Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivo
Identifieur interne : 001A12 ( Istex/Corpus ); précédent : 001A11; suivant : 001A13Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivo
Auteurs : Sandrine Daydé ; Montserrat Filella ; Guy BerthonSource :
- Journal of Inorganic Biochemistry [ 0162-0134 ] ; 1990.
Abstract
Following the discovery that specific health disorders affecting patients with renal disease were due to their excessive body accumulation of aluminum, it was established that aluminum toxicity was mainly due to the ingestion of aluminum-containing phosphate binders. Suspicion of toxicity was thus cast on aluminum-containing antacids, and subsequent tests held on healthy subjects did reveal that aluminum hydroxide gels were also potential oral sources of aluminum, especially in the presence of citric acid. Nevertheless, authors of these tests concluded that there was only marginal absorption of aluminum phosphate. In contrast with these clinical conclusions, it has recently been contended on theoretical grounds that aluminum phosphate represents a serious health hazard. To help elucidate this issue, this paper first deals with a quantitative investigation of aluminum-phosphate equilibria under physiological conditions. Then appropriate computer simulations based on corresponding results are used to assess the actual extent to which phosphate can influence aluminum bioavailability. These simulations confirm that aluminum phosphate is not expected to induce absorption of high amounts of aluminum when administered by itself. Nevertheless, this result may no longer apply in the presence of food, whose various acidic components are likely to modify the involved chemical equilibria. Moreover, it is shown that rising blood plasma phosphate levels should tend to increase aluminum tissue penetration and hence favor its potential toxicity.
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DOI: 10.1016/0162-0134(90)84016-I
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivo</title><author><name sortKey="Dayde, Sandrine" sort="Dayde, Sandrine" uniqKey="Dayde S" first="Sandrine" last="Daydé">Sandrine Daydé</name><affiliation><mods:affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</mods:affiliation></affiliation></author><author><name sortKey="Filella, Montserrat" sort="Filella, Montserrat" uniqKey="Filella M" first="Montserrat" last="Filella">Montserrat Filella</name><affiliation><mods:affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</mods:affiliation></affiliation></author><author><name sortKey="Berthon, Guy" sort="Berthon, Guy" uniqKey="Berthon G" first="Guy" last="Berthon">Guy Berthon</name><affiliation><mods:affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:6763026AC4CB9306D9BCAF0A540FA17460D85037</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1016/0162-0134(90)84016-I</idno><idno type="url">https://api.istex.fr/document/6763026AC4CB9306D9BCAF0A540FA17460D85037/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001A12</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivo</title><author><name sortKey="Dayde, Sandrine" sort="Dayde, Sandrine" uniqKey="Dayde S" first="Sandrine" last="Daydé">Sandrine Daydé</name><affiliation><mods:affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</mods:affiliation></affiliation></author><author><name sortKey="Filella, Montserrat" sort="Filella, Montserrat" uniqKey="Filella M" first="Montserrat" last="Filella">Montserrat Filella</name><affiliation><mods:affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</mods:affiliation></affiliation></author><author><name sortKey="Berthon, Guy" sort="Berthon, Guy" uniqKey="Berthon G" first="Guy" last="Berthon">Guy Berthon</name><affiliation><mods:affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Inorganic Biochemistry</title><title level="j" type="abbrev">JIB</title><idno type="ISSN">0162-0134</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="241">241</biblScope><biblScope unit="page" to="259">259</biblScope></imprint><idno type="ISSN">0162-0134</idno></series><idno type="istex">6763026AC4CB9306D9BCAF0A540FA17460D85037</idno><idno type="DOI">10.1016/0162-0134(90)84016-I</idno><idno type="PII">0162-0134(90)84016-I</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0162-0134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Following the discovery that specific health disorders affecting patients with renal disease were due to their excessive body accumulation of aluminum, it was established that aluminum toxicity was mainly due to the ingestion of aluminum-containing phosphate binders. Suspicion of toxicity was thus cast on aluminum-containing antacids, and subsequent tests held on healthy subjects did reveal that aluminum hydroxide gels were also potential oral sources of aluminum, especially in the presence of citric acid. Nevertheless, authors of these tests concluded that there was only marginal absorption of aluminum phosphate. In contrast with these clinical conclusions, it has recently been contended on theoretical grounds that aluminum phosphate represents a serious health hazard. To help elucidate this issue, this paper first deals with a quantitative investigation of aluminum-phosphate equilibria under physiological conditions. Then appropriate computer simulations based on corresponding results are used to assess the actual extent to which phosphate can influence aluminum bioavailability. These simulations confirm that aluminum phosphate is not expected to induce absorption of high amounts of aluminum when administered by itself. Nevertheless, this result may no longer apply in the presence of food, whose various acidic components are likely to modify the involved chemical equilibria. Moreover, it is shown that rising blood plasma phosphate levels should tend to increase aluminum tissue penetration and hence favor its potential toxicity.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Sandrine Daydé</name><affiliations><json:string>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</json:string></affiliations></json:item><json:item><name>Montserrat Filella</name><affiliations><json:string>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</json:string></affiliations></json:item><json:item><name>Guy Berthon</name><affiliations><json:string>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Following the discovery that specific health disorders affecting patients with renal disease were due to their excessive body accumulation of aluminum, it was established that aluminum toxicity was mainly due to the ingestion of aluminum-containing phosphate binders. Suspicion of toxicity was thus cast on aluminum-containing antacids, and subsequent tests held on healthy subjects did reveal that aluminum hydroxide gels were also potential oral sources of aluminum, especially in the presence of citric acid. Nevertheless, authors of these tests concluded that there was only marginal absorption of aluminum phosphate. In contrast with these clinical conclusions, it has recently been contended on theoretical grounds that aluminum phosphate represents a serious health hazard. To help elucidate this issue, this paper first deals with a quantitative investigation of aluminum-phosphate equilibria under physiological conditions. Then appropriate computer simulations based on corresponding results are used to assess the actual extent to which phosphate can influence aluminum bioavailability. These simulations confirm that aluminum phosphate is not expected to induce absorption of high amounts of aluminum when administered by itself. Nevertheless, this result may no longer apply in the presence of food, whose various acidic components are likely to modify the involved chemical equilibria. Moreover, it is shown that rising blood plasma phosphate levels should tend to increase aluminum tissue penetration and hence favor its potential toxicity.</abstract><qualityIndicators><score>7.628</score><pdfVersion>1.2</pdfVersion><pdfPageSize>468 x 756 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1555</abstractCharCount><pdfWordCount>7308</pdfWordCount><pdfCharCount>43969</pdfCharCount><pdfPageCount>19</pdfPageCount><abstractWordCount>219</abstractWordCount></qualityIndicators><title>Aluminum speciation studies in biological fluids. Part 3. 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Ser. 93</title></serie><host><volume>38</volume><pii><json:string>S0162-0134(00)X0188-2</json:string></pii><pages><last>259</last><first>241</first></pages><issn><json:string>0162-0134</json:string></issn><issue>3</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Journal of Inorganic Biochemistry</title><publicationDate>1990</publicationDate></host><categories><wos><json:string>science</json:string><json:string>chemistry, inorganic & nuclear</json:string><json:string>biochemistry & molecular biology</json:string></wos><scienceMetrix><json:string>natural sciences</json:string><json:string>chemistry</json:string><json:string>inorganic & nuclear chemistry</json:string></scienceMetrix></categories><publicationDate>1990</publicationDate><copyrightDate>1990</copyrightDate><doi><json:string>10.1016/0162-0134(90)84016-I</json:string></doi><id>6763026AC4CB9306D9BCAF0A540FA17460D85037</id><score>0.16159391</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/6763026AC4CB9306D9BCAF0A540FA17460D85037/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/6763026AC4CB9306D9BCAF0A540FA17460D85037/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/6763026AC4CB9306D9BCAF0A540FA17460D85037/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivo</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1990</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivo</title><author xml:id="author-1"><persName><forename type="first">Sandrine</forename><surname>Daydé</surname></persName><affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</affiliation></author><author xml:id="author-2"><persName><forename type="first">Montserrat</forename><surname>Filella</surname></persName><affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</affiliation></author><author xml:id="author-3"><persName><forename type="first">Guy</forename><surname>Berthon</surname></persName><note type="biography">Address reprint requests to: Dr. Guy Berthon, INSERM U305, Equipe “Bioreactifs: Speciation et Biodisponibilité, Université Paul Sabatier, 38, rue des Trente-Six Ponts, 31400, Toulouse, France.</note><affiliation>Address reprint requests to: Dr. Guy Berthon, INSERM U305, Equipe “Bioreactifs: Speciation et Biodisponibilité, Université Paul Sabatier, 38, rue des Trente-Six Ponts, 31400, Toulouse, France.</affiliation><affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</affiliation></author></analytic><monogr><title level="j">Journal of Inorganic Biochemistry</title><title level="j" type="abbrev">JIB</title><idno type="pISSN">0162-0134</idno><idno type="PII">S0162-0134(00)X0188-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990"></date><biblScope unit="volume">38</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="241">241</biblScope><biblScope unit="page" to="259">259</biblScope></imprint></monogr><idno type="istex">6763026AC4CB9306D9BCAF0A540FA17460D85037</idno><idno type="DOI">10.1016/0162-0134(90)84016-I</idno><idno type="PII">0162-0134(90)84016-I</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Following the discovery that specific health disorders affecting patients with renal disease were due to their excessive body accumulation of aluminum, it was established that aluminum toxicity was mainly due to the ingestion of aluminum-containing phosphate binders. Suspicion of toxicity was thus cast on aluminum-containing antacids, and subsequent tests held on healthy subjects did reveal that aluminum hydroxide gels were also potential oral sources of aluminum, especially in the presence of citric acid. Nevertheless, authors of these tests concluded that there was only marginal absorption of aluminum phosphate. In contrast with these clinical conclusions, it has recently been contended on theoretical grounds that aluminum phosphate represents a serious health hazard. To help elucidate this issue, this paper first deals with a quantitative investigation of aluminum-phosphate equilibria under physiological conditions. Then appropriate computer simulations based on corresponding results are used to assess the actual extent to which phosphate can influence aluminum bioavailability. These simulations confirm that aluminum phosphate is not expected to induce absorption of high amounts of aluminum when administered by itself. Nevertheless, this result may no longer apply in the presence of food, whose various acidic components are likely to modify the involved chemical equilibria. Moreover, it is shown that rising blood plasma phosphate levels should tend to increase aluminum tissue penetration and hence favor its potential toxicity.</p></abstract></profileDesc><revisionDesc><change when="1990">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6763026AC4CB9306D9BCAF0A540FA17460D85037/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JIB</jid><aid>9084016I</aid><ce:pii>0162-0134(90)84016-I</ce:pii><ce:doi>10.1016/0162-0134(90)84016-I</ce:doi><ce:copyright type="unknown" year="1990"></ce:copyright></item-info><head><ce:title>Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivo</ce:title><ce:author-group><ce:author><ce:given-name>Sandrine</ce:given-name><ce:surname>Daydé</ce:surname></ce:author><ce:author><ce:given-name>Montserrat</ce:given-name><ce:surname>Filella</ce:surname></ce:author><ce:author><ce:given-name>Guy</ce:given-name><ce:surname>Berthon</ce:surname><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</ce:textfn></ce:affiliation><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>Address reprint requests to: Dr. Guy Berthon, INSERM U305, Equipe “Bioreactifs: Speciation et Biodisponibilité, Université Paul Sabatier, 38, rue des Trente-Six Ponts, 31400, Toulouse, France.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="19" month="6" year="1989"></ce:date-received><ce:date-accepted day="28" month="7" year="1989"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Following the discovery that specific health disorders affecting patients with renal disease were due to their excessive body accumulation of aluminum, it was established that aluminum toxicity was mainly due to the ingestion of aluminum-containing phosphate binders. Suspicion of toxicity was thus cast on aluminum-containing antacids, and subsequent tests held on healthy subjects did reveal that aluminum hydroxide gels were also potential oral sources of aluminum, especially in the presence of citric acid. Nevertheless, authors of these tests concluded that there was only marginal absorption of aluminum phosphate. In contrast with these clinical conclusions, it has recently been contended on theoretical grounds that aluminum phosphate represents a serious health hazard. To help elucidate this issue, this paper first deals with a quantitative investigation of aluminum-phosphate equilibria under physiological conditions. Then appropriate computer simulations based on corresponding results are used to assess the actual extent to which phosphate can influence aluminum bioavailability. These simulations confirm that aluminum phosphate is not expected to induce absorption of high amounts of aluminum when administered by itself. Nevertheless, this result may no longer apply in the presence of food, whose various acidic components are likely to modify the involved chemical equilibria. Moreover, it is shown that rising blood plasma phosphate levels should tend to increase aluminum tissue penetration and hence favor its potential toxicity.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivo</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Aluminum speciation studies in biological fluids. Part 3. Quantitative investigation of aluminum-phosphate complexes and assessment of their potential significance in vivo</title></titleInfo><name type="personal"><namePart type="given">Sandrine</namePart><namePart type="family">Daydé</namePart><affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Montserrat</namePart><namePart type="family">Filella</namePart><affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Guy</namePart><namePart type="family">Berthon</namePart><affiliation>INSERM U305, Equipe “Bioréactifs: Spéciation et Biodisponibilité,” Université Paul Sabotier, Toulouse France</affiliation><description>Address reprint requests to: Dr. Guy Berthon, INSERM U305, Equipe “Bioreactifs: Speciation et Biodisponibilité, Université Paul Sabatier, 38, rue des Trente-Six Ponts, 31400, Toulouse, France.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1990</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Following the discovery that specific health disorders affecting patients with renal disease were due to their excessive body accumulation of aluminum, it was established that aluminum toxicity was mainly due to the ingestion of aluminum-containing phosphate binders. Suspicion of toxicity was thus cast on aluminum-containing antacids, and subsequent tests held on healthy subjects did reveal that aluminum hydroxide gels were also potential oral sources of aluminum, especially in the presence of citric acid. Nevertheless, authors of these tests concluded that there was only marginal absorption of aluminum phosphate. In contrast with these clinical conclusions, it has recently been contended on theoretical grounds that aluminum phosphate represents a serious health hazard. To help elucidate this issue, this paper first deals with a quantitative investigation of aluminum-phosphate equilibria under physiological conditions. Then appropriate computer simulations based on corresponding results are used to assess the actual extent to which phosphate can influence aluminum bioavailability. These simulations confirm that aluminum phosphate is not expected to induce absorption of high amounts of aluminum when administered by itself. Nevertheless, this result may no longer apply in the presence of food, whose various acidic components are likely to modify the involved chemical equilibria. Moreover, it is shown that rising blood plasma phosphate levels should tend to increase aluminum tissue penetration and hence favor its potential toxicity.</abstract><relatedItem type="host"><titleInfo><title>Journal of Inorganic Biochemistry</title></titleInfo><titleInfo type="abbreviated"><title>JIB</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199003</dateIssued></originInfo><identifier type="ISSN">0162-0134</identifier><identifier type="PII">S0162-0134(00)X0188-2</identifier><part><date>199003</date><detail type="volume"><number>38</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>169</start><end>260</end></extent><extent unit="pages"><start>241</start><end>259</end></extent></part></relatedItem><identifier type="istex">6763026AC4CB9306D9BCAF0A540FA17460D85037</identifier><identifier type="DOI">10.1016/0162-0134(90)84016-I</identifier><identifier type="PII">0162-0134(90)84016-I</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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