to distinguish PD patients without executive dysfunction, whose learning was normal, from PD patients with executive dysfunction, whose learning was severely impaired. These results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task. © 2002 Movement Disorder Society.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Marie Sarazin MD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</json:string><json:string>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</json:string><json:string>INSERM E 007 and Centre de Neuropsychologie, Fédération de Neurologie, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France</json:string></affiliations></json:item><json:item><name>Bernard Deweer PhD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</json:string><json:string>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Angela Merkl</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</json:string><json:string>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Natalia Von Poser</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</json:string><json:string>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Bernard Pillon PhD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</json:string><json:string>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</json:string></affiliations></json:item><json:item><name>Bruno Dubois MD</name><affiliations><json:string>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</json:string><json:string>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>procedural learning</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mirror reading</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>striatofrontal circuits</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>executive functions</value></json:item></subject><articleId><json:string>MDS10018</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The neural basis of procedural learning remains controversial. We further analyzed procedural learning in nondemented patients with Parkinson's disease (PD) according to the specific demands of the tasks and the severity of striatal and frontal lobe dysfunction. In the first experiment, the performance of 20 nondemented PD patients and matched normal control subjects was studied in two procedural learning tasks, rotor pursuit and mirror reading, that differ in terms of motor and cognitive involvement. A second experiment further assessed the relationship between learning in mirror reading and executive functions in a new group of 15 nondemented PD patients. In rotor pursuit, PD patients significantly progressed across the first sessions, although their asymptotic performance was inferior to that of controls. In mirror reading, both experiments showed substantial learning in PD patients considered as a group. However, subsequent analyses allowed us to distinguish PD patients without executive dysfunction, whose learning was normal, from PD patients with executive dysfunction, whose learning was severely impaired. These results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task. © 2002 Movement Disorder Society.</abstract><qualityIndicators><score>7.828</score><pdfVersion>1.4</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1356</abstractCharCount><pdfWordCount>6426</pdfWordCount><pdfCharCount>39039</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>194</abstractWordCount></qualityIndicators><title>Procedural learning and striatofrontal dysfunction in Parkinson's disease</title><refBibs><json:item><author><json:item><name>DL Schacter</name></json:item></author><host><volume>13</volume><pages><last>518</last><first>501</first></pages><author></author><title>J Exp Psychol, Learn Mem Cogn</title></host><title>Implicit memory: history and current 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Article</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>2002</publicationDate><copyrightDate>2002</copyrightDate><doi><json:string>10.1002/mds.10018</json:string></doi><id>65C6C06C7A3D7DF7919BDB290EE55475BC1FE9CB</id><score>0.20985126</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/65C6C06C7A3D7DF7919BDB290EE55475BC1FE9CB/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/65C6C06C7A3D7DF7919BDB290EE55475BC1FE9CB/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/65C6C06C7A3D7DF7919BDB290EE55475BC1FE9CB/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Procedural learning and striatofrontal dysfunction in Parkinson's disease</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><availability><p>Copyright © 2002 Movement Disorders Society</p></availability><date>2002</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Procedural learning and striatofrontal dysfunction in Parkinson's disease</title><author xml:id="author-1"><persName><forename type="first">Marie</forename><surname>Sarazin</surname></persName><roleName type="degree">MD</roleName><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation><affiliation>INSERM E 007 and Centre de Neuropsychologie, Fédération de Neurologie, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Bernard</forename><surname>Deweer</surname></persName><roleName type="degree">PhD</roleName><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Angela</forename><surname>Merkl</surname></persName><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Natalia</forename><surname>Von Poser</surname></persName><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">Bernard</forename><surname>Pillon</surname></persName><roleName type="degree">PhD</roleName><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">Bruno</forename><surname>Dubois</surname></persName><roleName type="degree">MD</roleName><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-03"></date><biblScope unit="volume">17</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="265">265</biblScope><biblScope unit="page" to="273">273</biblScope></imprint></monogr><idno type="istex">65C6C06C7A3D7DF7919BDB290EE55475BC1FE9CB</idno><idno type="DOI">10.1002/mds.10018</idno><idno type="ArticleID">MDS10018</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2002</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The neural basis of procedural learning remains controversial. We further analyzed procedural learning in nondemented patients with Parkinson's disease (PD) according to the specific demands of the tasks and the severity of striatal and frontal lobe dysfunction. In the first experiment, the performance of 20 nondemented PD patients and matched normal control subjects was studied in two procedural learning tasks, rotor pursuit and mirror reading, that differ in terms of motor and cognitive involvement. A second experiment further assessed the relationship between learning in mirror reading and executive functions in a new group of 15 nondemented PD patients. In rotor pursuit, PD patients significantly progressed across the first sessions, although their asymptotic performance was inferior to that of controls. In mirror reading, both experiments showed substantial learning in PD patients considered as a group. However, subsequent analyses allowed us to distinguish PD patients without executive dysfunction, whose learning was normal, from PD patients with executive dysfunction, whose learning was severely impaired. These results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task. © 2002 Movement Disorder Society.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Parkinson's disease</term></item><item><term>procedural learning</term></item><item><term>mirror reading</term></item><item><term>striatofrontal circuits</term></item><item><term>executive functions</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2001-01-07">Received</change><change when="2001-08-07">Registration</change><change when="2002-03">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/65C6C06C7A3D7DF7919BDB290EE55475BC1FE9CB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>New York</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="subtitle">Official Journal of the Movement Disorder Society</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley" registered="yes">10.1002/mds.v17:2</doi><numberingGroup><numbering type="journalVolume" number="17">17</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2002-03">March/April 2002</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="60" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.10018</doi><idGroup><id type="unit" value="MDS10018"></id></idGroup><countGroup><count type="pageTotal" number="9"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2002 Movement Disorders Society</copyright><eventGroup><event type="manuscriptReceived" date="2001-01-07"></event><event type="manuscriptRevised" date="2001-07-31"></event><event type="manuscriptAccepted" date="2001-08-07"></event><event type="publishedOnlineEarlyUnpaginated" date="2002-01-29"></event><event type="firstOnline" date="2002-01-29"></event><event type="publishedOnlineFinalForm" date="2002-03-18"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText mathml2tex" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">265</numbering><numbering type="pageLast">273</numbering></numberingGroup><correspondenceTo>INSERM E 007 and Centre de Neuropsychologie, Fédération de Neurologie, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS10018.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="0"></count><count type="referenceTotal" number="62"></count><count type="wordTotal" number="6237"></count></countGroup><titleGroup><title type="main" xml:lang="en">Procedural learning and striatofrontal dysfunction in Parkinson's disease</title><title type="short" xml:lang="en">Procedural Learning in Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Marie</givenNames><familyName>Sarazin</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Bernard</givenNames><familyName>Deweer</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Angela</givenNames><familyName>Merkl</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Natalia</givenNames><familyName>Von Poser</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Bernard</givenNames><familyName>Pillon</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1 #af2"><personName><givenNames>Bruno</givenNames><familyName>Dubois</familyName><degrees>MD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="FR" type="organization"><unparsedAffiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">procedural learning</keyword><keyword xml:id="kwd3">mirror reading</keyword><keyword xml:id="kwd4">striatofrontal circuits</keyword><keyword xml:id="kwd5">executive functions</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The neural basis of procedural learning remains controversial. We further analyzed procedural learning in nondemented patients with Parkinson's disease (PD) according to the specific demands of the tasks and the severity of striatal and frontal lobe dysfunction. In the first experiment, the performance of 20 nondemented PD patients and matched normal control subjects was studied in two procedural learning tasks, rotor pursuit and mirror reading, that differ in terms of motor and cognitive involvement. A second experiment further assessed the relationship between learning in mirror reading and executive functions in a new group of 15 nondemented PD patients. In rotor pursuit, PD patients significantly progressed across the first sessions, although their asymptotic performance was inferior to that of controls. In mirror reading, both experiments showed substantial learning in PD patients considered as a group. However, subsequent analyses allowed us to distinguish PD patients without executive dysfunction, whose learning was normal, from PD patients with executive dysfunction, whose learning was severely impaired. These results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task. © 2002 Movement Disorder Society.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Procedural learning and striatofrontal dysfunction in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Procedural Learning in Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Procedural learning and striatofrontal dysfunction in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Marie</namePart><namePart type="family">Sarazin</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation><affiliation>INSERM E 007 and Centre de Neuropsychologie, Fédération de Neurologie, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013 Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernard</namePart><namePart type="family">Deweer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Angela</namePart><namePart type="family">Merkl</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Natalia</namePart><namePart type="family">Von Poser</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bernard</namePart><namePart type="family">Pillon</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bruno</namePart><namePart type="family">Dubois</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Institut National de la Santé et de la Recherche Médicale E 007, Paris, France</affiliation><affiliation>Fédération de Neurologie, Hôpital de la Salpêtrière, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2002-03</dateIssued><dateCaptured encoding="w3cdtf">2001-01-07</dateCaptured><dateValid encoding="w3cdtf">2001-08-07</dateValid><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="references">62</extent><extent unit="words">6237</extent></physicalDescription><abstract lang="en">The neural basis of procedural learning remains controversial. We further analyzed procedural learning in nondemented patients with Parkinson's disease (PD) according to the specific demands of the tasks and the severity of striatal and frontal lobe dysfunction. In the first experiment, the performance of 20 nondemented PD patients and matched normal control subjects was studied in two procedural learning tasks, rotor pursuit and mirror reading, that differ in terms of motor and cognitive involvement. A second experiment further assessed the relationship between learning in mirror reading and executive functions in a new group of 15 nondemented PD patients. In rotor pursuit, PD patients significantly progressed across the first sessions, although their asymptotic performance was inferior to that of controls. In mirror reading, both experiments showed substantial learning in PD patients considered as a group. However, subsequent analyses allowed us to distinguish PD patients without executive dysfunction, whose learning was normal, from PD patients with executive dysfunction, whose learning was severely impaired. These results confirm the involvement of striatofrontal circuits in procedural learning and indicate that the intervention of the frontal network may depend on the characteristics of the task. © 2002 Movement Disorder Society.</abstract><subject lang="en"><genre>keywords</genre><topic>Parkinson's disease</topic><topic>procedural learning</topic><topic>mirror reading</topic><topic>striatofrontal circuits</topic><topic>executive functions</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>265</start><end>273</end><total>9</total></extent></part></relatedItem><identifier type="istex">65C6C06C7A3D7DF7919BDB290EE55475BC1FE9CB</identifier><identifier type="DOI">10.1002/mds.10018</identifier><identifier type="ArticleID">MDS10018</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2002 Movement Disorders Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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