Distribution and morphology of nigral axons projecting to the thalamus in primates
Identifieur interne : 001948 ( Istex/Corpus ); précédent : 001947; suivant : 001949Distribution and morphology of nigral axons projecting to the thalamus in primates
Auteurs : Chantal François ; Dominique Tande ; Jerome Yelnik ; Etienne C. HirschSource :
- Journal of Comparative Neurology [ 0021-9967 ] ; 2002-06-03.
English descriptors
Abstract
This study presents an analysis of the distribution and organization pattern of axons originating from the substantia nigra pars reticulata and projecting to the thalamus in monkeys. Biotin dextran amine was iontophoretically injected into different parts of the substantia nigra pars reticulata of monkeys (African green monkeys and macaques). In whatever part of the substantia nigra the injection was made, numerous axonal endings were found to be distributed within different thalamic regions: the ventral anterior nucleus and mainly its magnocellular part, the most ventromedial part of the ventral lateral nucleus, and the mediodorsal and parafascicular nuclei. Moreover, the nigrothalamic projection appeared to be topographically organized. Ten anterogradely labeled axons were reconstructed from serial sections. The axons terminated in three to six terminal fields per axon located in a relatively small portion of only one thalamic region. These terminal fields were variable in size and comprised 4–43 very thin, varicose branches. They consisted either of different axonal branches of the same axon or of different axons and covered 10–31 thalamic cell bodies. These findings demonstrate that the overall morphological organization of individual nigral axons is complex and allows single axons to influence thalamic neurons via a combination of divergent, convergent, and amplification processes. J. Comp. Neurol. 447:249–260, 2002. © 2002 Wiley‐Liss, Inc.
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DOI: 10.1002/cne.10227
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ISTEX:25BF01CEABE9F0A4924B7FC818D6EDDF0A57F326Le document en format XML
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Hirsch</name><affiliation><mods:affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:25BF01CEABE9F0A4924B7FC818D6EDDF0A57F326</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1002/cne.10227</idno><idno type="url">https://api.istex.fr/document/25BF01CEABE9F0A4924B7FC818D6EDDF0A57F326/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001948</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001948</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Distribution and morphology of nigral axons projecting to the thalamus in primates</title><author><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name><affiliation><mods:affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Tande, Dominique" sort="Tande, Dominique" uniqKey="Tande D" first="Dominique" last="Tande">Dominique Tande</name><affiliation><mods:affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jerome" last="Yelnik">Jerome Yelnik</name><affiliation><mods:affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C." last="Hirsch">Etienne C. Hirsch</name><affiliation><mods:affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Comparative Neurology</title><title level="j" type="abbrev">J. Comp. Neurol.</title><idno type="ISSN">0021-9967</idno><idno type="eISSN">1096-9861</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-06-03">2002-06-03</date><biblScope unit="volume">447</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="249">249</biblScope><biblScope unit="page" to="260">260</biblScope></imprint><idno type="ISSN">0021-9967</idno></series><idno type="istex">25BF01CEABE9F0A4924B7FC818D6EDDF0A57F326</idno><idno type="DOI">10.1002/cne.10227</idno><idno type="ArticleID">CNE10227</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0021-9967</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>basal ganglia</term><term>monkeys</term><term>parafascicular nucleus</term><term>tracing methods</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study presents an analysis of the distribution and organization pattern of axons originating from the substantia nigra pars reticulata and projecting to the thalamus in monkeys. Biotin dextran amine was iontophoretically injected into different parts of the substantia nigra pars reticulata of monkeys (African green monkeys and macaques). In whatever part of the substantia nigra the injection was made, numerous axonal endings were found to be distributed within different thalamic regions: the ventral anterior nucleus and mainly its magnocellular part, the most ventromedial part of the ventral lateral nucleus, and the mediodorsal and parafascicular nuclei. Moreover, the nigrothalamic projection appeared to be topographically organized. Ten anterogradely labeled axons were reconstructed from serial sections. The axons terminated in three to six terminal fields per axon located in a relatively small portion of only one thalamic region. These terminal fields were variable in size and comprised 4–43 very thin, varicose branches. They consisted either of different axonal branches of the same axon or of different axons and covered 10–31 thalamic cell bodies. These findings demonstrate that the overall morphological organization of individual nigral axons is complex and allows single axons to influence thalamic neurons via a combination of divergent, convergent, and amplification processes. J. Comp. Neurol. 447:249–260, 2002. © 2002 Wiley‐Liss, Inc.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Chantal François</name><affiliations><json:string>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</json:string><json:string>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013, Paris, France</json:string></affiliations></json:item><json:item><name>Dominique Tande</name><affiliations><json:string>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</json:string></affiliations></json:item><json:item><name>Jerome Yelnik</name><affiliations><json:string>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</json:string></affiliations></json:item><json:item><name>Etienne C. Hirsch</name><affiliations><json:string>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>monkeys</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tracing methods</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>basal ganglia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>parafascicular nucleus</value></json:item></subject><articleId><json:string>CNE10227</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>This study presents an analysis of the distribution and organization pattern of axons originating from the substantia nigra pars reticulata and projecting to the thalamus in monkeys. Biotin dextran amine was iontophoretically injected into different parts of the substantia nigra pars reticulata of monkeys (African green monkeys and macaques). In whatever part of the substantia nigra the injection was made, numerous axonal endings were found to be distributed within different thalamic regions: the ventral anterior nucleus and mainly its magnocellular part, the most ventromedial part of the ventral lateral nucleus, and the mediodorsal and parafascicular nuclei. Moreover, the nigrothalamic projection appeared to be topographically organized. Ten anterogradely labeled axons were reconstructed from serial sections. The axons terminated in three to six terminal fields per axon located in a relatively small portion of only one thalamic region. These terminal fields were variable in size and comprised 4–43 very thin, varicose branches. They consisted either of different axonal branches of the same axon or of different axons and covered 10–31 thalamic cell bodies. These findings demonstrate that the overall morphological organization of individual nigral axons is complex and allows single axons to influence thalamic neurons via a combination of divergent, convergent, and amplification processes. J. Comp. Neurol. 447:249–260, 2002. © 2002 Wiley‐Liss, Inc.</abstract><qualityIndicators><score>7.532</score><pdfVersion>1.2</pdfVersion><pdfPageSize>596 x 795 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1469</abstractCharCount><pdfWordCount>5732</pdfWordCount><pdfCharCount>34475</pdfCharCount><pdfPageCount>12</pdfPageCount><abstractWordCount>211</abstractWordCount></qualityIndicators><title>Distribution and morphology of nigral axons projecting to the thalamus in primates</title><refBibs><json:item><author><json:item><name>P Arecchi‐Bouchhioua</name></json:item><json:item><name>J Yelnik</name></json:item><json:item><name>C François</name></json:item><json:item><name>G Percheron</name></json:item><json:item><name>D Tandé</name></json:item></author><host><volume>7</volume><pages><last>984</last><first>981</first></pages><author></author><title>Neuroreport</title></host><title>3‐D tracing of biocytin‐labeled pallido‐thalamic axons in the 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Biotin dextran amine was iontophoretically injected into different parts of the substantia nigra pars reticulata of monkeys (African green monkeys and macaques). In whatever part of the substantia nigra the injection was made, numerous axonal endings were found to be distributed within different thalamic regions: the ventral anterior nucleus and mainly its magnocellular part, the most ventromedial part of the ventral lateral nucleus, and the mediodorsal and parafascicular nuclei. Moreover, the nigrothalamic projection appeared to be topographically organized. Ten anterogradely labeled axons were reconstructed from serial sections. The axons terminated in three to six terminal fields per axon located in a relatively small portion of only one thalamic region. These terminal fields were variable in size and comprised 4–43 very thin, varicose branches. They consisted either of different axonal branches of the same axon or of different axons and covered 10–31 thalamic cell bodies. These findings demonstrate that the overall morphological organization of individual nigral axons is complex and allows single axons to influence thalamic neurons via a combination of divergent, convergent, and amplification processes. J. Comp. 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Biotin dextran amine was iontophoretically injected into different parts of the substantia nigra pars reticulata of monkeys (African green monkeys and macaques). In whatever part of the substantia nigra the injection was made, numerous axonal endings were found to be distributed within different thalamic regions: the ventral anterior nucleus and mainly its magnocellular part, the most ventromedial part of the ventral lateral nucleus, and the mediodorsal and parafascicular nuclei. Moreover, the nigrothalamic projection appeared to be topographically organized. Ten anterogradely labeled axons were reconstructed from serial sections. The axons terminated in three to six terminal fields per axon located in a relatively small portion of only one thalamic region. These terminal fields were variable in size and comprised 4–43 very thin, varicose branches. They consisted either of different axonal branches of the same axon or of different axons and covered 10–31 thalamic cell bodies. These findings demonstrate that the overall morphological organization of individual nigral axons is complex and allows single axons to influence thalamic neurons via a combination of divergent, convergent, and amplification processes. J. Comp. Neurol. 447:249–260, 2002. © 2002 Wiley‐Liss, Inc.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Distribution and morphology of nigral axons projecting to the thalamus in primates</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Nigrothalamic Projection in Primates</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Distribution and morphology of nigral axons projecting to the thalamus in primates</title></titleInfo><name type="personal"><namePart type="given">Chantal</namePart><namePart type="family">François</namePart><affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</affiliation><affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 47 Boulevard de l'Hôpital, 75013, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dominique</namePart><namePart type="family">Tande</namePart><affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jerome</namePart><namePart type="family">Yelnik</namePart><affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Etienne C.</namePart><namePart type="family">Hirsch</namePart><affiliation>INSERM U289, Neurologie et Thérapeutique Expérimentale, Hôpital de la Salpêtrière, 75013, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">New York</placeTerm></place><dateIssued encoding="w3cdtf">2002-06-03</dateIssued><dateCaptured encoding="w3cdtf">2001-04-02</dateCaptured><dateValid encoding="w3cdtf">2002-01-25</dateValid><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">6</extent><extent unit="tables">1</extent><extent unit="references">46</extent><extent unit="words">6534</extent></physicalDescription><abstract lang="en">This study presents an analysis of the distribution and organization pattern of axons originating from the substantia nigra pars reticulata and projecting to the thalamus in monkeys. Biotin dextran amine was iontophoretically injected into different parts of the substantia nigra pars reticulata of monkeys (African green monkeys and macaques). In whatever part of the substantia nigra the injection was made, numerous axonal endings were found to be distributed within different thalamic regions: the ventral anterior nucleus and mainly its magnocellular part, the most ventromedial part of the ventral lateral nucleus, and the mediodorsal and parafascicular nuclei. Moreover, the nigrothalamic projection appeared to be topographically organized. Ten anterogradely labeled axons were reconstructed from serial sections. The axons terminated in three to six terminal fields per axon located in a relatively small portion of only one thalamic region. These terminal fields were variable in size and comprised 4–43 very thin, varicose branches. They consisted either of different axonal branches of the same axon or of different axons and covered 10–31 thalamic cell bodies. These findings demonstrate that the overall morphological organization of individual nigral axons is complex and allows single axons to influence thalamic neurons via a combination of divergent, convergent, and amplification processes. J. Comp. Neurol. 447:249–260, 2002. © 2002 Wiley‐Liss, Inc.</abstract><note type="funding">The National Parkinson Foundation, Miami, FL</note><subject lang="en"><genre>keywords</genre><topic>monkeys</topic><topic>tracing methods</topic><topic>basal ganglia</topic><topic>parafascicular nucleus</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Comparative Neurology</title></titleInfo><titleInfo type="abbreviated"><title>J. Comp. 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